46
BIT
RED
VI.
APPENDICES
47
Appendix
A:
Use
Patterns
Eligible
for
Reregistration
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Residential
and
public
access
premises
Soluble
Concentrate
1258­
1284
67071­
29
67071­
45
80285­
1
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
Laundry
Detergent
(
Residential)
Ready
to
Use
1258­
1289
49403­
14
67071­
22
67071­
23
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
Soluble
Concentrate
1258­
1284
67071­
22
67071­
23
67071­
29
67071­
45
80285­
1
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
Household
Cleaning
Products
Ready
to
Use
1258­
1289
70465­
3
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
48
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Soluble
Concentrate
1258­
1284
67071­
22
67071­
23
67071­
29
67071­
45
68575­
2
80285­
1
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
Car
Care
Products
Ready
to
Use
1258­
1289
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
Ready
to
Use
3997­
39
Used
in
Manufacturing
500
to
8,000
ppm
None
on
Label
House
Products
(
wax,
polishes,
inks)
Soluble
Concentrate
67071­
29
67071­
45
Used
in
Manufacturing
6
to
150
ppm
None
on
Label
Materials
preservatives
Ready
to
Use
5383­
107
Used
in
Manufacturing
0.05
to
0.5%
no
to
exceed
0.5%
by
weight
None
on
Label
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Coatings
Soluble
Concentrate
49403­
28
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05
to
0.5%
no
to
exceed
0.5%
by
weight
None
on
Label
49
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Soluble
Concentrate
67071­
22
67071­
23
67071­
24
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Building
Materials
Ready
to
Use
Solution
67071­
25
Used
in
Manufacturing
1
to
5
lbs
per
1,000
lbs
of
product
None
on
Label
Soluble
Concentrate
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Polymer
Latices
Ready
to
Use
Solutions
1258­
1260
1258­
1289
49403­
14
49403­
26
49403­
28
67071­
25
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
50
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Ready­
to­
Use
Solution
1258­
1255
1258­
1260
49403­
14
49403­
26
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Soluble
Concentrate
1258­
1256
1258­
1262
1529­
34
1529­
39
5383­
111
49403­
28
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Adhesives
(
Aqueous­
Based)
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Tackifiers
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
51
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Soluble
Concentrate
1258­
1248
1258­
1284
1258­
1289
49403­
28
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.10
to
0.30%
by
weight
None
on
Label
Ready
to
Use
5383­
107
39967­
39
67071­
25
70465­
3
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%;
alternatively,

500
to
4,000
ppm.
None
on
Label
Paints
and
Stains
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
52
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Soluble
Concentrate
1258­
1248
1258­
1256
1258­
1262
1258­
1284
1529­
34
1529­
39
5383­
111
49403­
27
49403­
28
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Aqueous
Industrial
Chemicals
(
Reagents/
Oil­
in­

Water
Emulsions/
Emulsion
Paints/
Photographic
Emulsion
Preservative/)
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Joint
Compounds
Soluble
Concentrate
1258­
1248
1258­
1262
1258­
1284
1529­
34
1529­
39
5383­
111
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
53
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Ready­
to­
Use
Solution
1258­
1255
1258­
1260
1258­
1289
5383­
107
39967­
39
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
alternatively,

2,000
to
4,000
ppm
None
on
Label
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Soluble
Concentrate
1258­
1248
1258­
1262
1258­
1284
1258­
1289
1529­
34
1529­
39
5383­
111
49403­
28
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Mineral
Slurries
(
Titanium
Dioxide)

Mineral
Slurries
(
Titanium
Dioxide)
Ready­
to­
Use
Solution
1258­
1255
1258­
1260
5383­
107
49403­
26
67071­
25
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
54
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
For
Use
in
Food
Contact
and
Non­
contact
Paper
Flowable
Concentrate
6836­
307
Used
in
Manufacturing
0.05%
to
0.3%
None
on
Label
Ink
(
fount
solution)
Soluble
Concentrate
1258­
1248
1258­
1284
5383­
111
49403­
28
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Ready
to
Use
1258­
1289
5383­
107
67071­
25
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Dyes
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
55
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Soluble
Concentrate
1258­
1248
1258­
1284
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Soluble
Concentrate
1258­
1248
1258­
1284
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Pigment
Dispersions
Ready
to
Use
1258­
1289
39967­
39
67071­
25
Used
in
Manufacturing
500
to
8,000
ppm
None
on
Label
Casein/
Rosin
Dispersions
Ready­
to­
Use
Solution
1258­
1255
1258­
1260
49403­
14
49403­
26
67071­
25
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
56
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Soluble
Concentrate
1529­
39
5383­
111
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Ready­
to­
Use
Solution
1258­
1255
1258­
1260
5383­
107
49403­
14
49403­
26
67071­
25
Used
in
Manufacturing
0.05%
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Textile
Spin­
Finish
Solutions
Textile
Spin­
Finish
Solutions
Soluble
Concentrate
1258­
1256
1258­
1262
1529­
34
1529­
39
5383­
111
49403­
28
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
57
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Ready­
to­
Use
Solution
1258­
1255
1258­
1260
1258­
1289
1529­
39
67071­
25
70465­
3
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Aqueous
Slurries
Aqueous
Slurries
Soluble
Concentrate
1258­
1262
1258­
1284
1529­
34
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
None
on
Label
Leather
Processing
Solutions
Ready­
to­
Use
Solution
1258­
1255
1258­
1289
67071­
25
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
58
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Leather
Processing
Solutions
Soluble
Concentrate
1258­
1262
1258­
1284
1529­
34
1529­
39
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Ready­
to­
Use
Solution
1258­
1255
1258­
1289
1529­
39
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
Used
in
Manufacturing
0.06
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Fresh
Animal
Hides
and
Skins
Soluble
Concentrate
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
2
to
48
lbs
per
1,000
lbs
of
skins
None
on
Label
Cutting
Oils
Soluble
Concentrate
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
59
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
1258­
1256
Soluble
Concentrate
1258­
1256
1258­
1284
1258­
1289
49403­
28
Used
in
Manufacturing
0.05
to
0.5%
by
weight
not
to
exceed
0.5%
None
on
Label
Flowable
Concentrates
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Paper
Coating
Compositions
Ready
to
Use
49403­
26
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Soluble
Concentrate
1258­
1284
5383­
111
67071­
22
67071­
23
67071­
24
67071­
29
67071­
45
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Adhesives
Adhesives
Ready
to
Use
1258­
1289
5383­
107
39967­
39
70465­
3
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
alternatively,

500
to
8,000
ppm
None
on
Label
60
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Ready
to
Use
5383­
107
39967­
39
70465­
3
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight.

Alternatively,

500
to
4,000
ppm
None
on
Label
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Metal
Working
Fluids
Soluble
Concentrate
5383­
111
49403­
28
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Ready
to
Use
5383­
107
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Thickeners
Soluble
Concentrate
5383­
111
49403­
28
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Plasters
Ready
to
Use
5383­
107
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Ready
to
Use
5383­
107
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Caulks
Soluble
Concentrate
5383­
111
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Ready
to
Use
5383­
107
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Sealants
Soluble
Concentrate
5383­
111
49403­
28
Used
in
Manufacturing
0.05%
to
0.5%
not
to
exceed
0.5%
by
weight
None
on
Label
Starch
Solutions
Soluble
Used
in
0.05%
to
0.5%
not
to
exceed
None
on
Label
61
Use
Site
Formulation
&
Product
Registration
Number
Method
of
Application
Application
Rate/
No.
of
Applications
Use
Limitations
Concentrate
5383­
111
Manufacturing
0.5%
by
weight
Surfactant
Solution
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Aqueous
Gels
Flowable
Concentrate
6836­
306
Used
in
Manufacturing
0.05%
to
1%
None
on
Label
Printing
Fluids
Ready
to
Use
39967­
39
Used
in
Manufacturing
10
to
2,000
ppm
None
on
Label
Oil
Recovery
Systems
Soluble
Concentrate
67071­
22
67071­
23
80285­
1
80285­
2
80285­
3
Used
in
Manufacturing
0.05
to
0.15%
based
on
fluid
weight
or
1.5
to
4.5%
based
on
polysaccharide
weight
None
on
Label
Drilling
Fluids
Read
to
Use
Solution
70465­
3
Used
in
Manufacturing
0.05
to
.025%
of
weight
of
finished
product
None
on
Label
Paperboard
Ready
to
Use
70465­
3
Used
in
Manufacturing
Solution0.05
to
0.25%
of
weight
of
finished
product
None
on
Label
Pulp
and
Paper
Mills
Systems
80285­
1
80285­
2
80285­
3
Shock
Dosing
recommended
5
to
18
ounces
for
each
ton
of
paper
produced
per
day
None
on
Label
62
Appendix
B.
Table
of
Generic
Data
Requirements
and
Studies
Used
to
Make
the
Reregistration
Decision
Guide
to
Appendix
B
Appendix
B
contains
listing
of
data
requirements
which
support
the
reregistration
for
active
ingredients
within
case
#
3026
(
BIT)
covered
by
this
RED.
It
contains
generic
data
requirements
that
apply
to
BIT
in
all
products,
including
data
requirements
for
which
a
"
typical
formulation"
is
the
test
substance.

The
data
table
is
organized
in
the
following
formats:

1.
Data
Requirement
(
Columns
1
&
2).
The
data
requirements
are
listed
in
the
order
in
which
they
appear
in
40
CFR
part
158.
The
reference
numbers
accompanying
each
test
refer
to
the
test
protocols
set
in
the
Pesticide
Assessment
Guidance,
which
are
available
from
the
National
technical
Information
Service,
5285
Port
Royal
Road,
Springfield,
VA
22161
(
703)
487­
4650.

2.
Guideline
Description
(
Column
3).
Identifies
the
guideline
type.

3.
Use
Pattern
(
Column
4).
This
column
indicates
the
standard
Antimicrobials
Division
use
patterns
categories
for
which
the
generic
(
not
product
specific)
data
requirements
apply.
The
number
designations
are
used
in
Appendix
A.

(
1)
Agricultural
premises
and
equipment
(
2)
Food
handling/
storage
establishments
premises
and
equipment
(
3)
Commercial,
institutional
and
industrial
premises
and
equipment
(
4)
Residential
and
public
access
premises
(
5)
Medical
premises
and
equipment
(
6)
Human
water
systems
(
7)
Materials
preservatives
(
8)
Industrial
processes
and
water
systems
(
9)
Antifouling
coatings
(
10)
Wood
preservatives
(
11)
Swimming
pools
(
12)
Aquatic
areas
63
4.
Bibliographic
Citation
(
Column
5).
If
the
Agency
has
acceptable
data
in
its
files,
this
column
list
the
identify
number
of
each
study.
This
normally
is
the
Master
Record
Identification
(
MRID)
number,
but
may
be
a
"
GS"
number
if
no
MRID
number
has
been
assigned.
Refer
to
the
Bibliography
appendix
for
a
complete
citation
of
the
study.

New
Guideline
Number
Old
Guideline
Number
Requirement
Use
Pattern
Bibliographic
Citation(
s)

PRODUCT
CHEMISTRY
830.1550
61­
1
Product
Identity
and
Composition
1­
12
44981602,
41710601
830.1600
61­
2
A
Description
of
Starting
Material
1­
12
44981602,

830.1620
61­
2
B
Description
of
Production
Process
1­
12
44981602
830.1670
61­
3
Discussion
of
Formation
of
Impurities
1­
12
44981602
830.1700
62­
1
Preliminary
Analysis
1­
12
44981602,
41710601
830.1750
62­
2
Certified
Limits
1­
12
44981602
830.1800
62­
3
Enforcement
of
Analytical
Method
1­
12
44981602
830.6302
63­
2
Color
1­
12
44981602,
41927501
830.6303
63­
3
Physical
State
1­
12
44981602,
41927501
830.7100
63­
18
Viscosity
1­
12
44981602
830.6314
63­
14
Oxidation/
Reduction
1­
12
44981602
830.6304
63­
4
Odor
1­
12
44981602,
41927501
830.6313
63­
13
Stability
1­
12
44981602
830.7000
63­
12
pH
1­
12
44981602,
41927501
830.7200
63­
5
Melting
Point
1­
12
44981602,
41927501
830.7300
63­
7
Density
1­
12
44981602,
41927501
64
New
Guideline
Number
Old
Guideline
Number
Requirement
Use
Pattern
Bibliographic
Citation(
s)

830.7550/

7560/
757
0
63­
11
Partition
Coefficient
1­
12
44981602,
41927501
830.6315
63­
15
Flammability
1­
12
44981602
830.6316
63­
16
Explodability
1­
12
44981602
830.6317
63­
17
Storage
Stability
1­
12
44981602
830.7370
63­
10
Dissociation
Constant
1­
12
44981602,
41927501
830.6319
63­
19
Miscibility
1­
12
44981602
830.7840/

7860
63­
8
Water
Solubility
1­
12
44981602,
41927501
830.7950
63­
9
Vapor
Pressure
1­
12
44981602,
41927501
830.6320
63­
20
Corrosion
Characteristics
1­
12
44981602
830.6321
63­
21
Dielectric
Breakdown
Voltage
1­
12
44981602
ECOLOGICAL
EFFECTS
850.2100
71­
1A
Avian
Acute
Oral
Toxicity
 

Quail/
Duck
1­
12
40991301
850.2200
71­
2A
Avian
Acute
Dietary
Toxicity
­
Quail
1­
12
41732001
850.1075
72­
1A/
C
Freshwater
Fish
Acute
Toxicity
­

Bluegill
or
Rainbow
Trout
1­
12
41687101,45534602
850.1010
72­
2A
Freshwater
Invertebrate
Acute
Toxicity
­
Daphnid
1­
12
42949001,45534601
65
New
Guideline
Number
Old
Guideline
Number
Requirement
Use
Pattern
Bibliographic
Citation(
s)

850.1075
72­
3A
Estuarine/
Marine
Toxicity
­
Fish
1­
12
42945001
850.1055
72­
3B
Estuarine/
Marine
Toxicity
­
Mollusk
1­
12
42952401
850.1035
72­
3C
Estuarine/
Marine
Toxicity
­
Shrimp
1­
12
42949002
TOXICOLOGY
870.1100
81­
1
Acute
Oral
Toxicity­

Rat
1­
12
42858101,
41022101
870.1200
81­
2
Acute
Dermal
Toxicity­
Rabbit/
Rat
1­
12
42858102,
41022102
870.1300
81­
3
Acute
Inhalation
Toxicity­
Rat
1­
12
42905103
870.2400
81­
4
Primary
Eye
Irritation­
Rabbit
1­
12
42905102
870.2500
81­
5
Primary
Skin
Irritation
1­
12
42905101
870.2600
81­
6
Dermal
Sensitization
1­
12
41750001,
42858103
870.3100
82­
1A
90­
Day
Feeding
­

Rodent
1­
12
41910401,
46346201
870.3150
82­
1B
90­
Day
Feeding
­

Non­
rodent
1­
12
42205701
870.3250
82­
3
90­
Day
Subchronic
Dermal
(
does
not
need
to
be
satisfied
if
870.3465
is
satisfied)
1­
12
45184601
66
New
Guideline
Number
Old
Guideline
Number
Requirement
Use
Pattern
Bibliographic
Citation(
s)

870.3465
82­
4
90­
day
Subchronic
Inhalation
Toxicity
Test­
Rat
(
does
not
need
to
be
satisfied
if
870.3250
is
satisfied)
1­
12
870.3700
83­
3A
Developmental
Toxicity
­
Rat
1­
12
42858104,
40961201,
43663008
870.3700
83­
3B
Developmental
Toxicity
­
Rabbit
1­
12
870.5265
84­
2A
Gene
Mutation
(
Ames
Test)
1­
12
42858105,
41022103
870.5300
84­
2B
Detection
of
Gene
Mutations
in
Somatic
Cells
(
CHO)
1­
12
42858105,
41022103
870.5395
84­
2
Mouse
Micronucleus
Assay
1­
12
41022104,
42858106
870.5550
84­
4
Other
Genotoxic
Effects
1­
12
42858107,
41022105
870.7485
85­
1
Metabolism
and
Pharmacokinetics
1­
12
45124901
875.2400/

2900
133­
3
Dermal
Passive
Dosimetry
Expo.
1­
12
Reserved
875.2500/

875.2900
133­
4
Inhalation
Passive
Dosimetry
Expo.
1­
12
Reserved
ENVIRONMENTAL
FATE
860.1100
171­
2
Chemical
Identity
1­
12
41710601
835.2120
161­
1
Hydrolysis
1­
12
41199101
67
Appendix
C.
Technical
Support
Documents
Additional
documentation
in
support
of
this
RED
is
maintained
in
the
OPP
docket,
located
in
room
119,
Crystal
Mall
#
2,
1801
Bell
St.,
Arlington,
VA
22202.
It
is
open
Monday
through
Friday,
excluding
legal
holidays,
from
8:
30
AM
to
4:
00
PM.

The
docket
initially
contained
preliminary
risk
assessments
and
related
documents
as
of
April
28,
2004.
Sixty
days
later
the
first
public
comment
period
closed.
The
EPA
then
considered
comments
and
revised
the
risk
assessments.

All
documents,
in
hard
copy
form,
may
be
viewed
in
the
OPP
docket
room
or
downloaded
or
viewed
via
the
Internet
at
the
following
site:
http://
www.
epa.
gov/
edockets
These
documents
include:

1.
1,2­
Benzisothiazolin­
3­
one
(
BIT)
Risk
Assessment,
July
12,
2005
2.
Dietary
Risk
Assessment
of
1,2­
Benzisothiazolin­
3­
one
(
BIT)
for
Reregistration
Eligibility
Decision
(
RED)
Document,
July
19,
2004
3.
Human
Exposure
Assessment
for
a
Reregistration
Submission
for
1,2­
Benzisothiazolin­
3­
one
(
BIT),
July
11,
2005
4.
Environmental
Fate
Science
Chapter
for
1,2­
Benzisothiazolin­
3­
one
(
BIT),
July
12,
2005
5.
Environmental
Risk
Assessment
and
Characterization
­
1,2­
Benzisothiazolin­
3­
one
(
BIT),
July
7,
2005
6.
1,2­
Benzisothiazolin­
3­
one
(
BIT)
Product
Chemistry
Chapter,
July
12,
2005
7.
1,2­
Benzisothizolin­
3­
one
(
BIT)­
Revised
Report
of
the
Antimicrobials
Division's
Toxicology
Endpoint
Selection
Committee
(
ADTC),
April
22,
2005
68
Appendix
D.
Citations
Considered
to
be
Part
of
the
Data
Base
Supporting
the
Reregistration
Decision
(
Bibliography)

830.1550
(
61­
1)
Chemical
Identity
MRID
Citation
Reference
134055
Imperial
Chemical
Industries
Ltd.
(
1970)
?
Chemistry
of
Proxel
PL|.
(
Compilation;
unpublished
study
received
Feb
23,
1971
under
0H2547;
CDL:
221692­
A)

40157601
Chevron
Chemical
Co.
(
1987)
Product
Identity
and
Composition:
Ana­
lysis
and
Certification
of
Product
Ingredients:
[
Ortho­
Mite
In­
secticidal
Soap]:
Laboratory
Project
ID:
8703674.
Unpublished
study.
15
p.

40691101
Troy
Chemical
Corp.
(
1988)
Product
Chemistry:
Troysan
Polyphase
RG­
1.
Unpublished
compilation
prepared
by
Troy
Chemical
Corp.
16
p.

40950601
Nipa
Laboratories,
Inc.
(
1988)
Product
Chemistry:
Nipacide
CR:
Nipa­
1988­
A.
Unpublished
study.
20
p.

40950701
Nipa
Laboratories,
Inc.
(
1988)
Product
Chemistry
(
Nipacide
X
(
17%
Solution):
NIPA­
1988­
A.
Unpublished
study.
18
p.

40994501
Feldberg,
B.
(
1988)
Proxel
DL:
Product
Chemistry.
Unpublished
study
prepared
by
ICI
Americas
Inc.
9
p.

41635401
Burt,
M.
(
1990)
Proxel
GXL
Industrial
Microbiostat:
Confidential
Statement
of
Formulation
and
MSDS
on
Inerts:
Lab
Project
Number:
10182­
30­
9­
6­
90.
Unpublished
study
prepared
by
ICI
Americas
Inc.
7
p.

41635501
Burt,
M.
(
1990)
Proxel
DL
Industrial
Microbiostat
Confidential
Statement
of
Formulation
and
MSDS
on
Inerts:
Lab
Project
Number:
182­
265­
9­
6­
90.
Unpublished
study
prepared
by
ICI
Americas
Inc.
27
p.

41635601
Burt,
M.
(
1990)
Proxel
BD
Industrial
Microbiocide
Confidential
Statement
of
Formulation
and
MSDS
on
Inerts:
Lab
Project
Number:
10182­
1­
9­
6­
90.
Unpublished
study
prepared
by
ICI
Americas
Inc.
26
p.

41710601
Evans,
K.
(
1990)
Proxel
Press
Paste:
Chemical
Characterisation
of
Material:
Representative
of
Huddersfield
Works
Manufacture:
Lab
Project
Number:
144.
Unpublished
study
prepared
by
ICI
Colours
and
Fine
Chemicals.
84
p.

41893901
Burt,
M.
(
1991)
Proxel
BD
Industrial
Microbiocide:
Lab
Project
Number:
10182­
1­
5­
16­
91.
Unpublished
study
prepared
by
ICI
Americas
Inc.
10
p.

41902701
Burt,
M.
(
1991)
Proxel
DL
Industrial
Microbiostat:
Lab
Project
Num­
ber:
69
10182­
265­
5­
16­
91.
Unpublished
study
prepared
by
ICI
Americas
Inc.
9
p.

41954401
Burt,
M.
(
1991)
Proxel
Press
Paste:
Confidential
Statement
of
Form­
ula
and
Certification
of
Limits:
Lab
Project
Number:
10182­
6­
91­
1.
Unpublished
study
prepared
by
ICI
Americas
Inc.
8
p.

42569801
Burt,
M.
(
1992)
Proxel
MX
Preservative:
Product
Chemistry:
Lab
Project
Number:
10182­
MX­
1.
Unpublished
study
prepared
by
ICI
Americas
Inc.
8
p.

42780201
Nipa
Laboratories,
Inc.
(
1993)
Product
Chemistry:
Product
Identity
and
Disclosure
of
Ingredients,
Description
of
Beginning
Materials
and
Manufacturing
Process
and
Discussion
of
Formation
of
Impurities
for
NIPA
BIT
Press
Paste.
Unpublished
study.
180
p.

42967101
Mahoney,
D.
(
1993)
End­
Use
Product
Chemistry
Data:
NUOSEPT
495
Preservative:
Lab
Project
Number:
LDR
93­
2712­
2501­
001.
Unpublished
study
prepared
by
Huls
America
Inc.
60
p.

43229801
Pierce,
J.
(
1994)
PARADYME
Preservative
Confidential
Statement
of
Formula:
Lab
Project
Number:
PARA­
4.
Unpublished
study
prepared
by
ZENECA
Inc.
8
p.

43489501
Burt,
M.
(
1994)
Proxel
BD
20:
Confidential
Statement
of
Formula:
Lab
Project
Number:
BD
20­
3.
Unpublished
study
prepared
by
Zeneca
Inc.
8
p.

43542901
Burt,
M.
(
1995)
Revised
PARADYME
Preservative:
Confidential
Statement
of
Formula:
Lab
Project
Number:
PARA­
4­
A.
Unpublished
study
prepared
by
Zeneca,
Inc.
8
p.

43586001
Burt,
M.
(
1995)
Purified
Proxel
Press
Paste
Confidential
Statement
of
Formula:
Lab
Project
Number:
P4­
2.
Unpublished
study
prepared
by
Zeneca,
Inc.
8
p.

43596001
Burt,
M.
(
1995)
PROXEL
XL
2:
Confidential
Statement
of
Formula:
Product
Identity
and
Disclosure
of
Ingredients:
Certification
of
Ingredient
Limits:
Lab
Project
Numbers:
PROJECT
XL
2­
3:
XL
2­
3.
Unpublished
study
prepared
by
Zeneca,
Inc.
8
p.

43607601
Berg,
C.
(
1995)
End­
Use
Product
Chemistry
Data:
BIT:
Final
Report:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
H
&
C
Prom
Kemi
ApS.
79
p.

43663001
PMC
Specialties
Group,
Inc.
(
1995)
Product
Composition
(
of
Xbinx).
Unpublished
study.
5
p.

43803901
Mahoney,
D.
(
1994)
End
Use
Product
Chemistry
Data:
Nuosept
495
Preservative:
Final
Report:
Lab
Project
Number:
LPP
94­
2712­
2501­
001.
Unpublished
study
prepared
by
Huls
America
Inc.
45
p.

43975302
Williams,
T.
(
1995)
Proxel
Press
Paste
Process
Change:
Characterisation
Study:
Lab
Project
Number:
306:
RD
012068B.
Unpublished
study
prepared
by
Zeneca
Specialties.
101
p.
70
44126301
Burgoyne,
S.
(
1996)
Product
Chemistry:
Nipacide
Bit
10:
1,2­
Benzisothiazoline
(
10%)
Solution:
Lab
Project
Number:
MOA004R:
MOA012B:
MOA014A.
Unpublished
study
prepared
by
Nipa
Hardwicke,
Inc.
20
p.

44211001
Williams,
T.
(
1996)
Proxel
Press
Paste­­
Bisamide
Process:
Characterisation
Study:
Lab
Project
Number:
604485:
RD
012396B.
Unpublished
study
prepared
by
Zeneca
Specialties.
86
p.

44211003
Burt,
M.
(
1997)
Proxel
Press
Paste
(
1,2­
Benzisothiazolin­
3­
one)
Confidential
Statement
of
Formula:
Lab
Project
Number:
P3/
12297­
2.
Unpublished
study
prepared
by
Zeneca
Biocides.
9
p.

44270701
Burt,
M.
(
1997)
Proxel
Press
Paste
(
1,2­
Benzisothiazolin­
3­
one)
Confidential
Statement
of
Formula:
Lab
Project
Number:
5197­
1.
Unpublished
study
prepared
by
Zeneca
Biocides.
9
p.

44726901
Burt,
M.
(
1998)
Proxel
TN
Preservative
Confidential
Statement
of
Formula:
Lab
Project
Number:
TN­
2.
Unpublished
study
prepared
by
Zeneca,
Inc.
8
p.

44981601
Coscia,
A.;
Rueb,
B.
(
1999)
Product
Identity
and
Composition
of
Acticide
BIT:
Lab
Project
Number:
9903­
BR­
61:
701763.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
186
p.

44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
p.

44982501
Coscia,
A.;
Rueb,
B.
(
1999)
Product
Identity
and
Composition
of
Acticide
B20:
Lab
Project
Number:
9904­
BR­
61.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
26
p.

44982502
Rub,
B.;
Coscia,
A.
(
1999)
Analysis
and
Certification
of
Product
Ingredients
in
Acticide
B20:
Lab
Project
Number:
9904­
BR­
62.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
20
p.

45009701
Rub,
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Coscia,
A.
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Analysis
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BIT:
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45026001
Subramaniam,
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(
1999)
End­
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Product
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Data
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Nuosept
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Unpublished
study
prepared
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Creanova,
Inc.
55
p.
{
OPPTS
830.1550,
830.1620,
830.1750,
830.1670,
830.1650}

45075601
Coscia,
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Rueb,
B.
(
2000)
Product
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45076001
Coscia,
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Product
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BW20:
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45076002
Rub,
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Analysis
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BR­
62.
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Gottlieb,
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Product
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Unpublished
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39
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.7100}

45100701
Gottlieb,
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(
2000)
Product
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Nipacide
CBX.
Unpublished
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Lewis
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Harrison,
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44
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{
OPPTS
860.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.1800,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.6317,
830.7100,
830.6320}

45116501
Coscia,
A.;
Rueb,
B.
(
2000)
Product
Identity
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Composition
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Acticide
B10:
Lab
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BR­
61.
Unpublished
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27
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45116502
Coscia,
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Analysis
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45179801
Blake,
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Proxel
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Lab
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Unpublished
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33
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{
OPPTS
830.6314
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45236801
Nye,
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Mergal
K10N:
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45358301
Burt,
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PROXEL
Ultra
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{
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830.1550,
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45389702
Bowhill,
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Purified
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{
OPPTS
830.1700,
830.6302,
830.6303,
830.6304,
830.6313,
830.6317,
830.7200,
830.7300,
830.1800,
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45410401
Troy
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{
OPPTS
830.1550,
830.1600,
830.1650,
830.1670,
830.1700,
830.1750,
830.1800,
830.6303,
830.6302,
830.6304,
830.7300,
830.7000,
830.6314,
830.6315,
830.6316,
830.6317,
830.7100,
830.6319,
830.6320,
830.6321}

45410402
Perkins,
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Berg,
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1,2­
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72
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OPPTS
830.1550,
830.1600,
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830.1670,
830.1750}

45444701
Coscia,
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Product
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45496301
Voemel,
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351
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{
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830.1800,
830.1550,
830.6303,
830.7100,
830.6314,
830.6315,
830.6317,
830.6320,
830.7000,
830.7300}

45515801
Berg,
C.
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2001)
1,2­
Benzisothiazolin­
3­
One
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Unpublished
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16
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{
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830.1550,
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830.1670,
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45553401
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31
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1700,
830.1750,
830.1800}

45553801
Berg,
C.
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2001)
1,2­
Benzisothiazolin­
3­
one
Product
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Lab
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{
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830.1550,
830.1600,
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830.1670,
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45686201
Vulcan,
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Vulcan,
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46565901
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Subramaniam,
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{
OPPTS
830.1550,
830.1620,
830.1750,
830.1670,
830.1650}

45075601
Coscia,
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Product
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Coscia,
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.6302,
830.6303,
830.6304,
830.7300,
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830.7100}

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Gottlieb,
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Lewis
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44
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{
OPPTS
860.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.1800,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.6317,
830.7100,
830.6320}

45116501
Coscia,
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(
2000)
Product
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B10:
Lab
Project
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BR­
61.
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Nye,
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45389701
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Ultra
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ULT­
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p.
{
OPPTS
830.1600
and
830.1620}

45410401
Troy
Corporation
(
2001)
Polyphase
663
Product
Chemistry
Data:
Lab
Project
Number:
TCC663REG2001A.
Unpublished
study
prepared
by
Troy
Analytical
76
Laboratory.
65
p.
{
OPPTS
830.1550,
830.1600,
830.1650,
830.1670,
830.1700,
830.1750,
830.1800,
830.6303,
830.6302,
830.6304,
830.7300,
830.7000,
830.6314,
830.6315,
830.6316,
830.6317,
830.7100,
830.6319,
830.6320,
830.6321}

45431303
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
One
Product
Identity
and
Composition:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
Prom
Chem
Ltd.
8
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45444701
Coscia,
A.
(
2000)
Product
Identity
and
Composition
of
Acticide
MBS:
Lab
Project
Number:
0010­
BR­
61.
Unpublished
study
prepared
by
Thor
GmbH.
22
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670}

45496301
Voemel,
R.
(
2001)
Product
Chemistry
Rocima
607,
End­
Use
Product:
Lab
Project
Number:
TR­
01­
023:
776834:
777587.
Unpublished
study
prepared
by
RCC
Ltd.
351
p.
{
OPPTS
830.1800,
830.1550,
830.6303,
830.7100,
830.6314,
830.6315,
830.6317,
830.6320,
830.7000,
830.7300}

45498301
Burt,
M.
(
2001)
PROXEL
Ultra
Technical­­
Manufacturing
Process
Addendum:
Lab
Project
Number:
ULT­
22.
Unpublished
study
prepared
by
Avecia
Inc.
11
p.
{
OPPTS
830.1600,
830.1620}

45515801
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
One
Product
Identity
and
Composition:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
Prom
Chem
Ltd.
16
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45553401
Tirendi,
C.
(
2001)
Product
Identity,
Composition
and
Analysis
of
Dantoserve:
Lab
Project
Number:
SP­
01054­
A.
Unpublished
study
prepared
by
Lonza,
Inc.
31
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1700,
830.1750,
830.1800}

45553801
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
one
Product
Identity
and
Composition:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
Prom
Chem
Ltd.
16
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45686201
Vulcan,
D.
(
2002)
Product
Chemistry:
Palene
710­
C:
Lab
Project
Number:
54736­
02.
Unpublished
study
prepared
by
Lockwood
Laboratories.
17
p.

45746201
Vulcan,
D.
(
2002)
Product
Chemistry:
Palene
710­
C:
Lab
Project
Number:
54736­
032.
Unpublished
study
prepared
by
Lockwood
Laboratories.
12
p.
{
OPPTS
830.1000}

45799801
Troy
Corporation.
(
2002)
Troysan
680:
Product
Chemistry
Data:
Lab
Project
Number:
TCC680REG2002A.
Unpublished
study
prepared
by
Troy
Analytical
Laboratory.
25
p.

46287401
Rueb,
B.;
Tordo,
L.
(
2004)
Product
Identity
and
Composition
of
Acticide
MBL
5515.
Project
Number:
042901/
LT/
61.
Unpublished
study
prepared
by
Thor
GmbH.
20
p.
77
46527401
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
Paste:
Product
Chemistry
Data.
Project
Number:
TCCBIT70REG2005,
ANM/
296.
25
p.

46528001
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
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2005)
Troy
2063:
Product
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Unpublished
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26
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46603401
Rueb,
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2005)
Product
Identity
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Acticide
MBL.
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Number:
050404/
LT/
61.
Unpublished
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prepared
by
Acti­
Chem
Specialities,
Inc.
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Thor
GmbH.
24
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830.1670
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Discussion
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MRID
Citation
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Troy
Chemical
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Product
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Troysan
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Nipa
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1988­
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20
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Nipa
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42569802
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Proxel
MX
Preservative
Discussion
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43489503
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Proxel
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Purified
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Paste
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43596003
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PROXEL
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Discussion
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Berg,
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2501­
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43975302
Williams,
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Proxel
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44126301
Burgoyne,
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Product
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Nipacide
Bit
10:
1,2­
Benzisothiazoline
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10%)
Solution:
Lab
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MOA004R:
MOA012B:
MOA014A.
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44211001
Williams,
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Proxel
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Paste­­
Bisamide
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44290101
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Analyses
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87:
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62
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44726903
Burt,
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Proxel
TN
Preservative
Discussion
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Lab
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3.
Unpublished
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prepared
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Zeneca,
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8
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44981601
Coscia,
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Rueb,
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(
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Product
Identity
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Composition
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Acticide
BIT:
Lab
Project
Number:
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BR­
61:
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Unpublished
study
prepared
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Chemie
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186
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44981602
Coscia,
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Summary
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Physical
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Chemical
Characteristics
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BIT:
Lab
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ATC­
63.
Unpublished
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prepared
by
Thor
Chemie
GmbH.
7
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44982501
Coscia,
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Rueb,
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(
1999)
Product
Identity
and
Composition
of
Acticide
B20:
Lab
Project
Number:
9904­
BR­
61.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
26
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45026001
Subramaniam,
C.
(
1999)
End­
Use
Product
Chemistry
Data
for
Nuosept
485
Preservative.
Unpublished
study
prepared
by
Creanova,
Inc.
55
p.
{
OPPTS
830.1550,
830.1620,
830.1750,
830.1670,
830.1650}

45075601
Coscia,
A.;
Rueb,
B.
(
2000)
Product
Identity
and
Composition
of
Acticide
BW10:
Lab
Project
Number:
9907­
BR­
61.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
29
p.

45076001
Coscia,
A.;
Rueb,
B.
(
2000)
Product
Identity
and
Composition
of
Acticide
BW20:
Lab
Project
Number:
9906­
BR­
61.
Unpublished
study
prepared
by
Acti­
Chem
Specialties
Inc.,
and
Thor
Chemie
GmbH.
38
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45086901
Gottlieb,
I.
(
2000)
Product
Chemistry
for
Nipacide
BFW:
Lab
Project
Number:
NBFW/
PC001.
Unpublished
study
prepared
by
NIPA
Inc.
39
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.7100}

45100701
Gottlieb,
I.
(
2000)
Product
Chemistry
for
Nipacide
CBX.
Unpublished
study
prepared
by
Lewis
and
Harrison,
LLC.
44
p.
{
OPPTS
860.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.1800,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.6317,
830.7100,
830.6320}

45116501
Coscia,
A.;
Rueb,
B.
(
2000)
Product
Identity
and
Composition
of
Acticide
B10:
Lab
Project
Number:
9905­
BR­
61.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
27
p.

45236801
Nye,
D.
(
2000)
Mergal
K10N:
Product
Chemistry
Data:
Lab
Project
Number:
ANMN­
210.
Unpublished
study
prepared
by
Troy
Corp.
34
p.

45358302
Burt,
M.
(
2001)
PROXEL
Ultra
Technical
­
Discussion
of
Formation
of
Impurities:
Lab
Project
Number:
ULT­
1.
Unpublished
study
prepared
by
Avecia,
Inc.
8
p.
{
OPPTS
830.1670}

45389702
Bowhill,
W.
(
1999)
Purified
Proxel
Press
(
Sumitomo
source)­
Physical/
Chemical
Characterisation
for
EPA
Submission
(
5
batch
Characterisation),
Project
900077:
Lab
Project
Number:
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RD012629B.
Unpublished
study
prepared
by
Avecia
Inc.
75
p.
{
OPPTS
830.1700,
830.6302,
830.6303,
830.6304,
830.6313,
830.6317,
830.7200,
830.7300,
830.1800,
830.7050}

45410401
Troy
Corporation
(
2001)
Polyphase
663
Product
Chemistry
Data:
Lab
Project
Number:
TCC663REG2001A.
Unpublished
study
prepared
by
Troy
Analytical
Laboratory.
65
p.
{
OPPTS
830.1550,
830.1600,
830.1650,
830.1670,
830.1700,
80
830.1750,
830.1800,
830.6303,
830.6302,
830.6304,
830.7300,
830.7000,
830.6314,
830.6315,
830.6316,
830.6317,
830.7100,
830.6319,
830.6320,
830.6321}

45431303
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
One
Product
Identity
and
Composition:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
Prom
Chem
Ltd.
8
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45444701
Coscia,
A.
(
2000)
Product
Identity
and
Composition
of
Acticide
MBS:
Lab
Project
Number:
0010­
BR­
61.
Unpublished
study
prepared
by
Thor
GmbH.
22
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670}

45496301
Voemel,
R.
(
2001)
Product
Chemistry
Rocima
607,
End­
Use
Product:
Lab
Project
Number:
TR­
01­
023:
776834:
777587.
Unpublished
study
prepared
by
RCC
Ltd.
351
p.
{
OPPTS
830.1800,
830.1550,
830.6303,
830.7100,
830.6314,
830.6315,
830.6317,
830.6320,
830.7000,
830.7300}

45515801
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
One
Product
Identity
and
Composition:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
Prom
Chem
Ltd.
16
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45553401
Tirendi,
C.
(
2001)
Product
Identity,
Composition
and
Analysis
of
Dantoserve:
Lab
Project
Number:
SP­
01054­
A.
Unpublished
study
prepared
by
Lonza,
Inc.
31
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1700,
830.1750,
830.1800}

45553801
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
one
Product
Identity
and
Composition:
Lab
Project
Number:
1.
Unpublished
study
prepared
by
Prom
Chem
Ltd.
16
p.
{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45746201
Vulcan,
D.
(
2002)
Product
Chemistry:
Palene
710­
C:
Lab
Project
Number:
54736­
032.
Unpublished
study
prepared
by
Lockwood
Laboratories.
12
p.
{
OPPTS
830.1000}

45799801
Troy
Corporation.
(
2002)
Troysan
680:
Product
Chemistry
Data:
Lab
Project
Number:
TCC680REG2002A.
Unpublished
study
prepared
by
Troy
Analytical
Laboratory.
25
p.

46287401
Rueb,
B.;
Tordo,
L.
(
2004)
Product
Identity
and
Composition
of
Acticide
MBL
5515.
Project
Number:
042901/
LT/
61.
Unpublished
study
prepared
by
Thor
GmbH.
20
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46460302
Klein,
S.
(
2004)
Product
Chemistry
Data:
Sanitized
Brand
TB
83­
35
DM.
Project
Number:
SAN/
P/
262/
96.
Unpublished
study
prepared
by
Sanitized,
Inc.
12
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46603401
Rueb,
B.;
Tordo,
L.
(
2005)
Product
Identity
and
Composition
of
Acticide
MBL.
Project
Number:
050404/
LT/
61.
Unpublished
study
prepared
by
Acti­
Chem
Specialities,
Inc.
and
Thor
GmbH.
24
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81
830.1700
(
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1)
Preliminary
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MRID
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Proxel
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Chemical
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Lab
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ICI
Colours
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84
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Burt,
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PCP
Analyses
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Paste:
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92.
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4
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42569803
Burt,
M.
(
1992)
Proxel
MX
Preservative
Preliminary
Analysis
and
Analytical
Method:
Lab
Project
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10182­
MX­
3.
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ICI
Americas
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42650801
Field,
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Proxel
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Paste:
Measurement
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Lab
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Nipa
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Product
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Preliminary
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Certification
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830.1800,
830.1550,
830.6303,
830.7100,
830.6314,
83
830.6315,
830.6317,
830.6320,
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45553401
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1700,
830.1750,
830.1800}

46287402
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44982502
Rub,
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Analysis
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45009701
Rub,
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Analysis
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BIT:
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{
OPPTS
830.1550,
830.1620,
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45075602
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Analysis
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45076001
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Product
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61.
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Analysis
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62.
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39
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.7100}

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Gottlieb,
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44
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{
OPPTS
860.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.1800,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.6317,
830.7100,
830.6320}

45116501
Coscia,
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2000)
Product
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Composition
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Project
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BR­
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27
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45116502
Coscia,
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Analysis
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Ingredients
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Acticide
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20
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ANMN­
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Ultra
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­
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{
OPPTS
830.1550,
830.1750}

45410401
Troy
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Polyphase
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65
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{
OPPTS
830.1550,
830.1600,
830.1650,
830.1670,
830.1700,
830.1750,
830.1800,
830.6303,
830.6302,
830.6304,
830.7300,
830.7000,
830.6314,
830.6315,
830.6316,
830.6317,
830.7100,
830.6319,
830.6320,
830.6321}

45431303
Berg,
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1,2­
Benzisothiazolin­
3­
One
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Unpublished
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8
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45444702
Coscia,
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Analysis
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MBS:
Lab
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0010­
BR­
62.
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16
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{
OPPTS
830.1700,
830.1750,
830.1620}

45515801
Berg,
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2001)
1,2­
Benzisothiazolin­
3­
One
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Unpublished
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prepared
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Chem
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16
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45553401
Tirendi,
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2001)
Product
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Lab
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SP­
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Unpublished
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prepared
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Lonza,
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31
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1700,
830.1750,
830.1800}

45553801
Berg,
C.
(
2001)
1,2­
Benzisothiazolin­
3­
one
Product
Identity
and
Composition:
Lab
Project
Number:
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Unpublished
study
prepared
by
Prom
Chem
Ltd.
16
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{
OPPTS
830.1550,
830.1600,
830.1620,
830.1670,
830.1750}

45799801
Troy
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Analytical
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25
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46287402
Rueb,
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Tordo,
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Analysis
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MBL
5515.
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042901/
LT/
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13
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46460302
Klein,
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Product
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83­
35
DM.
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45026003
Subramanium,
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{
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45075603
Rub,
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Summary
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Physical
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45076003
Rub,
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Summary
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{
OPPTS
830.1550,
830.1600,
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830.1750,
830.6302,
830.6303,
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45100701
Gottlieb,
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Product
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{
OPPTS
860.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.1800,
830.6302,
830.6303,
830.6304,
830.7300,
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45116503
Coscia,
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Summary
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45116504
Tognucci,
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Density,
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45116505
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Stability
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45219101
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45389702
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75
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{
OPPTS
830.1700,
830.6302,
830.6303,
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830.6304,
830.6313,
830.6317,
830.7200,
830.7300,
830.1800,
830.7050}

45410401
Troy
Corporation
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Polyphase
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{
OPPTS
830.1550,
830.1600,
830.1650,
830.1670,
830.1700,
830.1750,
830.1800,
830.6303,
830.6302,
830.6304,
830.7300,
830.7000,
830.6314,
830.6315,
830.6316,
830.6317,
830.7100,
830.6319,
830.6320,
830.6321}

45410402
Perkins,
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Product
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45431302
Comb,
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1,2­
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One
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45444703
Coscia,
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Summary
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Physical
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7
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{
OPPTS
830.6302,
830.7300,
830.6303,
830.6304,
830.6313,
830.6317,
830.6319,
830.6321,
830.7000,
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45496301
Voemel,
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Product
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351
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{
OPPTS
830.1800,
830.1550,
830.6303,
830.7100,
830.6314,
830.6315,
830.6317,
830.6320,
830.7000,
830.7300}

45515803
Comb,
A.
(
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1,2­
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3­
One
Physico­
Chemical
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Lab
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Vulcan,
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Product
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710­
C:
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45746201
Vulcan,
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Product
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710­
C:
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032.
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{
OPPTS
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45793601
Sinning,
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Physical
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Color,
Physical
State,
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Formulation
Type,
Container
Material
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Density,
pH,
Oxidizing/
Reducing
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9
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{
OPPTS
830.6302,
830.6303,
830.6304,
830.7000,
830.7300,
830.6314,
830.7100,
830.6315,
830.6316}

45799801
Troy
Corporation.
(
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Troysan
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830.6302
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Color
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54
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Coscia,
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Summary
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Physical
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Chemical
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BIT:
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Blake,
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46460303
Klein,
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Product
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46527401
Troy
Chemical
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46528001
Troy
Chemical
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BIT
20:
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46565901
Buck,
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Troy
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26
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830.6303
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Physical
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MRID
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41927501
Williams,
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Physical/
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Characteristics
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Unpublished
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54
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44981602
Coscia,
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(
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Summary
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Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
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Number:
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ATC­
63.
Unpublished
study
prepared
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Thor
Chemie
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7
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46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
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to
Support
US
EPA
Registration.
Project
Number:
PROJECT/
501962,
RD012135B,
501962.
Unpublished
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prepared
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Zeneca
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27
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46460303
Klein,
S.
(
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Product
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Sanitized
Brand
TB
83­
35
DM.
Project
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TB/
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Sanitized
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46527401
Troy
Chemical
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Mergal
BIT
Paste:
Product
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Project
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ANM/
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25
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46528001
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
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Troy
2063:
Product
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Number:
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Unpublished
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26
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830.6304
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Odor
MRID
Citation
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41927501
Williams,
D.
(
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Physical/
Chemical
Characteristics
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Proxel
Press
Paste:
Lab
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Unpublished
study
prepar­
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ICI
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54
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44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
Tests
to
Support
US
EPA
Registration.
Project
Number:
PROJECT/
501962,
RD012135B,
501962.
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study
prepared
by
Zeneca
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27
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46460303
Klein,
S.
(
2004)
Product
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Sanitized
Brand
TB
83­
35
DM.
Project
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83/
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Unpublished
study
prepared
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Sanitized
AG.
5
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46527401
Troy
Chemical
Corporation
(
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Mergal
BIT
Paste:
Product
Chemistry
Data.
Project
Number:
TCCBIT70REG2005,
ANM/
296.
25
p.

46528001
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
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(
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Troy
2063:
Product
Chemistry
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Project
Number:
TCC20632005.
Unpublished
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26
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830.7200
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63­
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Melting
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MRID
Citation
Reference
41927501
Williams,
D.
(
1991)
Physical/
Chemical
Characteristics
of
Proxel
Press
Paste:
Lab
Project
Number:
175.
Unpublished
study
prepar­
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by
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54
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44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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44981603
Tognucci,
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(
1999)
Melting
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Determination
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Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.5:
702731.
Unpublished
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prepared
by
Environmental
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RCC
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18
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830.7300
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MRID
Citation
Reference
41927501
Williams,
D.
(
1991)
Physical/
Chemical
Characteristics
of
Proxel
Press
Paste:
Lab
Project
Number:
175.
Unpublished
study
prepar­
ed
by
ICI
Specialists.
54
p.

44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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44982504
Tognucci,
A.
(
1999)
Density,
pH
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Viscosity
of
Acticide
B20:
Lab
Project
Number:
9904­
BR­
63.5:
712574.
Unpublished
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prepared
by
Environmental
Chemistry
RCC
Ltd.
and
Pharmanalytics
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24
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45075604
Tognucci,
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(
2000)
Density,
pH
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Viscosity
of
Acticide
BW10:
Lab
Project
Number:
9907­
BR­
63.5:
712563.
Unpublished
study
prepared
by
RCC
Ltd.
23
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45076004
Tognucci,
A.
(
2000)
Density,
pH
and
Viscosity
of
Acticide
BW20:
Lab
Project
Number:
9906­
BR­
63.5:
712585.
Unpublished
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prepared
by
RCC
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24
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Thomas,
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Determination
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BFW:
Lab
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SG001.
Unpublished
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prepared
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45100702
Thomas,
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(
2000)
Determination
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Specific
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for
Nipacide
CBX:
Lab
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NCBX/
SG001.
Unpublished
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prepared
by
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7
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45444706
Coscia,
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(
2000)
Density/
Specific
Gravity
of
Acticide
MBS:
Lab
Project
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BR­
63/
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12
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{
OPPTS
830.7300}

45553402
Sloan,
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Dantoserve­­
Chemical
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Lab
Project
Number:
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01055­
A.
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prepared
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Lonza,
Inc.
23
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{
OPPTS
830.6315,
830.7000,
830.7100,
830.7300}
98
46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
Tests
to
Support
US
EPA
Registration.
Project
Number:
PROJECT/
501962,
RD012135B,
501962.
Unpublished
study
prepared
by
Zeneca
Specialties.
27
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46565901
Buck,
C.
(
2005)
Troy
2063:
Product
Chemistry
Data.
Project
Number:
TCC20632005.
Unpublished
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26
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830.7840/
7860
(
63­
8)
Solubility
MRID
Citation
Reference
41927501
Williams,
D.
(
1991)
Physical/
Chemical
Characteristics
of
Proxel
Press
Paste:
Lab
Project
Number:
175.
Unpublished
study
prepar­
ed
by
ICI
Specialists.
54
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44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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44981604
Tognucci,
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(
1999)
Water
Solubility
of
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BIT:
Lab
Project
Number:
9904­
ATC­
63.6:
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Unpublished
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prepared
by
Environmental
Chemistry
RCC
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and
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830.7950
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MRID
Citation
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41927501
Williams,
D.
(
1991)
Physical/
Chemical
Characteristics
of
Proxel
Press
Paste:
Lab
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54
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Anthony,
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Product
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Water
Partition
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Sensitivity
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NIPA
BIT
Press
Paste:
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prepared
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Case
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32
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44051201
Macnab,
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Determination
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44981602
Coscia,
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1999)
Summary
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Physical
and
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BIT:
Lab
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9904­
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63.
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44981605
Tognucci,
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Vapor
Pressure
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Acticide
BIT:
Lab
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9904­
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63.7:
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Environmental
Chemistry
RCC
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Pharmanalytics
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31
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830.7370
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63­
10)
Dissociation
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41927501
Williams,
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Physical/
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Characteristics
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Press
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Lab
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54
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44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
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7
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45643502
Herling,
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(
2001)
Dissociation
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Bit:
Lab
Project
Number:
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Unpublished
study
prepared
by
Spectral
Service
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25
p.
{
OPPTS
830.7370}

830.7550/
7560/
7570
(
63­
11)
Oct/
Water
partition
Coef.

MRID
Citation
Reference
41927501
Williams,
D.
(
1991)
Physical/
Chemical
Characteristics
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Proxel
Press
Paste:
Lab
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Number:
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Unpublished
study
prepar­
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54
p.

42780204
Anthony,
C.
(
1993)
Product
Chemistry:
Vapor
Pressure,
Octanol/
Water
Partition
Coefficient
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Stability
(
Sensitivity
to
Sunlight):
NIPA
BIT
Press
Paste:
Lab
Project
Number:
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Unpublished
study
prepared
by
Case
Consulting
Labs,
Inc.
32
p.

43584001
Polson,
G.
(
1994)
Physical
and
Chemical
Properties
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1,2­
Benzoisothiazol­
3(
2H)­
One
(
sic)
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BIT):
Lab
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94B02BIT.
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94
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44981602
Coscia,
A.
(
1999)
Summary
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Physical
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Chemical
Characteristics
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Acticide
BIT:
Lab
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Number:
9904­
ATC­
63.
Unpublished
study
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7
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44981606
Tognucci,
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(
1999)
Octanol/
Water
Partition
Coefficient
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Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.8:
702718.
Unpublished
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prepared
by
Environmental
Chemistry
RCC
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and
Pharmanalytics
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22
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830.7000
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63­
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pH
MRID
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41927501
Williams,
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(
1991)
Physical/
Chemical
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Paste:
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Unpublished
study
prepar­
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ICI
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54
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44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
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7
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44982504
Tognucci,
A.
(
1999)
Density,
pH
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Viscosity
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Acticide
B20:
Lab
Project
Number:
9904­
BR­
63.5:
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Unpublished
study
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by
Environmental
Chemistry
RCC
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and
Pharmanalytics
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24
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45075604
Tognucci,
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2000)
Density,
pH
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Viscosity
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Acticide
BW10:
Lab
Project
Number:
9907­
BR­
63.5:
712563.
Unpublished
study
prepared
by
RCC
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23
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45076004
Tognucci,
A.
(
2000)
Density,
pH
and
Viscosity
of
Acticide
BW20:
Lab
Project
Number:
9906­
BR­
63.5:
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Unpublished
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45086903
Thomas,
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2000)
Determination
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Nipacide
BFW:
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PH001.
Unpublished
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6
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45100703
Thomas,
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(
2000)
Determination
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CBX:
Lab
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NCBX/
PH001.
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prepared
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45444704
Coscia,
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pH
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MBS:
Lab
Project
Number:
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BR­
63/
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Unpublished
study
prepared
by
Thor
GmbH.
11
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{
OPPTS
830.7000}

45553402
Sloan,
R.
(
2001)
Dantoserve­­
Chemical
and
Physical
Properties:
Lab
Project
Number:
SP­
01055­
A.
Unpublished
study
prepared
by
Lonza,
Inc.
23
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{
OPPTS
830.6315,
830.7000,
830.7100,
830.7300}

46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
Tests
to
Support
US
EPA
Registration.
Project
Number:
PROJECT/
501962,
RD012135B,
501962.
Unpublished
study
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Zeneca
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27
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46527401
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
Paste:
Product
Chemistry
Data.
Project
Number:
TCCBIT70REG2005,
ANM/
296.
25
p.
101
46528001
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
C.
(
2005)
Troy
2063:
Product
Chemistry
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Project
Number:
TCC20632005.
Unpublished
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26
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830.6313
(
63­
13)
Stability
MRID
Citation
Reference
42780204
Anthony,
C.
(
1993)
Product
Chemistry:
Vapor
Pressure,
Octanol/
Water
Partition
Coefficient
and
Stability
(
Sensitivity
to
Sunlight):
NIPA
BIT
Press
Paste:
Lab
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Number:
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Unpublished
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Case
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32
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42908201
Brennan,
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Proxel
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Paste:
Data
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Zeneca
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42943401
Comber,
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Proxel
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ZENECA
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16
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44981602
Coscia,
A.
(
1999)
Summary
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Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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44981607
Tognucci,
A.
(
1999)
Stability
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Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.9:
706026.
Unpublished
study
prepared
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Environmental
Chemistry
RCC
Ltd.
and
Pharmanalytics
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21
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44982505
Tognucci,
A.
(
1999)
Stability
and
Corrosion
Characteristics
of
Acticide
B20:
Lab
Project
Number:
9904­
BR­
63.6:
712596.
Unpublished
study
prepared
by
Environmental
Chemistry
RCC
Ltd.
and
Pharmanalytics
Division.
33
p.

45075605
Tognucci,
A.
(
2000)
Stability
and
Corrosion
Characteristics
of
Acticide
BW10:
Lab
Project
Number:
9907­
BR­
63.6:
712596.
Unpublished
study
prepared
by
RCC
Ltd.
33
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45076005
Tognucci,
A.
(
2000)
Stability
and
Corrosion
Characteristics
of
Acticide
BW20:
Lab
Project
Number:
9906­
BR­
63.6:
712596.
Unpublished
study
prepared
by
RCC
Ltd.
33
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830.6314
(
63­
14)
Oxidizing/
Reducting
Action
MRID
Citation
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102
44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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45179801
Blake,
J.
(
2000)
Proxel
TN:
EPA
Registration
Project
1248242:
(
Product
Chemistry):
Lab
Project
Number:
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1248242.
Unpublished
study
prepared
by
Avecia
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33
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{
OPPTS
830.6314
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830.6320}

46460303
Klein,
S.
(
2004)
Product
Chemistry
Data:
Sanitized
Brand
TB
83­
35
DM.
Project
Number:
TB/
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35.
Unpublished
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by
Sanitized
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5
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46528001
Troy
Chemical
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2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
C.
(
2005)
Troy
2063:
Product
Chemistry
Data.
Project
Number:
TCC20632005.
Unpublished
study.
26
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830.6315
(
63­
15)
Flammability
MRID
Citation
Reference
44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
p.

45553402
Sloan,
R.
(
2001)
Dantoserve­­
Chemical
and
Physical
Properties:
Lab
Project
Number:
SP­
01055­
A.
Unpublished
study
prepared
by
Lonza,
Inc.
23
p.
{
OPPTS
830.6315,
830.7000,
830.7100,
830.7300}

46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
Tests
to
Support
US
EPA
Registration.
Project
Number:
PROJECT/
501962,
RD012135B,
501962.
Unpublished
study
prepared
by
Zeneca
Specialties.
27
p.

46565901
Buck,
C.
(
2005)
Troy
2063:
Product
Chemistry
Data.
Project
Number:
TCC20632005.
Unpublished
study.
26
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830.6316
(
63­
16)
Explodability
MRID
Citation
Reference
44981602
Coscia,
A.
(
1999)
Summary
of
Physical
and
Chemical
Characteristics
of
Acticide
BIT:
Lab
Project
Number:
9904­
ATC­
63.
Unpublished
study
prepared
by
Thor
Chemie
GmbH.
7
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103
46528001
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
C.
(
2005)
Troy
2063:
Product
Chemistry
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26
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830.6317
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43584001
Polson,
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Physical
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43873801
Williams,
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44726906
Williams,
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44908201
Polson,
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Physical
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94B02BIT.
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Olin
Central
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44981602
Coscia,
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(
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Summary
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Physical
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Chemical
Characteristics
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BIT:
Lab
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9904­
ATC­
63.
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Chemie
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44982503
Rub,
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Summary
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Physical
and
Chemical
Characteristics
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B20:
Lab
Project
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9904­
BR­
63.
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Chemie
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45100701
Gottlieb,
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44
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{
OPPTS
860.1550,
830.1600,
830.1620,
830.1670,
830.1750,
830.1800,
830.6302,
830.6303,
830.6304,
830.7300,
830.7000,
830.6317,
830.7100,
830.6320}

45410403
Perkins,
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One
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Lab
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AWR2567A.
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Seal,
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Storage
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Bit:
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RS/
00/
010.
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Thor
Specialities
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UK)
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24
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{
OPPTS
830.6317}

45799801
Troy
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Troysan
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Product
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Analytical
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46528001
Troy
Chemical
Corporation
(
2005)
Mergal
BIT
20:
Product
Chemistry
Data.
Project
Number:
TCCBIT20REG2005,
ANM/
213A.
30
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46565901
Buck,
C.
(
2005)
Troy
2063:
Product
Chemistry
Data.
Project
Number:
TCC20632005.
Unpublished
study.
26
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830.7100
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63­
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Viscosity
MRID
Citation
Reference
44981602
Coscia,
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(
1999)
Summary
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Physical
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BIT:
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44982504
Tognucci,
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1999)
Density,
pH
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Viscosity
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B20:
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BR­
63.5:
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Unpublished
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RCC
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Pharmanalytics
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24
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45075604
Tognucci,
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(
2000)
Density,
pH
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Viscosity
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Lab
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63.5:
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Unpublished
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45076004
Tognucci,
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2000)
Density,
pH
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Viscosity
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Acticide
BW20:
Lab
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Number:
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BR­
63.5:
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45086904
Thomas,
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Determination
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45100704
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Determination
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45444705
Coscia,
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Viscosity
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BR­
63/
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14
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{
OPPTS
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45553402
Sloan,
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Dantoserve­­
Chemical
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Physical
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01055­
A.
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23
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106
{
OPPTS
830.6315,
830.7000,
830.7100,
830.7300}

46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
Tests
to
Support
US
EPA
Registration.
Project
Number:
PROJECT/
501962,
RD012135B,
501962.
Unpublished
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27
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46528001
Troy
Chemical
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2005)
Mergal
BIT
20:
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46565901
Buck,
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Troy
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Willis,
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BP­
1008:
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BP­
1008:
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495
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Summary
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ATC­
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44982505
Tognucci,
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Stability
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B20:
Lab
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63.6:
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Unpublished
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Tognucci,
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Stability
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Characteristics
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Acticide
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Lab
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9907­
BR­
63.6:
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Unpublished
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45076005
Tognucci,
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(
2000)
Stability
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Characteristics
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Acticide
BW20:
Lab
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9906­
BR­
63.6:
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Unpublished
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45179801
Blake,
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TN:
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Product
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Lab
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Unpublished
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33
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{
OPPTS
830.6314
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830.6320}

45643501
Seal,
K.
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2002)
Storage
Stability
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Bit:
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Number:
RS/
00/
010.
Unpublished
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by
Thor
Specialities
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UK)
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24
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{
OPPTS
830.6317}

46043901
Blake,
J.
(
1995)
Proxel
DL
­
Physical/
Chemical
Characterisation
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Support
US
EPA
Registration.
Project
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PROJECT/
501962,
RD012135B,
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27
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Klein,
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Product
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TB
83­
35
DM.
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TB/
83/
35.
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AG.
5
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830.6321
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Dielectric
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Bowhill,
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DS6256
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BIT/
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Phys/
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RD12903B.
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850.2100
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1)
Avian
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850.2200
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2)
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Fink,
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Final
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3;
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103899
Fink,
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Final
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day
Dietary
LC50­­
Bobwhite
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Technical
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135.
(
Un­
published
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received
Aug
29,
1973
under
10182­
3;
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ICI
Americas,
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DE;
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Fink,
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1973)
Eight­
day
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Bobwhite
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Final
rept.
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Aug
29,
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3;
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Americas,
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Wilmington,
DE;
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133669
Fink,
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day
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Mallard
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136.
Final
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29,
1973
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3;
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Americas,
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002­
01:
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Acute
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Brown,
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BL/
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2060.
(
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4;
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Determination
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(
Unpublished
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ceived
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29,
1973
under
10182­
4;
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Food
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Drug
Research
Laboratories,
Inc.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
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Brown,
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Proxel
Biocides:
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received
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23,
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under
10182­
109
3;
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Imperial
Chemical
Industries
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
238545­
C)

134039
Vogin,
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1971)
Determination
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CRL
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Laboratory
No.
0697.
(
Unpublished
study
received
Jan
10,
1972
under
10182­
3;
prepared
by
Food
and
Drug
Research
Laboratories,
Inc.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
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41687101
Brown,
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Proxel
Press
Paste:
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Rainbow
Trout
Salmo
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Lab
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BL/
B/
1986.
Unpublished
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prepared
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ICI
Brixham
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44398402
Terrell,
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XBINX
Acute
Effects
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Trout,
Oncorhynchus
mykiss:
Lab
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600110­
115­
2:
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10:
01.
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45534602
Scheerbaum,
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1998)
Fish
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Rainbow
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Acute
Toxicity
Test,
96
h,
Semi­
Static:
Acticide
BIT:
Lab
Project
Number:
98702TS:
FAR59991:
FAR5999­.
Unpublished
study
prepared
by
Dr
U.
Noack
Laboratorium
Fuer
Angewandte
Biologie.
50
p.
{
OPPTS
850.1075}

850.1010
(
72­
2)
Acute
Toxicity
to
Freshwater
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MRID
Citation
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133876
Thompson,
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Determination
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Acute
Toxicity
of
Proxel
Press
Paste
(
Active
Ingredient
1,2
Benzisothiazolin­
3­
one)
to
Daphnia
Magna.
(
Unpublished
study
received
Mar
23,
1979
under
10182­
3;
prepared
by
Imperial
Chemical
Industries
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
238545­
A)

42949001
Kent,
S.;
Roberts,
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Grinell,
A.
(
1993)
Proxel
Press
Paste:
Acute
Toxicity
to
Daphnia
magna:
Lab
Project
Number:
BL4847/
B:
X060/
B.
Unpublished
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prepared
by
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s
Brixham
Environmental
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20
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44398403
Terrell,
Y.
(
1997)
XBINX
Acute
Effects
on
the
Cladoceran,
Daphnia
magna:
Lab
Project
Number:
97­
300110­
115­
1:
3001­
10:
01.
Unpublished
study
prepared
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Aqua
Survey,
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78
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45534601
Noack,
U.
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1998)
Aquatic
Invertebrate
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48
h),
Freshwater
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Daphnia
magna
Straus:
Acticide
BIT:
Lab
Project
Number:
9807012TS:
DAI59991:
DAI5999­.
Unpublished
study
prepared
by
Dr.
U.
Noack
Laboratorium
fuer
Angewandte
Biologie.
55
p.
{
OPPTS
850.1010}

93053002
Smyth,
D.
(
1990)
ICI
Americas
Inc.
Phase
3
Summary
of
MRID
00133876.
Proxel
Press
Paste:
Determination
of
the
Acute
Toxicity
to
Daphnia
magna:
Report
No.
BL/
B/
1779;
Study
No.
D213/
A.
Prepared
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ICI
Brixham
110
Laboratory.
13
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850.1075/
1055/
1035
(
72­
3)
Acute
Toxicity
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Estuarine/
Marine
Organisms
MRID
Citation
Reference
81632
Brown,
D.
(
1980)
Determination
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the
Acute
Toxicity
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Proxel
Press
Paste
to
Brown
Shrimp
(~
Crangon
crangon~):
Brixham
Re­
port
No.
BL/
B/
2059.
(
Unpublished
study,
including
letter
dated
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1979
from
D.
Brown
to
unknown
recipient,
received
Jul
23,
1981
under
10182­
4;
prepared
by
Imperial
Chemical
Industries,
Ltd.,
England,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
245840­
B)

42945001
Roberts,
G.;
Caunter,
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Grinell,
A.
(
1993)
Proxel
Press
Paste:
Acute
Toxicity
to
Sheepshead
minnow
(
Cyprinodon
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Lab
Project
Number:
BL4869/
B:
X060/
A.
Unpublished
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prepared
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Zeneca
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Brixham
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20
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42949002
Kent,
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Roberts,
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Proxel
Press
Paste:
Acute
Toxicity
to
Mysid
Shrimp
(
Mysidopsis
bahia):
Lab
Project
Number:
BL4797/
B:
X060/
C.
Unpublished
study
prepared
by
Zeneca
Ltd.'
s
Brixham
Environmental
Lab.
20
p.

42952401
Roberts,
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Caunter,
J.;
Johnson,
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PROXEL
PRESS
PASTE:
Acute
Toxicity
to
Larvae
of
the
Pacific
Oyster
(
Crassostrea
gigas):
Lab
Project
Number:
BL4917/
B.
Unpublished
study
prepared
by
Brixham
Environmental
Lab,
ZENECA
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21
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870.1100
(
81­
1)
Acute
oral
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in
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MRID
Citation
Reference
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ICI
Americas,
Incorporated
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1969)
Proxel
PM
Paste.
(
Unpublished
study
received
May
5,
1969
under
10182­
1;
CDL:
100147­
A)

133637
Swan,
A.
(
1959)
Toxicological
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1,2
Benzisothiazolone:
?
Rab­
bits:
Rats|:
Report
No.
TR/
197.
(
Unpublished
study
received
Nov
29,
1968
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10182­
1;
prepared
by
Imperial
Chemical
Industries
Ltd.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
026179­
B)

133638
McElligott,
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Toxicological
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PM
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?
Rab­
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Mice|:
Report
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TR/
490.
(
Unpublished
study
re­
ceived
Nov
29,
1968
under
10182­
1;
prepared
by
Imperial
Chemical
Industries
Ltd.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
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026179­
C)
111
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Ball,
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Proxel
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Toxicity
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Report
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CTL/
T/
985.
(
Unpublished
study
received
Mar
6,
1979
under
10182­
30;
prepared
by
Imperial
Chem­
ical
Industries,
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
238168­
B)

134041
Surgikos,
Inc.
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Proxel
Press
Paste:
?
Summary
of
Toxicity
Studies|.
(
Unpublished
study
received
Nov
12,
1972
under
7078­
3;
CDL:
050670­
B)

134544
Swan,
A.
(
1959)
1,2­
Benzisothiazolone:
Toxicological
Report
197.
(
Unpublished
study
received
Feb
23,
1971
under
10182­
3;
prepared
by
Imperial
Chemical
Industries,
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
004863­
B)

134547
Kinch,
D.
(
1969)
Antibacterial
DS4547:
Toxicological
Report
697.
(
Unpublished
study
received
Feb
23,
1971
under
10182­
3;
prepared
by
Imperial
Chemical
Industries,
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
004863­
E)

159672
Moreno,
O.;
Cerven,
D.;
Altenbach,
E.
(
1985)
LD50
in
Rats:
Biochek
410:
MB
85­
7700A.
Unpublished
study
prepared
by
MB
Research
Laboratories,
Inc.
10
p.

40989201
Nitka,
S.
(
1988)
Acute
Oral
LD50
in
Rats:
Nipacide
X
(
1,2
Benziso­
thiazolin­
3­
one):
Study
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87448.
Unpublished
study
prepared
by
Consumer
Product
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14
p.

41022101
Leah,
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(
1988)
Proxel
Press
Paste:
Acute
Oral
Toxicity
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CTL/
P/
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Unpublished
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prepared
by
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63
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42429104
Shapiro,
R.
(
1992)
EPA
Acute
Oral
Toxicity­­
Defined
LD50:
IL­
2529:
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1121.
Unpublished
study
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31
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42858101
Burt,
M.
(
1993)
Proxel
Press
Paste:
Acute
Oral
Toxicity
to
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Rat:
Addendum:
Lab
Project
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CTL/
P/
2079.
Unpublished
study
prepared
by
Zeneca
Central
Toxicology
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4
p.

43229807
Shapiro,
R.
(
1993)
EPA
Acute
Oral
Toxicity­
Defined
LD50:
BP­
1008
Industrial
Preservative,
Lot
#
1:
Lab
Project
Number:
T­
2444:
P320:
E30615­
6.
Unpublished
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prepared
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Safety
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23
p.

43484501
Leah,
A.
(
1994)
First
Revision
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PROXEL
BD:
Acute
Oral
Toxicity
to
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Rat:
Lab
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CTL/
P/
2216:
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Unpublished
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19
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43489506
Robinson,
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Proxel
BD20:
Acute
Oral
Toxicity
to
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Rat:
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P/
4512:
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Unpublished
study
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Central
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91
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112
43584002
Glaza,
S.
(
1993)
Acute
Oral
Toxicity
Study
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XBINX
in
Rats:
Final
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Lab
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HWI
30601874:
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Unpublished
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Wisconsin,
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43596007
Southwood,
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1994)
First
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XL
2:
Acute
Oral
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in
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Lab
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P/
1837:
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43803801
Wnorowski,
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(
1995)
Nuosept
Bit
Technical:
Acute
Oral
Toxicity:
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LD50:
(
Rats):
Lab
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Number:
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P320.
Unpublished
study
prepared
by
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27
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43803903
Wnorowski,
G.
(
1995)
Acute
Oral
Toxicity
Defined
LD:
Nuosept
495:
(
Rats):
Lab
Project
Number:
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Unpublished
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prepared
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31
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44290102
Cerven,
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(
1997)
Single
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Oral
Toxicity
in
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LD
50
in
Rats:
Biochek
410:
(
Final
Report):
Lab
Project
Number:
MB
96­
5466.01:
67­
04.
Unpublished
study
prepared
by
MB
Research
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Inc.
18
p.

44726907
Robinson,
P.
(
1993)
Proxel
TN:
Acute
Oral
Toxicity
to
the
Rat:
Lab
Project
Number:
CTL/
P/
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Unpublished
study
prepared
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78
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44959801
Leah,
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(
1998)
Proxel
GXL:
Acute
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Toxicity
to
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Rat:
Lab
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CTL/
P/
2112:
CTL/
P/
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45026004
McRae,
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1999)
Nuosept
485
Acute
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Rat:
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Project
Number:
DNN
109.
Unpublished
study
prepared
by
Huntingdon
Life
Science,
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19
p.
{
OPPTS
870.1100}

45100705
Moore,
G.
(
2000)
Acute
Oral
Toxicity
Study
in
Rats:
Nipacide
CBX:
Lab
Project
Number:
8289:
P320.
Unpublished
study
prepared
by
Product
Safety
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19
p.
{
OPPTS
870.1100}

45175001
Cerven,
D.
(
1997)
Single
Dose
Oral
Toxicity
in
Rats:
XBINX
17G:
Lab
Project
Number:
MB
96­
5631.01:
1­
04
R/
A.
Unpublished
study
prepared
by
MB
Research
Laboratories,
Inc.
8
p.

45236803
Wnorowski,
G.
(
1998)
Acute
Oral
Toxicity
Defined
LD(
50)
(
in
Rats):
Mergal
K10N:
Lab
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TCO855:
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prepared
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35
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45308901
Graver,
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(
2001)
Acute
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Toxicity/
LD
50
in
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XBINX
19
G:
Lab
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Number:
MB
00­
8997.01:
1000.
Unpublished
study
prepared
by
MB
Research
Laboratories.
16
p.
{
OPPTS
870.1100}

45410404
Moore,
G.
(
2000)
Acute
Oral
Toxicity
Study
in
Rats­­
Defined
LD50:
Troy
EX663:
Lab
Project
Number:
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TC0992.
Unpublished
study
prepared
by
Product
Safety
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33
p.
{
OPPTS
870.1100}
113
45437101
Parno,
J.;
Craig,
L.;
Naudascher,
P.
(
2001)
Acute
Oral
Toxicity
Study
in
Male
and
Female
Rats:
Rocima
607:
Lab
Project
Number:
OOP­
210:
OOR­
210.
Unpublished
study
prepared
by
Rohm
and
Haas
Company.
26
p.
{
OPPTS
870.1100}

45444707
Rana,
M.
(
2001)
Acute
Oral
Toxicity
Study
of
Acticide
MBS
in
Rats:
Lab
Project
Number:
3088.
Unpublished
study
prepared
by
JAI
Research
Foundation.
40
p.
{
OPPTS
870.1100}

45553403
Merkel,
D.
(
2001)
Acute
Oral
Toxicity
Test
with
Dantoserve:
(
Rat):
Lab
Project
Number:
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Unpublished
study
prepared
by
Product
Safety
Labs.
24
p.
{
OPPTS
870.1100}

45793602
Merkel,
D.
(
2002)
Acute
Oral
Toxicity
Up
and
Down
Procedure
in
Rats:
Troy
EX
680:
Lab
Project
Number:
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TC1174:
P320
UDP.
Unpublished
study
prepared
by
Product
Safety
Labs.
26
p.
{
OPPTS
870.1100}

46287404
Tordo,
L.;
Rueb,
B.
(
2004)
Summary
of
the
Acute
Toxicity
Characteristics
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Acticide
MBL
5515.
Project
Number:
042901/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH.
5
p.

46603404
Tordo,
L.;
Rueb,
B.
(
2005)
Summary
of
the
Acute
Toxicity
Charateristics
of
Acticide
MBL.
Project
Number:
050404/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH
and
Acti­
Chem
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Inc.
5
p.

93053003
McCall,
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(
1990)
ICI
Americas
Inc.
Phase
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Summary
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MRID
41022101.
Proxel
Press
Paste:
Acute
Oral
Toxicity
to
the
Rat:
CTL
Report
No.
CTL/
P/
2079;
CTL
Study
No.
AR4542.
Prepared
by
ICI
Central
Toxicology
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7
p.

93053013
Pemberton,
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Leah,
A.
(
1990)
ICI
Americas
Inc.
Phase
3
Reformat
of
MRID
41022101.
Proxel
Press
Paste:
Acute
Oral
Toxicity
to
the
Rat:
CTL
Report
No.
CTL/
P/
2079.
Prepared
by
ICI
Central
Toxicology
Laboratory.
63
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870.1200
(
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2)
Acute
dermal
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in
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or
rats
MRID
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(
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received
Feb
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1971
under
10182­
3;
prepared
by
Imperial
Chemical
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Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
004863­
C)

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Cerven,
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Acute
Dermal
Toxicity/
LD50
in
Rabbits:
Biochek
410:
Project
No.
MB
85­
7700B.
Unpub­
lished
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MB
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Leah,
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Proxell
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Paste:
Acute
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to
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prepared
by
Imperial
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Shapiro,
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EPA
Acute
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Limit
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2529:
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1122.
Unpublished
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prepared
by
Product
Safety
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15
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42858102
Burt,
M.
(
1993)
Proxel
Press
Paste:
Acute
Dermal
Toxicity
to
the
Rat:
Addendum:
Lab
Project
Number:
CTL/
P/
2065.
Unpublished
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prepared
by
Zeneca
Central
Toxicology
Lab.
4
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43229808
Shapiro,
R.
(
1993)
EPA
Acute
Dermal
Toxicity
Limit
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BP­
1008
Industrial
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Lot
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1:
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2447.
Unpublished
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prepared
by
Product
Safety
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43489507
Robinson,
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Proxel
BD20:
Acute
Dermal
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CR3180.
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Central
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43584003
Glaza,
S.
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1993)
Acute
Dermal
Toxicity
Study
of
XBINX
in
Rabbits:
Final
Report:
Lab
Project
Numbers:
HWI
30601875:
30601875.
Unpublished
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prepared
by
Hazleton
Wisconsin,
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33
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43596008
Robinson,
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(
1994)
PROXEL
XL2:
Acute
Dermal
Toxicity
to
the
Rat:
Lab
Project
Numbers:
CTL/
P/
4517:
CR3182.
Unpublished
study
prepared
by
Zeneca
Central
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37
p.

43803802
Wnorowski,
G.
(
1995)
Nuosept
Bit
Technical:
Acute
Dermal
Toxicity:
Limit
Test:
(
Rats):
Lab
Project
Number:
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P322.
Unpublished
study
prepared
by
Product
Safety
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15
p.

43803904
Wnorowski,
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(
1995)
Acute
Dermal
Toxicity
Limit
Test:
Nuosept
495:
(
Rats):
Lab
Project
Number:
3848.
Unpublished
study
prepared
by
Product
Safety
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15
p.

44290103
Cerven,
D.
(
1997)
Acute
Dermal
Toxicity
in
Rabbits/
LD
50
in
Rabbits:
Biochek
410:
(
Final
Report):
Lab
Project
Number:
MB
96­
5466.02:
175­
04.
Unpublished
study
prepared
by
MB
Research
Labs,
Inc.
13
p.

44746201
Robinson,
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(
1993)
Proxel
TN:
Acute
Dermal
Toxicity
to
the
Rat:
Lab
Project
Number:
CTL/
P/
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Unpublished
study
prepared
by
Zeneca
Central
Toxicology
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46
p.

45026005
McRae,
L.
(
1999)
Nuosept
485
Acute
Dermal
Toxicity
to
the
Rat:
Lab
Project
Number:
DNN110.
Unpublished
study
prepared
by
Huntingdon
Life
Science,
Ltd.
15
p.
{
OPPTS
870.1200}

45100706
Moore,
G.
(
2000)
Acute
Dermal
Toxicity
Study
in
Rats
­
Limit
Test:
Nipacide
CBX:
Lab
Project
Number:
8290:
P322.
Unpublished
study
prepared
by
Product
115
Safety
Labs.
14
p.
{
OPPTS
870.1200}

45236804
Wnorowski,
G.
(
1998)
Acute
Dermal
Toxicity
Limit
Test
(
in
Rats):
Mergal
K10N:
Lab
Project
Number:
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TCO850:
P322.
Unpublished
study
prepared
by
Product
Safety
Labs.
27
p.

45240301
Cerven,
D.
(
2000)
Acute
Dermal
Toxicity
in
Rabbits/
LD
50
in
Rabbits:
XBINX:
Lab
Project
Number:
MB
00­
8634.02:
1100.
Unpublished
study
prepared
by
MB
Research
Laboratories.
14
p.
{
OPPTS
870.1200}

45410405
Moore,
G.
(
2000)
Acute
Dermal
Toxicity
Study
in
Rats
Defined­­
Limit
Test:
Troy
EX663:
Lab
Project
Number:
9114:
TC0993.
Unpublished
study
prepared
by
Product
Safety
Labs.
25
p.
{
OPPTS
870.1200}

45437102
Parno,
J.;
Naudascher,
P.;
Craig,
L.
(
2001)
Acute
Dermal
Toxicity
Study
in
Male
and
Female
Rats:
Rocima
607:
Lab
Project
Number:
OOP­
211:
00R­
211.
Unpublished
study
prepared
by
Rohm
and
Haas
Company.
27
p.
{
OPPTS
870.1200}

45444708
Rana,
M.
(
2001)
Acute
Dermal
Toxicity
Study
of
Acticide
MBS
in
Rats:
Lab
Project
Number:
3089.
Unpublished
study
prepared
by
JAI
Research
Foundation.
38
p.
{
OPPTS
870.1200}

45553404
Merkel,
D.
(
2001)
Acute
Dermal
Toxicity
Limit
Test
with
Dantoserve:
(
Rat):
Lab
Project
Number:
10983.
Unpublished
study
prepared
by
Product
Safety
Labs.
15
p.
{
OPPTS
870.1200}

45793603
Merkel,
D.
(
2002)
Acute
Dermal
Toxicity
Study
in
Rats­­
Limit
Test:
Troy
EX
680:
Lab
Project
Number:
11077:
TC1175:
P322.
Unpublished
study
prepared
by
Product
Safety
Labs.
24
p.
{
OPPTS
870.1200}

46287404
Tordo,
L.;
Rueb,
B.
(
2004)
Summary
of
the
Acute
Toxicity
Characteristics
of
Acticide
MBL
5515.
Project
Number:
042901/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH.
5
p.

46603404
Tordo,
L.;
Rueb,
B.
(
2005)
Summary
of
the
Acute
Toxicity
Charateristics
of
Acticide
MBL.
Project
Number:
050404/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH
and
Acti­
Chem
Specailities,
Inc.
5
p.

93053004
McCall,
J.
(
1990)
ICI
Americas
Inc.
Phase
3
Summary
of
MRID
41022102.
Proxel
Press
Paste:
Acute
Dermal
Toxicity
to
the
Rat:
CTL
Report
No.
CTL/
P/
2065;
CTL
Study
No.
CR2404.
Prepared
by
ICI
Central
Toxicology
Laboratory.
7
p.

93053014
Pemberton,
M.;
Leah,
A.
(
1990)
ICI
Americas
Inc.
Phase
3
Reformat
of
MRID
41022102.
Proxel
Press
Paste:
Acute
Dermal
Toxicity
to
the
Rat:
CTL
Report
No.
CTL/
P/
2065;
CTL
Study
No.
CR2404.
Prepared
by
ICI
Central
Toxicology
Laboratory.
31
p.
116
870.1300
(
81­
3)
Acute
inhalation
toxicity
in
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MRID
Citation
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A.
(
1991)
Proxel
GXL:
4­
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Acute
Inhalation
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Lab
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CTL/
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ICI
Americas
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Dobrzanski,
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BD:
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ICI
Central
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Central
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43585601
Wnorowski,
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43803905
Wnorowski,
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Inhalation
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495:
(
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prepared
by
Product
Safety
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39
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45100707
Moore,
G.
(
2000)
Acute
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Study
in
Rats
­
Limit
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Nipacide
CBX:
Lab
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P330.
Unpublished
study
prepared
by
Product
Safety
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22
p.
{
OPPTS
870.1300}

45133801
Smith,
P.
(
1999)
Nuosept
485:
Acute
(
Four­­
Hour)
Inhalation
Study
in
Rats:
Lab
Project
Number:
DNN
111/
992559.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
60
p.
{
OPPTS
870.1300}

45216601
Kirkpatrick,
D.
(
2000)
Acute
Inhalation
Toxicity
Study
of
Biochek
410
in
Albino
Rats:
Lab
Project
Number:
WIL­
391001.
Unpublished
study
prepared
by
WIL
Research
Laboratories,
Inc.
69
p.
{
OPPTS
870.1300}

45236805
Wnorowski,
G.
(
1998)
Acute
Inhalation
Toxicity
Defined
LC(
50)
(
in
Rats):
Mergal
K10N:
Lab
Project
Number:
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TCO854:
P330.
Unpublished
study
prepared
by
Product
Safety
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53
p.

45240302
Cerven,
D.
(
2000)
Acute
Inhalation
Toxicity
in
Rats/
LC
50
in
Rats:
XBINX:
Lab
Project
Number:
MB
00­
8634.05:
1300­
01.
Unpublished
study
prepared
by
MB
Research
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34
p.
{
OPPTS
870.1300}

45312601
Green,
C.
(
2001)
Proxel
TN:
Single
Exposure
(
Nose­
only)
Toxicity
Study
in
the
Rat:
Final
Report:
Lab
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Number:
1573/
9:
1573/
9­
D6154.
Unpublished
study
prepared
by
Covance
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47
p.
{
OPPTS
870.1300}
117
45410406
Moore,
G.
(
2000)
Acute
Inhalation
Toxicity
Study
in
Rats
Defined­­
Limit
Test:
Troy
EX663:
Lab
Project
Number:
9115:
TC0994.
Unpublished
study
prepared
by
Product
Safety
Labs.
34
p.
{
OPPTS
870.1300}

45437103
Hilaski,
R.
(
2001)
An
Acute
Inhalation
Toxicity
Study
of
Rocima
607
in
Rats:
Lab
Project
Number:
285­
059
A:
00RC­
215.
Unpublished
study
prepared
by
Rohm
and
Haas
Company.
76
p.
{
OPPTS
870.1300}

45444709
Roy,
B.
(
2001)
Acute
Inhalation
Toxicity
Study
of
Acticide
MBS
in
Rats:
Lab
Project
Number:
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Unpublished
study
prepared
by
JAI
Research
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53
p.
{
OPPTS
870.1300}

45515804
Yingling,
M.
(
2001)
Acute
Inhalation­
Generation
Feasibility
Study
(
1,2­
Benzisothiazolin­
3­
One):
Lab
Project
Number:
3864.
Unpublished
study
prepared
by
Prom
Chem
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11
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45553405
Merkel,
D.
(
2001)
Acute
Inhalation
Toxicity
Test
with
Dantoserve:
(
Rat):
Lab
Project
Number:
10984.
Unpublished
study
prepared
by
Product
Safety
Labs.
31
p.
{
OPPTS
870.1300}

45633901
Hilaski,
R.
(
2001)
Amendment
to
the
Final
Report
an
Acute
Inhalation
Toxicity
Study
of
Rocima
607
in
Rats:
Lab
Project
Number:
285­
059:
00RC­
215:
00P­
215.
Unpublished
study
prepared
by
MPI
Research,
Inc.
127
p.
{
OPPTS
870.1300}

45793604
Merkel,
D.
(
2002)
Acute
Inhalation
Toxicity
Study
in
Rats­­
Defined
LC50:
Troy
EX
680:
Lab
Project
Number:
11078:
TC1176:
P330.
Unpublished
study
prepared
by
Product
Safety
Labs.
45
p.
{
OPPTS
870.1300}

46287404
Tordo,
L.;
Rueb,
B.
(
2004)
Summary
of
the
Acute
Toxicity
Characteristics
of
Acticide
MBL
5515.
Project
Number:
042901/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH.
5
p.

46448001
Roy,
B.
(
2004)
Statement
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Director
on
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Questions
Raised
by
PSB
Experts
on
the
Following
Study:
Acute
Inhalation
Toxicity
Study
of
Acticide
MBL
USREG
in
Rats
(
Supplement
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MRID
46287409).
Project
Number:
111504/
LT/
81,
4589.
Unpublished
study
prepared
by:
Jai
Research
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6
p.

46603404
Tordo,
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Rueb,
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(
2005)
Summary
of
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Acute
Toxicity
Charateristics
of
Acticide
MBL.
Project
Number:
050404/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH
and
Acti­
Chem
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Inc.
5
p.

870.2400
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Primary
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1968
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1;
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ceived
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3;
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submitted
by
ICI
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3;
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submitted
by
ICI
Americas,
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Primary
Eye
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in
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Biochek
410:
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MB
85­
7700D.
Unpublished
study
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by
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42905102
Robinson,
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Proxel
Press
Paste:
Eye
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Lab
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FB4704.
Unpublished
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Central
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24
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43229809
Shapiro,
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(
1993)
EPA
Primary
Eye
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BP­
1008
Industrial
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43489508
Robinson,
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1994)
Proxel
BD20:
Eye
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P/
4515:
FB5013.
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prepared
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Central
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20
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43584004
Glaza,
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1993)
Primary
Eye
Irritation
Study
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XBINX
in
a
Rabbit:
Final
Report:
Lab
Project
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HWI
30601877:
30601877.
Unpublished
study
prepared
by
Hazleton
Wisconsin,
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29
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43803803
Wnorowski,
G.
(
1995)
Nuosept
Bit
Technical:
Primary
Eye
Irritation:
(
Rabbits):
Lab
Project
Number:
3860:
P324.
Unpublished
study
prepared
by
Product
119
Safety
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24
p.

44290105
Cerven,
D.
(
1997)
Primary
Eye
Irritation/
Corrosion
in
Rabbits:
Biochek
410:
(
Final
Report):
Lab
Project
Number:
MB
96­
5466.04:
236­
04
R/
A.
Unpublished
study
prepared
by
MB
Research
Labs,
Inc.
10
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44564001
Cerven,
D.
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1997)
Primary
Eye
Irritation/
Corrosion
in
Rabbits:
XBIX
17G:
Lab
Project
Number:
236­
04
R/
A:
MB96­
5631.04.
Unpublished
study
prepared
by
MB
Research
Labs.,
Inc.
11
p.

44726908
Lees,
D.
(
1998)
Proxel
TN:
Eye
Irritation
Study
in
Rabbits:
Lab
Project
Number:
CTL/
P/
5882:
FB5647.
Unpublished
study
prepared
by
Zeneca,
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42
p.

45026006
Parcell,
B.
(
1999)
Nuosept
485
Eye
Irritation
to
the
Rabbit:
Lab
Project
Number:
DNN112.
Unpublished
study
prepared
by
Huntingdon
Life
Science,
Ltd.
14
p.
{
OPPTS
870.2400}

45100708
Moore,
G.
(
2000)
Primary
Eye
Irritation
Study
in
Rabbits:
Nipacide
CBX:
Lab
Project
Number:
8292:
P324.
Unpublished
study
prepared
by
Product
Safety
Labs.
15
p.
{
OPPTS
870.2400}

45410407
Moore,
G.
(
2000)
Primary
Eye
Irritation
Toxicity
Study
in
Rabbits:
Troy
EX663:
Lab
Project
Number:
9116:
TC0995.
Unpublished
study
prepared
by
Product
Safety
Labs.
32
p.
{
OPPTS
870.2400}

45437104
Parno,
J.;
Craig,
L.;
Naudascher,
P.
(
2001)
Eye
Irritation
Study
in
Rabbits:
Rocima
607:
Lab
Project
Number:
00P­
213:
00R­
213.
Unpublished
study
prepared
by
Rohm
and
Haas
Company.
19
p.
{
OPPTS
870.2400}

45553406
Merkel,
D.
(
2001)
Primary
Eye
Irritation
Test
with
Dantoserve:
(
Rabbit):
Lab
Project
Number:
10985.
Unpublished
study
prepared
by
Product
Safety
Labs.
18
p.
{
OPPTS
870.2400}

45793605
Merkel,
D.
(
2002)
Primary
Eye
Irritation
Study
in
Rabbits:
Troy
EX
680:
Lab
Project
Number:
11079:
TC1177:
P324.
Unpublished
study
prepared
by
Product
Safety
Labs.
27
p.
{
OPPTS
870.2400}

46603404
Tordo,
L.;
Rueb,
B.
(
2005)
Summary
of
the
Acute
Toxicity
Charateristics
of
Acticide
MBL.
Project
Number:
050404/
LT/
81.
Unpublished
study
prepared
by
Thor
GmbH
and
Acti­
Chem
Specailities,
Inc.
5
p.

93053005
Parr­
Dobrzanski,
R.
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1990)
ICI
Americas
Inc.
Phase
3
Summary
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MRID
00133680.
Proxel
XL
(
BIT):
Eye
Irritation
to
the
Rabbit:
CTL
Report
NO.
CTL/
T/
985.
Prepared
by
ICI
Central
Toxicology
Laboratory.
6
p.

93053015
Ball,
S.
(
1990)
ICI
Americas
Inc.
Phase
3
Reformat
of
MRID
00133680.
Proxel
XL
(
BIT):
Eye
Irritation
to
the
Rabbit:
CTL
Report
No.
CTL/
T/
985.
Prepared
by
ICI
Central
Toxicology
Laboratory.
14
p.
120
870.2500
(
81­
5)
Primary
dermal
irritation
MRID
Citation
Reference
133637
Swan,
A.
(
1959)
Toxicological
Report:
1,2
Benzisothiazolone:
?
Rab­
bits:
Rats|:
Report
No.
TR/
197.
(
Unpublished
study
received
Nov
29,
1968
under
10182­
1;
prepared
by
Imperial
Chemical
Industries
Ltd.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
026179­
B)

133680
Ball,
S.;
Phillips,
J.
(
1976)
Proxel
XL:
Oral
Toxicity
and
Local
Irritant
Effects:
Report
No.
CTL/
T/
985.
(
Unpublished
study
received
Mar
6,
1979
under
10182­
30;
prepared
by
Imperial
Chem­
ical
Industries,
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
238168­
B)

134041
Surgikos,
Inc.
(
1973)
Proxel
Press
Paste:
?
Summary
of
Toxicity
Studies|.
(
Unpublished
study
received
Nov
12,
1972
under
7078­
3;
CDL:
050670­
B)

159674
Moreno,
O.;
Cerven,
D.;
Altenbach,
E.
(
1985)
Primary
Dermal
Irrita­
tion
in
Rabbits:
Biochek
410:
Project
No.
MB
85­
7700C.
Unpub­
lished
study
prepared
by
MB
Research
Laboratories,
Inc.
7
p.

42905101
Robinson,
P.
(
1993)
Proxel
Press
Paste:
Skin
Irritation
to
the
Rabbit:
Lab
Project
Number:
CTL/
P/
3958:
EB4147.
Unpublished
study
prepared
by
Zeneca
Central
Toxicology
Lab.
20
p.

43229810
Shapiro,
R.
(
1993)
EPA
Primary
Dermal
Irritation:
BP­
1008
Industrial
Preservative,
Lot
#
1:
Lab
Project
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2446:
P326:
E30615­
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43484502
Leah,
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First
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BD:
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Rabbit:
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CTL/
P/
2217:
EB1832.
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prepared
by
Zeneca
Central
Toxicology
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20
p.

43489509
Robinson,
P.
(
1994)
Proxel
BD20:
Skin
Irritation
to
the
Rabbit:
Lab
Project
Number:
CTL/
P/
4514:
EB4324.
Unpublished
study
prepared
by
Zeneca
Central
Toxicology
Lab.
21
p.

43584005
Glaza,
S.
(
1993)
Primary
Dermal
Irritation
Study
of
XBINX
in
Rabbits:
Final
Report:
Lab
Project
Numbers:
HWI
30601876:
30601876.
Unpublished
study
prepared
by
Hazleton
Wisconsin,
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27
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43596009
Robinson,
P.
(
1994)
PROXEL
XL2:
Skin
Irritation
to
the
Rabbit:
Lab
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CTL/
P/
4518:
EB4326.
Unpublished
study
prepared
by
Zeneca
Central
Toxicology
Lab.
22
p.

43803804
Wnorowski,
G.
(
1995)
Nuosept
Bit
Technical:
Primary
Skin
Irritation:
(
Rabbits):
Lab
Project
Number:
3861:
P326.
Unpublished
study
prepared
by
Product
Safety
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16
p.
121
43803906
Wnorowski,
G.
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1995)
Primary
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Irritation:
Nuosept
495:
(
Rabbits):
Lab
Project
Number:
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Unpublished
study
prepared
by
Product
Safety
Labs.
16
p.

44290104
Kieffer,
L.
(
1997)
Primary
Dermal
Irritation
in
Rabbits:
Biochek
410:
(
Final
Report):
Lab
Project
Number:
MB
96­
5466.03:
166­
05.
Unpublished
study
prepared
by
MB
Research
Labs,
Inc.
10
p.

44564002
Kieffer,
L.
(
1997)
Primary
Dermal
Irritation
in
Rabbits:
XBINX
17G:
Lab
Project
Number:
MB96­
5631.03:
166­
05
R/
A.
Unpublished
study
prepared
by
MB
Research
Labs.,
Inc.
11
p.

44726909
Lees,
D.
(
1998)
Proxel
TN:
Skin
Irritation
Study
in
Rabbits:
Lab
Project
Number:
EB4723:
CTL/
P/
5881.
Unpublished
study
prepared
by
Zeneca,
Inc.
21
p.

44966001
Haynes,
G.;
Middleton,
J.
(
1995)
First
Revision
to
Proxel
GXL:
Skin
Corrosivity
Study
(
in
Rabbits):
Lab
Project
Number:
CTL/
C/
782:
EB0430.
Unpublished
study
prepared
by
Toxicol
Laboratories
Limited.
29
p.

45026007
Parcell,
B.
(
1999)
Nuosept
485
Skin
Irritation
to
the
Rabbit:
Lab
Project
Number:
DNN113.
Unpublished
study
prepared
by
Huntingdon
Life
Science,
Ltd.
14
p.
{
OPPTS
870.2500}

45100709
Moore,
G.
(
2000)
Primary
Skin
Irritation
Study
in
Rabbits:
Nipacide
CBX:
Lab
Project
Number:
8293:
P326.
Unpublished
study
prepared
by
Product
Safety
Labs.
15
p.
{
OPPTS
870.2500}

45236806
Wnorowski,
G.
(
1998)
Primary
Skin
Irritation
(
in
Rabbits):
Mergal
K10N:
Lab
Project
Number:
6418:
TCO852:
P326.
Unpublished
study
prepared
by
Product
Safety
Labs.
28
p.

45410408
Moore,
G.
(
2000)
Primary
Skin
Irritation
Toxicity
Study
in
Rabbits:
Troy
EX663:
Lab
Project
Number:
9117:
TC0996.
Unpublished
study
prepared
by
Product
Safety
Labs.
26
p.
{
OPPTS
870.2500}

45437105
Parno,
J.;
Craig,
L.;
Naudascher,
P.
(
2000)
Skin
Irritation
Study
in
Rabbits:
Rocima
607:
Lab
Project
Number:
00P­
212:
00R­
212.
Unpublished
study
prepared
by
Rohm
and
Haas
Company.
17
p.

45444710
Rana,
M.
(
2001)
Acute
Dermal
Irritation
Study
of
Acticide
MBS
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{
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45553407
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Primary
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{
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45793606
Merkel,
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Primary
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EX
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{
OPPTS
870.2500}

46287404
Tordo,
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Summary
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46603404
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Summary
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Benzisothiazolin­
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EPA
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45236807
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OPPTS
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45437106
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45489402
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45799802
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EX
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{
OPPTS
870.2600}

46287404
Tordo,
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Summary
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Characteristics
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MBL
5515.
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LT/
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5
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46603404
Tordo,
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Summary
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submitted
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ICI
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DE;
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41910401
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870.3250
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submitted
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ICI
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Unpublished
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23,
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3;
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submitted
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ICI
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DE;
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Day
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88:
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7974­
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­­
2
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BIT
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Teratogenicity
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Paste:
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41022104
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Paste:
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Proxel
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Paste:
Assessment
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Paste:
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Burt,
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Paste:
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Mouse
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2215.
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Central
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Paste:
An
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Paste:
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one
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TK
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Mouse
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Callander,
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41022103.
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Paste:
Assessment
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Using
L5178Y
Mouse
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CTL
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41022104.
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Paste:
An
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2113;
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41022105.
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Press
Paste:
Assessment
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of
Unscheduled
DNA
Synthesis
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Primary
Rat
Hepatocyte
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CTL
Report
No.
CTL/
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2208;
CTL
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ICI
Central
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93053018
Cross,
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Reformat
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MRID
41022103.
Proxel
Press
Paste:
Assessment
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Potential
Using
L5178Y
Mouse
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CTL
Study
No.
VV0076;
CTL
Report
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CTL/
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ICI
Central
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43
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ICI
Americas
Inc.
Phase
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Reformat
of
MRID
41022104.
Proxel
Press
Paste:
An
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Mouse
Micronucleus
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CTL
Study
No.
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Trueman,
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of
MRID
41022105.
Proxel
Press
Paste:
Assessment
for
the
Induction
of
Unscheduled
DNA
Synthesis
in
Primary
Rat
Hepatocyte
Cultures:
CTL
Study
No.
SV0309;
CTL
Report
No:
CTL/
P/
2208.
Prepared
by
ICI
Central
Toxicology
Lab.
39
p.

870.5550
(
84­
4)
Other
Genotoxic
Effects
MRID
Citation
Reference
42858107
Burt,
M.
(
1993)
Proxel
Press
Paste:
Assessment
for
the
Induction
of
Unscheduled
DNA
Synthesis
in
Primary
Rat
Hepatocyte
Cultures:
Addendum:
Lab
Project
Number:
CTL/
P/
2208.
Unpublished
study
prepared
by
Zeneca
Central
Toxicology
Lab.
4
p.

41022105
Trueman,
R.
(
1988)
Proxel
Press
Paste:
Assessment
for
the
Induction
of
Unscheduled
DNA
Synthesis
in
Primary
Rat
Hepatocytes
Cul­
tures:
Report
No.
CTL/
P/
2208.
Unpublished
study
prepared
by
Imperial
Chemical
Industries
Ltd.
40
p.

870.7485
(
85­
1)
Metabolism
and
Pharmacokinetics
MRID
Citation
Reference
45124901
Conning,
D.
(
1972)
(
Inert
Ingredient):
Excretion
and
Tissue
Retention
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Rat:
Lab
Project
Number:
HO/
IH/
P/
3.
Unpublished
study
prepared
by
Imperial
128
Hygiene
Research
Laboratories.
10
p.

860.1100
(
171­
2)
Chemical
Identity
MRID
Citation
Reference
41710601
Evans,
K.
(
1990)
Proxel
Press
Paste:
Chemical
Characterisation
of
Material:
Representative
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Huddersfield
Works
Manufacture:
Lab
Project
Number:
144.
Unpublished
study
prepared
by
ICI
Colours
and
Fine
Chemicals.
84
p.

835.2120
(
161­
1)
Hydrolysis
MRID
Citation
Reference
41199101
Field,
B.
(
1989)
1,2­
Benzisothiazolin­
3­
one:
Hydrolysis
Study,
Report
D96901B.
Unpublished
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prepared
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10
p.

44182101
Cincinnati
Specialties,
Inc.
(
1996)
Hydrolysis
Study
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1,2­
Benzisothiazoline­
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IP­
091096.
Unpublished
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21
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44671501
Pearson,
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Response
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One
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01).
Unpublished
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12
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45929801
Geffke,
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2002)
Acticide
BIT:
Hydrolysis
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a
Function
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pH:
1st
Amendment
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Report:
Lab
Project
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001025TS:
CHP79841:
CPH7984.
Unpublished
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Noack­
Laboratorium
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Angewandte
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41
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45929802
Geffke,
T.
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2002)
Acticide
BIT:
Hydrolysis
as
a
Function
of
pH
(
1.2):
Lab
Project
Number:
001025TS:
CPX79841:
CPX7984.
Unpublished
study
prepared
by
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U.
Noack­
Laboratorium
fur
Angewandte
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35
p.

93053011
Burt,
M.
(
1990)
ICI
Americas
Inc.
Phase
3
Summary
of
MRID
41199101.
1,2­
Benzisothiazolin­
3­
One
Hydrolysis
Study.
Prepared
by
ICI
Colours
and
Fine
Chemicals.
11
p.

835.4100
(
162­
1)
Aerobic
soil
metabolism
MRID
Citation
Reference
41199102
Roberts,
G.
(
1989)
1,2,
Benzisothiazolin­
3­
one:
Aerobic
Degradation
in
Soil:
Study
ID:
R048/
D.
Unpublished
study
prepared
by
Imperial
Chemical
Industries
129
PLC.
35
p.

41199103
Powell,
B.
(
1989)
1,2­
Benzisothiazolin­
3­
one
(
BIT):
Identification
of
Metabolites
Formed
by
Aerobic
Degradation
in
Soil,
Report
No.
D97198B.
Unpublished
study
prepared
by
Imperial
Chemical
Indus­
tries
Ltd.
48
p.

93053012
Burt,
M.
(
1990)
ICI
Americas
Inc.
Phase
3
Summary
of
MRID
41199102
and
Related
MRIDs
41199103.
1,2­
Benzisothiazolin­
3­
One:
Aerobic
Degradation
in
Soil.
Prepared
by
Imperial
Chemical
Industries
PLC.
18
p.

835.1230/
1240
(
163­
1)
Leach/
adsorp/
desorption
MRID
Citation
Reference
41687102
Wilkes,
L.
(
1989)
Adsorption/
Desorption
Study
for
1,2­
Benzisothia­
zolin­
3­
One:
Lab
Project
Number:
ADC/
PROJECT/#
1129.
Unpublished
study
prepared
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Analytical
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127
p.

860.1400
(
171­
4C)
Magnitude
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the
Residue
[
by
commodity]

MRID
Citation
Reference
103900
Fink,
R.;
Guyton,
C.
(
1973)
Final
Report:
Tissue
Residue
Study­­
Bluegill
Sunfish...:
?
Benzisothiazolone
(
Analytical);
Benziso­
thiazolone
C14
(
Radioactive)|:
Project
No.
106­
133.
(
Unpub­
lished
study
received
Aug
29,
1973
under
10182­
3;
prepared
by
Environmental
Sciences
Corp.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
008767­
C)

870.7600
(
85­
3)
Dermal
penetration
MRID
Citation
Reference
46327901
O'Connor,
J.
(
1999)
Nipacide
Bit:
Preliminary
Study
to
Assess
the
Absorption
of
Nipacide
Bit
from
the
Skin
and
Gastrointestinal
Tract
in
the
Male
Rat.
Project
Number:
NLL060/
970078,
970078.
Unpublished
study
prepared
by
Huntington.
181
p.

Non­
Guideline
Study
MRID
Citation
Reference
130
24229
Schuder,
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L.;
Niemczyk,
H.
D.;
Reinert,
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A.;
et
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(
1976)
Turf
Pests.
(
Unpublished
study
including
published
data,
received
Jan
24,
1977
under
9198­
36;
prepared
in
cooperation
with
Purdue
Univ.,
Dept.
of
Entomology
and
others,
submitted
by
Anderson
Lawn
Fertilizer,
Div.
of
Free
Flow
Fertilizer
Co.,
Maumee,
Ohio;
CDL:
227632­
A)

46486
ICI
Americas,
Incorporated
(
19??)
?
Toxicity
of
Proxel
to
Rainbow
Trout
and
Various
Fish|.
(
Unpublished
study
received
Aug
18,
1980
under
10182­
3;
CDL:
243274­
B)

46487
ICI
Americas,
Incorporated
(
19??)
Miscellaneous
Environmental
Test.
(
Incomplete;
unpublished
study
received
Aug
18,
1980
under
10182­
3;
CDL:
243274­
C)

133636
ICI
Americas,
Inc.
(
19??)
?
Proxel
PM
Paste:
Efficacy
Data:
Paints|.
(
Compilation;
unpublished
study
received
Nov
29,
1968
under
10182­
1;
CDL:
026179­
A)

133639
Boardman,
G.
(
1969)
Proxel
PM
Paste­­
USDA
Application:
?
Bacterio­
logical
Tests:
Paints|.
(
Unpublished
study
received
May
5,
1969
under
10182­
1;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
026180­
A)

133667
Fink,
R.;
Guyton,
C.
(
1973)
Tissue
Residue
Study­­
Bluegill
Sunfish
(
Lepomis
macrochirus)
?
Using|
Benzisothiazolone
(
Analytical)
?
and|
Benzisothiazolone
C14
(
Radioactive):
Project
No.
106­
133.
Final
rept.
(
Unpublished
study
received
Aug
29,
1973
under
10182­
3;
prepared
by
Hazleton
Laboratories,
Inc.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
131696­
A)

133877
Palmer,
R.;
Jones,
B.
(
1976)
1,2­
Benzisothiazolin­
3­
one:
Biodegra­
dation
in
Aqueous
Systems:
Report
No.
HO/
IH/
P/
94.
(
Unpublished
study
received
Mar
23,
1979
under
10182­
3;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
238545­
B)

134038
ICI
Americas,
Inc.
(
1971)
?
Efficacy:
Proxel
CRL|.
(
Compilation;
unpublished
study
received
Jan
10,
1972
under
10182­
3;
CDL:
016020­
F)

134043
Majors,
P.;
Ede,
M.
(
1972)
Repeated
Insult
Patch
Test
of
Proxel
CRL
(
250
PPM):
?
Human
Subjects|:
Report
72­
462­
71.
(
Unpublished
study
received
Aug
22,
1973
under
10182­
3;
prepared
by
Hill
Top
Research,
Inc.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
050749­
A)

134044
Majors,
P.;
Ede,
M.
(
1972)
Repeated
Insult
Patch
Test
of
Proxel
CRL
(
500
PPM):
?
Human
Subjects|:
Report
72­
469­
71.
(
Unpublished
study
received
Aug
22,
1973
under
10182­
3;
prepared
by
Hill
Top
Research,
Inc.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
050749­
B)

134056
Imperial
Chemical
Industries
Ltd.
(
1961)
?
Efficacy
Studies
of
Benzisothiazolone
and
Its
Safety|.
(
Compilation;
unpublished
study
received
131
Feb
23,
1971
under
0H2547;
CDL:
221692­
B)

134057
Cartmell,
A.
(
1970)
Letter
sent
to
L.
Ter
Bush
dated
Sep
28,
1970
?
Benzisothiazolone:
Food
additive
data|.
(
Unpublished
study
received
Feb
23,
1971
under
10182­
1;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
221693­
A)

134548
Clark,
D.
(
1970)
Irritant
Properties
of
Antibacterial
DS4547
(
Prox­
el
PL):
Report
HO/
IH/
T740.
(
Unpublished
study
received
Feb
23,
1971
under
10182­
3;
prepared
by
Imperial
Chemical
Industries,
Ltd.,
Eng.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
004863­
F)

40157600
Chevron
Chemical
Co.
(
1987)
Submission
of
Product
Chemistry
Data
To
Support
the
Registration
of
Ortho­
Mite
Insecticidal
Soap.
Transmittal
of
1
study.

40650900
ICI
Americas
Inc.
(
1988)
Submission
of
Chemistry
Data
in
Support
of
Proxel
GXL.
Transmittal
of
1
study.

40691100
Troy
Chemical
Corp.
(
1988)
Application
for
Pesticide
Registration:
Troysan
Polyphase
RG­
1.
Transmittal
of
1
study.

40950600
Nipa
Laboratories,
Inc.
(
1988)
Submission
of
Data
To
Support
the
Application
for
Nipacide
Registration:
Product
Chemistry
Data.
Transmittal
of
1
study.

40950700
Nipa
Laboratories,
Inc.
(
1988)
Submission
of
Data
To
Support
the
Registration
of
Nipacide
X:
Product
Chemistry
Data.
Transmittal
of
1
study.

40961200
ICI
Americas
Inc.
(
1989)
Submission
of
Toxicology
Data
to
Support
the
Registration
for
Proxel
DL
Microbiostat.
Transmittal
of
1
study.

40989200
Nipa
Laboratories,
Inc.
(
1988)
Submission
of
Toxicity
Data
to
Sup­
port
the
Registration
for
Nipacide
X.
Transmittal
of
1
study.

40991300
ICI
Americas,
Inc.
(
1988)
Submission
of
Toxicity
Data
to
Support
the
Continued
Registration
of
Products
Containing
1,2­
Benziso­
thiazolin­
3­
one.
Transmittal
of
1
study.

40994500
ICI
Americas
Inc.
(
1988)
Submission
of
Data
To
Support
the
Applica­
tion
for
Registration
of
Proxel
DL:
Product
Chemistry
Data.
Transmittal
of
1
study.

41022100
ICI
Americas
Inc.
(
1988)
Submission
of
Data
To
Support
Registration
of
Proxell
Press
Paste:
Toxicology
Data.
Transmittal
of
5
stu­
dies.

41199100
ICI
Americas
Inc.
(
1989)
Submission
of
Data
To
Support
Registration
of
Proxel
DL
Microbiostat:
Environmental
Fate
Studies.
Trans­
mittal
of
3
studies.

41635400
ICI
Americas
Inc.
(
1990)
Submission
of
Data
To
Support
the
Applica­
tion
for
Registration
of
Proxel
GXL
Industrial
Microbiostat:
Product
Chemistry
Study.
Transmittal
of
1
study.

41635500
ICI
Americas
Inc.
(
1990)
Submission
of
Data
To
Support
the
Application
for
132
Registration
of
Proxel
DL
Industrial
Microbio­
stat:
Product
Chemistry
Study.
Transmittal
of
1
study.

41635600
ICI
Americas
Inc.
(
1990)
Submission
of
Data
To
Support
the
Application
for
Registration
of
Proxel
BD
Industrial
Micro­
biocide:
Product
Chemistry
Study.
Transmittal
of
1
study.

41687100
ICI
Americas,
Inc.
(
1990)
Submission
of
Product
Chemistry,
Toxi­
city,
and
Environmental
Fate
Data
to
Support
the
Reregistration
of
Proxel
Press
Paste.
Transmittal
of
4
Studies.

41710600
ICI
Americas,
Inc.
(
1990)
Submission
of
Chemistry
Data
in
Support
of
Proxel
Reregistration.
Transmittal
of
1
study.

41732000
ICI
America
Inc.
(
1990)
Submission
of
Toxicological
Effects
Data
In
Support
of
Benzisothiazolin­
3­
one
Reregistration.
Transmit­
tal
of
1
Study.

41750000
ICI
Americas
Inc.
(
1991)
Submission
of
Data
To
Support
Reregistra­
tion
of
Benzisothiazolin­
3­
One:
Toxicology
Study.
Transmittal
of
1
study.

41893900
ICI
Americas
Inc.
(
1991)
Submission
of
Data
to
Support
the
Regist­
ration
of
Proxel
BD:
Product
Chemistry
Data.
Transmittal
of
1
Study.

41902700
ICI
Americas,
Inc.
(
1991)
Submission
of
Data
to
Support
the
Regist­
ration
of
Proxel
DL:
Procduct
Chemistry
Data.
Transmittal
of
1
Study.

41910400
ICI
Americas
Inc.
(
1991)
Submission
of
toxicity
data
to
support
the
reregistration
of
Proxel
Press
Paste
(
Benzisothiazolin­
3­
one).
Transmittal
of
1
study.

41927500
ICI
Americas,
Inc.
(
1991)
Submission
of
product
chemistry
data
in
support
of
reregistration
of
benzisothiazolin­
3­
one.
Transmit­
tal
of
1
study.

41954400
ICI
Americas
Inc.
(
1991)
Submission
of
Data
to
Support
the
Reregistration
of
Benzisothiazolin­
3­
one:
Product
Chemistry
Data.
Transmittal
of
1
Study.

42196200
ICI
Americas
Inc.
(
1991)
Submission
of
Acute
Inhalation
Toxicity
study
in
support
of
registration
of
Proxel
GXL
Industrial
Micro­
biostat.
Transmittal
of
1
study.

42205700
ICI
Americas,
Inc.
(
1992)
Submission
of
toxicity
data
in
support
of
reregistration
of
Proxel
Press
Paste.
Transmittal
of
2
studies.

42205702
Allen,
S.
(
1991)
Proxel
Press
Paste:
6­
Week
Preliminary
Study
in
Dogs:
Lab
Project
Number:
CTL/
L/
3933:
PD0786.
Unpublished
study
prepared
by
ICI
Central
Toxicology
Lab.
8
p.

42398100
ICI
Specialty
Chemicals
(
1992)
Submission
of
product
chemistry
data
in
support
of
the
reregistration
of
Benzisothiazolin­
3­
one.
Transmittal
of
1
study.

42398101
Guyan,
S.
(
1992)
Final
Report
of
the
Determination
of
Polychlorinated
Dibenzo­
p­
dioxins
and
Dibenzofurans
in
Proxel
Press
Paste:
Lab
Project
133
Number:
16510.
Unpublished
study
prepared
by
Triangle
Laboratories,
Inc.
51
p.

42429100
ICI
Americas
Inc.
(
Specialty
Chem.)
(
1992)
Submission
of
product
chemistry
and
toxicity
data
to
support
the
registration
of
Proxel
MX
Preservative
(
IL
2529).
Transmittal
of
6
studies.

42515100
ICI
Americas,
Inc.
(
1992)
Submission
of
product
chemistry
data
in
support
of
the
reregistration
of
Benzisothiazolin­
3­
one.
Transmittal
of
1
study.

42524300
ICI
Specialties
(
1992)
Submission
of
product
chemistry
data
in
support
of
the
registration
of
Proxel
Press
Paste.
Transmittal
of
1
study.

42555600
ICI
Americas
Inc.
(
1992)
Submission
of
toxicity
data
in
support
of
reregistration
for
Benzisothiazolin­
3­
one.
Transmittal
of
1
study.

42569800
ICI
Americas
Inc.
(
1992)
Submission
of
product
chemistry
data
in
support
of
registration
for
Proxel
MX
Preservative.
Transmittal
of
3
studies.

42650800
Zeneca
(
1993)
Submission
of
product
chemistry
data
in
support
of
the
reregistration
for
Benzisothiazolin­
3­
one.
Transmittal
of
1
study.

42780200
Nipa
Laboratories,
Inc.
(
1993)
Submission
of
product
chemistry
data
in
support
of
the
registration
for
NIPA
BIT
Press
Paste.
Transmittal
of
4
studies.

42858100
Zeneca
Biocides
(
1993)
Submission
of
supplemental
toxicity
data
in
support
of
phase
3
reregistration
for
Proxel
Press
Paste
(
Benzisothiazolin­
3­
One).
Transmittal
of
7
studies.

42905100
Zeneca
Inc.
(
1993)
Submission
of
Toxicity
Data
for
Proxel
Press
Paste
in
Support
of
Reregistration.
Transmittal
of
3
Studies.

42908200
Zeneca
Inc.
(
1993)
Submission
of
Product
Chemistry
Data
in
Support
of
Reregistration
of
Benzisothiazolin­
3­
one.
Transmittal
of
1
study.

42943400
ZENECA
Inc.
(
1993)
Submission
of
Product
Chemistry
Data
for
Benzisothiazolin­
3­
one
in
Support
of
Reregistration.
Transmittal
of
1
Study.

42945000
Zeneca
Biocides
(
1993)
Submission
of
Toxicology
Data
in
Support
of
the
Reregistration
of
Benzisothiazolin­
3­
one.
Transmittal
of
1
1
study.

42949000
Zeneca
Inc.
(
1993)
Submission
of
Acute
Toxicology
Data
in
Support
of
Benzisothiazolin­
3­
one
Reregistration.
Transmittal
of
2
Studies.

42952400
Zeneca
Inc.
(
1993)
Submission
of
Toxicity
Data
for
Benzisothiazolin­
3­
one
in
Support
of
Reregistration.
Transmittal
of
1
study.

42961100
ZENECA
Inc.
(
1993)
Submission
of
Product
Chemistry
Data
in
Response
to
EPA
Questions
of
Studies
Submitted
to
Support
Reregistration
of
Benzisothiazolin­
3­
one.
Transmittal
of
1
Study.

42967100
Huls
America
Inc.
(
1993)
Submission
of
Product
Chemistry
Data
for
NUOSEPT
134
495
Preservative
in
Support
of
a
Me­
Too
Registration.
Transmittal
of
2
Studies.

43229800
ZENECA
Inc.
(
1994)
Submission
of
Product
Chemistry
Data
and
Toxicity
Data
for
PARADYME
Preservative
in
Support
of
Registration.
Transmittal
of
11
studies.

43354200
Zeneca,
Inc.
(
1994)
Submission
of
Product
Chemistry
Data
in
Support
of
Registration
Amendment
for
Proxel
GXL
Industrial
Microbiostat.
Transmittal
of
1
Study.

43398200
Zeneca
Inc.
(
1994)
Submittal
of
Product
Chemistry
Data
in
Support
of
Registration
for
Paradyme
Preservative.
Transmittal
of
1
study.

43424800
Zeneca,
Inc.
(
1994)
Submission
of
Manufacturing
Process
Data
in
Support
of
Registration
Amendment
for
Proxel
MX
Preservative
(
Reputain).
Submission
of
1
Study.

43484500
Zeneca,
Inc.
(
1994)
Submission
of
Toxicity
Data
in
Support
of
Application
for
Label
Amendment
for
PROXEL
BD
Industrial
Microbiocide.
Transmittal
of
2
Studies.

43489500
Zeneca,
Inc.
(
1994)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Registration
of
PROXEL
BD20
Industrial
Microbiostat.
Transmittal
of
10
Studies.

43536300
ZENECA
Biocides
(
1995)
Submission
of
product
chemistry
data
in
support
of
registration
of
Proxel
MX
Preservative.
Transmittal
of
1
study.

43542900
Zeneca,
Inc.
(
1995)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
PARADYME
Preservative.
Transmittal
of
2
Studies.

43584000
PMC
Specialties
Group
(
1995)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Registration
of
the
1,2­
Benzoisothiazol­
3(
2H)­
one
Containing
Product
XBINX.
Transmittal
of
9
Studies.

43585600
Zeneca,
Inc.
(
1995)
Submission
of
Toxicity
Data
in
Support
of
a
Registration
Amendment
for
Proxel
MX.
Transmittal
of
1
Study.

43586000
Zeneca
Biocides
(
1995)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
Application
for
Registration
of
Purified
Proxel
Press
Paste.
Transmittal
of
5
Studies.

43586005
Burt,
M.
(
1995)
Purified
Proxel
Press
Paste:
Assessment
of
Toxicity
and
Environmental
Effects:
Lab
Project
Number:
P4­
A.
Unpublished
study
prepared
by
Zeneca,
Inc.
5
p.

43596000
Zeneca
Biocides
(
1995)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Registration
of
PROXEL
XL
2.
Transmittal
of
10
Studies.

43607600
Steptoe
&
Johnson
(
1995)
Submission
of
product
chemistry
data
in
support
of
registration
of
Nuosept
495
Preservative.
Transmittal
of
1
study.
135
43663000
PMC
Specialties
Group,
Inc.
(
1995)
Submission
of
Product
Chemistry
and
Toxicology
Data
in
Support
of
Application
for
Registration
of
XBINX.
Transmittal
of
8
Studies.

43674600
Zeneca,
Inc.
(
1995)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Purified
Proxel
Press
Paste.
Transmittal
of
1
Study.

43724100
Huls
America,
Inc.
(
1995)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Nuosept
BIT
Technical.
Transmittal
of
2
Studies.

43803800
Huls
America,
Inc.
(
1995)
Submission
of
Toxicology
Data
in
Support
of
the
Registration
of
NUOSEPT
BIT
Technical.
Transmittal
of
5
Studies.

43803900
Huls
America
Inc.
(
1995)
Submission
of
product
chemistry
and
toxicity
data
in
support
of
registration
for
Nuosept
495
Preservative.
Transmittal
of
7
studies.

43873800
Zeneca,
Inc.
(
1995)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Proxel
XL
2.
Transmittal
of
1
Study.

43975300
Zeneca
Inc.
(
1996)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
Amendment
for
PROXEL
Press
Paste.
Transmittal
of
2
Studies.

44051200
Zeneca
Inc.
(
1996)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Proxel
XL
2.
Transmittal
of
1
Study.

44126300
Nipa
Hardwicke,
Inc.
(
1996)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Nipacide
BIT
10.
Transmittal
of
1
Study.

44133000
Huls
America
Inc.
(
1996)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
for
Nuosept
495
Preservative.
Transmittal
of
1
Study.

44182100
PMC
Specialties
Group,
Inc.
(
1996)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Application
for
Registration
of
RJ
Advantage,
Inc.'
s
XBINX.
Transmittal
of
1
Study.

44211000
Zeneca,
Inc.
(
1997)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Amended
Registration
for
Proxel
Press
Paste.
Transmittal
of
3
Studies.

44270700
Zeneca,
Inc.
(
1997)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Amended
Registration
for
Proxel
Press
Paste.
Transmittal
of
2
Studies.

44290100
Calgon
Corp.
(
1997)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Product
Specific
RED
for
1,2­
Dibromo­
2,4­
dicyanobutane
Containing
Product
Biochek
410.
Transmittal
of
5
Studies.

44398400
RJ
Advantage
Inc.
(
1997)
Submission
of
Toxicity
Data
in
Support
of
the
Registration
for
XBINX.
Transmittal
of
3
Studies.

44450400
PMC
Specialties
Group,
Inc.
(
1997)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
XBINX.
Transmittal
of
1
Study.
136
44482900
Cincinnati
Specialties,
Inc.
(
1998)
Submission
of
Hazard
to
Wildlife
Data
in
Support
of
the
Registration
of
XBINX.
Transmittal
of
1
Study.

44514400
PMC
Specialties
Group,
Inc.
(
1998)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
XBINX
50W.
Transmittal
of
3
Studies.

44564000
PMC
Specialties
Group,
Inc.
(
1998)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
XBINX
50W.
Transmittal
of
2
Studies.

44671500
Cincinnati
Specialties,
Inc.
(
1998)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Application
for
Registration
of
XBINX.
Transmittal
of
1
Study.

44726900
Zeneca,
Inc.
(
1999)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Proxel
TN.
Transmittal
of
10
Studies.

44746200
Zeneca
Inc.
(
1998)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Proxtel
TN.
Transmittal
of
1
Study.

44810500
Trutec
Industries,
Inc.
(
1999)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Palene
610­
C.
Transmittal
of
1
Study.

44908200
PMC
Specialties
Group
(
1999)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
XBINX
88.
Transmittal
of
1
Study.

44959800
Avecia
Biocides
(
1999)
Submission
of
Toxicity
Data
in
Support
of
the
Registration
of
Proxel
GXL.
Transmittal
of
2
Studies.

44966000
Avecia,
Inc.
(
1999)
Submission
of
Toxicity
Data
in
Support
of
the
Registration
of
Proxel
GXL.
Transmittal
of
1
Study.

44981600
Thor
Chemie
GmbH
(
1999)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
BIT.
Transmittal
of
7
Studies.

44982500
Thor
Chemie
GmbH
(
1999)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
B20.
Transmittal
of
5
Studies.

45009700
Thor
Chemie
GmbH
(
1999)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
BIT.
Transmittal
of
1
Study.

45026000
Creanova,
Inc.
(
2000)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Nuosept
485.
Transmittal
of
8
Studies.

45075600
Thor
Chemie
GmbH
(
2000)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
BW10.
Transmittal
of
5
Studies.

45076000
Thor
Chemie
GmbH
(
2000)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
BW20.
Transmittal
of
5
Studies.

45086900
NIPA
Inc.
(
2000)
Submission
of
Product
Chemistry
Data
in
Support
of
the
137
Application
for
Registration
of
Nipacide
BFW.
Transmittal
of
5
Studies.

45100700
NIPA
Inc.
(
2000)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Nipacide
CBX.
Transmittal
of
9
Studies.

45116500
Thor
Chemie
GmbH
(
2000)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
B10.
Transmittal
of
5
Studies.

45133800
Creanova
Inc.
(
2000)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Nuosept
485
Preservative.
Transmittal
of
1
Study.

45175000
Cincinnati
Specialties,
Inc.
(
2000)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
XBINX
17G.
Transmittal
of
1
Study.

45179800
Avecia
Inc.
(
2000)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Proxel
TN.
Transmittal
of
1
study.

45184600
MB
Research
Laboratories
(
2000)
Submission
of
Toxicity
Data
in
Support
of
the
Registration
of
XBINX
88.
Transmittal
of
1
Study.

45216600
Nalco
Chemical
Company
(
2000)
Submission
of
Toxicity
Data
in
Support
of
the
Reregistration
of
the
1,2­
dibromo­
2,
4­
dicyanobutane
and
1,2­
benzisothiazolin­
3­
one
Containing
Product
Biochek
410.
Transmittal
of
1
Study.

45219100
Avecia
(
2000)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Proxel
GXL.
Transmittal
of
1
Study.

45236800
Troy
Corp.
(
2000)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Mergal
K10N.
Transmittal
of
7
Studies.

45240300
PMC
Specialties
Group,
Inc.
(
2000)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
XBINX
17G.
Transmittal
of
2
Studies.

45308900
PMC
Specialties
Group,
Inc.
(
2001)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
the
Registration
of
XBINX
19G.
Transmittal
of
1
Study.

45312600
Avecia,
Inc.
(
2001)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
the
Registration
of
Proxel
TN.
Transmittal
of
1
Study.

45358300
Avecia,
Inc.
(
2001)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
the
Registration
of
PROXEL
Ultra
Technical.
Transmittal
of
2
Studies.

45389700
Avecia,
Inc.
(
2001)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
the
Registration
of
Proxel
Ultra
Technical.
Transmittal
of
2
Studies.

45410400
Troy
Chemical
Corporation
(
2001)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
the
Registration
of
Polyphase
663.
Transmittal
of
9
Studies.
138
45431300
Creanova
Inc.
(
2001)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Nuosept
Bit
Technical.
Transmittal
of
2
Studies.

45431301
Comb,
A.
(
2000)
1,2­
Benzisothiazol­
3(
2H)­
One
Five­
Batch
Analysis:
Lab
Project
Number:
DNN/
131:
DNN131/
004725.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
34
p.
{
OPPTS
830.1700}

45437100
Rohm
and
Haas
(
2001)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Rocima
607
Industrial
Microbicide.
Transmittal
of
6
Studies.

45444700
Acti­
Chem
Specialties,
Inc.
(
2001)
Submission
of
Toxicity
and
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Acticide
MBS.
Transmittal
of
10
Studies.

45489400
Thor
GmbH
(
2001)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Acticide
MBS.
Transmittal
of
2
Studies.

45489401
Coscia,
A.
(
2001)
Summary
of
the
Acute
Toxicity
Characteristics
of
Acticide
MBS:
Lab
Project
Number:
NO.
01
TOX
SUMMARY/
MBS.
Unpublished
study
prepared
by
Acti­
Chem
Specialties,
Inc.
5
p.
{
OPPTS
870.1100,
870.1200,
870.1300,
870.2400,
870.2500,
870.2600}

45496300
Rohm
and
Haas
Co
(
2001)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
of
Registration
of
Rocima
607
Industrial
Microbicide.
Transmittal
of
1
Study.

45498300
Avecia
Inc.
(
2001)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Proxel
Ultra
Technical.
Transmittal
of
1
Study.

45515800
Prom
Chem
Ltd
(
2001)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Promex
BIT.
Transmittal
of
4
Studies.

45534600
Prom
Chem
Ltd.
(
2001)
Submission
of
Toxicity
Data
in
Support
of
the
Application
of
Registration
of
Promex
BIT.
Transmittal
of
3
Studies.

45553400
Lonza,
Inc.
(
2001)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Applications
for
Registration
of
Dantoserve
SG
and
Dantoserve
MS.
Transmittal
of
7
Studies.

45553800
Prom
Chem
Ltd.
(
2001)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Promex
BIT.
Transmittal
of
1
Study.

45633900
Rohm
and
Haas
Company
(
2002)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Rocima
607.
Transmittal
of
1
Study.

45643500
THOR
GmbH
(
2002)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Acticide
Bit.
Transmittal
of
2
Studies.

45686200
Trutec
Industries,
Inc.
(
2002)
Submission
of
Product
Chemistry
Data
in
Support
139
of
the
Application
for
Registration
of
Palene
710­
C.
Transmittal
of
1
Study.

45746200
Trutec
Industries,
Inc.
(
2002)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Palene
710­
C.
Transmittal
of
1
Study.

45770300
Avecia
Inc.
(
2002)
Submission
of
Toxicity
Data
in
Support
of
the
Registration
of
Proxel
Press
Paste.
Transmittal
of
1
Study.

45793600
Troy
Corporation
(
2002)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Troysan
680.
Transmittal
of
6
Studies.

45799800
Troy
Corporation
(
2002)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Troysan
680.
Transmittal
of
2
Studies.

45929800
Prom
Chem
Ltd.
(
2003)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Amended
Registration
of
Promex
BIT.
Transmittal
of
2
Studies.

46009000
Prom
Chem
Ltd
(
2003)
Submission
of
Toxicity
Study
in
Support
of
the
Amended
Registration
of
Promex
BIT.
Transmittal
of
3
Studies.

46043900
Avecia
Inc.
(
2003)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Proxel
DL.
Transmittal
of
1
Study.

46063600
Avecia
Inc
(
2003)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Proxel
AQ
Preservative.
Transmittal
of
7
Studies.

46097100
Avecia
Biocides
(
2003)
Submission
of
Toxicity
Data
in
Support
of
the
Reregistration
of
Proxel
Containing
Product
Proxel
Press
Paste
(
BIT).
Transmittal
of
1
Study.

46113100
PromChemie
Ag
(
2003)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Promex
20S.
Transmittal
of
1
Study.

46113200
PromChemie
Ag
(
2003)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Promex
10S.
Transmittal
of
1
Study.

46113300
PromChemie
Ag
(
2003)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Promex
20D.
Transmittal
of
1
Study.

46179900
Clariant
Corporation
(
2003)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Nipacide
TBX.
Transmittal
of
3
Studies.

46184900
PromChemie
AG
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Promex
20D.
Transmittal
of
1
Study.

46185100
PromChemie
AG
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Promex
10S.
Transmittal
of
1
Study.

46185300
PromChemie
AG
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
140
the
Application
for
Registration
of
Promex
20S
and
Promex
10S.
Transmittal
of
1
Study
46187400
PromChemie
AG
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
Application
for
Registration
of
Promex
20D.
Transmittal
of
1
Study.

46239600
Avecia,
Inc.
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Reregistration
of
Proxel
Press
Paste.
Transmittal
of
1
Study.

46246900
Prom
Chem
Limited
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Promex
BIT.
Transmittal
of
1
Study.

46287400
Thor
GmbH
(
2004)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Acticide
MBL
5515.
Transmittal
of
9
Studies.

46327900
Clariant
Corporation
(
2004)
Submission
of
Toxicity
Data
in
Support
of
the
Reregistration
of
1,2­
Benzisothiazolin­
3­
one.
Transmittal
of
1
Study.

46346200
Prom
Chem
Ltd
(
2004)
Submission
of
Toxicity
Data
in
Support
of
FIFRA
6(
a)(
2)
Data
Requirements
for
Promex
BIT.
Transmittal
of
1
Study.

46357400
Acti­
Chem
Specialties
Inc.
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Amended
Registration
of
Acticide
BW20.
Transmittal
of
1
Study.

46382700
THOR
GMBH
(
2004)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Amended
Registration
of
Acticide
B20.
Transmittal
of
1
Study.

46448000
Thor
Gmbh
(
2005)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Acticide
MBL
5515.
Transmittal
of
1
Study.

46455000
Sanitized,
Inc.
(
2004)
Submission
of
Efficacy
Data
in
Support
of
the
Application
for
Registration
of
Sanitized
Brand
TB
83­
35
MUP­
DM.
Transmittal
of
1
Study.

46455001
Klein,
S.
(
2004)
Laboratory
Assessment
of
the
Efficacy
of
a
Fabric
Treatment
to
Control
House
Dust
Mites.
Project
Number:
972/
0904R.
Unpublished
study
prepared
by
Laboratoire
T.
E.
C/
Techniques
Environnement
Consultants.
18
p.

46460300
Sanitized,
Inc.
(
2005)
Submission
of
Product
Chemistry
and
Efficacy
Data
in
Support
of
the
Application
for
Registration
of
Sanitized
Brand
TB
83­
35
DM.
Transmittal
of
3
Studies.

46460301
Klein,
S.
(
2004)
Laboratory
Assessment
of
the
Efficacy
of
a
Fabric
Treatment
to
Control
House
Dust
Mites.
Project
Number:
972/
0904R,
NF/
G/
39/
011.
Unpublished
study
prepared
by
Laboratoire
T.
E.
C/
Techniques
Environnement
Consultants.
18
p.

46467900
Arch
Chemicals,
Inc.
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Proxel
UL
7
Preservative.
Transmittal
of
4
Studies.
141
46490200
Arch
Chemicals,
Inc.
(
2005)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Proxel
BN
Preservative.
Transmittal
of
10
Studies.

46496800
Sanitized,
Inc.
(
2005)
Submission
of
Exposure
and
Risk
Data
in
Support
of
the
Application
for
Registration
of
Sanitized
Brand
TB
83­
35
MUP­
DM.
Transmittal
of
1
Study.

46496801
Marconi,
C.
(
2004)
Risk
Assessment
of
Sanitized
TB
83­
85.
Project
Number:
502/
003.
Unpublished
study
prepared
by
Sanitized
AG.
118
p.

46504600
Clariant
Corporation
(
2003)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
of
Registration
of
Nipacide
TBX.
Transmittal
of
7
Studies.

46504605
Whatmough,
M.
(
2002)
Determination
of
Viscosity
for
Nipacide
TBX.
Project
Number:
MOA019D,
CAL011.
Unpublished
study
prepared
by
Clariant
UK
Ltd.
and
Nipa
Laboratories,
Ltd.
6
p.

46509300
Arch
Chemicals,
Inc.
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Proxel
BN
Preservative.
Transmittal
of
2
Studies.

46527400
Troy
Chemical
Corp.
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Mergal
BIT
Paste.
Transmittal
of
2
Studies.

46527700
Arch
Chemicals,
Inc.
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Proxel
BN
Preservative.
Transmittal
of
1
Study.

46528000
Troy
Chemical
Corp.
(
2005)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Mergal
BIT
20.
Transmittal
of
8
Studies.

46542200
ProChemie
AG
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Amended
Registration
of
Promex
20D.
Transmittal
of
1
Study.

46565900
Troy
Chemical
Corp.
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
the
Registration
of
Troy
2063.
Transmittal
of
2
Studies.

46603400
Thor
GmbH
(
2005)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Acticide
MBL.
Transmittal
of
8
Studies.

93053000
Ici
Americas
Inc.
(
1990)
Reregistration
Phase
3
Response:
Benzisothiazolin­
3­
one.

93053999
Ici
Americas
Inc.
(
1990)
Reregistration
Phase
3
Response:
Benzisothiazolin­
3­
one.
Correspondence
and
Supporting
Material.

93287000
Nipa
Laboratories
Inc.
(
1993)
Reregistration
Phase
3
Response:
142
Benzisothiazolin­
3­
one.

93287999
Nipa
Laboratories
Inc.
(
1993)
Reregistration
Phase
3
Response:
Benzisothiazolin­
3­
one.
Correspondence
and
Supporting
Material.
143
Appendix
E.
Generic
Data
Call­
In
The
Agency
intends
to
issue
a
Generic
Data
Call­
In
at
a
later
date.
144
Appendix
F.
Product
Specific
Data
Call­
In
The
Agency
intends
to
issue
a
Product
Specific
Data
Call­
In
at
a
later
date.
145
Appendix
G.
ANTIMICROBIAL
DIVISION'S
BATCHING
OF
PRODUCTS
CONTAINING
BENZISOTHIAZOLIN­
3­
ONE
AS
THE
ACTIVE
INGREDIENT
FOR
MEETING
ACUTE
TOXICITY
DATA
REQUIREMENTS
FOR
REREGISTRATION
In
an
effort
to
reduce
the
time,
resources
and
number
of
animals
needed
to
fulfill
the
acute
toxicity
data
requirements
for
reregistration
of
products
containing
Benzisothiazolin­
3­
one
as
an
active
ingredient,
the
Agency
has
batched
products
which
can
be
considered
similar
for
purposes
of
acute
toxicity.
Factors
considered
in
the
sorting
process
include
each
product's
active
and
inert
ingredients
(
identity,
percent
composition
and
biological
activity),
type
of
formulation
(
e.
g.,
emulsifiable
concentrate,
aerosol,
wettable
powder,
granular),
and
labeling
(
e.
g.,
signal
word,
use
classification,
precautionary
labeling).
Note
that
the
Agency
is
not
describing
batched
products
as
"
substantially
similar,"
since
they
may
not
have
similar
use
patterns.

Using
available
information,
batching
has
been
accomplished
by
the
process
described
in
the
preceding
paragraph.
Notwithstanding
the
batching
process,
the
Agency
reserves
the
right
to
require,
at
any
time,
acute
toxicity
data
for
an
individual
product
should
the
need
arise.

Registrants
of
products
within
a
batch
may
choose
to
cooperatively
generate,
submit
or
cite
a
single
battery
of
six
acute
toxicological
studies
to
represent
all
the
products
within
that
batch.
It
is
the
registrants'
option
to
participate
in
the
process
with
all
other
registrants,
only
some
of
the
other
registrants,
or
only
their
own
products
within
a
batch,
or
to
generate
all
the
required
acute
toxicological
studies
for
each
of
their
own
products.
If
a
registrant
chooses
to
generate
the
data
for
a
batch,
he/
she
must
use
one
of
the
products
within
the
batch
as
the
test
material.
If
a
registrant
chooses
to
rely
upon
previously
submitted
acute
toxicity
data,
he/
she
may
do
so
provided
that
the
data
base
is
complete
and
valid
by
today's
standards
(
see
partial
list
of
acceptance
criteria
attached),
the
formulation
tested
is
considered
by
EPA
to
be
similar
for
acute
toxicity,
and
the
formulation
has
not
been
significantly
altered
since
submission
and
acceptance
of
the
acute
toxicity
data.
The
Agency
must
approve
any
new
or
canceled
formulations
(
that
were
presented
to
the
Agency
after
the
completion
of
the
RED)
before
data
derived
from
them
can
be
used
to
cover
other
products
in
a
batch.
Regardless
of
whether
new
data
is
generated
or
existing
data
is
referenced,
registrants
must
clearly
identify
the
test
material
by
EPA
Registration
Number.
If
more
than
one
confidential
statement
of
formula
(
CSF)
exists
for
a
product,
the
registrant
must
indicate
the
formulation
actually
tested
by
identifying
the
corresponding
CSF.

In
deciding
how
to
meet
the
product
specific
data
requirements,
registrants
must
follow
the
directions
given
in
the
Data
Call­
In
Notice
and
its
attachments
appended
to
the
RED.
The
DCI
Notice
contains
two
response
forms
which
are
to
be
completed
and
submitted
to
the
Agency
within
90
days
of
receipt.
The
first
form,
"
Data
Call­
In
Response,"
asks
whether
the
registrant
will
meet
the
data
requirements
for
each
product.
The
second
form,
"
Requirements
Status
and
Registrant's
Response,"
lists
the
product
specific
data
required
for
each
product,
including
the
standard
six
acute
toxicity
tests.
A
registrant
who
wishes
to
participate
in
a
batch
must
decide
whether
he/
she
will
provide
the
data
or
depend
on
someone
else
to
do
so.
If
a
registrant
supplies
the
data
to
support
a
batch
of
products,
he/
she
must
select
one
of
the
following
options:
146
Developing
Data
(
Option
1),
Submitting
an
Existing
Study
(
Option
4),
Upgrading
an
Existing
Study
(
Option
5)
or
Citing
an
Existing
Study
(
Option
6).
If
a
registrant
depends
on
another's
data,
he/
she
must
choose
among:
Cost
Sharing
(
Option
2),
Offers
to
Cost
Share
(
Option
3)
or
Citing
an
Existing
Study
(
Option
6).
If
a
registrant
does
not
want
to
participate
in
a
batch,
the
choices
are
Options
1,
4,
5
or
6.
However,
a
registrant
should
know
that
choosing
not
to
participate
in
a
batch
does
not
preclude
other
registrants
in
the
batch
from
citing
his/
her
studies
and
offering
to
cost
share
(
Option
3)
those
studies.

If
a
registrant
would
like
to
have
the
batching
status
of
a
product
reconsidered,
he/
she
needs
to
submit
detailed
information
on
the
product,
including
a
detailed
rationale
for
the
inclusion
of
the
product
into
a
batch.
An
MSDS
for
each
"
inert"
ingredient
should
be
included
where
possible.
However,
registrants
and
manufacturers
should
realize
that
the
more
unusual
their
formulation
is,
the
less
likely
it
is
to
be
able
to
batch
that
product.

Table
1
displays
the
batches
for
products
containing
the
active
ingredient
Benzisothiazolin­
3­
one.
Table
1
Batch
Registration
Number
Percent
Active
Ingredient
1
365­
82
Benzisothiazolin­
3­
one
...
87.6%

1258­
1261
Benzisothiazolin­
3­
one
...
80.0%

1258­
1268
Benzisothiazolin­
3­
one
...
84.0%

1529­
36
Benzisothiazolin­
3­
one
...
82.0%

73930­
1
Benzisothiazolin­
3­
one
...
83.8%

1A*
1258­
1254
Benzisothiazolin­
3­
one
...
72.0%

49403­
20
Benzisothiazolin­
3­
one
...
63.0%

67071­
21
Benzisothiazolin­
3­
one
...
72.0%

2
1258­
1255
Benzisothiazolin­
3­
one
...
19.3%

1258­
1260
Benzisothiazolin­
3­
one
...
19.3%

1529­
34
Benzisothiazolin­
3­
one
...
19.0%

49403­
14
Benzisothiazolin­
3­
one
...
18.0%

67071­
22
Benzisothiazolin­
3­
one
...
20.0%

67071­
23
Benzisothiazolin­
3­
one
...
20.0%
147
70465­
3
Benzisothiazolin­
3­
one
...
19.8%

80285­
2
Benzisothiazolin­
3­
one
...
19.0%

80285­
3
Benzisothiazolin­
3­
one
...
19.0%

3
1258­
1256
Benzisothiazolin­
3­
one
...
9.0%

1258­
1262
Benzisothiazolin­
3­
one
...
9.0%

1258­
1284
Benzisothiazolin­
3­
one
...
9.25%

1529­
39
Benzisothiazolin­
3­
one
...
8.5%

5383­
107
Benzisothiazolin­
3­
one
...
9.5%

49403­
26
Benzisothiazolin­
3­
one
...
8.5%

67071­
24
Benzisothiazolin­
3­
one
...
10.0%

67071­
25
Benzisothiazolin­
3­
one
...
10.0%

80285­
1
Benzisothiazolin­
3­
one
...
9.0%

4*
1258­
1289
Benzisothiazolin­
3­
one
...
7.0%

49403­
27
Benzisothiazolin­
3­
one
...
7.0%

*
Batch
1A:
The
three
products
placed
in
Batch
1A
may
cite
data
from
any
of
the
products
in
Batch
#
1.
Otherwise,
the
products
may
be
considered
to
be
in
the
"
No
Batch"
Group.

*
Batch
4:
The
two
products
placed
in
Batch
4
may
cite
each
other's
eye
irritation
data
only
if
the
data
indicate
corrosiveness.
148
Table
2
lists
the
products
that
fall
into
the
"
No
Batch"
group.
These
products
can
not
be
batched
because
they
were
not
considered
to
be
similar
to
the
other
products
in
terms
of
acute
toxicity
or
because
there
was
insufficient
information
available
to
assist
in
making
the
decision.
Registrants
of
these
products
may
only
cite
data
obtained
from
the
specific
product
itself
to
support
the
acute
toxicity
data
requirements
for
that
product.
No
other
product
data
will
suffice.

Table
2.
No
Batch
Group
Registration
Number
Percent
Active
Ingredient(
s)

707­
295
Benzisothiazolin­
3­
one
...
12.0%
Bronopol
...
10.0%

1258­
1248
Benzisothiazolin­
3­
one
...
4.5%
Hexahydro­
1,3,5­
tris(
2­
hydroxythyl)­
Striazine
...
50.5%

1258­
1257
Benzisothiazolin­
3­
one
...
12.0%
Zinc
2­
Pyridinethiol­
1­
oxide
...
8.0%

1258­
1290
Benzisothiazolin­
3­
one
...
13.5%
Bronopol
...
6.5%

3090­
217
Benzisothiazolin­
3­
one
...
0.9%
Octhilinone
...
2.25%

5383­
111
Benzisothiazolin­
3­
one
...
10.9%
1,3,­
Bis(
hydroxymethyl)­
5,5­
dimethylhydantoin
...
12.5%
Hydroxymethyl­
5,5­
dimethylhydantoin
...
2.9%

6836­
306
Benzisothiazolin­
3­
one
...
1.1%
1,3,­
Bis(
hydroxymethyl)­
5,5­
dimethylhydantoin
...
29.4%
Hydroxymethyl­
5,5­
dimethylhydantoin
...
27.9%

6836­
307
Benzisothiazolin­
3­
one
...
1.1%
1,3,­
Bis(
hydroxymethyl)­
5,5­
dimethylhydantoin
...
29.4%
Hydroxymethyl­
5,5­
dimethylhydantoin
...
27.9%

39967­
39
Benzisothiazolin­
3­
one
...
6.0%
1,2­
dibromo­
2,4­
dicyanobutane
...
19.0%
149
49403­
28
Benzisothiazolin­
3­
one
...
5.0%
5­
Chloro­
2­
Methyl­
4­
isothiazolin­
3­
one
...
0.74%
2­
Methyl­
4­
isothiazolin­
3­
one
...
0.26%

67071­
29
Benzisothiazolin­
3­
one
...
2.5%
2­
Methyl­
4­
isothiazolin­
3­
one
...
2.5%

67071­
45
Benzisothiazolin­
3­
one
...
5.0%
2­
Methyl­
4­
isothiazolin­
3­
one
...
5.0%
Bronopol
...
15.0%

68575­
2
Benzisothiazolin­
3­
one
...
4.5%
150
Appendix
H.
List
of
All
Registrants
Sent
the
Data
Call­
In
A
list
of
registrants
sent
the
Data
Call­
In
will
be
posted
at
a
later
date.
151
Appendix
I.
List
of
Available
Related
Documents
and
Electronically
Available
Forms
Pesticide
Registration
Forms
are
available
at
the
following
EPA
internet
site:
http://
www.
epa.
gov/
opprd001/
forms/
.

Pesticide
Registration
Forms
(
These
forms
are
in
PDF
format
and
require
the
Acrobat
reader)

Instructions
1.
Print
out
and
complete
the
forms.
(
Note:
Form
numbers
that
are
bolded
can
be
filled
out
on
your
computer
then
printed.)

2.
The
completed
form(
s)
should
be
submitted
in
hardcopy
in
accord
with
the
existing
policy.

3.
Mail
the
forms,
along
with
any
additional
documents
necessary
to
comply
with
EPA
regulations
covering
your
request,
to
the
address
below
for
the
Document
Processing
Desk.

DO
NOT
fax
or
e­
mail
any
form
containing
`
Confidential
Business
Information'
or
`
Sensitive
Information.'

If
you
have
any
problems
accessing
these
forms,
please
contact
Nicole
Williams
at
(
703)
308­
5551
or
by
e­
mail
at
williams.
nicole@
epamail.
epa.
gov.

The
following
Agency
Pesticide
Registration
Forms
are
currently
available
via
the
internet
at
the
following
locations:
8570­
1
Application
for
Pesticide
Registration/
Amendment
http://
www.
epa.
gov/
opprd001/
forms/
8570­
1.
pdf
8570­
4
Confidential
Statement
of
Formula
http://
www.
epa.
gov/
opprd001/
forms/
8570­
4.
pdf
8570­
5
Notice
of
Supplemental
Registration
of
Distribution
of
a
Registered
Pesticide
Product
http://
www.
epa.
gov/
opprd001/
forms/
8570­
5.
pdf
8570­
17
Application
for
an
Experimental
Use
Permit
http://
www.
epa.
gov/
opprd001/
forms/
8570­
17.
pdf
8570­
25
Application
for/
Notification
of
State
Registration
of
a
Pesticide
To
Meet
a
Special
Local
Need
http://
www.
epa.
gov/
opprd001/
forms/
8570­
25.
pdf
8570­
27
Formulator's
Exemption
Statement
http://
www.
epa.
gov/
opprd001/
forms/
8570­
27.
pdf
8570­
28
Certification
of
Compliance
with
Data
Gap
Procedures
http://
www.
epa.
gov/
opprd001/
forms/
8570­
28.
pdf
8570­
30
Pesticide
Registration
Maintenance
Fee
Filing
http://
www.
epa.
gov/
opprd001/
forms/
8570­
30.
pdf
8570­
32
Certification
of
Attempt
to
Enter
into
an
Agreement
with
other
Registrants
for
Development
of
Data
http://
www.
epa.
gov/
opprd001/
forms/
8570­
32.
pdf
8570­
34
Certification
with
Respect
to
Citations
of
Data
(
in
PR
Notice
98­
5)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr98­
5.
pdf
8570­
35
Data
Matrix
(
in
PR
Notice
98­
5)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr98­
5.
pdf
8570­
36
Summary
of
the
Physical/
Chemical
Properties
(
in
PR
Notice
98­
1)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr98­
1.
pdf
152
8570­
37
Self­
Certification
Statement
for
the
Physical/
Chemical
Properties
(
in
PR
Notice
98­
1)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr98­
1.
pdf
Pesticide
Registration
Kit
www.
epa.
gov/
pesticides/
registrationkit/.

Dear
Registrant:

For
your
convenience,
we
have
assembled
an
online
registration
kit
that
contains
the
following
pertinent
forms
and
information
needed
to
register
a
pesticide
product
with
the
U.
S.
Environmental
Protection
Agency's
Office
of
Pesticide
Programs
(
OPP):

1.
The
Federal
Insecticide,
Fungicide,
and
Rodenticide
Act
(
FIFRA)
and
the
Federal
Food,
Drug
and
Cosmetic
Act
(
FFDCA)
as
Amended
by
the
Food
Quality
Protection
Act
(
FQPA)
of
1996.

2.
Pesticide
Registration
(
PR)
Notices
a.
83­
3
Label
Improvement
Program 
Storage
and
Disposal
Statements
b.
84­
1
Clarification
of
Label
Improvement
Program
c.
86­
5
Standard
Format
for
Data
Submitted
under
FIFRA
d.
87­
1
Label
Improvement
Program
for
Pesticides
Applied
through
Irrigation
Systems
(
Chemigation)

e.
87­
6
Inert
Ingredients
in
Pesticide
Products
Policy
Statement
f.
90­
1
Inert
Ingredients
in
Pesticide
Products;
Revised
Policy
Statement
g.
95­
2
Notifications,
Non­
notifications,
and
Minor
Formulation
Amendments
h.
98­
1
Self
Certification
of
Product
Chemistry
Data
with
Attachments
(
This
document
is
in
PDF
format
and
requires
the
Acrobat
reader.)

Other
PR
Notices
can
be
found
at
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices.

3.
Pesticide
Product
Registration
Application
Forms
(
These
forms
are
in
PDF
format
and
will
require
the
Acrobat
reader.)

a.
EPA
Form
No.
8570­
1,
Application
for
Pesticide
Registration/
Amendment
b.
EPA
Form
No.
8570­
4,
Confidential
Statement
of
Formula
c.
EPA
Form
No.
8570­
27,
Formulator's
Exemption
Statement
d.
EPA
Form
No.
8570­
34,
Certification
with
Respect
to
Citations
of
Data
153
e.
EPA
Form
No.
8570­
35,
Data
Matrix
4.
General
Pesticide
Information
(
Some
of
these
forms
are
in
PDF
format
and
will
require
the
Acrobat
reader.)

a.
Registration
Division
Personnel
Contact
List
b.
Biopesticides
and
Pollution
Prevention
Division
(
BPPD)
Contacts
c.
Antimicrobials
Division
Organizational
Structure/
Contact
List
d.
53
F.
R.
15952,
Pesticide
Registration
Procedures;
Pesticide
Data
Requirements
(
PDF
format)

e.
40
CFR
Part
156,
Labeling
Requirements
for
Pesticides
and
Devices
(
PDF
format)

f.
40
CFR
Part
158,
Data
Requirements
for
Registration
(
PDF
format)

g.
50
F.
R.
48833,
Disclosure
of
Reviews
of
Pesticide
Data
(
November
27,
1985)

Before
submitting
your
application
for
registration,
you
may
wish
to
consult
some
additional
sources
of
information.
These
include:

1.
The
Office
of
Pesticide
Programs'
Web
Site
2.
The
booklet
"
General
Information
on
Applying
for
Registration
of
Pesticides
in
the
United
States",
PB92­
221811,
available
through
the
National
Technical
Information
Service
(
NTIS)
at
the
following
address:

National
Technical
Information
Service
(
NTIS)
5285
Port
Royal
Road
Springfield,
VA
22161
The
telephone
number
for
NTIS
is
(
703)
605­
6000.
Please
note
that
EPA
is
currently
in
the
process
of
updating
this
booklet
to
reflect
the
changes
in
the
registration
program
resulting
from
the
passage
of
the
FQPA
and
the
reorganization
of
the
Office
of
Pesticide
Programs.
We
anticipate
that
this
publication
will
become
available
during
the
Fall
of
1998.

3.
The
National
Pesticide
Information
Retrieval
System
(
NPIRS)
of
Purdue
University's
Center
for
Environmental
and
Regulatory
Information
Systems.
This
service
does
charge
a
fee
for
subscriptions
and
custom
searches.
You
can
contact
NPIRS
by
telephone
at
(
765)
494­
6614
or
through
their
Web
site.

4.
The
National
Pesticide
Telecommunications
Network
(
NPTN)
can
provide
information
on
active
ingredients,
uses,
toxicology,
and
chemistry
of
pesticides.
You
can
contact
NPTN
by
telephone
at
(
800)
858­
7378
or
through
their
Web
site:
ace.
orst.
edu/
info/
nptn.
154
The
Agency
will
return
a
notice
of
receipt
of
an
application
for
registration
or
amended
registration,
experimental
use
permit,
or
amendment
to
a
petition
if
the
applicant
or
petitioner
encloses
with
his
submission
a
stamped,
self­
addressed
postcard.
The
postcard
must
contain
the
following
entries
to
be
completed
by
OPP:

Date
of
receipt
EPA
identifying
number
Product
Manager
assignment
Other
identifying
information
may
be
included
by
the
applicant
to
link
the
acknowledgment
of
receipt
to
the
specific
application
submitted.
EPA
will
stamp
the
date
of
receipt
and
provide
the
EPA
identifying
File
Symbol
or
petition
number
for
the
new
submission.
The
identifying
number
should
be
used
whenever
you
contact
the
Agency
concerning
an
application
for
registration,
experimental
use
permit,
or
tolerance
petition.
To
assist
us
in
ensuring
that
all
data
you
have
submitted
for
the
chemical
are
properly
coded
and
assigned
to
your
company,
please
include
a
list
of
all
synonyms,
common
and
trade
names,
company
experimental
codes,
and
other
names
which
identify
the
chemical
(
including
"
blind"
codes
used
when
a
sample
was
submitted
for
testing
by
commercial
or
academic
facilities).
Please
provide
a
CAS
number
if
one
has
been
assigned.
155
