PRODUCT
CHEMISTRY
SCIENCE
CHAPTER
ON
Azadioxabicycooctane
FOR
REREGISTRATION
ELIGIBILITY
DECISION
(
RED)
2
April
6,
2005
MEMORANDUM
SUBJECT:
Product
Chemistry
Science
Chapter
on
Azadioxybiscyclooctane
For
Reregistration
Eligibility
Decision
(
RED)
Process
From:
A.
Najm
Shamim,
Ph.
D.,
Chemist
Regulatory
Management
Branch
II
Antimicrobials
Division
(
7510C)

To:
Tim
McMahon,
Ph.
D.,
Chair
ADTC
Senior
Toxicologist
Antimicrobials
Division
(
7510C)

Thru:
Mark
Hartman,
Branch
Chief
Regulatory
Management
Branch
II
Antimicrobials
Division
(
7510C)

Enclosed
please
find
the
Product
Chemistry
Science
Chapter
on
Azadioxybicycloctane
submitted
for
consideration
of
RED
Process.
3
PRODUCT
CHEMISTRY
CHAPTER
A.
Chemical
Overview
The
chemical
hydroxypoly
(
methyleneoxy)
bicyclic
oxazolidine
is
found
as
the
active
ingredient
in
Nuosept
95
preservative.
This
preservative
is
a
50%
aqueous
solution
used
in
waterbased
products.
It
effectively
prevents
deterioration
and
spoilage
during
the
manufacture,
storage
and
service
of
products
such
as
latex
paints,
latex
emulsions,
pigment
dispersions
and
slurries,
inks,
adhesives,
caulks,
sealants,
metalworking
fluids,
textile
fiber­
finish
solutions,
paper
coatings,
drilling
muds
and
flooding
fluids.

B.
Chemical
Identification
°
Name:
Hydroxypoly
(
methyleneoxy)
bicyclic
oxazolidine
°
Common/
Trade
Names:
Nuosept
95,
Azadioxabicycooctane
°
CAS
Number:
56709­
13­
8
°
Active
ingredients:
5­
Hydroxymethyl­
1­
aza­
3,7­
dioxabicyclo(
3.3.0)
octane
(
28.80%)
5­
Hydroxymethoxymethyl­
1­
aza­
3,7­
dioxabicyclo(
3.3.0)
octane
(
16.00%)
5­
Hydroxypoly[
mrthyleneoxy(
74%
C2,
21%
C3,
4%
C4,
1%
C5)]­
methyl­
1­
aza­
3,7­
dioxabicyclo(
3.3.0)
octane
(
5.20%)

C.
Physical/
Chemical
Properties
As
a
TGAI,
the
following
characteristics
have
been
reported
for
hydroxypoly
(
methyleneoxy)
bicyclic
oxazolidine:

°
Color:
Pale
yellow
°
Physical
State:
Clear
liquid
°
Odor:
Mild,
characteristic
°
Specific
gravity:
1.144
at
25oC
°
Dissociation
Constant:
4.5
±
0.5
°
pH:
6.33
at
25oC
°
Stability:
Stable
°
Melting
point:
NA
°
Boiling
point:
104.7oC
at
760
mmHg
°
Water
Solubility:
11.1
±
0.1
g/
100ml
at
20oC
°
Solubility
in
organic
solvents:
Hexane
0.2
g/
100
g
at
25oC
Petroleum
ether
0.2
g/
100
g
at
25oC
Xylene
1.5
g/
100
g
at
25oC
Benzene
2.8
g/
100
g
at
25oC
Ethyl
ether
28.0
g/
100
g
at
25oC
4
°
Octanol­
water
Partition
Coefficient:
<
10
°
Vapor
Pressure:
<
2.1
x
10­
5
mm
Hg
at
20oC
°
Viscosity:
3.5
to
4
Centistokes
at
25oC
°
Flash
Point
(
SCC):
140oF
°
Flash
Point
(
TCC):
>
200oF
D.
Use
Profile
The
following
information
was
obtained
for
Nuosept
95
from
the
web
page
of
the
manufacturing
company,
ISP
(
http://
www.
ispcorp.
com/
products/
biocides/
index.
html).

Recommended
Use
by
Industry
End
Use
Reason
for
Treatment
Recommended
Use
Level
of
Nuosept
95
Preservative
(
percent
by
weight
of
formulation)
Point
of
Addition
Adhesives
(
Natural­
based)
To
prevent
spoilage
during
manufacture
and
storage
0.2­
0.5
Add
to
water
phase
or
post
add
Adhesives
(
Synthetics)
To
prevent
spoilage
during
manufacture
and
storage
0.1­
0.5
Add
to
water
phase
or
post
add
Caulks
To
increase
shelf
life
0.1­
0.5
Add
to
water
phase
during
manufacture
Drilling
Muds
To
prevent
spoilage
during
manufacture,
storage
and
service
0.05­
0.2
Add
to
water
phase
or
post
add
Flooding
Fluids
To
prevent
spoilage
during
storage
and
service
0.01­
0.1
Post
addition
Latex
Emulsion
To
prevent
spoilage
during
transit
and
storage
0.05­
0.3
Post
addition
Latex
Paint
To
prevent
spoilage
during
manufacture
and
to
increase
shelf
life
0.1­
0.5
Add
at
any
point
during
manufacture
Inks
To
prevent
spoilage
during
storage
and
service
0.1­
0.5
Post
addition
Paper
Coatings
To
prevent
spoilage
during
manufacture
and
storage
0.1­
0.5
Add
to
water
phase
or
post
add
Pigment
Dispersion
To
increase
shelf
life
0.1­
0.3
Add
at
any
point
during
manufacture
Pigment
Slurry
To
prevent
spoilage
during
transit
and
storage
0.05­
0.1
Add
to
water
phase
or
post
add
Sealants
To
increase
shelf
life
0.1­
0.5
Add
to
water
phase
during
manufacture
Metalworking
fluids
To
protect
during
manufacture
and
service
0.1­
0.3
Add
to
water
phase
Textile
Fiber
finish
To
prevent
spoilage
during
manufacture
and
service
0.05­
0.1
Add
at
any
point
during
manufacture
5
BIBLIOGRAPHY
1)
MRID
No.:
42734301
2)
and
MRID
No:
42740801
