Page
1
of
4
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON
D.
C.,
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
August
2,
2005
MEMORANDUM
Subject:
Transmission
of
the
Preliminary
Cumulative
Risk
Assessment
for
the
NMethyl
Carbamate
Pesticides
for
review
by
the
FIFRA
Scientific
Advisory
Panel.

To:
Myrta
Christian,
Designated
Federal
Official
FIFRA
SAP
Office
of
Science
Coordination
and
Policy
(
7101C)

From:
Dr.
Anna
B.
Lowit
and
CAPT
David
J.
Miller
Office
of
Pesticide
Programs,
Health
Effects
Division
(
7509C)

Through:
Dr.
Tina
Levine,
Director
Office
of
Pesticide
Programs,
Health
Effects
Division
(
7509C)

A
meeting
of
the
FIFRA
SAP
is
scheduled
for
August
23­
26,
2005.
This
meeting
will
focus
on
the
Preliminary
Cumulative
Risk
Assessment
for
the
N­
Methyl
Carbamate
Pesticides.
This
memo
provides
a
list
of
documents
provided
by
EPA
at
this
point.
The
charge
and
issue
questions
will
be
transmitted
separately.
Page
2
of
4
List
of
Documents
Provided
to
the
SAP
(
as
of
August
2,
2005)

I.
Preliminary
N­
Methyl
Carbamate
Cumulative
Risk
Assessment
II.
Appendices
A.
Introduction
(
None)
B.
Hazard
1.
Spreadsheet
of
RBC
and
whole/
half
brain
AChE
data
(
means,
standard
deviations)
used
in
the
Preliminary
Cumulative
Risk
Assessment
of
the
N­
methyl
carbamate
pesticides
a.
Agg
Data
b.
Padilla
Data
2.
Dose­
response
modeling
of
rat
RBC
and
brain
AChE
for
the
Preliminary
Cumulative
Risk
Assessment
of
the
N­
methyl
carbamate
pesticides
a.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Aldicarb
Gavage
Dosing
b.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Aldicarb
Gavage
Dosing
c.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Carbaryl
Dermal
Exposure
d.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Carbaryl
Dermal
Dosing
e.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Carbaryl
Gavage
Dosing
f.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Carbaryl
Gavage
Dosing
g.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Carbofuran
Gavage
Dosing
h.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Carbofuran
Gavage
Dosing
i.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Formetanate
Gavage
Dosing
j.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Formetanate
Gavage
Dosing
k.
Dose­
Time
Response
Modeling
of
Rabbit
Brain
AChE
Activity:
Methiocarb
Dermal
Dosing
l.
Dose­
Time
Response
Modeling
of
Rabbit
RBC
AChE
Activity:
Methiocarb
Dermal
Dosing
m.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Methiocarb
Gavage
Dosing
n.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Methiocarb
Gavage
Dosing
Page
3
of
4
o.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Methomyl
Gavage
Dosing
p.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Methomyl
Gavage
Dosing
q.
Dose
Response
Modeling
of
Rabbit
Brain
AChE
Activity:
Oxamyl
Dermal
Dosing
r.
Dose
Response
Modeling
of
Rabbit
RBC
AChE
Activity:
Oxamyl
Dermal
Dosing
s.
Dose
Response
Modeling
of
Rat
Brain
AChE
Activity:
Oxamyl
Inhalation
Exposure
t.
Dose
Response
Modeling
of
Rat
RBC
AChE
Activity:
Oxamyl
Inhalation
Exposure
u.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Oxamyl
Gavage
Dosing
v.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Oxamyl
Gavage
Dosing
w.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Primicarb
Gavage
Dosing
x.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Pirimicarb
Gavage
Dosing
y.
Dose­
Time
Response
Modeling
of
Rabbit
Brain
AChE
Activity:
Propoxur
Dermal
Dosing
z.
Dose­
Time
Response
Modeling
of
Rabbit
RBC
AChE
Activity:
Propoxur
Dermal
Dosing
aa.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Propoxur
Inhalation
Exposure
bb.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Propoxur
Inhalation
Exposure
cc.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Propoxur
Gavage
Dosing
dd.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Propoxur
Gavage
Dosing
ee.
Dose­
Time
Response
Modeling
of
Rat
Brain
AChE
Activity:
Thiodicarb
Gavage
Dosing
ff.
Dose­
Time
Response
Modeling
of
Rat
RBC
AChE
Activity:
Thiodicarb
Gavage
Dosing
3.
N­
M­
CarbamateDoseResponse
(
computer
code,
zip
file)
4.
R­
packages
(
computer
code,
zip
file)
5.
Summary
of
AChE
protocol
evaluations,
mixture
experiments,
motor
activity
measurements
6.
Physiologically­
Based
Pharmacokinetic
Modeling
for
the
N­
methyl
carbamate
cumulative
risk
assessment
C.
Dietary
1.
Processing
Factors
Used
in
Cumulative
Dietary
Exposure
Assessment
D.
Drinking
Water
Page
4
of
4
1.
Summary
of
USGS
NAWQA
Monitoring
for
N­
Methyl
Carbamates
2.
Summary
of
State
Monitoring
for
N­
Methyl
Carbamates
3.
Drinking
Water
Treatment
Effects
on
N­
Methyl
Carbamate
Pesticides
4.
N­
Methyl
Carbamate
Usage
Estimates
5.
Chemical­
Specific
Fate
and
Transport
Properties
Used
for
the
Water
Exposure
Models
6.
N­
Methyl
Carbamate
Surface
Water
Exposure
Assessment
7.
N­
Methyl
Carbamate
Ground
Water
Exposure
Assessment
E.
Residential
1.
Residential
Pesticide
Use
Inputs
from
REJV
Survey
Data
2.
Residential
Exposure
Scenarios
Appendix
F.
Cumulative
Risk
1.
Temporal
Exposure
Profile
Plot
for
Florida
Central
Ridge
Ground
Water
2.
Temporal
Exposure
Profile
Plot
for
North
Carolina
Coastal
Plain
Ground
Water
3.
Temporal
Exposure
Profile
Plot
for
North
Carolina
Coastal
Plain
Surface
Water
G.
Model
Comparison
(
None)
H.
Risk
Characterization
(
None)
I.
Future
Steps
(
None)
J.
References
(
None)
