  SEQ CHAPTER \h \r 1 

     

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

                                                                        
                                                                        
                                            

                                                                        
                                                                        
        			      OFFICE OF     

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	23-MAY-2007 

SUBJECT:	PP#s:  5E6911, 5E6926, 5E6991, 3F6576, and 2E6482.  Indoxacarb:
 Acute and Chronic Dietary Exposure and Risk Assessments for the
Proposed Section 3 Registrations and Petitions for Tolerances on Grapes;
Vegetable, Brassica, Leafy, Group 5; Turnip Greens; Vegetable, Leafy,
Except Brassica (Group 4); Pome Fruits (Group 11, except pear); Tuberous
and Corm Vegetables (Subgroup 1C); Cucurbit Vegetables (Group 9); Stone
Fruits (Group 12); Cranberry; Mint; Okra; and Southern Pea.

PC Code:	067710			Decision#:	355154

DP#:	 	339398			40 CFR:	180.564

FROM	:		Mohsen Sahafeyan, Chemist

				Sarah J. Levy, Chemist

				Registration Action Branch 1/Health Effects Division (RAB1/HED;
7509P)

THROUGH:	Doug Dotson, Ph.D., Chemist

				Sarah Winfield, Biologist

	Dietary Exposure Science Advisory Council (DE SAC)

	and

	George F. Kramer, Ph.D., Senior Chemist (RAB1/HED; 7509P)

TO:		Sarah J. Levy, Risk Assessor

RAB1/HED (7509P)

Executive Summary

Acute and chronic dietary risk assessments were conducted for indoxacarb
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database (DEEM-FCID(, Version 2.03), which uses food
consumption data from the U.S. Department of Agriculture’s (USDA)
Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996
and 1998.  

The last dietary risk assessment for indoxacarb was conducted on
26-AUG-2004 (Memo, M. Sahafeyan; DP#: 305966).  This previous analysis
was conducted following the removal of an acute toxicity endpoint for
females 13-49 years old, adjustment of the no-observed adverse-effect
level (NOAEL) for 100% active ingredient from the 75% isomer
formulation, and addition of a 10X uncertainty factor to the acute
toxicity endpoint for the U.S. general population and other population
subgroups by the Hazard Identification Assessment Review Committee
(HIARC) on March 2, 2004 (Memo, P. Terse, 12-APR-2004; TXR No. 0052478).
 The assessment included only the currently registered uses at that
time, and was meant to determine the dietary risk after the safety
factor change.  The assessment did not include the new proposed uses
(i.e., grapes, Brassica leafy vegetables, and turnip greens).  Even
without these uses, the acute dietary exposure estimate for the highest
exposed population subgroup (children 1-2 years old) was over 300% of
the acute population-adjusted dose (aPAD) at the 99.9th%.

Since this assessment, the RAB1 toxicologists met in March, 2007 to
re-evaluate the indoxacarb toxicological endpoints and uncertainty
factors in light of new studies.  The RAB1 toxicologists concluded that
the database uncertainty factor for the lack of DNT study should be
removed since the DNT results are available.  This dietary risk
assessment takes into account the new uses associated with the previous
petition (i.e., grapes, Brassica leafy vegetables, and turnip greens;
Memo, S. Levy, 18-FEB-2005; DP#: 290126), the addition of poultry
tolerances (as a result of a requested poultry feeding study - Memo, S.
Levy, 22-SEP-2004; DP#: 297936), and the current new uses (vegetable,
leafy, except Brassica (group 4), pome fruits (group 11, except pear),
tuberous and corm vegetables (subgroup 1C), cucurbit vegetables (group
9), stone fruits (group 12), cranberry, mint, okra, and southern pea
(Memo, S. Levy, 09-MAR-2007; DP#: 325479).  

Refined acute probabilistic and chronic dietary exposure assessments
were conducted for all existing and proposed new food uses of
indoxacarb.  A cancer dietary exposure assessment was not conducted for
indoxacarb, because indoxacarb has been classified as “not likely to
be carcinogenic.”  Estimated drinking water concentrations (EDWCs),
provided by the Environmental Fate and Effects Division (EFED), were
included in the current assessments as well.  Anticipated residues (ARs)
for all registered and proposed food commodities were based on field
trial data (FTD).  ARs for all current uses were further refined using
percent crop treated (%CT) data (Memo, A. Halvorson, 05-APR-2007; DP#:
338731, and electronic communication, A. Halvorson to M. Sahafeyan,
12-APR-2007, and A. Halvorson to S. Levy, 10-MAY-2007), following the
guidance provided in HED Standard Operating Procedure (SOP) 99.6
(Classification of Food Forms with Respect to level of Blending;
20-AUG-1999).  100% CT was assumed for the remaining new uses. 
Available processing data for indoxacarb were used to refine ARs for
apples/pears (juice), potato (dry, chips), cotton (oil), tomato (paste
and puree), peanut (oil), soybean (oil), grapes (raisin and juice),
prunes (dried), and mint (oil), and other commodities where translation
was applicable.  For all other processed commodities, DEEM-FCID( (ver.
7.81) default processing factors (PFs) were assumed.

EDWCs were provided by EFED (Memo, J. Hetrick, 01-FEB-2007; DP#: 293793)
and incorporated directly into the DEEM-FCID( analyses.  Both the acute
and chronic analyses were conducted using estimated surface water
residues generated using the Pesticide Root Zone/Exposure Analysis
Modeling System (PRZM/EXAMS).  EFED provided modeling results for
several crop scenarios.  The scenarios resulting in the highest EDWCs
(cotton in Mississippi) were used in this assessment.  For the acute and
chronic assessment, the estimated 1-in-10 year annual peak and 1-in-10
year annual mean residue in surface water respectively were used as
point estimates in the DEEM-FCID( analysis.

Acute Dietary Exposure Results

  

Estimated acute dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern for all population subgroups. 
Combined dietary exposure from food and drinking water at the 99.9th
percentile of exposure is estimated to be 0.034881 mg/kg/day for the
overall U.S. population, equivalent to 39% of the aPAD.  The population
subgroup with the highest estimated acute dietary exposure to indoxacarb
is children, 3 to 5 years old, with an estimated exposure at the 99.9th
percentile of 0.075914 mg/kg/day, equivalent to 84% of the aPAD.

Chronic Dietary Exposure Results

Estimated chronic dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern.  Combined dietary exposure from
food and drinking water is estimated at 0.002411 mg/kg/day for the
general U.S. population (16% of the chronic population-adjusted dose
(cPAD) and 0.007940 mg/kg/day (53% of the cPAD) for children, 1 to 2
years old, the population subgroup with the highest estimated chronic
dietary exposure to indoxacarb.

I.   Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the PAD.  The PAD is equivalent
to the point of departure (POD; e.g., NOAEL, LOAEL) divided by the
appropriate uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000,
web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (20-AUG-1999).

II.   Food Residue Information

Tolerances for the combined residues of indoxacarb + its R-enantiomer
are published in 40 CFR §180.564.  There are currently two end-use
products of indoxacarb with food/feed uses registered to DuPont:  a 30%
water-dispersible granular (WDG) formulation (DuPont Avaunt(
Insecticide, EPA Reg. No. 352-597) and a 1.25 lb/gal (15%) suspension
concentrate (SC) formulation (DuPont Steward® Insecticide, EPA Reg. No.
352-598).  These formulations contain an isometric mixture of 75%
indoxacarb (insecticidally active S-enantiomer; DPX-KN128) and 25% of
the R-enantiomer (insecticidally inactive; IN-KN127).  The percentage of
active ingredient (a.i.) listed on each label and the labeled use rates
for each crop are based only on the amount of indoxacarb.  The initial
petitions were on Brassica, sweet corn, cotton, fruiting vegetables,
lettuce (head and leaf) and pome fruits, in which the crop field trial
data were conducted with a formulation containing an isometric 50:50
racemic mixture.  Once the formulations were changed by DuPont to a
75:25 mixture, the residue values from the associated crops were
multiplied by 0.67 to account for the reduced application rate of total
indoxacarb + its R-enantiomer.

Residues of Concern:  The nature of the residue in plants and livestock
is adequately understood.  Data from the plant and ruminant metabolism
studies, as well as toxicological and environmental fate data were
presented to the HED Metabolism Assessment Review Committee (MARC) for
determination of the residues of concern (Memo, S. Levy, 10-JUL-2000;
DP#: 263986).  See DP#: 324855 for the chemical structures of indoxacarb
and its metabolites.

For poultry commodities, the HED MARC recommended that the following
compounds be determined in the poultry feeding study:  parent, IN-JT333,
IN-KG433, IN-KT319, IN-JU873, 5-HO-IN-JT333, Metabolite F, and IN-KB687
(Memo, S. Levy, 10-JUL-2000; DP#: 263986).  However, the petitioner
stated that two of the metabolites (5-OH-IN-JT333 and Metabolite F)
cannot be synthesized in sufficient quantities to permit development of
analytical methods.  The HED MARC determined that, based on the
toxicology profile for the parent compound, and similarity in structure
to the parent compound as well as other structure-activity relationship
(SAR) considerations, that metabolites 5-OH-IN-JT333 and Metabolite F
could be of comparable toxicity to the parent and should be considered
residues of concern for risk assessment purposes.  Furthermore, other
metabolites which will be determined in the poultry feeding study can
serve as marker compounds for 5-OH-IN-JT333 and Metabolite F.  The ratio
of the marker compounds to 5-OH-IN-JT333 and Metabolite F derived from
the metabolism study, can be applied to the results of the magnitude of
the residue study to estimate the amounts of 5-OH-IN-JT333 and
Metabolite F (Memo, S. Levy, 04-OCT-2001; DP#: 277922).  A poultry
feeding study was submitted and reviewed.  Tolerances on poultry were
recommended (Memo, S. Levy, 22-SEP-2004; DP#: 297936).  No dietary risk
assessment was done prior to this document to assess the risk of
secondary residues in poultry.  See Table 1 for a summary of the
residues of concern determined by the MARC.



Table 1.  Indoxacarb Residues of Concern.

Matrix	Tolerance Expression	Residues for Risk Assessment

Plants	Indoxacarb + R-enantiomer	Indoxacarb + R-enantiomer

Ruminants	Indoxacarb + R-enantiomer	Indoxacarb + R-enantiomer.  In milk,
also include IN-MP819.

Poultry	Indoxacarb + its R-enantiomer, IN-JT333, IN-KT319, IN-JU873,
IN-KG433, and IN-KB687	Indoxacarb + its R-enantiomer, IN-JT333,
IN-KG433, IN-KT319, IN-JU873, 5-HO-IN-JT333, Metabolite F, and IN-KB687

Rotational Crops	Indoxacarb + R-enantiomer	Indoxacarb + R-enantiomer

Drinking Water	NA	Parent, IN-JT333, IN-KG433, IN-KT413, IN-JU 873,
IN-ML437-OH.



Tolerances:  Permanent tolerances have been established under 40 CFR
§180.564(a) for the combined residues of indoxacarb + its R-enantiomer
as follows:  apple (1.0 ppm); apple, wet pomace (3.0 ppm); Brassica,
head and stem, subgroup 5A (5.0 ppm); alfalfa, forage (10 ppm); alfalfa,
hay (50 ppm); corn, sweet, forage (10 ppm); corn, sweet, kernel plus cob
with husk removed (0.02 ppm); corn, sweet, stover (15 ppm); cotton gin
byproducts (15 ppm); cotton, undelinted seed (2.0 ppm); lettuce, head
(5.0 ppm); lettuce, leaf (10 ppm); pear (0.20 ppm); peanut (0.01 ppm);
peanut, hay (40 ppm); potato (0.01 ppm); soybean, aspirated grain
fractions (45 ppm); soybean, hulls (4.0 ppm); soybean, seed (0.80 ppm);
vegetables, fruiting, group 8 (0.50 ppm); milk (0.15 ppm); milk fat (4.0
ppm); and in fat (1.5 ppm); meat (0.05 ppm); and meat-byproducts (0.03
ppm) of cattle, goat, hog, horse, and sheep.  Time-limited tolerances
are established in connection with an Expermimental-Use Permit (EUP;
peach at 10 ppm; set to expire 15-MAY-2006) and in connection with
Section 18 Emergency Exemptions (cranberry at 0.50 ppm; set to expire
31-DEC-2004 and collards at 3.0 ppm; set to expire 30-JUN-2006). 

Dupont and Interregional Research Project No. 4 (IR-4) have proposed
tolerances for indoxacarb on a variety of commodities.  The proposed
tolerances are summarized below together with HED’s recommendations
based on review of the residue data submitted to support these petitions
(Memos, S. Levy, 18-FEB-2005; DP#: 290126, 22-SEP-2004; DP#: 297936, and
09-MAR-2007; DP#: 325479).

  

Table 2.  Tolerance Summary for Indoxacarb.

Crop Commodity	Proposed or Established Tolerance (ppm)	Recommended
Tolerance (ppm)	Comments



Grape	2.0	2.0	Adequate residue data are available.



Raisin	6.0	5.0	Adequate processing data are available.

Grape, raisin

Vegetables, Leafy, Brassica (Group 5)	12	12	Adequate residue data on
mustard green, broccoli, and cabbage are available.  Once the tolerance
is established on group 5, the established 5.0 tolerance for Brassica,
head and stem, subgroup 5A should be revoked. 

Turnip Greens	12	12	Turnip green tolerance can be established based on
mustard green data.

Egg	0.2	0.20

	Poultry, fat	0.2	0.20

	Poultry, meat	0.06	0.06

	Poultry, meat byproducts	0.06	0.06

	Leafy vegetables except Brassica	14	14	The existing residue data on
leaf and head lettuce are adequate, as the currently-submitted spinach
and celery data will support a crop group tolerance for Vegetable,
Leafy, Except Brassica, Group 4.  Once the tolerance is established on
Vegetable, Leafy, except Brassica, Group 4, the separate tolerances on
leaf and head lettuce should be deleted.

Fruit, pome, except pear, group 11	1.0	1.0	Once the tolerance is
established on group 11, the separate tolerance on apple should be
deleted.  The existing residue data on apples are adequate and will
support an expanded use and a tolerance on Fruit, pome, group 11, except
pear.

Vegetable, tuberous and corm, subgroup 1C	0.01	0.01	The existing residue
data on potatoes are adequate and will support an expanded use and a
tolerance on Vegetable, tuberous and corm, subgroup 1C.  Once the
tolerance is established on subgroup 1C, the separate tolerance on
potato should be deleted.

Vegetable, cucurbit, group 9	0.5	0.60	Adequate residue data are
available on cucumbers, squash, and cantaloupes.  The tolerance is based
on residue data from cantaloupes.

Fruit, stone group 12	1	0.90	Adequate residue data are available on
cherries, plums and peaches.  The group tolerance is based on residue
data from cherries.  Fruit, stone, group 12



Cranberry	1	0.90	Adequate residue data are available.

Mint	10	11	Adequate residue data are available.

Separate tolerances should be established for Peppermint, tops and
Spearmint, tops.

Okra	0.5	0.50	The existing residue data on tomatoes and  peppers will be
translated to support the same use pattern and tolerance on okra, as
okra is now considered part of the “vegetable, fruiting, group 8”
crop group.

Pea (southern)	0.1	0.10	Adequate residue data are available for dried
pea only.

Pea, southern, seed



Residue Data used for the Acute and Chronic Assessments:  

Food Commodities (except livestock commodities):  Refined acute
probabilistic and chronic dietary exposure assessments were conducted
for all existing and proposed new food uses of indoxacarb and drinking
water.  ARs for all registered and proposed food commodities were based
on FTD.  When a commodity had a number of <LOQ residue values, either
the highest FTD or tolerance was used for ease of calculation (i.e., for
apples, the corrected highest field trial value was used for the
“treated” commodity, instead of constructing a RDF with the full
distribution of corrected values).  ARs for all current uses were
further refined using %CT data, following the guidance provided in HED
SOP 99.6 (Classification of Food Forms with Respect to level of
Blending; 20-AUG-1999).  100% CT was assumed for the remaining new uses.
 Available processing data were used to refine ARs for apples/pears
(juice), potato (dry, chips), cotton (oil), tomato (paste and puree),
peanut (oil), soybean (oil), grapes (raisin and juice), prunes (dried),
and mint (oil), and commodities were translated as appropriate.  For all
other processed commodities, DEEM-FCID(  (ver. 7.81) default PFs were
assumed.

Acute Assessment:

For non-blended and partially blended commodities:  A
residue-distribution file (RDF) was constructed using the entire
distribution of field trial residue values, with zeros incorporated to
account for the untreated portion of the crop (untreated portion = 100%
minus the estimated maximum %CT).  The resulting residue distributions
were used probabilistically in the acute assessment.  All PFs were
inserted in DEEM-FCID( under “adjustment factor 1.”

For blended commodities:  A point estimate was calculated by taking the
average field trial residue and adjusting it by the maximum %CT estimate
(point estimate = average residue x maximum %CT).  All PFs were inserted
in DEEM-FCID( under “adjustment factor 1.”

Chronic Assessment:

For non-blended, partially blended and blended commodities:  A point
estimate was calculated by taking the average field trial value and
adjusting it by the average %CT estimate (Point estimate = average
residue x average %CT).  All PFs were inserted in DEEM-FCID( under
“adjustment factor 1.”

Livestock commodities:  For poultry, egg and milk, since the residues of
concern were different than the tolerance expression, the metabolism
study, in conjunction with feeding studies were used to calculate the
secondary residues in those tissues (see detail discussion later in this
section).  For ruminant and hog tissues, since the tolerance expression
was the same as the residues of concern, the tolerance values were used
as conservative estimates of the indoxacarb residues.

The food residue data used in the acute and chronic dietary assessments
are summarized in Table 3.  RDFs used in the acute assessment are
included in the attachments to this document.

Table 3.  Data and Residue Estimates Used in the Acute and Chronic
Dietary Analyses.

Commodity	Classification	ave.

% CT	Max

% CT	Source of Data	# of FTD	# of zeroes in RDF	sum (FTD)	mean of RDF	PF
Acute Value	Chronic

Value

apple juice	PB	1	5	highest FTD (DP#:  244253)	5	95	3.7	0.037	0.01	rdf x
PF	0.0074 x PF

apples	NB	1	5	highest FTD (DP#: 244253)	5	95	3.7	0.037

rdf	0.0074

apples, dried	B	1	5	highest FTD (DP#: 244253)	5	95	3.7	0.037	8	0.037 x
PF	0.0074 x PF

Apricot	PB	100	100	peach FTD (DP#: 325479)	30	0	4.66	0.1553

rdf	0.155333

Apricot, dried	B	100	100	FTD

 (DP#: 325479)	30	0	4.66	0.1553	6	0.1553 x PF	0.1553 x PF

Broccoli	NB	40	50	FTD 

(DP#: 244253)	20	20	12.95	0.3238

rdf	0.2590

Cabbage

(no wrapper)	NB	15	25	FTD 

(DP#: 244253)	22	66	1.27	0.0144

rdf	0.0087

Cantaloupe	NB	100	100	FTD 

(DP#: 325479)	22	0	2.236	0.1016

rdf	0.1016

Cauliflower	NB	35	55	broccoli FTD	20	16	12.95	0.3561

rdf	0.2266

Celery-untrimmed	PB	100	100	FTD

 (DP#: 325479)	12	0	23.2	1.9333

rdf	1.9333

Cherry	PB	100	100	FTD

 (DP#: 325479)	32	0	8	0.25

rdf	0.25

Cherry juice	PB	100	100	FTD 

(DP#: 325479)	32	0	8	0.25	1.5	rdf x PF	0.25 x PF

Corn, sweet	NB	1	2.5	highest FTD (DP#: 244253)	1	39	0.008	0.0002

rdf	0.00008

Cottonseed oil	B	100	100	highest FTD (DP#: 244253)	1	0	0.67	0.67	0.04
0.67 x PF	0.67 x PF

Cranberry	PB	100	100	FTD 

(DP#: 325479)	12	0	2.591	0.2159

rdf	0.2159

Cucumber	NB	100	100	FTD 

(DP#: 325479)	20	0	0.459	0.0230

rdf	0.0230

Eggs	NB	100	100	see text	1	0	0.119	0.119

0.119	0.119

Group 8, the rest (okra, eggplant, tomatillo)	PB	100	100	highest tomato
FTD 

(DP#: 244253)	1	0	0.27	0.27

0.27	0.27

Grape	PB	100	100	FTD 

(DP#: 290126)	20	0	10.06	0.5030

rdf	0.5030

Grape juice/wine	PB	100	100	FTD 

(DP#: 290126)	20	0	10.06	0.5030	0.007	rdf x PF	0.5030 x PF

Grape leaves	PB	100	100	FTD 

(DP#: 290126)	20	0	10.06	0.5030

rdf	0.5030

Grape raisins	PB	100	100	FTD

(DP#: 290126)	20	0	10.06	0.5030	2.7	rdf x PF	0.5030 x PF

Group 11, except apples and pears	NB	100	100	highest FTD for apples

(DP#: 244253)	1	0	0.74	0.7400

0.74	0.7400

Lettuce head, no wrapper	NB	18	25

18	54	3.97	0.0551

rdf	0.0397

Lettuce, leaf	NB	9	11	DP#: 244253	18	146	108.2	0.6612

rdf	0.5410

Milk fat	PB	100	100	see text	1	0	3.28	3.28

2.43	2.43

Milk water	PB	100	100	see text	1	0	0.11	0.11

0	0

Milk, non-fat solids	PB	100	100	see text	1	0	0.29	0.29

0.495	0.495

Mint	B	100	100	FTD 

(DP#: 325479)	12	0	46.44	3.8700

3.8700	3.8700

Mint oil	B	100	100

12	0	46.44	3.8700	0.028	3.87 x PF	3.87 x PF

Mustard Green	PB	100	100	FTD 

(DP#: 325479)	8	0	47.8	5.9750

rdf	5.9750

Nectarine	PB	100	100	Peach FTD (DP#: 325479)	30	0	4.66	0.1553

rdf	0.1553

Peach 	NB	100	100	FTD 

(DP#: 325479)	30	0	4.66	0.155

rdf	0.155

Peach Dried	B	100	100	FTD 

(DP#: 325479)	30	0	4.66	0.155	4	0.155 x PF	0.155 X PF

Peanut	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.003	0.000075

0.000075	0.00003

Peanut butter	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.003	0.000075	1.89
0.000075 x 1.89	0.00003 x1.89

Peanut oil	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.003	0.000075	1.4
0.000075 x 1.4	0.00003 x 1.4

Pear	NB	1	2.5	highest FTD (DP#: 244253)	1	39	0.08	0.002

rdf	0.0008

Pear juice 	PB	1	2.5	highest FTD (DP#: 244253)	1	39	0.08	0.002	0.01	rdf
x PF	0.0008 x PF

Pears, dried	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.08	0.002	6.25
0.002 x PF	0.0008 x PF

Pepper (bell or non-bell)	PB	10	15	highest FTD (DP#: 244253)	15	85	1.005
0.0101

rdf	0.0067

Pepper, dried	B	10	15	highest FTD (DP#: 244253)	15	85	1.005	0.0101

0.0101	0.0067

Pepper, dry (bell or non-bell)	B	10	15	highest FTD (DP#: 244253)	15	85
1.005	0.0101

0.0101	0.0067

Plums-prunes	NB	100	100	FTD

(DP#: 325479)	22	0	0.99	0.0450

rdf	0.0450

Plums-prunes (dried)	PB	100	100	FTD 

(DP#: 325479)	22	0	0.99	0.0450	4	0.045 x PF	0.045 x PF

Pork	NB	100	100	tolerance





tolerance	tolerance

Potato	NB	1	2.5	tolerance	1	39	0.01	0.00025

rdf	0.0001

Potato

(dry, chips)	B	1	2.5	average FTD	1	39	0.004	0.0001	0.85	0.0001 x PF
0.00004 x PF

Potato, flour	B	1	2.5	average FTD	1	39	0.004	0.0001

0.0001	0.00004

Poultry, fat	NB	100	100	see text





0.457	0.457

Poultry, liver	NB	100	100	see text





0.052	0.052

Poultry, meat	NB	100	100	see text





0.045	0.045

Poultry, meat byproduct	NB	100	100	see text





0.052	0.052

Poultry, skin	NB	100	100	see text





0.079	0.079

Ruminants	NB	100	100	tolerance





tolerance	tolerance

Southern Pea	PB	100	100	FTD 

(DP#: 325479)	14	0	0.319	0.0228

rdf	0.0228

Soybean	B	1	1	average FTD	1	99	0.088	0.00088	0.64 (for oil)	.00088 x PF
.00088 x PF

Spinach	NB	5	5	FTD 

(DP#: 325479)	16	304	84.3	0.2634

rdf	0.2634

Squash	NB	100	100	FTD 

(DP#: 325479)	22	0	0.729	0.0331

rdf	0.0331

Subgroup 1C, the rest	NB	100	100	tolerance	1	0	0.01	0.01

0.01	0.01

Subgroup 4A, the rest (not spinach & lettuce)	NB	100	100	FTD 

(DP#: 325479)	16	0	84.3	5.2688

rdf	5.2688

Subgroup 4B 	NB	100	100	Celery FTD (DP#: 325479)	12	0	23.2	1.9333

rdf	1.9333

Subgroup 5A (the rest)	PB	35	55	broccoli FTD	20	16	12.95	0.3561

rdf	0.2266

Subgroup 5B 	PB	100	100	Mustard green FTD 

(DP#: 325479)	8	0	47.8	5.9750

rdf	5.9750

Subgroup 9A, melons	NB	100	100	Cantaloupe FTD 

(DP#: 325479)	22	0	2.236	0.1016

rdf	0.1016

Subgroup 9B except cucumber	NB	100	100	summer squash FTD 

(DP#: 325479)	22	0	0.729	0.0331

rdf	0.0331

Tomatoes	PB	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675

rdf	0.0405

Tomatoes, dried	B	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675	14.3
0.0675 x PF	0.0405 x PF

Tomatoes, paste	B	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675	1.4
0.0675 x PF	0.0405 x PF

Tomatoes, puree	B	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675	0.52
0.0675 x PF	0.0405 x PF

Water (all sources)



see text





0.025	0.00537



Food Residues – Details

Vegetables, leafy, except Brassica, group 4:  The submitted field trials
for celery and spinach were conducted at different pre-harvest intervals
(PHIs) (celery at 7-, 14-, and 21-day PHIs while spinach at 3-, 7-, and
14-day PHIs).  The proposed label for leaf petiole vegetables (celery is
in subgroup 4B) lists 3-day PHI, 3-day retreatment interval (RTI),
maximum seasonal application of 0.26 lb ai/A.  Note that data are not
available for untrimmed celery at the proposed PHI of 3 days.  However,
HED used the trimmed celery residue data to estimate untrimmed celery
residues as follows:  Indoxacarb residue concentrations in trimmed and
untrimmed celery were compared for 0-day, 7-day, and 14-day PHI samples.
 Based on this comparison, trimmed to untrimmed ratios were determined
to be 2.32 for the 0-day PHI samples, 3.0 for the 7-day PHI samples and
2.3 for the 14-day PHI samples.  The average residue ratio for these
three sampling intervals was calculated to be 2.5.  The 3-day trimmed
celery residue data were entered into the U.S. EPA tolerance calculator,
resulting in a trimmed celery tolerance of 3.5 ppm.  To determine an
untrimmed tolerance value, the 3.5 ppm value was multiplied by the
average trimmed to untrimmed residue ratio of 2.5, resulting in a value
of ~9.0 ppm.

Therefore, for celery, the trimmed, 3-day PHI celery FTD were multiplied
by 2.5 and were used in an RDF
(Indoxacarb-040907-3-dayPHI-UntrimdCelery.rdf).  This RDF, with
assumption of 100% CT due to unavailability of usage data for new uses,
was used for all subgroup 4B crops (leaf petiole vegetables).

On the other hand, for crop subgroup 4A (leafy greens subgroup) except
for lettuce and spinach, spinach FTD with 100% CT assumptions were used.
 For lettuce and spinach, their corresponding FTD and %CT were used in
three separate RDFs (leaf lettuce, head lettuce and spinach).  The crops
had the same use rates (4 applications, maximum use rate – 0.26 lb
ai/A, 3-day PHI).

Brassica, leafy, group 5:  Broccoli, cabbage, and mustard green FTD are
available (Memos, S. Levy, 19-JAN-2000; DP#: 244253 and 18-FEB-2005;
DP#: 290126) and were within 5x of each other, with mustard green FTD
being the highest.  The suggested use rate is the same for all crops in
this group (maximum application rate = 0.26 lb ai/A, PHI=3 days).  
Broccoli field trials were not conducted at a 1x application rate;
therefore, broccoli data were used for broccoli only after being
adjusted for rate of exaggeration (multiplied by 0.67; see DP#: 244253,
page 119) and cabbage data were used for cabbage only.  For the rest of
the crop subgroup 5A, broccoli data (higher residues than cabbage)
adjusted for zeroes with %CT for cauliflower (highest %CT in that
subgroup and in all crops), were used.  For crop subgroup 5B, mustard
green data with 100% CT were used (no %CT on any of the crops in
subgroup 5B are available).

Grape, grape juice, raisins:  Grape FTD with 100% CT assumptions were
used for grape, grape juice and raisins.  PFs (as adjustment factors in
DEEM-FCID() were also incorporated (PF for grape juice/wine and
sherry=0.007, PF for raisins=2.7).

Cucurbit Vegetables (group 9):  Cantaloupe, summer squash, and cucumber
FTD with 100% CT assumptions were used for group 9 crops.  Cantaloupe
data were used for all melons (subgroup 9A) and summer squash data
(higher than cucumber data) were utilized for all crops in subgroup 9B
except for cucumber.

Pome Fruit group (11):

Apple, apple juice, dried apple:  The highest FTD for apple which were
adjusted for rate of exaggeration (0.74 ppm) were used in an RDF.  The
RDF also incorporated zeroes according to %CT (maximum 5% and average
1%).  A PF of 0.01 was used in DEEM-FCID( as the second adjustment
factor for apple juice, and a DEEM-FCID(  default PF of 8 was used for
dried apple.  

Pear, pear juice, dried pear:  The highest FTD for pear which were
adjusted for rate of exaggeration (0.08 ppm) were used in an RDF.  The
RDF also incorporated zeroes according to %CT (maximum 2.5% and average
1%).  A PF for apple juice (0.01) was translated to pear juice as the
second adjustment factor in DEEM-FCID( as for pear juice, and a
DEEM-FCID( as default PF of 6.25 was used for dried pear.

	

For the rest of the crops in group 11, apple FTD with the same %CT were
used.

Fruit Stone, group 12:  FTD for cherries, peaches, and plums with the
same use rate were submitted; FTD residues were highest for cherries. 
The registrant requested four applications with a maximum use of 0.44 lb
ai/A and 14-day PHI.  The submitted FTD were used for the respective
crops in DEEM-FCID( as (in form of RDFs).  For other crops in group 12,
FTD for the similar fruit were used.  %CT data for cherries and peaches
provided by BEAD were based on their uses as emergency use permits
(EUPs), not as Section 3 registrations and hence were not used. 
Therefore, for all crops in group 12, 100% CT were assumed.  An
empirical PF of 4x was used for dried plums.  For the other crops in
group 12, DEEM-FCID( default PFs were used for juice and the dried food
form.

Mint:  The average of the submitted mint FTD were used as a point
estimate (assuming 100% CT) for peppermint, spearmint, and their
corresponding oil in DEEM-FCID(.  Mint and mint oil are considered
blended commodities.  An empirical PF (0.028x) was used for mint oil.

Fruiting Vegetables (group 8):  FTD were submitted for non-bell pepper,
bell pepper, and tomatoes (Memo, S. Levy, 19-JAN-1000; DP#: 244253),
with residues being highest for tomatoes.  The highest FTD residue for
both non-bell pepper and bell pepper which was adjusted for the rate
exaggeration was 0.067 ppm and that for tomato FTD was 0.27 ppm.  Two
RDFs were generated for pepper and tomatoes, using their highest FTD and
incorporating the available %CT values; the RDFs were used for
corresponding crops.  For the rest of this group (eggplant, tomatillo,
and okra), the highest FTD for tomatoes (0.27 ppm) were used, as well as
100% CT.  Empirical PFs for tomato paste (1.4x) and puree (0.52x) were
used.  The PF for tomato puree (0.52x) was also used for tomato juice. 
The DEEM-FCID( default PF for dried tomato (14.3x) was used.

Pea, southern, seed:  The submitted FTD with 100% CT assumption were
used for cowpea beans seed (per electronic communication with B.
Schneider, 10-APR-2007).  HED accepted the submitted data for dry seeds
not succulent.  As such, the FTD were used for only dry cowpea beans.

Cranberry:  The submitted FTD with assumption of 100% CT were used in an
RDF.  The DEEM-FCID( default PF for cranberry juice (1.1) was used.

Peanut, peanut butter, peanut oil:  All are considered blended
commodities.  The highest FTD for peanut (0.003 ppm) with 2.5% CT were
used to derive a point estimate for acute (0.003 X 0.025= 0.000075 ppm)
and with 1% CT for chronic (0.003 X 0.01=0.00003 ppm).  An empirical PF
of 1.4x was used for peanut oil and DEEM-FCID( default PF of 1.89x was
used for peanut butter.

Tuberous and corm vegetables, subgroup 1C: 

Potato:  For non-blended food forms, a tolerance-level residue (0.01
ppm) was used in the RDF with inserting zeroes according to %CT value. 
For blended food forms (dry potato, chips, flour), the average FTD were
used with PFs (0.85x for chips and dry potato) (Memo, S. Levy,
30-MAY-2002; DP#: 276516) inserted as adjustment factor 1 and %CT value
as adjustment factor 2 in DEEM-FCID(.

Other crops:  The tolerance level residue (0.01 ppm), with assumption of
100% CT were used for the rest of the crops in subgroup 1C.

Soybean:  Since all the soybean food forms are blended, the average FTD
(0.088 ppm) (Memo, S. Levy, 30-MAY-2002; DP#: 276516) were used as a
point estimate in conjunction with PF (0.64x for soybean oil only) as
adjustment factor 1 and %CT value as adjustment factor 2 in DEEM-FCID(.

Cottonseed oil:  The average FTD and the empirical PF (0.04x) as
adjustment factor were used.

Corn:  The highest FTD were used in an RDF incorporating zeroes
corresponding to %CT.

Livestock Commodities

Poultry- From the poultry metabolism study, the ratios of all the
metabolites of concern to those that were measured in the feeding study
were calculated to be: 1.81 for egg yolk, 2.8 for fat, 1.5 for muscle,
2.5 for liver, and 1.8 for skin (DP#: 244253).  These ratios were
multiplied by estimated measured residues in each tissue in the feeding
study to arrive at the total metabolites of concern.  The following
dietary burden in conjunction with the feed-tissue chart was used to
estimate the measured residues in each tissue.  As per HED policy,
residues in poultry tissues were not adjusted for % dry matter (DM). 
These secondary residues in livestock tissues are given in Attachment 8.
 The calculated dietary burden is 2.72 ppm (electronic communication, J.
Stokes, 17-APR-2007).



Table 4.  Calculation of Poultry Dietary Burden.

Feedstuff	%DM	Classification	Tolerance	% In Diet	Dietary Burden

Corn, grain	

NA	CC4	0	70	0

Wheat, grain

CC	0	5	0

Soybean, meal1

PC5	0.8	15	0.12

Cottonseed, meal2

PC	2.0	5	0.10

Alfalfa, meal3

PC	50	5	2.50

Total

100	2.72

1   Based on soybean seed tolerance

2   Based  on undelinted cottonseed tolerance

3   Based on alfalfa hay tolerance

4   CC = carbohydrate concentrate

5   PC = protein concentrate

The estimated residues of concern were used as a point estimate in
DEEM-FCID( for the corresponding poultry tissues in both acute and
chronic assessments, assuming 100% CT.  The estimated residue value in
poultry liver tissue was used for meat by-product tissues. 

Milk – From a “reasonably-balanced diet” guidelines (J. Stokes,
Revisions of Livestock Diets Percents), the following diet for dairy
cattle was made.

Table 5.  Dietary Burden for Dairy Cattle Based on Indoxacarb Proposed
Uses.  

Feedstuff	%DM	Classification	Tolerance	% In Diet	Dietary Burden

Corn, grain	88	CC	0	30	0

Wheat, grain	89	CC	0	10	0

Apple wet pomace	40	CC	3.0	5	0.38

Cottonseed, undelinted	88	PC	2.0	10	0.23

Alfalfa, forage	35	R1	10	15	4.29

Alfalfa, hay	89	R	50	30	16.85

Total

100	21.75

1   R = roughage

The calculated 21.75 ppm is anticipated to result in 0.054 ppm
indoxacarb residue in whole milk based on the feeding study (DP#:
276518, p.14) and a constructed dose-residue chart (see attachment 7). 
However, the residues of concern are indoxacarb and MP-819.  From
metabolism study (DP#: 244253, p.141), the highest ratio of metabolites
of concern to indoxacarb is 1.82; therefore, the estimated highest
residues of concern in whole milk is 0.0972 ppm.  Due to high
lipophilicity of indoxacarb (KOW = 4.65 at pH 5) those residues are
expected to be concentrated in the milk fat. Therefore, the residues in
milk fat are estimated to be at 2.43 ppm (i.e., 0.0972/4%, assuming milk
fat is 4% of whole milk).  From the same feeding study residues in cream
and skim milk were also measured; however, the fat content of the cream
is undetermined and thus, those data for cream can not be used.  The
expected indoxacarb residue in skim milk from the dose-residue chart
(see attachment 7) is 0.022 ppm; therefore, the calculated residues of
concern is 0.0396 ppm (i.e., 0.022*1.8).  With the assumption that the
residues are concentrated in non-fat solids of the skim milk (~ 8% of
the milk w/w), the estimated residues of concern in non-fat solids is
0.495 ppm (i.e., 0.0396/8%).  No residues are expected in milk water and
lactose.

Ruminants (beef, goat, sheep, horse) and Pork – Corresponding
tolerance values as point estimates (assuming 100% CT) were used for
both acute and chronic assessments. 

III.   Drinking Water Data

Reference:  Memo, J. Hetrick, 01-FEB-2007; DP#: 293793.

 25.1 μg/L.  The 1- in -10 year annual average concentration
(non-cancer chronic) and 30-year annual average concentration (cancer)
of DPX-JW062 residues are not likely to exceed 5.37 and 2.78 μg/L,
respectively.  SCI-GROW modeling indicates concentrations of DPX-JW062
are not expected to exceed 0.21 μg/L.  The highest indoxacarb residue
concentrations are associated with the Mississippi cotton scenario
(Table 6).  

For acute and chronic dietary risk assessments, the 1-in -10 year peak
(25.1 ppb) and the 1-in -10 year annual average, (5.37 ppb) indoxacarb
residues of concern in water from cotton scenario were used.

Table 6.  Default PCA Corrected PRZM/EXAMS Indoxacarb Residue
Concentrations (µg/L).



Scenario	

1- in -10 year peak	

1- in -10 year annual average	

30-year annual average



Cotton (MS)	25.068	5.373	2.782



Turf (FL)1	0.05	0.014	0.008



Apples (NC)	18.093	4.738	2.560



Cabbage (FL)	8.275	1.940	1.185



Potato (ME)	11.083	5.346	3.961



Swiss Chard (CA)

Aerial Application	9.220	3.788	2.643



Swiss Chard (CA)

Ground  Application	9.173	3.564	2.379

1- The default PCA correction (0.87) was not used for turf because this
use pattern was not considered in development of  PCAs.

IV.   DEEM-FCID™ Program and Consumption Information

Indoxacarb acute and chronic dietary exposure assessments were conducted
using the DEEM-FCID™, Version 2.03, which incorporates consumption
data from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are
based on the reported consumption of more than 20,000 individuals over
two non-consecutive survey days.  Foods “as consumed” (e.g., apple
pie) are linked to EPA-defined food commodities (e.g. apples, peeled
fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or
N/S, baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.



V.   Toxicological Information

RAB1 toxicologists met in March 2007 to re-evaluate the indoxacarb
toxicological endpoints and uncertainty factors in light of new studies.
 The RAB1 toxicologists concluded that the database uncertainty factor
for the lack of a developmental neurotoxicity study should be removed
since the DNT results are available.  Table 7 below summarizes the HED
decisions on endpoints as related to the dietary risk assessment.

Table 7.  Summary of Toxicological Doses and Endpoints for Indoxacarb
for Use in Dietary Exposure Assessment1.

Exposure

Scenario	Dose Used in Risk Assessment, UF	FQPA SF* and Level of Concern
for Risk Assessment	Study and Toxicological Effects

Acute Dietary

females 13-49 years of age	An endpoint of concern attributable to a
single dose was not identified.  An acute RfD was not established.

Acute Dietary

general population including infants and children	NOAEL= 9 mg/kg

UF = 100

Acute RfD =

 0. 09 mg/kg	FQPA SF = 1X

aPAD = 0.09 mg/kg                 (aRfD)        

         1X (FQPA SF)

= 0.09 mg/kg	Acute oral rat neurotoxicity study (MP062).  

LOAEL = 38 mg/kg based on decreased body weight and body weight gain in
females.

Chronic Dietary 

all Populations	NOAEL= 1.5 mg/kg

UF = 100

Acute RfD =

 0. 015 mg/kg/day	FQPA SF = 1X

cPAD = 0.015 mg/kg                 (cRfD)        

         1X (FQPA SF)

= 0.015 mg/kg/day	Weight of evidence approach was used from four
studies: 

1) Subchronic toxicity study- rat (MP062)

2) Subchronic neurotoxicity study - rat (MP062)	

3) Chronic/carcinogenicity study - rat (JW062)

4) Two generation rat reproduction study (JW062).

LOAEL is based on decreased body weight, body weight gain, food
consumption and food efficiency; decreased hematocrit, hemoglobin and
red blood cells only at 6 months.



Cancer (oral, dermal, inhalation)	

“not likely” to be carcinogenic to humans since no evidence of
carcinogenicity in either the rat or mouse studies, and no evidence of
mutagenicity.

1 UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no
observed adverse effect level, LOAEL = lowest observed adverse effect
level, PAD = population adjusted dose (a = acute, c = chronic) RfD =
reference dose, MP062 = 75%KN128:25%KN127 formulation; JW062 =
50%KN128:50%KN127.

VI.   Characterization of Inputs and Outputs

These analyses are considered to be somewhat conservative dietary
exposure assessments.  In some cases, tolerance-level residues, default
DEEM processing factors, and/or 100% CT data were used.  Further
refinement to the analyses could be made through the use of ARs,
incorporation of %CT for new uses and/or monitoring data that better
reflect residues at the time of consumption.  Since both acute and
chronic risk estimates are below HED’s level of concern, more highly
refined analyses are not needed at this time. 

, 

VII.   Results/Discussion

.  The DEEM-FCID™ analyses estimate the dietary exposure of the U.S.
population and various population subgroups.  The acute and chronic
results reported in Tables 8 and 9 are for the general U.S. population,
all infants (<1 year old), children 1-2, children 3-5, children 6-12,
youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Acute Dietary Exposure Results

  

Estimated acute dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern for all population subgroups. 
Combined dietary exposure from food and drinking water at the 99.9th
percentile of exposure is estimated to be 0.034881 mg/kg/day for the
overall U.S. population, equivalent to 39% of the aPAD.  The population
subgroup with the highest estimated acute dietary exposure to indoxacarb
is children, 3 to 5 years old, with an estimated exposure at the 99.9th
percentile of 0.075914 mg/kg/day, equivalent to 84% of the aPAD.

Table 8.  Summary of Acute Dietary (Food + Drinking Water) Exposure and
Risk for Indoxacarb.

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile
99.9th Percentile



Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure
(mg/kg/day)	% aPAD

General U.S. Population	0.09	0.007763	8.6	0.015056	17	0.034881	39

All Infants (< 1 year old)

0.011092	12	0.021882	24	0.039554	44

Children 1-2 years old

0.018245	20	0.027641	31	0.070299	78

Children 3-5 years old1

0.013500	15	0.021957	24	0.075914	84

Children 6-12 years old

0.008839	9.8	0.013521	15	0.029817	33

Youth 13-19 years old

0.005670	6.3	0.011517	13	0.039626	44

Adults 20-49 years old

0.004719	5.2	0.008655	9.6	0.027228	30

Adults 50+ years old

0.004489	5.0	0.012210	14	0.031662	35

1The population subgroup with the highest estimated acute dietary (food
+ drinking water) exposure and risk is indicated by bold text.

Chronic Dietary Exposure Results

Estimated chronic dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern.  Combined dietary exposure from
food and drinking water is estimated at  0.002411mg/kg/day for the
general U.S. population (16% of the cPAD) and 0.007940 mg/kg/day (53% of
the cPAD) for children, 1 to 2 years old, the population subgroup with
the highest estimated chronic dietary exposure to indoxacarb.

Table 9.  Summary of Chronic Dietary (Food + Drinking Water) Exposure
and Risk for Indoxacarb.

Population Subgroup	cPAD (mg/kg/day)	Exposure (mg/kg/day)	% cPAD

General U.S. Population	0.015	0.002411	16

All Infants (< 1 year old)

0.002574	17

Children 1-2 years old1

0.007940	53

Children 3-5 years old

0.006068	41

Children 6-12 years old

0.003701	25

Youth 13-19 years old

0.002197	15

Adults 20-49 years old

0.001764	12

Adults 50+ years old

0.001747	12

Females 13-49 years old

0.001693	11

1The population subgroup with the highest estimated chronic dietary
(food + drinking water) exposure and risk is indicated by bold text.

	VIII.   Conclusions

The results of the acute and chronic dietary assessments indicate that
dietary exposure to indoxacarb from food and drinking water is below
HED’s level of concern for the general U.S. population and all
population subgroups.

IX.   List of Attachments

Attachment 1:	 RDFs for the Acute Analysis

Attachment 2:	 DEEM-FCID( Acute Residue File

Attachment 3:	 DEEM-FCID( Acute Exposure Estimates

Attachment 4:	 DEEM-FCID( Chronic Residue File

Attachment 5:	 DEEM-FCID( Chronic Exposure Estimates

Attachment 6:	 Poultry Dose-Residue Chart and Tables

Attachment 7:	 Milk Dose-Residue Chart and Tables

Attachment 8:	 BEAD Projected %CT Data

cc: M. Sahafeyan; D. Rosenblatt (RD; 7505P)

RDI: DE SAC (08-MAY-2007), G.F. Kramer (16-MAY-2007)

M. Sahafeyan:S10944:PY-S:(703)305-0776:7509P:RAB1

Attachment 1:   RDFs for the Acute Analysis

RDF 1

Apple, highest adjusted FTD (D244253, p.128)=0.74

ToTALZ=95

doc max %CT=5%

5,0.74

	RDF 2 (blank)

RDF 3

Indoxacarb-Broccoli

doc Max %CT=50%

ToTALZ=20

doc adjusted for exaggeration rate (multiplied by 0.67) (MRID 44477401)

0.19

0.23

1.34

1.5

0.57

0.62

0.25

0.45

1.34

1.68

0.80

0.94

0.26

0.52

0.36

0.49

0.23

0.26

0.38

0.54	RDF 4

Indoxacarb-subgroup 5A, Broccoli FTD,  

doc Max %CT=55% of Cauliflower (highest)

ToTALZ=16

doc adjusted for exaggeration rate(multiplied by 0.67) (MRID 44477401)

0.19

0.23

1.34

1.5

0.57

0.62

0.25

0.45

1.34

1.68

0.80

0.94

0.26

0.52

0.36

0.49

0.23

0.26

0.38

0.54



RDF 5

Indoxacarb-Cabbage without Wrapper Leaves

doc Max %CT=25%

ToTALZ=66

0.02

0.04

0.01

0.03

0.08

0.11

0.05

0.05

0.03

0.07

0.06

0.1

0.01

0.02

0.11

0.21

0.02

0.03

0.03

0.04

0.02

0.02

0.03

0.08

	RDF 6

Indox-Cherries, 46651504.der

doc max CT= 100

.07

.07

.15

.45

.22

.19

.15

.16

.3

.51

.24

.12

.26

.31

.13

.62

.07

.07

.15

.45

.21

.19

.15

.15

.32

.51

.28

.15

.26

.32

.13

.64	RDF 7

Indoxacarb, Mustard Green FTD, PHI=3 days, D290126, 45718701.der

doc max CT=100%

totalz=0

3.5

3.4

1.2

1.2

9.6

10

9.5

9.4

RDF 8

Indoxacarb - Head Lettuce w/o wrapper leaves

doc 35% CT Max

TOTALZ=33

0.033

0.016

0.067

0.082

0.051

0.044

0.14

0.24

0.061

0.047

0.11

0.029

0.48

0.34

0.13

0.24

1.1

0.76	RDF 9

Indoxacarb - Leaf Lettuce

doc 11% CT Max

TOTALZ=146

8

8.7

6.8

7.9

6.6

5.6

3.5

4.6

6.6

7.7

5.9

7.2

8.3

8.1

3.4

3.7

2.7

2.9	RDF 10

Indox-Peach FTD, 46651505.der

doc max CT=100% 

07

.26

.13

.03

.04

.1

.09

.3

.16

.19

.58

.07

.06

.29

.13

.04

.04

.3

.16

.2

.59

.07

.09

.09

.09

.09

.1

.1

.1

.1

RDF 11

Indox-Pear, highest FTD, D244253, p.128

doc max CT=2.5%

ToTALZ=39

0.08

	RDF 12

Indox-tomato, highest adjusted FTD, D244253

ToTALZ=75

25,0.27	RDF 13

Indox-fruiting veg. besides pepper and tomatoes

doc highest adjusted FTD for tomatoes is used, D244253

ToTALZ=0

doc max % CT=100%

0.27

RDF 14

Indox-Corn Sweet(k+CWHR), adjusted highest FTD, D244253

ToTALZ=39

doc max %CT=2.5

0.008	RDF 15

Indox-pepper(bell or non-bell), FTD, D244253

doc highest FTD used (adjusted for exaggeration)

ToTALZ=85

15,0.067

	RDF 16-20 blank





RDF 21

Indox-Mint, FTD, 46520902.der

doc max CT=100%

totalz=0

6.84

5.9

5.3

6.81

3.61

2.62

2.24

2.73

2.18

2.1

2.75

3.36

	RDF 22

Indox-Spinach FTD, 46487001.der

doc max CT=5%

totalz=304

7.9

13

2.5

4.5

3.7

3.3

5.7

5.7

4.7

4.3

4.3

4.2

7.2

6.7

2.2

4.4	RDF 23

Indox-Plum, FTD, 46651506.der

doc max CT=100%

TotalZ=0

.01

.01

.02

.02

.02

.03

.07

.04

.07

.19

.02

.02

.01

.02

.02

.02

.03

.07

.04

.07

.18

.01



RDF 24

Indox-trimmed celery, FTD x 2.5, see p.14 of D325479

doc max CT=100%

totalz=0

0.155

0.145

3.25

3

1.075

1.375

1.9

1.325

1.05

1.175

4.75

4	RDF 25

Indox-southern pea, FTD, 46520901.der

doc max CT=100%

totalz=0

4,.01

.0670

.0630

.0130

.0140

.0110

.0110

.0330

.0200

.0150

.0320	RDF 26

Indoxacarb, Grapes, FTD, D290126, 45900301.der, PHI=7 days

doc max CT=100%

totalz=0

0.196

0.163

1.72

1.32

0.133

0.198

0.105

0.0661

0.306

0.328

0.448

0.423

0.292

0.0888

0.482

0.353

1.35

1.31

0.447

0.329



RDF 27

indox-squash, FTD, 46651503.der

doc max CT=100%

totalz=0

0.12

.014

.11

.04

.01

.022

.035

.012

.026

.01

.01

.084

.013

.048

.032

.01

.034

.026

.013

.028

.01

.022

	RDF 28

Indox-Cucumber, FTD, 46651502.der

doc max CT=100%

totalz=0

.018

.015

.025

.025

.01

.023

.04

.031

.013

.019

.016

.02

.028

.014

.01

.022

.069

.031

.012

.018	RDF 29

Indox-Cantaloupe, FTD, 46651501.der

doc max CT=100%

totalz=0

0.027

0.247

0.13

.393

.088

.031

.05

.036

.05

.116

.018

.064

.197

.17

.23

.068

.022

.064

.035

.052

.124

.024	RDF 27

	RDF 28



RDF 30

Indox-Apricot, Nectarine, used Peach FTD, 46651505.der

ToTALZ=0

doc max CT=100%

.07

.26

.13

.03

.04

.1

.09

.3

.16

.19

.58

.07

.06

.29

.13

.04

.04

.3

.16

.2

.59

.07

.09

.09

.09

.09

.1

.1

.1

.1	RDF 31

Indox-cranberry, FTD, 46651507.der, PHI=28-30 days

doc max CT=100%

totalz=0

.086

.151

.099

.190

.13

.57

.146

.149

.11

.16

.11

.69	RDF 32

Indox-Spinach FTD, 46487001.der used for rest of group 4A (100% CT
assumption)

doc max CT=100%

totalz=0

7.9

13

2.5

4.5

3.7

3.3

5.7

5.7

4.7

4.3

4.3

4.2

7.2

6.7

2.2

4.4	RDF 31

	RDF 32





RDF 33

Indox-potato ; tolerance, D276516

doc max % CT=2.5

totalz=39

0.01	





Attachment 2:	 DEEM-FCID( Acute Residue File

Filename: C:\Documents and
Settings\msahafey\Desktop\indox-053007\067710a-Rev2-053007.R98

Chemical: Indoxacarb

RfD(Chronic): .015 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .09 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 05-30-2007/09:57:09/8          Program ver.
2.03

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1        Param #2  Param #3  Comment

  #   Code 

----- ---- ------------        --------  --------  -------

  1    6   Indoxacarb-041207-apple.rdf

  2    6   Indoxacarb-blank6.rdf

  3    6   Indoxacarb-041207-broccoli.rdf

  4    6   Indoxacarb-041207-Grp5A-rest.rdf

  5    6   Indoxacarb-041107-cabbage-WithoutWrapper.rdf

  6    6   Indoxacarb-053007-cherries.rdf

  7    6   indoxacarb-040307-MustrdGrn-FTD.rdf

  8    6   Indoxacarb-041107-HeadLettuce-NoWrapper.rdf

  9    6   Indoxacarb-041707-LeafLettuce.rdf

  10   6   Indoxacarb-053007-peach.rdf

  11   6   Indoxacarb-041207-pear.rdf

  12   6   Indoxacarb-041507-tomato.rdf

  13   6   Indoxacarb-041507-FruitgVeg.rdf

  14   6   Indoxacarb-041707-sweet-corn.rdf

  15   6   Indoxacarb-041507-Pepper.rdf

  16   6   Indoxacarb-blank1.rdf

  17   6   Indoxacarb-blank2.rdf

  18   6   Indoxacarb-blank3.rdf

  19   6   Indoxacarb-blank4.rdf

  20   6   Indoxacarb-blank5.rdf

  21   6   Indoxacarb-041007-mint.rdf

  22   6   indoxacarb-040907-spinach.rdf

  23   6   Indoxacarb-040907-plum.rdf

  24   6   Indoxacarb-040907-3-dayPHI-UntrimdCelery.rdf

  25   6   Indoxacarb-040907-southern-pea.rdf

  26   6   indoxacarb-040307-grapeFTD.rdf

  27   6   Indoxacarb-041007.squash.rdf

  28   6   Indoxacarb-041007-cucumber.rdf

  29   6   Indoxacarb-041007-cantaloupe.rdf

  30   6   Indoxacarb-040907-Apricot-Nectarine.rdf

  31   6   Indoxacarb-041007-cranberry.rdf

  32   6   indoxacarb-042307-Grp-4A-rest.rdf

  33   6   Indoxacarb-042307-potato.rdf

  EPA    Crop Commodity Name                    Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

04010050 4A   Amaranth, leafy                   14.000000   1.000  1.000
 32  

11000070 11   Apple, fruit with peel             1.000000   1.000  1.000
  1  

11000080 11   Apple, peeled fruit                1.000000   1.000  1.000
  1  

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000
  1  

11000090 11   Apple, dried                       0.037000   8.000  1.000
     

11000091 11   Apple, dried-babyfood              0.037000   8.000  1.000
     

11000100 11   Apple, juice                       1.000000   0.010  1.000
  1  

11000101 11   Apple, juice-babyfood              1.000000   0.010  1.000
  1  

11000110 11   Apple, sauce                       1.000000   1.000  1.000
  1  

11000111 11   Apple, sauce-babyfood              1.000000   1.000  1.000
  1  

12000120 12   Apricot                            0.900000   1.000  1.000
 30  

12000121 12   Apricot-babyfood                   0.900000   1.000  1.000
 30  

12000130 12   Apricot, dried                     0.155300   6.000  1.000
     

12000140 12   Apricot, juice                     0.900000   1.000  1.000
 30  

12000141 12   Apricot, juice-babyfood            0.900000   1.000  1.000
 30  

01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000
     

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000
     

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000
     

04010180 4A   Arugula                           14.000000   1.000  1.000
 32  

09020210 9B   Balsam pear                        0.600000   1.000  1.000
 27  

06030340 6C   Bean, cowpea, seed                 0.100000   1.000  1.000
 25  

21000440 M    Beef, meat                         0.050000   1.000  1.000
     

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
     

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
     

21000460 M    Beef, meat byproducts              0.030000   1.000  1.000
     

21000461 M    Beef, meat byproducts-babyfood     0.030000   1.000  1.000
     

21000470 M    Beef, fat                          1.500000   1.000  1.000
     

21000471 M    Beef,fat-babyfood                  1.500000   1.000  1.000
     

21000480 M    Beef, kidney                       0.030000   1.000  1.000
     

21000490 M    Beef, liver                        0.030000   1.000  1.000
     

21000491 M    Beef, liver-babyfood               0.030000   1.000  1.000
     

05010610 5A   Broccoli                          12.000000   1.000  1.000
  3  

05010611 5A   Broccoli-babyfood                 12.000000   1.000  1.000
  3  

05010620 5A   Broccoli, Chinese                 12.000000   1.000  1.000
  3  

05020630 5B   Broccoli raab                     12.000000   1.000  1.000
  7  

05010640 5A   Brussels sprouts                  12.000000   1.000  1.000
  4  

05010690 5A   Cabbage                           12.000000   1.000  1.000
  5  

05020700 5B   Cabbage, Chinese, bok choy        12.000000   1.000  1.000
  7  

05010710 5A   Cabbage, Chinese, napa            12.000000   1.000  1.000
  4  

05010720 5A   Cabbage, Chinese, mustard         12.000000   1.000  1.000
  4  

09010750 9A   Cantaloupe                         0.600000   1.000  1.000
 29  

04020760 4B   Cardoon                           14.000000   1.000  1.000
 24  

09010800 9A   Casaba                             0.600000   1.000  1.000
 29  

01030820 1CD  Cassava                            0.010000   1.000  1.000
     

01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000
     

05010830 5A   Cauliflower                       12.000000   1.000  1.000
  4  

04020850 4B   Celery                            14.000000   1.000  1.000
 24  

04020851 4B   Celery-babyfood                   14.000000   1.000  1.000
 24  

04020860 4B   Celery, juice                     14.000000   1.000  1.000
 24  

04020870 4B   Celtuce                           14.000000   1.000  1.000
 24  

09020880 9B   Chayote, fruit                     0.600000   1.000  1.000
 27  

12000900 12   Cherry                             0.900000   1.000  1.000
  6  

12000901 12   Cherry-babyfood                    0.900000   1.000  1.000
  6  

12000910 12   Cherry, juice                      0.900000   1.500  1.000
  6  

12000911 12   Cherry, juice-babyfood             0.900000   1.500  1.000
  6  

40000930 P    Chicken, meat                      0.045000   1.000  1.000
     

40000931 P    Chicken, meat-babyfood             0.045000   1.000  1.000
     

40000940 P    Chicken, liver                     0.052000   1.000  1.000
     

40000950 P    Chicken, meat byproducts           0.052000   1.000  1.000
     

40000951 P    Chicken, meat byproducts-babyfoo   0.052000   1.000  1.000
     

40000960 P    Chicken, fat                       0.457000   1.000  1.000
     

40000961 P    Chicken, fat-babyfood              0.457000   1.000  1.000
     

40000970 P    Chicken, skin                      0.079000   1.000  1.000
     

40000971 P    Chicken, skin-babyfood             0.079000   1.000  1.000
     

09021020 9B   Chinese waxgourd                   0.600000   1.000  1.000
 27  

04011040 4A   Chrysanthemum, garland            14.000000   1.000  1.000
 32  

05021170 5B   Collards                          12.000000   1.000  1.000
  7  

15001270 15   Corn, sweet                        0.020000   1.000  1.000
 14  

15001271 15   Corn, sweet-babyfood               0.020000   1.000  1.000
 14  

95001280 O    Cottonseed, oil                    0.670000   0.040  1.000
     Blende

    Full comment: Blended

95001281 O    Cottonseed, oil-babyfood           0.670000   0.040  1.000
     Blende

    Full comment: Blended

11001290 11   Crabapple                          1.000000   1.000  1.000
  1  

95001300 O    Cranberry                          0.900000   1.000  1.000
 31  

95001301 O    Cranberry-babyfood                 0.900000   1.000  1.000
 31  

95001310 O    Cranberry, dried                   0.900000   1.000  1.000
 31  

95001320 O    Cranberry, juice                   0.900000   1.100  1.000
 31  

95001321 O    Cranberry, juice-babyfood          0.900000   1.100  1.000
 31  

04011330 4A   Cress, garden                     14.000000   1.000  1.000
 32  

04011340 4A   Cress, upland                     14.000000   1.000  1.000
 32  

09021350 9B   Cucumber                           0.600000   1.000  1.000
 28  

04011380 4A   Dandelion, leaves                 14.000000   1.000  1.000
 32  

01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000
     

70001450 P    Egg, whole                         0.119000   1.000  1.000
     

70001451 P    Egg, whole-babyfood                0.119000   1.000  1.000
     

70001460 P    Egg, white                         0.119000   1.000  1.000
     

70001461 P    Egg, white (solids)-babyfood       0.119000   1.000  1.000
     

70001470 P    Egg, yolk                          0.119000   1.000  1.000
     

70001471 P    Egg, yolk-babyfood                 0.119000   1.000  1.000
     

08001480 8    Eggplant                           0.270000   1.000  1.000
     

04011500 4A   Endive                            14.000000   1.000  1.000
 32  

04021520 4B   Fennel, Florence                  14.000000   1.000  1.000
 24  

01031660 1CD  Ginger                             0.010000   1.000  1.000
     

01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000
     

01031670 1CD  Ginger, dried                      0.010000   1.000  1.000
     

23001690 M    Goat, meat                         0.050000   1.000  1.000
     

23001700 M    Goat, meat byproducts              0.030000   1.000  1.000
     

23001710 M    Goat, fat                          1.500000   1.000  1.000
     

23001720 M    Goat, kidney                       0.030000   1.000  1.000
     

23001730 M    Goat, liver                        0.030000   1.000  1.000
     

95001750 O    Grape                              2.000000   1.000  1.000
 26  

95001760 O    Grape, juice                       2.000000   0.007  1.000
 26  

95001761 O    Grape, juice-babyfood              2.000000   0.007  1.000
 26  

95001770 O    Grape, leaves                      2.000000   1.000  1.000
 26  

95001780 O    Grape, raisin                      6.000000   2.700  1.000
 26  

95001790 O    Grape, wine and sherry             2.000000   0.007  1.000
 26  

09011870 9A   Honeydew melon                     0.600000   1.000  1.000
 29  

24001890 M    Horse, meat                        0.050000   1.000  1.000
     

05021940 5B   Kale                              12.000000   1.000  1.000
  7  

05011960 5A   Kohlrabi                          12.000000   1.000  1.000
  4  

04012040 4A   Lettuce, head                     14.000000   1.000  1.000
  8  

04012050 4A   Lettuce, leaf                     14.000000   1.000  1.000
  9  

11002100 11   Loquat                             1.000000   1.000  1.000
  1  

27002220 D    Milk, fat                          2.430000   1.000  1.000
     

27002221 D    Milk, fat - baby food/infant for   2.430000   1.000  1.000
     

27012230 D    Milk, nonfat solids                0.500000   1.000  1.000
     

27012231 D    Milk, nonfat solids-baby food/in   0.500000   1.000  1.000
     

05022290 5B   Mustard greens                    12.000000   1.000  1.000
  7  

12002300 12   Nectarine                          0.900000   1.000  1.000
 30  

08002340 8    Okra                               0.270000   1.000  1.000
     

04012480 4A   Parsley, leaves                   14.000000   1.000  1.000
 32  

12002600 12   Peach                              0.900000   1.000  1.000
 10  

12002601 12   Peach-babyfood                     0.900000   1.000  1.000
 10  

12002610 12   Peach, dried                       0.003900   4.000  1.000
     

12002611 12   Peach, dried-babyfood              0.003900   4.000  1.000
     

12002620 12   Peach, juice                       0.900000   1.000  1.000
 10  

12002621 12   Peach, juice-babyfood              0.900000   1.000  1.000
 10  

95002630 O    Peanut                             0.000075   1.000  1.000
     Blende

    Full comment: Blended

95002640 O    Peanut, butter                     0.000075   1.890  1.000
     Blende

    Full comment: Blended

95002650 O    Peanut, oil                        0.000075   1.400  1.000
     Blende

    Full comment: Blended

11002660 11   Pear                               0.110000   1.000  1.000
 11  

11002661 11   Pear-babyfood                      0.110000   1.000  1.000
 11  

11002670 11   Pear, dried                        0.002000   6.250  1.000
     Blende

    Full comment: Blended

11002680 11   Pear, juice                        0.110000   0.010  1.000
 11  

11002681 11   Pear, juice-babyfood               0.110000   0.010  1.000
 11  

08002700 8    Pepper, bell                       0.500000   1.000  1.000
 15  

08002701 8    Pepper, bell-babyfood              0.500000   1.000  1.000
 15  

08002710 8    Pepper, bell, dried                0.010100   1.000  1.000
     Blende

    Full comment: Blended

08002711 8    Pepper, bell, dried-babyfood       0.010100   1.000  1.000
     Blende

    Full comment: Blended

08002720 8    Pepper, nonbell                    0.500000   1.000  1.000
 15  

08002721 8    Pepper, nonbell-babyfood           0.500000   1.000  1.000
 15  

08002730 8    Pepper, nonbell, dried             0.010100   1.000  1.000
     Blende

    Full comment: Blended

95002750 O    Peppermint                         3.870000   1.000  1.000
 21  

95002760 O    Peppermint, oil                    3.870000   0.028  1.000
     Blende

    Full comment: Blended

12002850 12   Plum                               0.900000   1.000  1.000
 23  

12002851 12   Plum-babyfood                      0.900000   1.000  1.000
 23  

12002860 12   Plum, prune, fresh                 0.900000   1.000  1.000
 23  

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000  1.000
 23  

12002870 12   Plum, prune, dried                 0.045000   4.000  1.000
     Blende

    Full comment: Blended

12002871 12   Plum, prune, dried-babyfood        0.045000   4.000  1.000
     Blende

    Full comment: Blended

12002880 12   Plum, prune, juice                 0.900000   1.400  1.000
 23  

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400  1.000
 23  

25002900 M    Pork, meat                         0.050000   1.000  1.000
     

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
     

25002910 M    Pork, skin                         1.500000   1.000  1.000
     

25002920 M    Pork, meat byproducts              0.030000   1.000  1.000
     

25002921 M    Pork, meat byproducts-babyfood     0.030000   1.000  1.000
     

25002930 M    Pork, fat                          1.500000   1.000  1.000
     

25002931 M    Pork, fat-babyfood                 1.500000   1.000  1.000
     

25002940 M    Pork, kidney                       0.030000   1.000  1.000
     

25002950 M    Pork, liver                        0.030000   1.000  1.000
     

01032960 1C   Potato, chips                      0.000100   0.850  1.000
     Blende

    Full comment: Blended, %CT unknown

01032970 1C   Potato, dry (granules/ flakes)     0.000100   0.850  1.000
     Blende

    Full comment: Blended

01032971 1C   Potato, dry (granules/ flakes)-b   0.000100   0.850  1.000
     Blende

    Full comment: Blended

01032980 1C   Potato, flour                      0.000100   1.000  1.000
     Blende

    Full comment: Blended

01032981 1C   Potato, flour-babyfood             0.000100   1.000  1.000
     Blende

    Full comment: Blended

01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000
 33  

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000
 33  

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000
 33  

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000
 33  

60003010 P    Poultry, other, meat               0.045000   1.000  1.000
     

60003020 P    Poultry, other, liver              0.052000   1.000  1.000
     

60003030 P    Poultry, other, meat byproducts    0.052000   1.000  1.000
     

60003040 P    Poultry, other, fat                0.457000   1.000  1.000
     

60003050 P    Poultry, other, skin               0.079000   1.000  1.000
     

09023080 9B   Pumpkin                            0.600000   1.000  1.000
 27  

09023090 9B   Pumpkin, seed                      0.600000   1.000  1.000
 27  

11003100 11   Quince                             1.000000   1.000  1.000
  1  

04013130 4A   Radicchio                         14.000000   1.000  1.000
 32  

05023180 5B   Rape greens                       12.000000   1.000  1.000
  7  

04023220 4B   Rhubarb                           14.000000   1.000  1.000
 24  

26003390 M    Sheep, meat                        0.050000   1.000  1.000
     

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
     

26003400 M    Sheep, meat byproducts             0.030000   1.000  1.000
     

26003410 M    Sheep, fat                         1.500000   1.000  1.000
     

26003411 M    Sheep, fat-babyfood                1.500000   1.000  1.000
     

26003420 M    Sheep, kidney                      0.030000   1.000  1.000
     

26003430 M    Sheep, liver                       0.030000   1.000  1.000
     

06003470 6    Soybean, seed                      0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003480 6    Soybean, flour                     0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003481 6    Soybean, flour-babyfood            0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003490 6    Soybean, soy milk                  0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003491 6    Soybean, soy milk-babyfood or in   0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003500 6    Soybean, oil                       0.000880   0.640  1.000
     Blende

    Full comment: Blended

06003501 6    Soybean, oil-babyfood              0.000880   0.640  1.000
     Blende

    Full comment: Blended

95003520 O    Spearmint                          3.870000   1.000  1.000
 21  

95003530 O    Spearmint, oil                     3.870000   0.028  1.000
     Blende

    Full comment: Blended

04013550 4A   Spinach                           14.000000   1.000  1.000
 22  

04013551 4A   Spinach-babyfood                  14.000000   1.000  1.000
 22  

09023560 9B   Squash, summer                     0.600000   1.000  1.000
 27  

09023561 9B   Squash, summer-babyfood            0.600000   1.000  1.000
 27  

09023570 9B   Squash, winter                     0.600000   1.000  1.000
 27  

09023571 9B   Squash, winter-babyfood            0.600000   1.000  1.000
 27  

01033660 1CD  Sweet potato                       0.010000   1.000  1.000
     

01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000
     

04023670 4B   Swiss chard                       14.000000   1.000  1.000
 24  

01033710 1CD  Tanier, corm                       0.010000   1.000  1.000
     

08003740 8    Tomatillo                          0.270000   1.000  1.000
     

08003750 8    Tomato                             0.500000   1.000  1.000
 12  

08003751 8    Tomato-babyfood                    0.500000   1.000  1.000
 12  

08003760 8    Tomato, paste                      0.067500   1.400  1.000
     Blende

    Full comment: Blended

08003761 8    Tomato, paste-babyfood             0.067500   1.400  1.000
     Blende

    Full comment: Blended

08003770 8    Tomato, puree                      0.067500   0.520  1.000
     Blende

    Full comment: Blended

08003771 8    Tomato, puree-babyfood             0.067500   0.520  1.000
     Blende

    Full comment: Blended

08003780 8    Tomato, dried                      0.067500  14.300  1.000
     Blende

    Full comment: Blended

08003781 8    Tomato, dried-babyfood             0.067500  14.300  1.000
     Blende

    Full comment: Blended

08003790 8    Tomato, juice                      0.500000   0.520  1.000
 12  

50003820 P    Turkey, meat                       0.045000   1.000  1.000
     

50003821 P    Turkey, meat-babyfood              0.045000   1.000  1.000
     

50003830 P    Turkey, liver                      0.052000   1.000  1.000
     

50003831 P    Turkey, liver-babyfood             0.052000   1.000  1.000
     

50003840 P    Turkey, meat byproducts            0.052000   1.000  1.000
     

50003841 P    Turkey, meat byproducts-babyfood   0.052000   1.000  1.000
     

50003850 P    Turkey, fat                        0.460000   1.000  1.000
     

50003851 P    Turkey, fat-babyfood               0.460000   1.000  1.000
     

50003860 P    Turkey, skin                       0.079000   1.000  1.000
     

50003861 P    Turkey, skin-babyfood              0.079000   1.000  1.000
     

01033870 1CD  Turmeric                           0.010000   1.000  1.000
     

05023890 5B   Turnip, greens                    12.000000   1.000  1.000
  7  

86010000 O    Water, direct, all sources         0.025000   1.000  1.000
     

86020000 O    Water, indirect, all sources       0.025000   1.000  1.000
     

09013990 9A   Watermelon                         0.600000   1.000  1.000
 29  

09014000 9A   Watermelon, juice                  0.600000   1.000  1.000
 29  

01034060 1CD  Yam, true                          0.010000   1.000  1.000
     

01034070 1CD  Yam bean                           0.010000   1.000  1.000
  



Attachment 3: DEEM-FCID( Acute Exposure Estimates

U.S. Environmental Protection Agency                 Ver. 2.02

DEEM-FCID ACUTE Analysis for INDOXACARB              (1994-98 data)

Residue file: 067710a-Rev2-053007.R98             Adjustment factor #2
NOT used.

Analysis Date: 05-30-2007/10:28:35    Residue file dated:
05-30-2007/09:57:09/8

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 10

Run Comment: "Revised run using 100%CT for cherries and peaches"

========================================================================
=====

Summary calculations (per capita):

                  95th Percentile      99th Percentile      99.9th
Percentile

                  Exposure   % aRfD    Exposure   % aRfD    Exposure   %
aRfD 

                  ---------- --------  ---------- --------  ----------
------

U.S. Population:

                  0.007763     8.63    0.015056    16.73    0.034881   
38.76 

All infants:

                  0.011092    12.32    0.021882    24.31    0.039554   
43.95 

Children 1-2 yrs:

                  0.018245    20.27    0.027641    30.71    0.070299   
78.11 

Children 3-5 yrs:

                  0.013500    15.00    0.021957    24.40    0.075914   
84.35 

Children 6-12 yrs:

                  0.008839     9.82    0.013521    15.02    0.029817   
33.13 

Youth 13-19 yrs:

                  0.005670     6.30    0.011517    12.80    0.039626   
44.03 

Adults 20-49 yrs:

                  0.004719     5.24    0.008655     9.62    0.027228   
30.25 

Adults 50+ yrs:

                  0.004489     4.99    0.012210    13.57    0.031662   
35.18 



Attachment 4: DEEM-FCID( Chronic Residue File

Filename: C:\Documents and
Settings\msahafey\Desktop\indox-053007\067710c-Rev2-053007.R98

Chemical: Indoxacarb

RfD(Chronic): .015 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .09 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 05-30-2007/09:58:48/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95000010 O    Acerola                            0.000000   1.000  1.000
 

18000020 18   Alfalfa, seed                      0.000000   1.000  1.000
 

14000030 14   Almond                             0.000000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.000000   1.000  1.000
 

14000040 14   Almond, oil                        0.000000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.000000   1.000  1.000
 

04010050 4A   Amaranth, leafy                    5.270000   1.000  1.000
 

95000060 O    Amaranth, grain                    0.000000   1.000  1.000
 

11000070 11   Apple, fruit with peel             0.007400   1.000  1.000
 

11000080 11   Apple, peeled fruit                0.007400   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       0.007400   1.000  1.000
 

11000090 11   Apple, dried                       0.007400   8.000  1.000
 

11000091 11   Apple, dried-babyfood              0.007400   8.000  1.000
 

11000100 11   Apple, juice                       0.007400   0.010  1.000
 

11000101 11   Apple, juice-babyfood              0.007400   0.010  1.000
 

11000110 11   Apple, sauce                       0.007400   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              0.007400   1.000  1.000
 

12000120 12   Apricot                            0.155000   1.000  1.000
 

12000121 12   Apricot-babyfood                   0.155000   1.000  1.000
 

12000130 12   Apricot, dried                     0.155000   6.000  1.000
 

12000140 12   Apricot, juice                     0.155000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            0.155000   1.000  1.000
 

01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000
 

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000
 

95000160 O    Artichoke, globe                   0.000000   1.000  1.000
 

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000
 

04010180 4A   Arugula                            5.270000   1.000  1.000
 

95000190 O    Asparagus                          0.000000   1.000  1.000
 

95000200 O    Avocado                            0.000000   1.000  1.000
 

09020210 9B   Balsam pear                        0.033000   1.000  1.000
 

95000220 O    Bamboo, shoots                     0.000000   1.000  1.000
 

95000230 O    Banana                             0.000000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.000000   1.000  1.000
 

95000240 O    Banana, dried                      0.000000   1.000  1.000
 

95000241 O    Banana, dried-babyfood             0.000000   1.000  1.000
 

15000250 15   Barley, pearled barley             0.000000   1.000  1.000
 

15000251 15   Barley, pearled barley-babyfood    0.000000   1.000  1.000
 

15000260 15   Barley, flour                      0.000000   1.000  1.000
 

15000261 15   Barley, flour-babyfood             0.000000   1.000  1.000
 

15000270 15   Barley, bran                       0.000000   1.000  1.000
 

19010280 19A  Basil, fresh leaves                0.000000   1.000  1.000
 

19010281 19A  Basil, fresh leaves-babyfood       0.000000   1.000  1.000
 

19010290 19A  Basil, dried leaves                0.000000   1.000  1.000
 

19010291 19A  Basil, dried leaves-babyfood       0.000000   1.000  1.000
 

06030300 6C   Bean, black, seed                  0.000000   1.000  1.000
 

06020310 6B   Bean, broad, succulent             0.000000   1.000  1.000
 

06030320 6C   Bean, broad, seed                  0.000000   1.000  1.000
 

06020330 6B   Bean, cowpea, succulent            0.000000   1.000  1.000
 

06030340 6C   Bean, cowpea, seed                 0.022800   1.000  1.000
 

06030350 6C   Bean,  great northern, seed        0.000000   1.000  1.000
 

06030360 6C   Bean, kidney, seed                 0.000000   1.000  1.000
 

06020370 6B   Bean, lima, succulent              0.000000   1.000  1.000
 

06030380 6C   Bean, lima, seed                   0.000000   1.000  1.000
 

06030390 6C   Bean, mung, seed                   0.000000   1.000  1.000
 

06030400 6C   Bean, navy, seed                   0.000000   1.000  1.000
 

06030410 6C   Bean, pink, seed                   0.000000   1.000  1.000
 

06030420 6C   Bean, pinto, seed                  0.000000   1.000  1.000
 

06010430 6A   Bean, snap, succulent              0.000000   1.000  1.000
 

06010431 6A   Bean, snap, succulent-babyfood     0.000000   1.000  1.000
 

21000440 M    Beef, meat                         0.050000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.030000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.030000   1.000  1.000
 

21000470 M    Beef, fat                          1.500000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  1.500000   1.000  1.000
 

21000480 M    Beef, kidney                       0.030000   1.000  1.000
 

21000490 M    Beef, liver                        0.030000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.030000   1.000  1.000
 

01010500 1AB  Beet, garden, roots                0.000000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.000000   1.000  1.000
 

02000510 2    Beet, garden, tops                 0.000000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.000000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.000000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.000000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.000000   1.000  1.000
 

95000540 O    Belgium endive                     0.000000   1.000  1.000
 

13010550 13A  Blackberry                         0.000000   1.000  1.000
 

13010560 13A  Blackberry, juice                  0.000000   1.000  1.000
 

13010561 13A  Blackberry, juice-babyfood         0.000000   1.000  1.000
 

13020570 13B  Blueberry                          0.000000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 0.000000   1.000  1.000
 

13010580 13A  Boysenberry                        0.000000   1.000  1.000
 

14000590 14   Brazil nut                         0.000000   1.000  1.000
 

95000600 O    Breadfruit                         0.000000   1.000  1.000
 

05010610 5A   Broccoli                           0.259000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  0.259000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  0.226600   1.000  1.000
 

05020630 5B   Broccoli raab                      5.980000   1.000  1.000
 

05010640 5A   Brussels sprouts                   0.226600   1.000  1.000
 

15000650 15   Buckwheat                          0.000000   1.000  1.000
 

15000660 15   Buckwheat, flour                   0.000000   1.000  1.000
 

01010670 1AB  Burdock                            0.000000   1.000  1.000
 

14000680 14   Butternut                          0.000000   1.000  1.000
 

05010690 5A   Cabbage                            0.008700   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy         5.980000   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             0.226600   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          0.226600   1.000  1.000
 

95000730 O    Cactus                             0.000000   1.000  1.000
 

95000740 O    Canistel                           0.000000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.101600   1.000  1.000
 

04020760 4B   Cardoon                            1.930000   1.000  1.000
 

95000770 O    Carob                              0.000000   1.000  1.000
 

01010780 1AB  Carrot                             0.000000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.000000   1.000  1.000
 

01010790 1AB  Carrot, juice                      0.000000   1.000  1.000
 

09010800 9A   Casaba                             0.101600   1.000  1.000
 

14000810 14   Cashew                             0.000000   1.000  1.000
 

01030820 1CD  Cassava                            0.010000   1.000  1.000
 

01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000
 

05010830 5A   Cauliflower                        0.226600   1.000  1.000
 

01010840 1AB  Celeriac                           0.000000   1.000  1.000
 

04020850 4B   Celery                             1.930000   1.000  1.000
 

04020851 4B   Celery-babyfood                    1.930000   1.000  1.000
 

04020860 4B   Celery, juice                      1.930000   1.000  1.000
 

04020870 4B   Celtuce                            1.930000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.033100   1.000  1.000
 

95000890 O    Cherimoya                          0.000000   1.000  1.000
 

12000900 12   Cherry                             0.250000   1.000  1.000
 

12000901 12   Cherry-babyfood                    0.250000   1.000  1.000
 

12000910 12   Cherry, juice                      0.250000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             0.250000   1.500  1.000
 

14000920 14   Chestnut                           0.000000   1.000  1.000
 

40000930 P    Chicken, meat                      0.045000   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.045000   1.000  1.000
 

40000940 P    Chicken, liver                     0.052000   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.052000   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.052000   1.000  1.000
 

40000960 P    Chicken, fat                       0.457000   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.457000   1.000  1.000
 

40000970 P    Chicken, skin                      0.079000   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.079000   1.000  1.000
 

06030980 6C   Chickpea, seed                     0.000000   1.000  1.000
 

06030981 6C   Chickpea, seed-babyfood            0.000000   1.000  1.000
 

06030990 6C   Chickpea, flour                    0.000000   1.000  1.000
 

01011000 1AB  Chicory, roots                     0.000000   1.000  1.000
 

02001010 2    Chicory, tops                      0.000000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.033100   1.000  1.000
 

19011030 19A  Chive                              0.000000   1.000  1.000
 

04011040 4A   Chrysanthemum, garland             5.270000   1.000  1.000
 

19021050 19B  Cinnamon                           0.000000   1.000  1.000
 

19021051 19B  Cinnamon-babyfood                  0.000000   1.000  1.000
 

10001060 10   Citrus citron                      0.000000   1.000  1.000
 

10001070 10   Citrus hybrids                     0.000000   1.000  1.000
 

10001080 10   Citrus, oil                        0.000000   1.000  1.000
 

95001090 O    Cocoa bean, chocolate              0.000000   1.000  1.000
 

95001100 O    Cocoa bean, powder                 0.000000   1.000  1.000
 

95001110 O    Coconut, meat                      0.000000   1.000  1.000
 

95001111 O    Coconut- meat-babyfood             0.000000   1.000  1.000
 

95001120 O    Coconut, dried                     0.000000   1.000  1.000
 

95001130 O    Coconut, milk                      0.000000   1.000  1.000
 

95001140 O    Coconut, oil                       0.000000   1.000  1.000
 

95001141 O    Coconut, oil-babyfood              0.000000   1.000  1.000
 

95001150 O    Coffee, roasted bean               0.000000   1.000  1.000
 

95001160 O    Coffee, instant                    0.000000   1.000  1.000
 

05021170 5B   Collards                           5.980000   1.000  1.000
 

19011180 19A  Coriander, leaves                  0.000000   1.000  1.000
 

19011181 19A  Coriander, leaves-babyfood         0.000000   1.000  1.000
 

19021190 19B  Coriander, seed                    0.000000   1.000  1.000
 

19021191 19B  Coriander, seed-babyfood           0.000000   1.000  1.000
 

15001200 15   Corn, field, flour                 0.000000   1.000  1.000
 

15001201 15   Corn, field, flour-babyfood        0.000000   1.000  1.000
 

15001210 15   Corn, field, meal                  0.000000   1.000  1.000
 

15001211 15   Corn, field, meal-babyfood         0.000000   1.000  1.000
 

15001220 15   Corn, field, bran                  0.000000   1.000  1.000
 

15001230 15   Corn, field, starch                0.000000   1.000  1.000
 

15001231 15   Corn, field, starch-babyfood       0.000000   1.000  1.000
 

15001240 15   Corn, field, syrup                 0.000000   1.000  1.000
 

15001241 15   Corn, field, syrup-babyfood        0.000000   1.000  1.000
 

15001250 15   Corn, field, oil                   0.000000   1.000  1.000
 

15001251 15   Corn, field, oil-babyfood          0.000000   1.000  1.000
 

15001260 15   Corn, pop                          0.000000   1.000  1.000
 

15001270 15   Corn, sweet                        0.000080   1.000  1.000
 

15001271 15   Corn, sweet-babyfood               0.000080   1.000  1.000
 

95001280 O    Cottonseed, oil                    0.670000   0.040  1.000
 

95001281 O    Cottonseed, oil-babyfood           0.670000   0.040  1.000
 

11001290 11   Crabapple                          0.740000   1.000  1.000
 

95001300 O    Cranberry                          0.216000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 0.216000   1.000  1.000
 

95001310 O    Cranberry, dried                   0.216000   1.000  1.000
 

95001320 O    Cranberry, juice                   0.216000   1.100  1.000
 

95001321 O    Cranberry, juice-babyfood          0.216000   1.100  1.000
 

04011330 4A   Cress, garden                      5.270000   1.000  1.000
 

04011340 4A   Cress, upland                      5.270000   1.000  1.000
 

09021350 9B   Cucumber                           0.023000   1.000  1.000
 

13021360 13B  Currant                            0.000000   1.000  1.000
 

13021370 13B  Currant, dried                     0.000000   1.000  1.000
 

04011380 4A   Dandelion, leaves                  5.270000   1.000  1.000
 

01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000
 

02001400 2    Dasheen, leaves                    0.000000   1.000  1.000
 

95001410 O    Date                               0.000000   1.000  1.000
 

13011420 13A  Dewberry                           0.000000   1.000  1.000
 

19021430 19B  Dill, seed                         0.000000   1.000  1.000
 

19011440 19A  Dillweed                           0.000000   1.000  1.000
 

70001450 P    Egg, whole                         0.119000   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.119000   1.000  1.000
 

70001460 P    Egg, white                         0.119000   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.119000   1.000  1.000
 

70001470 P    Egg, yolk                          0.119000   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.119000   1.000  1.000
 

08001480 8    Eggplant                           0.270000   1.000  1.000
 

13021490 13B  Elderberry                         0.000000   1.000  1.000
 

04011500 4A   Endive                             5.270000   1.000  1.000
 

95001510 O    Feijoa                             0.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                   1.930000   1.000  1.000
 

95001530 O    Fig                                0.000000   1.000  1.000
 

95001540 O    Fig, dried                         0.000000   1.000  1.000
 

14001550 14   Filbert                            0.000000   1.000  1.000
 

14001560 14   Filbert, oil                       0.000000   1.000  1.000
 

80001570 F    Fish-freshwater finfish            0.000000   1.000  1.000
 

80001580 F    Fish-freshwater finfish, farm ra   0.000000   1.000  1.000
 

80001590 F    Fish-saltwater finfish, tuna       0.000000   1.000  1.000
 

80001600 F    Fish-saltwater finfish, other      0.000000   1.000  1.000
 

80001610 F    Fish-shellfish, crustacean         0.000000   1.000  1.000
 

80001620 F    Fish-shellfish, mollusc            0.000000   1.000  1.000
 

20001630 20   Flaxseed, oil                      0.000000   1.000  1.000
 

03001640 3    Garlic                             0.000000   1.000  1.000
 

03001650 3    Garlic, dried                      0.000000   1.000  1.000
 

03001651 3    Garlic, dried-babyfood             0.000000   1.000  1.000
 

01031660 1CD  Ginger                             0.010000   1.000  1.000
 

01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000
 

01031670 1CD  Ginger, dried                      0.010000   1.000  1.000
 

01011680 1AB  Ginseng, dried                     0.000000   1.000  1.000
 

23001690 M    Goat, meat                         0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.030000   1.000  1.000
 

23001710 M    Goat, fat                          1.500000   1.000  1.000
 

23001720 M    Goat, kidney                       0.030000   1.000  1.000
 

23001730 M    Goat, liver                        0.030000   1.000  1.000
 

13021740 13B  Gooseberry                         0.000000   1.000  1.000
 

95001750 O    Grape                              0.503000   1.000  1.000
 

95001760 O    Grape, juice                       0.503000   0.007  1.000
 

95001761 O    Grape, juice-babyfood              0.503000   0.007  1.000
 

95001770 O    Grape, leaves                      0.503000   1.000  1.000
 

95001780 O    Grape, raisin                      0.503000   2.700  1.000
 

95001790 O    Grape, wine and sherry             0.503000   0.007  1.000
 

10001800 10   Grapefruit                         0.000000   1.000  1.000
 

10001810 10   Grapefruit, juice                  0.000000   1.000  1.000
 

06031820 6C   Guar, seed                         0.000000   1.000  1.000
 

06031821 6C   Guar, seed-babyfood                0.000000   1.000  1.000
 

95001830 O    Guava                              0.000000   1.000  1.000
 

95001831 O    Guava-babyfood                     0.000000   1.000  1.000
 

19011840 19A  Herbs, other                       0.000000   1.000  1.000
 

19011841 19A  Herbs, other-babyfood              0.000000   1.000  1.000
 

14001850 14   Hickory nut                        0.000000   1.000  1.000
 

95001860 O    Honey                              0.000000   1.000  1.000
 

95001861 O    Honey-babyfood                     0.000000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.101600   1.000  1.000
 

95001880 O    Hop                                0.000000   1.000  1.000
 

24001890 M    Horse, meat                        0.050000   1.000  1.000
 

01011900 1AB  Horseradish                        0.000000   1.000  1.000
 

13021910 13B  Huckleberry                        0.000000   1.000  1.000
 

95001920 O    Jaboticaba                         0.000000   1.000  1.000
 

95001930 O    Jackfruit                          0.000000   1.000  1.000
 

05021940 5B   Kale                               5.980000   1.000  1.000
 

95001950 O    Kiwifruit                          0.000000   1.000  1.000
 

05011960 5A   Kohlrabi                           0.226600   1.000  1.000
 

10001970 10   Kumquat                            0.000000   1.000  1.000
 

03001980 3    Leek                               0.000000   1.000  1.000
 

10001990 10   Lemon                              0.000000   1.000  1.000
 

10002000 10   Lemon, juice                       0.000000   1.000  1.000
 

10002001 10   Lemon, juice-babyfood              0.000000   1.000  1.000
 

10002010 10   Lemon, peel                        0.000000   1.000  1.000
 

19012020 19A  Lemongrass                         0.000000   1.000  1.000
 

06032030 6C   Lentil, seed                       0.000000   1.000  1.000
 

04012040 4A   Lettuce, head                      0.039700   1.000  1.000
 

04012050 4A   Lettuce, leaf                      0.541000   1.000  1.000
 

10002060 10   Lime                               0.000000   1.000  1.000
 

10002070 10   Lime, juice                        0.000000   1.000  1.000
 

10002071 10   Lime, juice-babyfood               0.000000   1.000  1.000
 

13012080 13A  Loganberry                         0.000000   1.000  1.000
 

95002090 O    Longan                             0.000000   1.000  1.000
 

11002100 11   Loquat                             0.740000   1.000  1.000
 

95002110 O    Lychee                             0.000000   1.000  1.000
 

95002120 O    Lychee, dried                      0.000000   1.000  1.000
 

14002130 14   Macadamia nut                      0.000000   1.000  1.000
 

95002140 O    Mamey apple                        0.000000   1.000  1.000
 

95002150 O    Mango                              0.000000   1.000  1.000
 

95002151 O    Mango-babyfood                     0.000000   1.000  1.000
 

95002160 O    Mango, dried                       0.000000   1.000  1.000
 

95002170 O    Mango, juice                       0.000000   1.000  1.000
 

95002171 O    Mango, juice-babyfood              0.000000   1.000  1.000
 

95002180 O    Maple, sugar                       0.000000   1.000  1.000
 

95002190 O    Maple syrup                        0.000000   1.000  1.000
 

19012200 19A  Marjoram                           0.000000   1.000  1.000
 

19012201 19A  Marjoram-babyfood                  0.000000   1.000  1.000
 

28002210 M    Meat, game                         0.000000   1.000  1.000
 

27002220 D    Milk, fat                          2.430000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   2.430000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.500000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.500000   1.000  1.000
 

27022240 D    Milk, water                        0.000000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.000000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.000000   1.000  1.000
 

15002260 15   Millet, grain                      0.000000   1.000  1.000
 

95002270 O    Mulberry                           0.000000   1.000  1.000
 

95002280 O    Mushroom                           0.000000   1.000  1.000
 

05022290 5B   Mustard greens                     5.980000   1.000  1.000
 

12002300 12   Nectarine                          0.155300   1.000  1.000
 

15002310 15   Oat, bran                          0.000000   1.000  1.000
 

15002320 15   Oat, flour                         0.000000   1.000  1.000
 

15002321 15   Oat, flour-babyfood                0.000000   1.000  1.000
 

15002330 15   Oat, groats/rolled oats            0.000000   1.000  1.000
 

15002331 15   Oat, groats/rolled oats-babyfood   0.000000   1.000  1.000
 

08002340 8    Okra                               0.270000   1.000  1.000
 

95002350 O    Olive                              0.000000   1.000  1.000
 

95002360 O    Olive, oil                         0.000000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.000000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.000000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.000000   1.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.000000   1.000  1.000
 

03002390 3    Onion, green                       0.000000   1.000  1.000
 

10002400 10   Orange                             0.000000   1.000  1.000
 

10002410 10   Orange, juice                      0.000000   1.000  1.000
 

10002411 10   Orange, juice-babyfood             0.000000   1.000  1.000
 

10002420 10   Orange, peel                       0.000000   1.000  1.000
 

95002430 O    Palm heart, leaves                 0.000000   1.000  1.000
 

95002440 O    Palm, oil                          0.000000   1.000  1.000
 

95002441 O    Palm, oil-babyfood                 0.000000   1.000  1.000
 

95002450 O    Papaya                             0.000000   1.000  1.000
 

95002451 O    Papaya-babyfood                    0.000000   1.000  1.000
 

95002460 O    Papaya, dried                      0.000000   1.000  1.000
 

95002470 O    Papaya, juice                      0.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                    5.270000   1.000  1.000
 

19012490 19A  Parsley, dried leaves              0.000000   1.000  1.000
 

19012491 19A  Parsley, dried leaves-babyfood     0.000000   1.000  1.000
 

01012500 1AB  Parsley, turnip rooted             0.000000   1.000  1.000
 

01012510 1AB  Parsnip                            0.000000   1.000  1.000
 

01012511 1AB  Parsnip-babyfood                   0.000000   1.000  1.000
 

95002520 O    Passionfruit                       0.000000   1.000  1.000
 

95002521 O    Passionfruit-babyfood              0.000000   1.000  1.000
 

95002530 O    Passionfruit, juice                0.000000   1.000  1.000
 

95002531 O    Passionfruit, juice-babyfood       0.000000   1.000  1.000
 

95002540 O    Pawpaw                             0.000000   1.000  1.000
 

06022550 6B   Pea, succulent                     0.000000   1.000  1.000
 

06022551 6B   Pea, succulent-babyfood            0.000000   1.000  1.000
 

06032560 6C   Pea, dry                           0.000000   1.000  1.000
 

06032561 6C   Pea, dry-babyfood                  0.000000   1.000  1.000
 

06012570 6A   Pea, edible podded, succulent      0.000000   1.000  1.000
 

06032580 6C   Pea, pigeon, seed                  0.000000   1.000  1.000
 

06022590 6B   Pea, pigeon, succulent             0.000000   1.000  1.000
 

12002600 12   Peach                              0.155000   1.000  1.000
 

12002601 12   Peach-babyfood                     0.155000   1.000  1.000
 

12002610 12   Peach, dried                       0.155000   4.000  1.000
 

12002611 12   Peach, dried-babyfood              0.155000   4.000  1.000
 

12002620 12   Peach, juice                       0.155000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              0.155000   1.000  1.000
 

95002630 O    Peanut                             0.000030   1.000  1.000
 

95002640 O    Peanut, butter                     0.000030   1.890  1.000
 

95002650 O    Peanut, oil                        0.000030   1.400  1.000
 

11002660 11   Pear                               0.000800   1.000  1.000
 

11002661 11   Pear-babyfood                      0.000800   1.000  1.000
 

11002670 11   Pear, dried                        0.000800   6.250  1.000
 

11002680 11   Pear, juice                        0.000800   0.010  1.000
 

11002681 11   Pear, juice-babyfood               0.000800   0.010  1.000
 

14002690 14   Pecan                              0.000000   1.000  1.000
 

08002700 8    Pepper, bell                       0.006700   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              0.006700   1.000  1.000
 

08002710 8    Pepper, bell, dried                0.006700   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       0.006700   1.000  1.000
 

08002720 8    Pepper, nonbell                    0.006700   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           0.006700   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             0.006700   1.000  1.000
 

19022740 19B  Pepper, black and white            0.000000   1.000  1.000
 

19022741 19B  Pepper, black and white-babyfood   0.000000   1.000  1.000
 

95002750 O    Peppermint                         3.870000   1.000  1.000
 

95002760 O    Peppermint, oil                    3.870000   0.028  1.000
 

95002770 O    Persimmon                          0.000000   1.000  1.000
 

95002780 O    Pine nut                           0.000000   1.000  1.000
 

95002790 O    Pineapple                          0.000000   1.000  1.000
 

95002791 O    Pineapple-babyfood                 0.000000   1.000  1.000
 

95002800 O    Pineapple, dried                   0.000000   1.000  1.000
 

95002810 O    Pineapple, juice                   0.000000   1.000  1.000
 

95002811 O    Pineapple, juice-babyfood          0.000000   1.000  1.000
 

14002820 14   Pistachio                          0.000000   1.000  1.000
 

95002830 O    Plantain                           0.000000   1.000  1.000
 

95002840 O    Plantain, dried                    0.000000   1.000  1.000
 

12002850 12   Plum                               0.045000   1.000  1.000
 

12002851 12   Plum-babyfood                      0.045000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 0.045000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        0.045000   1.000  1.000
 

12002870 12   Plum, prune, dried                 0.045000   4.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        0.045000   4.000  1.000
 

12002880 12   Plum, prune, juice                 0.045000   1.000  1.000
 

12002881 12   Plum, prune, juice-babyfood        0.045000   1.000  1.000
 

95002890 O    Pomegranate                        0.000000   1.000  1.000
 

25002900 M    Pork, meat                         0.050000   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
 

25002910 M    Pork, skin                         1.500000   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.030000   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.030000   1.000  1.000
 

25002930 M    Pork, fat                          1.500000   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 1.500000   1.000  1.000
 

25002940 M    Pork, kidney                       0.030000   1.000  1.000
 

25002950 M    Pork, liver                        0.030000   1.000  1.000
 

01032960 1C   Potato, chips                      0.000040   1.000  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.000040   0.850  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.000040   0.850  1.000
 

01032980 1C   Potato, flour                      0.000040   1.000  1.000
 

01032981 1C   Potato, flour-babyfood             0.000040   1.000  1.000
 

01032990 1C   Potato, tuber, w/peel              0.000100   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.000100   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.000100   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.000100   1.000  1.000
 

60003010 P    Poultry, other, meat               0.045000   1.000  1.000
 

60003020 P    Poultry, other, liver              0.052000   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.052000   1.000  1.000
 

60003040 P    Poultry, other, fat                0.457000   1.000  1.000
 

60003050 P    Poultry, other, skin               0.079000   1.000  1.000
 

95003060 O    Psyllium, seed                     0.000000   1.000  1.000
 

10003070 10   Pummelo                            0.000000   1.000  1.000
 

09023080 9B   Pumpkin                            0.033100   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.033100   1.000  1.000
 

11003100 11   Quince                             0.740000   1.000  1.000
 

95003110 O    Quinoa, grain                      0.000000   1.000  1.000
 

29003120 M    Rabbit, meat                       0.000000   1.000  1.000
 

04013130 4A   Radicchio                          5.270000   1.000  1.000
 

01013140 1AB  Radish, roots                      0.000000   1.000  1.000
 

02003150 2    Radish, tops                       0.000000   1.000  1.000
 

01013160 1AB  Radish, Oriental, roots            0.000000   1.000  1.000
 

02003170 2    Radish, Oriental, tops             0.000000   1.000  1.000
 

05023180 5B   Rape greens                        5.980000   1.000  1.000
 

20003190 20   Rapeseed, oil                      0.000000   1.000  1.000
 

20003191 20   Rapeseed, oil-babyfood             0.000000   1.000  1.000
 

13013200 13A  Raspberry                          0.000000   1.000  1.000
 

13013201 13A  Raspberry-babyfood                 0.000000   1.000  1.000
 

13013210 13A  Raspberry, juice                   0.000000   1.000  1.000
 

13013211 13A  Raspberry, juice-babyfood          0.000000   1.000  1.000
 

04023220 4B   Rhubarb                            1.930000   1.000  1.000
 

15003230 15   Rice, white                        0.000000   1.000  1.000
 

15003231 15   Rice, white-babyfood               0.000000   1.000  1.000
 

15003240 15   Rice, brown                        0.000000   1.000  1.000
 

15003241 15   Rice, brown-babyfood               0.000000   1.000  1.000
 

15003250 15   Rice, flour                        0.000000   1.000  1.000
 

15003251 15   Rice, flour-babyfood               0.000000   1.000  1.000
 

15003260 15   Rice, bran                         0.000000   1.000  1.000
 

15003261 15   Rice, bran-babyfood                0.000000   1.000  1.000
 

01013270 1AB  Rutabaga                           0.000000   1.000  1.000
 

15003280 15   Rye, grain                         0.000000   1.000  1.000
 

15003290 15   Rye, flour                         0.000000   1.000  1.000
 

20003300 20   Safflower, oil                     0.000000   1.000  1.000
 

20003301 20   Safflower, oil-babyfood            0.000000   1.000  1.000
 

01013310 1AB  Salsify, roots                     0.000000   1.000  1.000
 

02003320 2    Salsify, tops                      0.000000   1.000  1.000
 

95003330 O    Sapote, Mamey                      0.000000   1.000  1.000
 

19013340 19A  Savory                             0.000000   1.000  1.000
 

95003350 O    Seaweed                            0.000000   1.000  1.000
 

95003351 O    Seaweed-babyfood                   0.000000   1.000  1.000
 

95003360 O    Sesame, seed                       0.000000   1.000  1.000
 

95003361 O    Sesame, seed-babyfood              0.000000   1.000  1.000
 

95003370 O    Sesame, oil                        0.000000   1.000  1.000
 

95003371 O    Sesame, oil-babyfood               0.000000   1.000  1.000
 

03003380 3    Shallot                            0.000000   1.000  1.000
 

26003390 M    Sheep, meat                        0.050000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.030000   1.000  1.000
 

26003410 M    Sheep, fat                         1.500000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                1.500000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.030000   1.000  1.000
 

26003430 M    Sheep, liver                       0.030000   1.000  1.000
 

15003440 15   Sorghum, grain                     0.000000   1.000  1.000
 

15003450 15   Sorghum, syrup                     0.000000   1.000  1.000
 

95003460 O    Soursop                            0.000000   1.000  1.000
 

06003470 6    Soybean, seed                      0.000880   1.000  1.000
 

06003480 6    Soybean, flour                     0.000880   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            0.000880   1.000  1.000
 

06003490 6    Soybean, soy milk                  0.000880   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   0.000880   1.000  1.000
 

06003500 6    Soybean, oil                       0.000880   0.640  1.000
 

06003501 6    Soybean, oil-babyfood              0.000880   0.640  1.000
 

95003510 O    Spanish lime                       0.000000   1.000  1.000
 

95003520 O    Spearmint                          3.870000   1.000  1.000
 

95003530 O    Spearmint, oil                     3.870000   0.028  1.000
 

19023540 19B  Spices, other                      0.000000   1.000  1.000
 

19023541 19B  Spices, other-babyfood             0.000000   1.000  1.000
 

04013550 4A   Spinach                            0.263400   1.000  1.000
 

04013551 4A   Spinach-babyfood                   0.263400   1.000  1.000
 

09023560 9B   Squash, summer                     0.033100   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.033100   1.000  1.000
 

09023570 9B   Squash, winter                     0.033100   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.033100   1.000  1.000
 

95003580 O    Starfruit                          0.000000   1.000  1.000
 

95003590 O    Strawberry                         0.000000   1.000  1.000
 

95003591 O    Strawberry-babyfood                0.000000   1.000  1.000
 

95003600 O    Strawberry, juice                  0.000000   1.000  1.000
 

95003601 O    Strawberry, juice-babyfood         0.000000   1.000  1.000
 

95003610 O    Sugar apple                        0.000000   1.000  1.000
 

95003620 O    Sugarcane, sugar                   0.000000   1.000  1.000
 

95003621 O    Sugarcane, sugar-babyfood          0.000000   1.000  1.000
 

95003630 O    Sugarcane, molasses                0.000000   1.000  1.000
 

95003631 O    Sugarcane, molasses-babyfood       0.000000   1.000  1.000
 

20003640 20   Sunflower, seed                    0.000000   1.000  1.000
 

20003650 20   Sunflower, oil                     0.000000   1.000  1.000
 

20003651 20   Sunflower, oil-babyfood            0.000000   1.000  1.000
 

01033660 1CD  Sweet potato                       0.010000   1.000  1.000
 

01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000
 

04023670 4B   Swiss chard                        1.930000   1.000  1.000
 

95003680 O    Tamarind                           0.000000   1.000  1.000
 

10003690 10   Tangerine                          0.000000   1.000  1.000
 

10003700 10   Tangerine, juice                   0.000000   1.000  1.000
 

01033710 1CD  Tanier, corm                       0.010000   1.000  1.000
 

95003720 O    Tea, dried                         0.000000   1.000  1.000
 

95003730 O    Tea, instant                       0.000000   1.000  1.000
 

08003740 8    Tomatillo                          0.270000   1.000  1.000
 

08003750 8    Tomato                             0.040500   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.040500   1.000  1.000
 

08003760 8    Tomato, paste                      0.040500   1.400  1.000
 

08003761 8    Tomato, paste-babyfood             0.040500   1.400  1.000
 

08003770 8    Tomato, puree                      0.040500   0.520  1.000
 

08003771 8    Tomato, puree-babyfood             0.040500   0.520  1.000
 

08003780 8    Tomato, dried                      0.040500  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             0.040500  14.300  1.000
 

08003790 8    Tomato, juice                      0.040500   0.520  1.000
 

95003800 O    Tomato, Tree                       0.000000   1.000  1.000
 

15003810 15   Triticale, flour                   0.000000   1.000  1.000
 

15003811 15   Triticale, flour-babyfood          0.000000   1.000  1.000
 

50003820 P    Turkey, meat                       0.045000   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.045000   1.000  1.000
 

50003830 P    Turkey, liver                      0.052000   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.052000   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.052000   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.052000   1.000  1.000
 

50003850 P    Turkey, fat                        0.457000   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.457000   1.000  1.000
 

50003860 P    Turkey, skin                       0.079000   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.079000   1.000  1.000
 

01033870 1CD  Turmeric                           0.010000   1.000  1.000
 

05023890 5B   Turnip, greens                     5.980000   1.000  1.000
 

01013880 1AB  Turnip, roots                      0.000000   1.000  1.000
 

95003900 O    Vinegar                            0.000000   1.000  1.000
 

14003910 14   Walnut                             0.000000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.005370   1.000  1.000
 ave. 1

          Full comment: ave. 1 in 10 yr, cotton scenario

86011000 O    Water, direct, tap                 0.000000   1.000  1.000
 

86012000 O    Water, direct, bottled             0.000000   1.000  1.000
 

86013000 O    Water, direct, other               0.000000   1.000  1.000
 

86014000 O    Water, direct, source-NS           0.000000   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.005370   1.000  1.000
 ave. 1

          Full comment: ave. 1 in 10 yr, cotton scenario

86021000 O    Water, indirect, tap               0.000000   1.000  1.000
 

86022000 O    Water, indirect, bottled           0.000000   1.000  1.000
 

86023000 O    Water, indirect, other             0.000000   1.000  1.000
 

86024000 O    Water, indirect, source-NS         0.000000   1.000  1.000
 

95003970 O    Water chestnut                     0.000000   1.000  1.000
 

95003980 O    Watercress                         0.000000   1.000  1.000
 

09013990 9A   Watermelon                         0.101600   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.101600   1.000  1.000
 

15004010 15   Wheat, grain                       0.000000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.000000   1.000  1.000
 

15004020 15   Wheat, flour                       0.000000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.000000   1.000  1.000
 

15004030 15   Wheat, germ                        0.000000   1.000  1.000
 

15004040 15   Wheat, bran                        0.000000   1.000  1.000
 

15004050 15   Wild rice                          0.000000   1.000  1.000
 

01034060 1CD  Yam, true                          0.010000   1.000  1.000
 

01034070 1CD  Yam bean                           0.010000   1.000  1.000
 



Attachment 5: DEEM-FCID( Chronic Exposure Estimates

U.S. Environmental Protection Agency          Ver. 2.00

DEEM-FCID Chronic analysis for INDOXACARB     (1994-98 data)

Residue file name: C:\Documents and
Settings\msahafey\Desktop\indox-053007\067710c-Rev2-053007.R98
Adjustment factor #2 NOT used.

Analysis Date 05-30-2007/10:32:22  Residue file dated:
05-30-2007/09:58:48/8

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: Revised run using 100%CT for cherries and peach

========================================================================
=====

                    Total exposure by population subgroup

------------------------------------------------------------------------
-----

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.002411               
16.1%

U.S. Population (spring season)             0.002415               
16.1%

U.S. Population (summer season)             0.002457               
16.4%

U.S. Population (autumn season)             0.002445               
16.3%

U.S. Population (winter season)             0.002320               
15.5%

Northeast region                            0.002490               
16.6%

Midwest region                              0.002414               
16.1%

Southern region                             0.002311               
15.4%

Western region                              0.002497               
16.6%

Hispanics                                   0.002601               
17.3%

Non-hispanic whites                         0.002238               
14.9%

Non-hispanic blacks                         0.003021               
20.1%

Non-hisp/non-white/non-black                0.003057               
20.4%

All infants (< 1 year)                      0.002574               
17.2%

Nursing infants                             0.000861                
5.7%

Non-nursing infants                         0.003224               
21.5%

Children 1-6  yrs                           0.006514               
43.4%

Children 7-12 yrs                           0.003467               
23.1%

Females 13-19 (not preg or nursing)         0.001891               
12.6%

Females 20+ (not preg or nursing)           0.001665               
11.1%

Females 13-50 yrs                           0.001852               
12.3%

Females 13+ (preg/not nursing)              0.001972               
13.1%

Females 13+ (nursing)                       0.001987               
13.2%

Males 13-19 yrs                             0.002483               
16.6%

Males 20+ yrs                               0.001850               
12.3%

Seniors 55+                                 0.001768               
11.8%

Children 1-2 yrs                            0.007940               
52.9%

Children 3-5 yrs                            0.006068               
40.5%

Children 6-12 yrs                           0.003701               
24.7%

Youth 13-19 yrs                             0.002197               
14.6%

Adults 20-49 yrs                            0.001764               
11.8%

Adults 50+ yrs                              0.001747               
11.6%

Females 13-49 yrs                           0.001693               
11.3%

Attachment 6: Poultry Dose-Residue Chart and Tables

	Combined Indoxacarb Residues (ppm) in Poultry Feeding Study (D297936)

dose (ppm)	Egg	Fat	Muscle	Liver	Skin

1.75	0.08	0.1	0.03	0.03	0.07

7	0.17	0.44	0.03	0.08	0.12

21	0.54	1.4	0.06	0.18	0.51

70	1.69	4.13	0.12	0.52	1.06







	slope of line	0.0243	0.0597	0.0018	0.0076	0.0159

R-sqrd	R2 = 0.9985	R2 = 0.9976	R2 = 0.7141	R2 = 0.9894	R2 = 0.9433







	Res. From dose of 2.72 ppm 	0.066	0.162	0.005 but change to 0.03 due to
<LOQ	0.021	0.043

Total Res. Of Concern / Res. From Feeding Study	1.800	2.813	1.500	2.500
1.818

Total Res. Of Concern	0.119	0.457	0.045	0.052	0.079





Attachment 7: Milk Dose-Residue Chart and Tables

Dietary Burden\	21.75



Dose (ppm)	Residue in whole milk(ave on day 28), (ppm)	Residue in Skim
milk, (ppm)

 7.5	0.021	0.01

22.5	0.054	0.022

75	0.19	0.078

 	 	 

slope of  line	0.0025	0.001

R squared	0.9992	0.997



Attachment 8:	 BEAD %CT Data

April 2, 2007

Screening Level Estimates of Agricultural Uses of Indoxacarb 067710

Sorted Alphabetically

	  		  	 	

		Crop				Lbs. A.I.			Percent Crop Tteated

	  	 								Avg.	      Max.

	2 	Alfalfa	10,000	<1            <2.5

	3 	Apples
1〬〰㰉‱††††††㔠ऍ‴䈉潲捣汯⩩पⰴ〰र〴
††††††㔠ര㔉ठ牂獵敳獬匠牰畯獴प㔼〰三䌯†
††††⽎ൃ㘉ठ慃扢条॥ⰲ〰र㔱††††††㈠വ
㜉ठ慃汵晩潬敷⩲पⰱ〰र㔳††††††㔠വ㠉ठ桃
牥楲獥㰉〵रㄼ††††††㈼㔮



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	9 	Cotton	30,000	<1              5

	10	Lettuce***	6,000	20             35

	11	Peaches	<500	<1            <2.5

	12	Peanuts	<500	<1            <2.5

	13	Pears	<500	<1            <2.5

	14	Peppers	1,000	10             15

	15	Potatoes	1,000	<1            <2.5

	17	Spinach	<500	  5              5

	18	Sweet Corn	<500	<1            <2.5

	19	Tomatoes	4,000	15             25

All numbers rounded.		

'<500' indicates less than 500 pounds of active ingredient.		

'<2.5' indicates less than 2.5 percent of crop is treated.		

'<1' indicates less than 1 percent of crop is treated.	

* CA data only, but 95% or more of U.S. acres are in California		

**  Electronic communication, A. Halvorson to S. Levy, 10-MAY-2007
(Either cauliflower or broccoli %CT may be used for the following 4
minor crops:  Chinese broccoli, Chinese napa cabbage, Chinese mustard
cabbage, and kohlrabi.)

*** Electronic communication, A. Halvorson to M. Sahafeyan, 12-APR-2007
(head lettuce:  18% average, 25% maximum; other lettuce:  9% average,
11% maximum)

N/C = Not Calculated

 ai = active ingredient is defined as the S isomer of indoxacarb
(KN128).  The R isomer (KN127) is an inactive isomer.  

 PAGE   

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