UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
October
19,
2004
MEMORANDUM:

SUBJECT:
Ametryn.
HED
Occupational
and
Residential
Exposure
Chapter
of
the
Reregistration
Eligibility
Decision
Document
(
RED)

FROM:
Robert
Travaglini,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

THRU:
Danette
Drew,
Senior
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

TO:
Mark
Howard,
Chemical
Review
Manager
Reregistration
Branch
1
Special
Review
&
Reregistration
Division
(
7508W)

This
memorandum
and
the
accompanying
attachments
serve
as
the
Occupational
and
Residential
(
ORE)
chapter
of
the
HED
RED
chapter
for
ametryn.
Included
as
an
attachment
is
the
Ametryn
Incident
Report
(
J.
Blondell,
June
24,
2004.
D
307172.
This
document
reflects
current
HED
policy.

Cumulative
risk
assessment
considering
risks
from
other
pesticides
which
have
a
common
mechanism
of
toxicity
is
not
addressed
in
this
document.

DP
Barcode:
D307102.

PC
Code:
080801
EPA
Reg.
Nos.:
100­
579;
100­
786;

Expo
Sac
Reviewers:
Attachments
cc:
RF,
SF,
List
B
File,
RRB3
File,
C.
Eiden
3
TABLE
OF
CONTENTS
1.0
EXECUTIVE
SUMMARY
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4
1.1
Background
and
Purpose
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4
1.2
Use
Patterns
and
Formulations
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4
1.3
Occupational
Exposure
&
Risk
Estimates
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4
2.0
HAZARD
IDENTIFICATION
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4
2.1
Toxicological
Endpoints
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5
3.0
INCIDENT
REPORTS
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6
4.0
OCCUPATIONAL
EXPOSURE
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6
4.1
Use
Patterns,
Formulations,
Equipment
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6
4.2
Crops
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4.3
Occupational
Exposure
Scenarios
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4.4
Occupational
Exposure
Estimates
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4.5
Occupational
Risk
Estimates
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10
1.0
EXECUTIVE
SUMMARY
1.1
Background
4
This
document,
prepared
for
utilization
in
EPA's
development
of
the
Ametryn
Reregistration
Eligibility
Decision,
presents
HED's
results
of
its
review
of
the
potential
human
health
effects
of
occupational
exposure
to
ametryn.

An
occupational
and/
or
residential
exposure
assessment
is
required
for
an
active
ingredient
if
(
1):
certain
toxicological
criteria
are
triggered
and
there
is
potential
exposure
to
handlers
(
mixers,
loader,
applicators,
etc.)
during
use
or
to
persons
entering
treated
sites
after
application
is
complete.
These
criteria
have
been
met
with
ametryn.

Ametryn
is
registered
as
a
pre­
plant
or
at­
plant
and
post­
emergent
herbicide
for
the
control
of
various
weeds
and
grasses
in
agricultural
settings,
there
are
no
residential
uses
for
this
chemical
at
this
time.
In
the
reregistration
process
for
this
active
ingredient,
the
registrant,
Syngenta
Crop
Protection,
Inc.
has
dropped
several
use
sites
and/
or
crops
and
chosen
to
support
ametryn
on
only
the
three
following
crops:
corn
(
field,
sweet
and
pop),
pineapples,
and
sugarcane.
The
supported
end­
use
ametryn
product
is
formulated
as
a
wettable
powder
and
applied
as
a
liquid.

HED
has
identified
14
occupational
handler
scenarios
for
which
short­
and
intermediateterm
exposure
to
ametryn
may
occur.
Long­
term
exposures
are
not
anticipated
for
handlers.
Post­
application
short­
term
occupational
exposure
is
not
expected
from
the
use
of
this
herbicide
on
the
supported
crops,
therefore
post­
application
risks
have
not
been
estimated.
In
this
assessment,
Margins
of
Exposure
(
MOEs)
>
100
do
not
exceed
HED's
level
of
concern.

With
the
exception
of
three
handler
scenarios
involving
aerial
application
to
sugarcane,
MOEs
for
all
(
14)
handler
scenarios
exceed
100
at
either
baseline
or
minimum
PPE
protection
levels
and
are
not
of
concern.
Using
engineering
controls
to
mitigate
exposures,
MOEs
for
aerial
application
to
sugarcane
exceed
100,
and
are
not
of
concern.

2.0
Hazard
Identification
The
HED
Ametryn
Risk
Assessment
Team
(
RAT­
RRB3)
identified
toxicological
endpoints
of
concern
for
this
herbicide.
All
calculations
completed
in
this
document
are
based
on
the
most
current
toxicity
information
available
for
ametryn.
Endpoints
used
to
complete
this
assessment
are
summarized
in
Table
1.

For
short
and
intermediate
term
dermal
exposure,
a
NOAEL
of
100
mg/
kg/
day
from
a
21
day
dermal
toxicity
study
in
rabbits
,
based
on
decreased
body
weight
gain
was
selected.
As
a
route
specific
(
i.
e.,
dermal)
study
is
the
basis
of
the
endpoint
selected
for
dermal
risk
assessment,
it
is
not
necessary
to
apply
a
dermal
absorption
factor
in
calculating
the
estimated
dermal
dose.
For
inhalation
exposures
(
short
and
intermediate
­
term)
a
NOAEL
of
10
mg/
kg/
day
was
selected
from
a
rabbit
developmental
study
based
on
decreased
feed
consumption
and
increased
liver
weight.
5
Because
the
toxic
endpoints
selected
for
dermal
and
inhalation
risk
assessments
are
the
same,
i.
e.,
decreased
body
weight
gain,
the
estimated
dermal
and
inhalation
risks
have
been
aggregated
in
this
document,
via
the
1/
Total
MOE
approach.

The
Ametryn
Risk
Assessment
Team
determined
that
a
Margin
Of
Exposure
(
MOE)
of
100,
based
on
the
traditional
100X
uncertainty
factor
for
inter
(
10X)
and
intra
(
10X)
species
variation
is
adequate
for
both
occupational
exposures.

The
ametryn
team
in
consultation
with
the
HED
Hazard
Assessment
Science
Policy
Council
(
HASPC)
determined
that
it
would
be
appropriate
to
estimate
the
cancer
risk
to
humans
associated
with
the
various
uses
of
ametryn
by
using
a
Q1*
based
on
the
mammary
tumors
in
a
rat
carcinogenicity
study
on
a
trial
basis.
The
team
recognizes
that
the
HED
CARC
found
that
the
rat
cancer
study
developed
tumors
at
dose
levels
also
associated
with
excess
weight
loss
to
confound
the
interpretation
of
the
significance
of
these
tumors.
Consequently,
the
CARC
recommended
that
a
new
cancer
study
in
rats
be
provided.
However,
the
ametryn
team
believes
that
using
the
Q1*
based
on
existing
data
will
reasonably
approximate
cancer
risk
to
humans
and
considers
it
unlikely
that
the
new
cancer
study
will
result
in
a
higher
risk
for
ametryn.
Support
for
this
conclusion
comes
from
the
observation
that
there
were
no
tumors
in
the
rat
study
at
500
ppm,
a
dose
resulting
in
minimal
body
weight
decrease
and
the
fact
that
there
were
no
compound
related
tumors
in
the
mouse
study
at
dose
levels
up
to
and
including
2000
ppm.

2.1
Toxicological
Endpoints
The
doses
and
toxicological
endpoints
selected
and
the
Margins
of
Exposures
(
MOEs)
for
various
ametryn
exposure
scenarios
are
summarized
below
in
Table
1.

Table
1.
Summary
of
Toxicological
Dose
and
Endpoints
for
Ametryn
for
Use
in
Human
Risk
Assessment
(
dr.
8/
23/
04)

Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF*
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
females
13­
49)
No
selection.

Acute
Dietary
(
general
population)
No
selection.

Chronic
Dietary
(
all
populations)
NOAEL
=
7.2
mg/
kg/
day
UF
=
100
1
X
Dog
chronic
feeding
study
with
indications
of
degenerative
and
inflammatory
liver
effects
at
70
mg/
kg/
day.

Incidental
Oral
Short­
Term
(
1
­
30
days)
10
mg/
kg/
day
UF
=
100
1
X
MOE
=
100
Rabbit
developmental
toxicity.
Body
weight
and
deceased
feed
consumption
and
increased
liver
weight
at
60
mg/
kg/
day.

Incidental
Oral
Intermediate­
Term
(
1
­
6
months)
10
mg/
kg/
day
UF
=
100
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF*
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
6
Dermal
Short­
Term
(
1
­
30
days)
NOAEL
=
100
mg/
kg/
day
UF
=
100
None
Rabbit
21day
dermal
toxicity
study.
Body
weight
gain
decrease
at
1000
mg/
kg/
day.

Dermal
Intermediate­
Term
(
1
­
6
months)
Same
as
for
short
term.

Dermal
Long­
Term
(>
6
months)
Same
as
for
Chronic
RFD.
MOE
=
100.
Dermal
absorption
factor
of
6%
recommended.

Inhalation
Short­
Term
(
1
­
30
days)
Same
as
for
incidental
oral.
MOE
=
100.
Assume
100%
absorption
following
inhalation.

Inhalation
Intermediate­
Term
(
1
­
6
months)
Same
as
for
incidental
oral.
MOE
=
100.
Assume
100%
absorption
following
inhalation.

Inhalation
Long­
Term
(>
6
months)
Same
as
for
Chronic
RFD.
MOE
=
100.
Assume
100%
absorption
following
inhalation.

Cancer
(
oral,
dermal,
inhalation)
Classification:
In
accordance
with
the
EPA
draft
Guidelines
fo
Carcinogen
Risk
Assessment,
the
Committee
classified
ametryn
into
the
category
"
Data
Are
Inadequate
fo
an
Assessment
of
Human
Carcinogenic
Potential".

UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose,
MOE
=
margin
of
exposure,
LOC
=
level
of
concern,
NA
=
Not
Applicable
3.0
Incident
Reports
Relatively
few
incidents
of
illness
have
been
reported
due
to
ametryn.
Four
exposures
to
ametryn
products
were
reported
to
Poison
Control
Center
from
1993
through
2001.
Two
of
the
four
cases,
all
adults
involved
minor
symptoms.
One
of
the
cases
was
seen
in
a
health
care
facility
and
was
not
hospitalized
and
another
case
reported
diarrhea
and
drowsiness/
lethargy.
On
the
list
of
the
200
chemicals
for
which
NPIC
received
calls
from
1984­
1991
inclusively,
ametryn
was
not
reported
to
be
involved
in
human
incidents.
No
scientific
literature
was
located
concerning
acute
poisoning
due
to
exposure
to
ametryn.

4.0
Occupational
Exposure
and
Risk
Estimates
4.1
Formulations,
Use
Patterns,
Methods
&
Equipment
Ametryn
is
registered
as
a
pre­
or
at
­
plant
and
also
as
a
post
­
emergent
herbicide
for
the
control
of
various
weeds
and
grasses
on
various
agricultural
crops
and
non­
crop
settings.
According
to
the
Office
of
Pesticide
Program
(
OPP)
databases,
there
is
currently
one
technical
ametryn
formulation
and
three
end­
use
pesticide
products
containing
ametryn
for
agricultural
applications.
All
ametryn
products
are
intended
for
agricultural
and/
or
occupational
uses
only.
7
There
are
no
residential
uses
for
this
herbicide.
According
to
the
OPP's
Special
Review
and
Reregistration
Division
(
SRRD),
the
primary
registrant
for
the
herbicide,
Syngenta
Crop
Protection,
Inc.
is
only
supporting
three
crops
for
the
reregistration
process:
corn
(
field,
pop
and
sweet),
pineapples
and
sugarcane.
There
are
no
Special
Local
Need
registrations
on
record
for
ametryn
at
this
time.
SRRD
has
stated
that
for
the
purposes
of
the
RED
process
for
this
herbicide,
this
document
need
only
address
the
registered
Syngenta,
Inc.
Products
(
100­
579
&
100­
786).
The
end­
use
label,
EPA
Reg.
No.
100­
786,
named
Evik
DF
and
submitted
in
support
of
the
RED
was
used
in
this
assessment.

For
personal
protective
equipment
(
PPE),
the
label
specifically
requires:
long­
sleeved
shirt
and
long
pants;
chemical
resistant
gloves;
shoes
plus
socks.
It
also
includes
instructions
for
the
use
of
closed
systems
allowing
for
modifications
to
the
PPE
under
the
provisions
of
the
Worker
Protection
Standard
(
WPS).

4.2
Crops
For
the
control
of
various
broadleaf
and
grass
weeds
in
corn,
the
label
specifies
use
of
the
product
as
a
post­
emergence
directed
spray
to
weeds
after
the
smallest
corn
is
at
least
12
inches
tall
at
a
maximum
rate
of
2.5
pounds
active
ingredient
per
acre
(
lbs.
ai/
acre).
The
label
instructs
not
to
use
the
product
within
21
days
of
tassling
and
30
days
before
harvesting,
grazing
or
feeding
forage
to
livestock.

For
the
control
of
broadleaf
and
grass
weeds
in
pineapple
crops,
the
label
directs
application
of
a
blanket
spray
immediately
after
planting
or
after
harvesting
no
more
than
one
time
per
crop
cycle
and
not
within
160
days
of
harvest.
Maximum
label
application
rate
for
pineapples
is
9
lbs.
ai/
acre
and
is
also
specified
as
the
maximum
amount
which
can
be
applied
per
crop
cycle.

For
use
on
sugarcane
the
label
specifies
pre­
emergent
application
as
well
as
postemergent
directed
spray
and
broadcast
application.
The
use
directions
and
varying
application
rates
are
specified
for
the
differing
sugarcane
producing
states.
Maximum
application
range
from
1.5
lbs.
ai/
acre
in
Florida
(
FL),
2.5
lbs:
Louisiana
(
LA)
and
Texas
(
TX),
9
lbs.:
Hawaii
(
HI),
and
10
lbs.
ai/
acre
Puerto
Rico
(
PR).
The
product
label
does
not
specify
a
maximum
amount
of
ametryn
lbs.
ai./
acre
for
sugarcane
per
growing
season
as
it
does
for
pineapples.

Since
ametryn
is
formulated
as
a
liquid
(
water
dispersable
granules)
and
has
a
low
vapor
pressure
of
2.74
x
10­
6
mm
Hg
at
25

C
,
HED
expects
dermal
occupational
exposure
to
be
more
significant
than
inhalation.

HED
determines
potential
exposures
to
pesticide
handlers
by
identifying
exposure
scenarios
from
various
types
of
application
equipment
that
are
recommended
on
ametryn
labeling.
Based
on
the
product
labeling,
agricultural
use
patterns
specific
to
ametryn
are
associated
with
the
following
types
of
equipment:
aerial
(
sugarcane)
and
groundboom
sprayer
for
sugarcane,
pineapples
and
corn.

Based
on
product
labeling
and
information
provided
for
the
completion
of
the
RED
process
for
this
pesticide,
HED
has
identified
14
occupational
handler
scenarios
for
which
shortand
intermediate­
term
exposure
to
ametryn
may
occur.
Exposure
estimates
were
conducted
using
the
maximum
application
rates
for
each
of
the
crops.
8
Ametryn
product
labeling
specifies
application
as
either
a
directed
spray
at
weeds
or
as
a
pre­
emergent
broadcast
spray,
and
includes
instructions
to
avoid
application
to
the
crop
foliage.
Additionally,
for
corn
and
pineapples,
the
label
specifies
last
ametryn
application
be
made
30
and
160
days
prior
to
harvesting
respectively.
For
sugarcane,
the
label
specifies
"
Avoid
wetting
sugarcane
foliage,
or
injury
may
occur"
and
also
recommends
against
application
after
"
close­
in"
­
when
the
sugarcane
grows
over
the
planting
beds
prior
to
harvesting.
For
these
reasons,
HED
does
not
anticipate
any
foliar
residues
on
the
ametryn
treated
crops.
Therefore,
HED
does
not
expect
there
to
be
any
post­
application
foliar
exposures
to
occur
and
post­
application
occupational
exposures
were
not
assessed.

4.3
Occupational
Handler
Exposure
Scenarios
The
following
14
occupational
handler
scenarios
were
evaluated
for
short
and
intermediate
term
exposure
to
ametryn.

2.
Mix/
load:
Liquids
for
Groundboom
to
Support
Application
to
Corn;

3.
Mix/
load:
Liquids
for
Groundboom
to
Support
Application
to
Pineapples;

4.
Mix/
load:
Liquids
for
Groundboom
to
Support
Application
to
Sugarcane;

5.
Mix/
load:
Liquids
for
Aerial
to
Support
Application
Sugarcane;

6.
Mix/
load:
Liquids
to
Support
Groundboom
Application
on
Sugarcane*;

7.
Mix/
load:
Liquids
for
Aerial
Application
on
Sugarcane*;

8.
Application:
Groundboom
Spray
Application
on
Corn;

9.
Application:
Groundboom
Spray
Application
on
Pineapples;

10.
Application:
Groundboom
Spray
Application
on
Sugarcane;

11.
Application:
Aerial
Spray
Application
on
Sugarcane;

12.
Application:
Groundboom
Spray
Application
on
Sugarcane*;

13.
Application:
Aerial
Application
of
Sprays
on
Sugarcane*;

14.
Flagger:
Aerial
on
Sugarcane;

15.
Flagger:
Aerial
on
Sugarcane*.

(*
denotes
lower
application
rates:
2.5
lbs
ai/
acre,
as
described
in
Table
2.)

The
potential
handler
exposures
associated
with
these
scenarios
are
assessed
in
this
RED
chapter
using
the
toxicological
endpoints
and
uncertainty
factors
associated
with
the
active
ingredient
as
outlined
in
Section
2
of
this
document.

Table
2.
represents
the
specific
crops
or
areas
and
related
acreage
thereof
subject
to
ametryn
treatment
including
application
method
addressed
in
the
occupational
assessment
portion
of
the
RE
D.

Table
2.
Use
Patterns,
Rates,
Methods
&
Acreage
for
Ametryn
Application
9
Crop
Max
Appl.
Rate
(
lbs
ai/
acre)
Appl.
Method
Formulation
Acres
Treated
per
Day**

Corn
2.5
groundboom
liquid
200
Pineapples
9.0
groundboom
liquid
80
Sugarcane
2.5
/
9.0
Groundboom
liquid
80
Sugarcane
2.5
/
9.0
aerial
liquid
350
(**
see
below:
Acreage)

4.3
Occupational
Handlers
Exposure
Estimates
Because
no
chemical
specific
data
and/
or
studies
were
submitted
in
support
of
the
reregistration
process
for
this
chemical,
PHED
V1.1
has
been
used
to
assess
the
exposure
scenarios
for
ametryn.
PHED
was
designed
by
a
Task
Force
of
representatives
from
the
U.
S.
EPA,
Health
Canada,
the
California
Department
of
Pesticide
Regulation,
and
member
companies
of
the
American
Crop
Protection
Association.
PHED
is
a
software
system
consisting
of
two
parts
­­
a
database
of
measured
exposure
values
for
workers
involved
in
the
handling
of
pesticides
under
actual
field
conditions
and
a
set
of
computer
algorithms
used
to
subset
and
statistically
summarize
the
selected
data.
Currently,
the
database
contains
values
for
over
1,700
monitored
individuals
(
i.
e.,
replicates).

Users
select
criteria
to
subset
the
PHED
database
to
reflect
the
exposure
scenario
being
evaluated.
The
subsetting
algorithms
in
PHED
are
based
on
the
central
assumption
that
the
magnitude
of
handler
exposures
to
pesticides
are
primarily
a
function
of
activity
(
e.
g.,
mixing/
loading,
applying),
formulation
type
(
e.
g.,
wettable
powders,
granulars),
application
method
(
e.
g.,
aerial,
groundboom),
and
clothing
scenarios
(
e.
g.,
gloves,
double
layer
clothing).
Once
the
data
for
a
given
exposure
scenario
has
been
selected,
the
data
are
normalized
(
i.
e.,
divided
by)
by
the
amount
of
pesticide
handled
resulting
in
standard
unit
exposures
(
milligrams
of
exposure
per
pound
of
active
ingredient
handled).
Following
normalization,
the
data
are
statistically
summarized.
The
distribution
of
exposure
values
for
each
body
part
(
e.
g.,
chest,
upper
arm)
is
categorized
as
normal,
lognormal,
or
"
other"
(
i.
e.,
neither
normal
nor
lognormal).
A
central
tendency
value
is
then
selected
from
the
distribution
of
the
exposure
values
for
each
body
part.
These
values
are
the
arithmetic
mean
for
normal
distributions,
the
geometric
mean
for
lognormal
distributions,
and
the
median
for
all
"
other"
distributions.
Once
selected,
the
central
tendency
values
for
each
body
part
are
composited
into
a
"
best
fit"
exposure
value
representing
the
entire
body.

The
handler
assessments
encompass
all
of
the
major
uses
of
ametryn
being
supported
throughout
the
country.
The
assumptions
used
in
calculating
exposures
and
risks
are
listed
below:


Application
Rates:
The
application
rates
are
the
maximum
allowable
that
were
identified
on
the
available
product
labels
for
each
use
assessed
in
this
document.


Acreage
Treated**:
The
daily
acres
treated
are
HED
standard
values
(
EXPO
SAC
policy
9.1).
However,
for
sugarcane
HED
used
350
acres
(
low
acreage)
rather
than
1200
acres
(
high
acreage)
in
the
aerial
assessment
for
this
crop
based
10
on
information
that
typically
ametryn
is
not
applied
to
sugarcane
aerially,
but
is
more
typically
applied
by
ground
boom
equipment,
and
is
as
such
considered
a
high
acreage
groundboom
crop
and
a
rather
low
acreage
aerial
crop.


Unit
Exposures:
The
unit
exposure
values
calculated
by
PHED
generally
range
from
the
geometric
mean
to
the
median
of
the
selected
data
set.
To
add
consistency
and
quality
control
to
the
values
produced
from
this
system,
the
PHED
Task
Force
has
evaluated
all
data
within
the
system
and
has
developed
a
set
of
grading
criteria
to
characterize
the
quality
of
the
original
study
data.
The
assessment
of
data
quality
is
based
on
the
number
of
observations
and
the
available
quality
control
data.
While
data
from
PHED
provides
the
best
available
information
on
handler
exposures,
it
should
be
noted
that
some
aspects
of
the
included
studies
(
e.
g.,
duration,
acres
treated,
pounds
of
active
ingredient
handled)
may
not
accurately
represent
labeled
uses
in
all
cases.


Amount
Handled:
Based
on
the
daily
acres
treated.


Personal
Protective
Equipment
(
PPE):
HED
calculated
MOEs
for
the
baseline,
minimum
PPE,
and
PPE
with
engineering
controls
for
each
occupational
exposure
scenario
under
the
following
assumptions:

All
Scenarios:
All
occupational
handlers
are
wearing
footwear
(
socks
plus
shoes
or
boots),
foot
exposure
is
not
traditionally
monitored,
and
therefore,
a
100
percent
protection
factor
is
implied.

Baseline
Attire:
All
handlers
are
wearing
long­
sleeved
shirts,
long
pants,
no
gloves,
and
no
respirator.

Minimum
PPE:
All
handlers
are
wearing
long­
sleeved
shirts,
long
pants,
gloves,
and
no
respirator.

Engineering
Controls:
Represents
the
use
of
an
appropriate
engineering
control
such
as
a
closed
tractor
cab
or
closed
loading
system
for
granulars
or
liquids.

Potential
daily
dermal
exposure
is
calculated
using
the
following
formula:

Daily
Dermal
Exposure
(
mg
ai/
day)
=

Dermal
Unit
Exposure
(
mg
ai/
lb
ai)
x
Application
Rate
(
lb
ai/
lb
of
seed
)
x
Daily
amount
Treated
(
lbs)

Potential
daily
inhalation
exposure
is
calculated
using
the
following
formula:

Daily
Inhalation
Exposure
(
mg
ai/
day)
=

Inhalation
Unit
Exposure
(
mg
ai/
lb
ai)
x
Application
Rate
(
lb
ai/
lb
of
seed)
x
Daily
amount
Treated
(
lbs)

The
inhalation
and
dermal
daily
doses
were
calculated
using
the
following
formulas:

Daily
dermal
dose
(
mg/
kg/
day)
=
daily
dermal
exposure(
mg
ai/
day)/
body
weight(
kg)
x
dermal
absorption
factor(
100%)

Daily
Inhalation
dose
(
mg/
kg/
day)
=
daily
Inhalation
exposure(
mg
ai/
day)/
body
weight(
kg)
x
100%

(
where
body
weight
=
70kg.)

4.4
Occupational
Handlers
Risk
Estimates
Using
the
daily
dermal
exposure
scenarios
identified
in
the
exposure
section,
HED
calculated
the
potential
risk
to
persons
from
handler
exposures
using
MOEs.

The
MOEs
were
calculated
using
the
following
formulas:

Dermal
MOE
=
Dermal
NOAEL(
mg/
kg/
day)/
Daily
Dermal
Dose
(
mg/
kg/
day)
11
Inhalation
MOE
=
Inhalation
NOAEL(
mg/
kg/
day)/
Daily
Inhalation
Dose
(
mg/
kg/
day)

Margins
of
exposure
(
MOEs)
were
calculated
for
handlers
for
short­
term
(
up
to
1
month)
and
intermediate­
term
(
1
to
6
months)
durations.

The
results
of
the
dermal
and
inhalation
handler
risk
estimates
for
short
and
intermediateterm
exposure
durations
to
ametryn
are
summarized
in
tables
3,
4,
&
5.

MOEs
for
11
of
the
14
handler
scenarios
are
>
100
at
either
baseline
or
minimum
PPE
protection
levels
and
are
not
of
concern.
The
three
scenarios
with
MOEs
which
do
not
exceed
100
at
baseline
or
PPE1
protection
levels:
Scenario
4
­
mixing/
loading
liquids
for
aerial
application
to
sugarcane
at
the
application
rate
of
10
lbs
ai/
acre;
Scenario
10
­
applying
spray
for
aerial
application
to
sugarcane
at
2.5
lbs.
ai/
acre
and
Scenario
12
­
applying
spray
for
aerial
application
to
sugarcane
at
10.0
lbs
ai/
acre.
All
three
of
these
scenarios
attain
MOEs
>
100
with
engineering
controls.
12
Table
3.
Short
&
Intermediate
­
Term
Ametryn
Baseline
Exposure
Estimates
Exposure
Scenario
(
Scenario
#)
Dermal
Unit
Exposure
(
mg/
lb
ai)
1
Inhalation
Unit
Exposure
(
Ug/
lb
ai)
2
Crop3
Application
Rate4
Daily
Area
Treated5
Dermal
Dose
(
mg/
kg/
day)
6
Dermal
MOE
7
Inhalation
Dose
(
mg/
kg/
day)
8
Inhalation
MOE9
Total
MOE10
Mixer/
Loader
Mixing/
Loading
Liquids
for
Groundboom
application
(
1)
2.9
1.2
Corn
2.50
lb
ai
per
acre
200
Acres
per
day
21
5
0.0086
1200
4.8
Mixing/
Loading
Liquids
for
Groundboom
application
(
2)
2.9
1.2
Pineapple
9
lb
ai
per
acre
40
Acres
per
day
15
7
0.0062
1600
6.7
Mixing/
Loading
Liquids
for
Groundboom
application
(
3)
2.9
1.2
Sugarcane
10
lb
ai
per
acre
80
Acres
per
day
33
3
0.014
730
3
Mixing/
Loading
Liquids
for
Aerial
application
(
4)
2.9
1.2
Sugarcane
9
lb
ai
per
acre
350
Acres
per
day
130
1
0.054
190
0.76
Mixing/
Loading
Liquids
for
Groundboom
application
(
5)
2.9
1.2
Sugarcane
2.50
lb
ai
per
acre
40
Acres
per
day
4.1
24
0.0017
5800
24
Mixing/
Loading
Liquids
for
Aerial
application
(
6)
2.9
1.2
Sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
36
3
0.015
670
2.7
Applicator
Sprays
for
Groundboom
application
(
7)
0.014
0.74
Corn
2.50
lb
ai
per
acre
200
Acres
per
day
0.1
1000
0.0053
1900
650
Sprays
for
Groundboom
application
(
8)
0.014
0.74
Pineapple
9
lb
ai
per
acre
80
Acres
per
day
0.14
690
0.0076
1300
450
Sprays
for
Groundboom
application
(
9)
0.014
0.74
Sugarcane
10
lb
ai
per
acre
80
Acres
per
day
0.16
630
0.0085
1200
410
Sprays
for
Aerial
application
(
10)
No
Data
No
Data
sugarcane
10
lb
ai
per
acre
350
Acres
per
day
No
Data
No
Data
No
Data
No
Data
No
Data
Table
3.
Short
&
Intermediate
­
Term
Ametryn
Baseline
Exposure
Estimates
Exposure
Scenario
(
Scenario
#)
Dermal
Unit
Exposure
(
mg/
lb
ai)
1
Inhalation
Unit
Exposure
(
Ug/
lb
ai)
2
Crop3
Application
Rate4
Daily
Area
Treated5
Dermal
Dose
(
mg/
kg/
day)
6
Dermal
MOE
7
Inhalation
Dose
(
mg/
kg/
day)
8
Inhalation
MOE9
Total
MOE10
13
Sprays
for
Groundboom
application
(
11)
0.014
0.74
Sugarcane
2.50
lb
ai
per
acre
80
Acres
per
day
0.04
2500
0.0021
4700
1600
Sprays
for
Aerial
application
(
12)
No
Data
No
Data
sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
No
Data
No
Data
No
Data
No
Data
No
Data
Flagger
Flagging
for
Sprays
application
(
13)
0.011
0.35
Sugarcane
10
lb
ai
per
acre
350
Acres
per
day
0.55
180
0.018
570
140
Flagging
for
Sprays
application
(
14)
0.011
0.35
Sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
0.14
730
0.0044
2300
550
1Baseline
dermal
unit
exposures
represent
long
pants,
long
sleeved
shirts,
shoes,
and
socks.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

2Baseline
inhalation
unit
exposures
represent
no
respirator.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

3Crops
and
use
patterns
are
from
product
labeling.

4Application
rates
are
based
on
maximum
values
found
in
various
sources
including
LUIS
and
various
labels.
In
most
scenarios,
a
range
of
maximum
application
rates
is
used
to
represent
the
range
of
rates
for
different
crops/
sites/
uses.
Application
rates
upon
which
the
analysis
is
based
are
presented
as
lb
ai/
A.

5Amount
treated
is
based
on
the
area
or
gallons
that
can
be
reasonably
applied
in
a
single
day
for
each
exposure
scenario
of
concern
based
on
the
application
method
and
formulation/
packaging
type.

(
Standard
EPA/
OPP/
HED
values).

6Dermal
dose
(
mg/
kg/
day)
=
[
unit
exposure
(
mg/
lb
ai)
*
Dermal
absorption
(
100%)
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Daily
area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

7Dermal
MOE
=
Short
&
Intermediate­
term
dermal
NOAEL
(
100
mg/
kg/
day)
/
Daily
Dermal
Dose.
Target
Dermal
MOE
is
100.

8Inhalation
dose
(
mg/
kg/
day)
=
[
unit
exposure
(
ug/
lb
ai)
*
0.001
mg/
g
unit
conversion
*
Inhalation
absorption
(
100%)
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Daily
area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

9Inhalation
MOE
=
Short
&
Intermediate­
term
developmental
NOAEL
(
10
mg/
kg/
day)
/
Daily
Inhalation
Dose.
Target
Inhalation
MOE
is
100.

10Total
MOE
=
[
1/
(
1/
dermal
Moe
+
1/
inhalation
MOE)]
14
Table
4.
Short
&
Intermediate
­
Term
PPE
1
(
Single
Layer
Protection,
Gloves,
No
Respirator)
Ametryn
Exposure
Estimates
Exposure
Scenario
(
Scenario
#)
Dermal
Unit
Exposure
(
mg/
lb
ai)
1
Inhalation
Unit
Exposure
(
Ug/
lb
ai)
2
Crop3
Application
Rate4
Daily
Area
Treated5
Dermal
Dose
(
mg/
kg/
day)
6
Dermal
MOE
7
Inhalation
Dose
(
mg/
kg/
day)
8
Inhalation
MOE9
Total
MOE10
Mixer/
Loader
Mixing/
Loading
Liquids
for
Groundboom
application
(
1)
0.023
1.2
Corn
2.50
lb
ai
per
acre
200
Acres
per
day
0.16
610
0.0086
1200
400
Mixing/
Loading
Liquids
for
Groundboom
application
(
2)
0.023
1.2
Pineapple
9
lb
ai
per
acre
40
Acres
per
day
0.12
850
0.0062
1600
560
Mixing/
Loading
Liquids
for
Groundboom
application
(
3)
0.023
1.2
Sugarcane
10
lb
ai
per
acre
80
Acres
per
day
0.26
380
0.014
730
250
Mixing/
Loading
Liquids
for
Aerial
application
(
4)
0.023
1.2
Sugarcane
9
lb
ai
per
acre
350
Acres
per
day
1
97
0.054
190
63
Mixing/
Loading
Liquids
for
Groundboom
application
(
5)
0.023
1.2
Sugarcane
2.50
lb
ai
per
acre
40
Acres
per
day
0.033
3000
0.0017
5800
2000
Mixing/
Loading
Liquids
for
Aerial
application
(
6)
0.023
1.2
Sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
0.29
350
0.015
670
230
Applicator
Sprays
for
Groundboom
application
(
7)
0.014
0.74
Corn
2.50
lb
ai
per
acre
200
Acres
per
day
0.1
1000
0.0053
1900
650
Sprays
for
Groundboom
application
(
8)
0.014
0.74
Pineapple
9
lb
ai
per
acre
80
Acres
per
day
0.14
690
0.0076
1300
450
Sprays
for
Groundboom
application
(
9)
0.014
0.74
Sugarcane
10
lb
ai
per
acre
80
Acres
per
day
0.16
630
0.0085
1200
410
Sprays
for
Aerial
application
(
10)
No
Data
No
Data
sugarcane
10
lb
ai
per
acre
350
Acres
per
day
No
Data
No
Data
No
Data
No
Data
No
Data
Table
4.
Short
&
Intermediate
­
Term
PPE
1
(
Single
Layer
Protection,
Gloves,
No
Respirator)
Ametryn
Exposure
Estimates
Exposure
Scenario
(
Scenario
#)
Dermal
Unit
Exposure
(
mg/
lb
ai)
1
Inhalation
Unit
Exposure
(
Ug/
lb
ai)
2
Crop3
Application
Rate4
Daily
Area
Treated5
Dermal
Dose
(
mg/
kg/
day)
6
Dermal
MOE
7
Inhalation
Dose
(
mg/
kg/
day)
8
Inhalation
MOE9
Total
MOE10
15
Sprays
for
Groundboom
application
(
11)
0.014
0.74
Sugarcane
2.50
lb
ai
per
acre
80
Acres
per
day
0.04
2500
0.0021
4700
1600
Sprays
for
Aerial
application
(
12)
No
Data
No
Data
sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
No
Data
No
Data
No
Data
No
Data
No
Data
Flagger
Flagging
for
Sprays
application
(
13)
0.01
0.35
Sugarcane
10
lb
ai
per
acre
350
Acres
per
day
0.5
200
0.018
570
150
Flagging
for
Sprays
application
(
14)
0.01
0.35
Sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
0.13
800
0.0044
2300
590
1
PPE1
dermal
unit
exposures
represent
long
pants,
long
sleeved
shirts,
and
chemical­
resistant
gloves.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

2PPE1
inhalation
unit
exposures
represent
no
respirator.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

2Baseline
inhalation
unit
exposures
represent
no
respirator.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

3Crops
and
use
patterns
are
from
product
labeling.

4Application
rates
are
based
on
maximum
values
found
in
various
sources
including
LUIS
and
various
labels.
In
most
scenarios,
a
range
of
maximum
application
rates
is
used
to
represent
the
range
of
rates
for
different
crops/
sites/
uses.
Application
rates
upon
which
the
analysis
is
based
are
presented
as
lb
ai/
A.

5Amount
treated
is
based
on
the
area
or
gallons
that
can
be
reasonably
applied
in
a
single
day
for
each
exposure
scenario
of
concern
based
on
the
application
method
and
formulation/
packaging
type.

(
Standard
EPA/
OPP/
HED
values).

6Dermal
dose
(
mg/
kg/
day)
=
[
unit
exposure
(
mg/
lb
ai)
*
Dermal
absorption
(
100%)
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Daily
area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

7Dermal
MOE
=
Short
&
Intermediate­
term
dermal
NOAEL
(
100
mg/
kg/
day)
/
Daily
Dermal
Dose.
Target
Dermal
MOE
is
100.

8Inhalation
dose
(
mg/
kg/
day)
=
[
unit
exposure
(
ug/
lb
ai)
*
0.001
mg/
g
unit
conversion
*
Inhalation
absorption
(
100%)
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Daily
area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

9Inhalation
MOE
=
Short
&
Intermediate­
term
developmental
NOAEL
(
10
mg/
kg/
day)
/
Daily
Inhalation
Dose.
Target
Inhalation
MOE
is
100.

10Total
MOE
=
[
1/
(
1/
dermal
Moe
+
1/
inhalation
MOE)]
16
Table
5.
Short
&
intermediate
­
Term
Ametryn
Exposure
Estimates
with
Engineering
Controls
Exposure
Scenario
(
Scenario
#)
Dermal
Unit
Exposure
(
mg/
lb
ai)
1
Inhalation
Unit
Exposure
(
Ug/
lb
ai)
2
Crop3
Application
Rate4
Daily
Area
Treated5
Dermal
Dose
(
mg/
kg/
day)
6
Dermal
MOE
7
Inhalation
Dose
(
mg/
kg/
day)
8
Inhalation
MOE9
Total
MOE10
Mixer/
Loader
Mixing/
Loading
Liquids
for
Groundboom
application
(
1)
0.0086
0.083
corn
2.50
lb
ai
per
acre
200
Acres
per
day
0.061
1600
0.00059
17000
1500
Mixing/
Loading
Liquids
for
Groundboom
application
(
2)
0.0086
0.083
pineapple
9
lb
ai
per
acre
40
Acres
per
day
0.044
2300
0.00043
23000
2100
Mixing/
Loading
Liquids
for
Groundboom
application
(
3)
0.0086
0.083
sugarcane
10
lb
ai
per
acre
80
Acres
per
day
0.098
1000
0.00095
11000
930
Mixing/
Loading
Liquids
for
Aerial
application
(
4)
0.0086
0.083
sugarcane
9
lb
ai
per
acre
350
Acres
per
day
0.39
260
0.0037
2700
240
Mixing/
Loading
Liquids
for
Groundboom
application
(
5)
0.0086
0.083
sugarcane
2.50
lb
ai
per
acre
40
Acres
per
day
0.012
8100
0.00012
84000
7400
Mixing/
Loading
Liquids
for
Aerial
application
(
6)
0.0086
0.083
sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
0.11
930
0.0010
9600
850
Applicator
Sprays
for
Groundboom
application
(
7)
0.005
0.043
corn
2.50
lb
ai
per
acre
200
Acres
per
day
0.036
2800
0.00031
33000
2600
Sprays
for
Groundboom
application
(
8)
0.005
0.043
pineapple
9
lb
ai
per
acre
80
Acres
per
day
0.051
1900
0.00044
23000
1800
Sprays
for
Groundboom
application
(
9)
0.005
0.043
sugarcane
10
lb
ai
per
acre
80
Acres
per
day
0.057
1800
0.00049
20000
1600
Sprays
for
Aerial
application
(
10)
0.005
0.068
sugarcane
10
lb
ai
per
acre
350
Acres
per
day
0.25
400
0.0034
2900
350
Table
5.
Short
&
intermediate
­
Term
Ametryn
Exposure
Estimates
with
Engineering
Controls
Exposure
Scenario
(
Scenario
#)
Dermal
Unit
Exposure
(
mg/
lb
ai)
1
Inhalation
Unit
Exposure
(
Ug/
lb
ai)
2
Crop3
Application
Rate4
Daily
Area
Treated5
Dermal
Dose
(
mg/
kg/
day)
6
Dermal
MOE
7
Inhalation
Dose
(
mg/
kg/
day)
8
Inhalation
MOE9
Total
MOE10
17
Sprays
for
Groundboom
application
(
11)
0.005
0.043
sugarcane
2.50
lb
ai
per
acre
80
Acres
per
day
0.014
7000
0.00012
81000
6400
Sprays
for
Aerial
application
(
12)
0.005
0.068
sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
0.063
1600
0.00085
12000
1400
Flagger
Flagging
for
Sprays
application
(
13)
0.00022
0.007
sugarcane
10
lb
ai
per
acre
350
Acres
per
day
0.011
9100
0.00035
29000
6900
Flagging
for
Sprays
application
(
14)
0.00022
0.007
sugarcane
2.50
lb
ai
per
acre
350
Acres
per
day
0.0028
36000
0.000088
110000
28000
1Engineering
controls
dermal
unit
exposures
represent
long
pants
and
long
sleeved
shirts.
For
mixers
and
loaders,
chemical­
resistant
gloves
are
also
included.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

2Engineering
controls
inhalation
unit
exposures
represent
no
respirator.
Values
are
reported
in
the
PHED
Surrogate
Exposure
Guide
dated
August
1998
or
are
from
data
submitted
by
the
Outdoor
Residential
Exposure
Task
Force
dated
May
2000.

3Crops
and
use
patterns
are
from
product
labeling.

4Application
rates
are
based
on
maximum
values
found
in
various
sources
including
LUIS
and
various
labels.
In
most
scenarios,
a
range
of
maximum
application
rates
is
used
to
represent
the
range
of
rates
for
different
crops/
sites/
uses.
Application
rates
upon
which
the
analysis
is
based
are
presented
as
lb
ai/
A.

5Amount
treated
is
based
on
the
area
or
gallons
that
can
be
reasonably
applied
in
a
single
day
for
each
exposure
scenario
of
concern
based
on
the
application
method
and
formulation/
packaging
type.

(
Standard
EPA/
OPP/
HED
values).

6Dermal
dose
(
mg/
kg/
day)
=
[
unit
exposure
(
mg/
lb
ai)
*
Dermal
absorption
(
100%)
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Daily
area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

7Dermal
MOE
=
Short
&
Intermediate­
term
dermal
NOAEL
(
100
mg/
kg/
day)
/
Daily
Dermal
Dose.
Target
Dermal
MOE
is
100.

8Inhalation
dose
(
mg/
kg/
day)
=
[
unit
exposure
(
ug/
lb
ai)
*
0.001
mg/
g
unit
conversion
*
Inhalation
absorption
(
100%)
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Daily
area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

9Inhalation
MOE
=
Short
&
Intermediate­
term
developmental
NOAEL
(
10
mg/
kg/
day)
/
Daily
Inhalation
Dose.
Target
Inhalation
MOE
is
100.

10Total
MOE
=
[
1/
(
1/
dermal
Moe
+
1/
inhalation
MOE)]

4.5
Occupational
Cancer
Risk
Estimates
18
The
Agency
has
defined
a
range
of
acceptable
cancer
risks
based
on
a
policy
memorandum
issued
in
1996
by
then
office
director,
Dan
Barolo.
This
memo
refers
to
a
predetermined
quantified
"
level
of
concern"
for
occupational
carcinogenic
risk.
In
summary,
this
policy
memo
indicates
occupational
carcinogenic
risks
that
are
1
x
10­
6
or
lower
require
no
risk
management
action.
For
those
chemicals
subject
to
reregistration,
the
Agency
is
to
carefully
examine
uses
with
estimated
risks
in
the
10­
6
to
10­
4
range
to
seek
ways
of
cost­
effectively
reducing
risks.
If
carcinogenic
risks
are
in
this
range
for
occupational
handlers,
increased
levels
of
personal
protection
would
be
warranted
as
is
commonly
applied
with
noncancer
risk
estimates
(
e.
g.,
additional
PPE
or
engineering
controls).

Table
6.
Cancer(
Q*)
Risk
Table
Exposure
Scenario
(
Scenario
#)
Crop1
Baseline
Total
Daily
Dose2,
3
Baseli
ne
Daily
LADD
2,
4
Baseline
Risk2,
5
Maximu
m
PPE
Total
Daily
Dose2,
6
Maximu
m
PPE
LADD3,
6
Maxim
um
PPE
Risk4,
6
Eng
Cont
Total
Daily
Dose2,
7
Eng
Cont
LADD3,
7
Eng
Cont
Risk4
,
7
Mixer/
Loader
Table
6.
Cancer(
Q*)
Risk
Table
Exposure
Scenario
(
Scenario
#)
Crop1
Baseline
Total
Daily
Dose2,
3
Baseli
ne
Daily
LADD
2,
4
Baseline
Risk2,
5
Maximu
m
PPE
Total
Daily
Dose2,
6
Maximu
m
PPE
LADD3,
6
Maxim
um
PPE
Risk4,
6
Eng
Cont
Total
Daily
Dose2,
7
Eng
Cont
LADD3,
7
Eng
Cont
Risk4
,
7
19
Mixing/
Loadin
g
Liquids
for
Groundboom
application
(
1)
corn
21
8.52E­

1
5.64E­
3
0.12
5.03E­
3
3.33E­

5
0.062
2.55E­
3
1.69
E­
5
Mixing/
Loadi
ng
Liquids
for
Groundboom
application
(
2)
pineappl
e
15
6.13E­

1
4.06E­
3
0.088
3.62E­
3
2.40E­

5
0.045
1.84E­
3
1.21
E­
5
Mixing/
Loadi
ng
Liquids
for
Groundboom
application
(
3)
sugarcan
e
33
1.36E
+
0
9.02E­
3
0.20
8.04E­
3
5.32E­

5
0.099
4.08E­
3
2.70
E­
5
Mixing/
Loadi
ng
Liquids
for
Aerial
application
(
4)
sugarcan
e
130
5.37E
+
0
3.55E­
2
0.77
3.17E­
2
2.10E­

4
0.39
1.61E­
2
1.06
E­
4
Mixing/
Loadi
ng
Liquids
for
Groundboom
application
(
5)
sugarcan
e
4.1
1.70E­

1
1.13E­
3
0.024
1.01E­
3
6.65E­

6
0.012
5.10E­
4
3.37
E­
6
Mixing/
Loadi
ng
Liquids
for
Aerial
application
(
6)
sugarcan
e
36
1.49E
+
0
9.87E­
3
0.21
8.79E­
3
5.82E­

5
0.11
4.46E­
3
2.95
E­
5
Applicator
Sprays
for
Groundboom
application
(
7)
corn
0.11
4.33E­

3
2.86E­
5
0.079
3.25E­
3
2.15E­

5
0.036
1.48E­
3
9.80
E­
6
Sprays
for
Groundboom
application
(
8)
pineappl
e
0.15
6.23E­

3
4.12E­
5
0.11
4.68E­
3
3.10E­

5
0.052
2.13E­
3
1.41
E­
5
Sprays
for
Groundboom
application
(
9)
sugarcan
e
0.17
6.92E­

3
4.58E­
5
0.13
5.20E­
3
3.44E­

5
0.058
2.37E­
3
1.57
E­
5
Table
6.
Cancer(
Q*)
Risk
Table
Exposure
Scenario
(
Scenario
#)
Crop1
Baseline
Total
Daily
Dose2,
3
Baseli
ne
Daily
LADD
2,
4
Baseline
Risk2,
5
Maximu
m
PPE
Total
Daily
Dose2,
6
Maximu
m
PPE
LADD3,
6
Maxim
um
PPE
Risk4,
6
Eng
Cont
Total
Daily
Dose2,
7
Eng
Cont
LADD3,
7
Eng
Cont
Risk4
,
7
20
Sprays
for
Aerial
application
(
10)
sugarcan
e
No
Data
No
Data
No
Data
No
Data
No
Data
No
Data
0.25
1.04E­
2
6.89
E­
5
Sprays
for
Groundboom
application
(
11)
sugarcan
e
0.042
1.73E­

3
1.15E­
5
0.032
1.30E­
3
8.61E­

6
0.014
5.92E­
4
3.92
E­
6
Sprays
for
Aerial
application
(
12)
sugarcan
e
No
Data
No
Data
No
Data
No
Data
No
Data
No
Data
0.063
2.60E­
3
1.72
E­
5
Flagger
Flagging
for
Sprays
application
(
13)
sugarcan
e
0.57
2.33E­

2
1.54E­
4
0.50
2.06E­
2
1.37E­

4
0.011
4.66E­
4
3.09
E­
6
Flagging
for
Sprays
application
(
14)
sugarcan
e
0.14
5.83E­

3
3.86E­
5
0.13
5.15E­
3
3.41E­

5
0.0028
1.17E­
4
7.72
E­
7
1Crops
and
use
patterns
are
from
product
labeling.

2Baseline
represents
the
use
of
long
pants
and
long
sleeved
shirt
(
no
respirator),
while
using
equipment
and
systems
that
are
not
engineering
controls.

3Total
daily
absorbed
dose
(
mg/
kg/
day)
=
[((
dermal
unit
exposure
(
mg/
lb
ai)
*
100%
dermal
absorption)
+
(
inhalation
unit
exposure
(
ug/
lb
ai)
*
0.001
mg/
ug
unit
conversion
*

100%
inhalation
absorption))
*
Application
rate
(
lb
ai/
acre
or
lb
ai/
gallon)
*
Area
treated
(
acres
or
gallons)]
/
Body
weight
(
70
kg).

4LADD
(
Lifetime
average
daily
dose)
mg/
kg/
day
=
Total
daily
absorbed
dose
(
mg/
kg/
day)
*
(
30
days
worked
per
year
days
worked
per
year/
365
days
per
year)
*
(
35
years
worked
years
worked/
70
year
lifetime).
Days
worked
per
year
are
estimates.

5Cancer
Risk
=
LADD
(
mg/
kg/
day)
*
Q1*
=
0.00662
(
mg/
kg/
day)­
1.

6Maximum
PPE
represents
the
use
of
coveralls
worn
over
long­
sleeved
shirt
and
long
pants,
plus
chemical
resistant
gloves
and
an
organic­
vapor­
removing
respirator
or
equivalent
(
10­
fold
PF),
while
using
equipment
and
systems
that
are
not
engineering
controls.

7Engineering
controls
represents
the
use
of
long
pants
and
long
sleeved
shirt
(
no
respirator),
plus
 
when
mixing/
loading
 
chemical­
resistant
gloves,
while
using
equipment
and
systems
that
are
engineering
controls
(
e.
g.,
closed
mixing/
loading,
enclosed
cockpits,
and/
or
enclosed
cabs).
Note
that
data
for
airblast
applicators
includes
the
use
of
chemical
resistant
gloves,
because
data
are
not
available
for
the
"
no
glove"
scenario.
21
