UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
August
31,
2004
Subject:
Flumetsulam.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Tolerance
Reassessment
Eligibility
Decision
(
TRED)
Document.

DP
Barcode:
D306242
PC
Code:
129016
Chemical
Class:
Triazolopyrimidine
40
CFR
§
:
180.468
From:
Samuel
Ary,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Through:
Sherrie
Kinard,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

William
Hazel,
Branch
Chief
(
Acting)
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

To:
Elissa
Reaves,
Risk
Assessor
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

This
summary
of
analytical
chemistry
and
residue
data
document
was
originally
prepared
under
contract
by
Versar,
Inc.
(
6850
Versar
Center,
Springfield,
VA
22151;
submitted
June
11,
2004).
The
summary
document
has
been
reviewed
by
the
Health
Effects
Division
(
HED)
and
revised
to
reflect
current
Office
of
Pesticide
Program
(
OPP)
policies.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
2
of
32
Executive
Summary
Flumetsulam,
N­(
2,6­
difluorophenyl)­
5­
methyl­(
1,2,4)­
triazolo­[
1,5a]­
pyrimidine­
2­
sulfonamide,
is
a
herbicide
in
the
triazolopyrimidine
chemical
class.
The
mode
of
action
of
flumetsulam
is
similar
to
the
sulfonylurea
herbicides,
which
are
acetolactate
synthase
(
ALS)
inhibitors.
Registered
food/
feed
uses
of
flumetsulam
in
the
U.
S.
are
on
field
corn
and
soybeans.
Additionally,
Dow
AgroSciences,
LLC
(
Dow)
has
petitioned
(
Petition
Number:
7F4851)
for
the
establishment
of
a
tolerance
of
flumetsulam
in/
on
dry
beans
at
0.05
ppm.
Current
formulations
of
flumetsulam
include
emulsifiable
concentrate
(
EC),
wettable
powder
(
WP),
and
water
dispersible
granules
(
WDG).
Flumetsulam
as
an
active
ingredient
(
ai)
ranges
in
formulations
from
2.1
to
80%.
Flumetsulam
can
be
applied
to
corn
and
soybeans
at
the
pre­
plant
(
surface
or
incorporated),
preemergence,
or
postemergence
stage
using
ground
equipment
with
up
to
0.070
lb
ai/
A
applied
per
year.
Flumetsulam
can
also
be
applied
to
corn
as
a
foliar
application
via
aircraft
up
to
0.03478
lb
ai/
A.
For
the
proposed
use
on
dry
beans,
flumetsulam
can
only
be
applied
at
the
pre­
plant
(
surface
or
incorporated)
or
at
the
preemergence
stage.
The
pre­
harvest
intervals
(
PHI)
for
flumetsulam
range
from
70
to
85
days.

The
nature
of
residues
in
corn
and
soybeans
is
adequately
delineated
based
on
acceptable
plant
metabolism
studies.
The
Health
Effects
Division
(
HED)
Metabolism
Committee
concluded
that
the
residue
of
concern
resulting
from
the
uses
on
field
corn
and
soybeans
is
flumetsulam
per
se.
Plant
metabolism
studies
for
dry
beans
have
not
been
submitted;
however,
metabolism
data
from
soybeans
may
be
translated
to
dry
beans
because
of
the
similarities
between
the
two
crops.
The
HED
Metabolism
Committee
has
not
determined
the
residue
of
concern
in
livestock;
however,
based
on
the
submitted
data,
the
nature
of
the
residue
in
livestock
(
goats
and
hens)
is
adequately
defined
because
no
detectable
residues
of
flumetsulam
per
se
were
found
in
feed
items.
The
available
analytical
methodology
(
GC/
MS)
is
considered
adequate
for
tolerance
enforcement
of
flumetsulam
in/
on
plant
commodities.
The
method
is
available
and
has
been
submitted
for
inclusion
in
the
Pesticide
Analytical
Manual
(
PAM),
Volume
II;
however,
the
methods
have
not
yet
been
included.
The
limit
of
quantitation
(
LOQ)
of
the
method
is
0.010
ppm
and
the
estimated
limit
of
detection
(
LOD)
is
0.005
ppm.

Tolerances
have
been
established
under
40
CFR
§
180.468
for
residues
of
flumetsulam
in/
on
field
corn
(
forage,
grain,
and
stover)
and
soybean
at
0.05
ppm.
A
tolerance
of
0.05
ppm
for
dry
beans
has
been
proposed.
Field
trials
conducted
on
field
corn,
soybeans,
and
dry
beans
show
that
residues
of
flumetsulam
are
consistently
below
the
LOD
in
all
crops
which
received
flumetsulam
at
approximately
the
maximum
label
rate
through
preplant
soil
incorporated,
preemergence,
or
postemergence
applications.
The
corn
field
trials
were
conducted
using
a
75%
WDG
formulation
of
flumetsulam,
the
soybean
field
trials
were
conducted
using
a
75%
WDG
formulation
or
an
aqueous
concentrate
formulation
of
flumetsulam,
and
the
dry
bean
field
trials
were
conducted
using
an
80.8%
WDG
formulation
of
flumetsulam.
Corn
from
field
trials
conducted
at
approximately
3x
the
maximum
application
rate
were
processed
into
grits,
meal,
flour,
refined
oil,
crude
oil,
and
starch
using
either
wet
or
dry
milling
practices.
Even
though
the
application
rate
for
the
processing
study
should
have
been
5x
or
higher,
provided
that
phytotoxicity
was
not
a
concern,
the
absence
of
detectable
residues
in
all
the
processed
fractions
and
the
properties
of
flumetsulam
(
low
octanol/
water
partition
coefficient
[
log
P
=
0.21]
and
greater
solubility
in
water
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
3
of
32
N
S
F
F
N
N
N
N
CH
3
O
O
H
than
in
hexane)
indicate
that
the
concentration
of
residues
in
oil
is
highly
unlikely.
A
processing
study
and
food
additive
tolerances
are
not
required
for
soybeans
because
no
detectable
residues
were
found
in
soybeans
resulting
from
postemergence
treatment
at
6x
the
maximum
application
rate,
which
is
the
theoretical
concentration
factor
for
soybean
oil.
A
processing
study
for
dry
beans
is
not
required
because
dry
beans
are
not
processed
into
food/
feed
items.

Regulatory
Recommendations
and
Residue
Chemistry
Deficiencies
Tolerances
have
been
established
under
40
CFR
§
180.468
for
residues
of
flumetsulam
per
se
(
N­
(
2,6­
difluorophenyl)­
5­
methyl­(
1,2,4)­
triazolo­[
1,5a]­
pyrimidine­
2­
sulfonamide)
in/
on
field
corn
(
forage,
grain,
and
stover)
and
soybean
at
0.05
ppm.
HED
supports
these
tolerances,
and
the
proposed
tolerance
of
0.05
ppm
in/
on
dry
beans.

Background
The
nomenclature
of
flumetsulam
is
listed
below
in
Table
1
and
the
physicochemical
properties
are
listed
in
Table
2.

Table
1.
Test
Compound
Nomenclature.

Chemical
Structure
Common
name
Flumetsulam
Company
experimental
name
DE­
498
and
TSN­
100986
Molecular
formula
C
12
H
9
F
2
N
5
O
2
S
Molecular
weight
325.30
IUPAC
name
2­(
2,6­
difluorophenylsulphamoyl)­
5­
methyl(
1,2,4)­
Triazolo(
1,5­
a)
pyrimidine
CAS
name
N­(
2,6­
difluorophenyl)­
5­
methyl­(
1,2,4)
triazolo(
1,5­
a)
pyrimidine­
2­
sulfonamide
CAS
number
98967­
40­
9
Current
food/
feed
site
registrations
Corn
and
soybean
(
a
petition
for
dry
beans
has
been
submitted)

Table
2.
Physicochemical
Properties
of
the
Technical
Grade
Test
Compound.

Parameter
Value
Reference
Melting
point
252.9

C
N.
Dodd,
PP#
1G4006,
3/
27/
92
pH
3.44
at
24.4

C
for
a
10%
suspension
in
water
Density
1.77
g/
cm3
at
21

C
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Table
2.
Physicochemical
Properties
of
the
Technical
Grade
Test
Compound.

Parameter
Value
Reference
4
of
32
Water
solubility
49.1
±
0.5
mg/
L
at
25

C,
pH
2.5
5.65
±
0.01
g/
L
at
25

C,
pH
7.0
Solvent
solubility
17.0
g/
L
in
acetone
5.2
g/
L
in
acetonitrile
0.0016
g/
L
in
aromatic
100
9.0
g/
L
in
cyclohexanone
261.0
g/
L
in
dimethylformamide
Less
than
0.001
g/
L
in
hexane
3.3
g/
L
in
methanol
Less
than
0.001
g/
L
in
o­
xylene
0.06
g/
L
in
octanol
11.0
g/
L
in
tetrahydrofuran
N.
Dodd,
PP#
2F4036,
4/
14/
93
Vapor
pressure
1.0
x
10­
15
mm
Hg
at
25

C
N.
Dodd,
PP#
1G4006,
3/
27/
92
Dissociation
constant
pK
a
=
4.6
Octanol/
water
partition
coefficient
Log(
K
OW)
log
P
=
0.21
860.1200
Directions
for
Use
Product
List
Currently,
there
are
two
registered
manufacturing­
use
products
(
MPs)
and
thirteen
end­
use
products
(
EPs)
registered
for
use
on
food/
feed
sites.
The
MPs
are
registered
to
Dow
and
contain
98%
(
EPA
Reg.
No.
62719­
223)
and
23.1%
flumetsulam
(
EPA
Reg.
No.
62719­
300).
Eleven
EPs
are
registered
to
Dow
and
two
EPs
are
registered
to
E.
I.
du
Pont
De
Nemours
and
Company,
Inc.
(
DuPont).
The
EPs
are
listed
in
Table
3
below.
Table
3
also
lists
if
the
product
is
intended
for
use
on
field
corn,
soybeans,
and/
or
dry
beans.
There
are
no
special
local
need
(
SLN)
registrations
associated
with
flumetsulam.

Table
3.
Flumetsulam
End­
Use
Products
(
EPs)
with
Food/
Feed
Uses.

EPA
Reg.
No.
Formulation
1
Label
Acceptance
Date
Registrant
Product
Name
Commodity
352­
593
19.1%
WDG
9/
11/
03
E.
I.
du
Pont
De
Nemours
and
Co.,
Inc.
Accent
Gold
®
Herbicide
Field
corn
352­
612
15.9%
WDG
3/
5/
03
E.
I.
du
Pont
De
Nemours
and
Co.,
Inc.
Dupont
Accent
Gold
®
WDG
Herbicide
Field
corn
62719­
222
2.67%
EC
2/
16/
99
Dow
AgroSciences,
LLC
Broadstrike
®
+
Treflan
®
Soybean,
dry
bean
62719­
224
74.9%
WDG
10/
20/
93
Dow
AgroSciences,
LLC
Broadstrike
®
Field
corn,
soybean
62719­
239
2.1%
EC
2/
23/
98
Dow
AgroSciences,
LLC
Broadstrike
®
+
Dual
®
Field
corn,
soybean,
dry
bean
62719­
240
2.6%
EC
3/
19/
98
Dow
AgroSciences,
LLC
Broadstrike
®
SF
+
Dual
®
Field
corn,
soybean
62719­
253
23.1%
WP
6/
14/
01
Dow
AgroSciences,
LLC
Hornet
®
Field
corn
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Table
3.
Flumetsulam
End­
Use
Products
(
EPs)
with
Food/
Feed
Uses.

EPA
Reg.
No.
Formulation
1
Label
Acceptance
Date
Registrant
Product
Name
Commodity
5
of
32
62719­
264
9.3%
WP
10/
26/
00
Dow
AgroSciences,
LLC
Scorpion
III
®
Field
corn
62719­
277
80%
WDG
9/
24/
03
Dow
AgroSciences,
LLC
Python
®
WDG
Soybean,
dry
bean
62719­
278
13.9%
WP
3/
26/
96
Dow
AgroSciences,
LLC
NAF­
280
®
Field
corn
62719­
279
12.1%
WP
3/
26/
96
Dow
AgroSciences,
LLC
NAF­
281
®
Field
corn
62719­
299
40%
WDG
7/
2/
02
Dow
AgroSciences,
LLC
Frontrow
®
Soybean
62719­
315
18.5%
WDG
2/
20/
03
Dow
AgroSciences,
LLC
Hornet
®
WDG
Field
corn
1.
WDG
=
water­
dispersible
granules;
EC
=
emulsifiable
concentrate;
WP
=
wettable
powder.

Use
Patterns
For
the
purposes
of
reregistration,
the
registered
food/
feed
uses
of
flumetsulam
have
been
reevaluated
for
field
corn
and
soybeans.
Additionally,
food/
feed
uses
of
flumetsulam
are
being
evaluated
for
use
on
dry
beans.
A
comprehensive
summary
of
use
patterns
was
originally
prepared
by
the
Biological
and
Economic
Analysis
Division
(
BEAD)
and
is
presented
in
Appendix
A.
Currently,
there
are
no
registered
non­
food/
feed
use
patterns.
A
tabular
summary
of
the
chemistry
science
assessments
is
presented
in
Table
4.
The
conclusions
listed
in
Table
4
regarding
the
reregistration
eligibility
of
flumetsulam
food/
feed
uses
are
based
on
the
use
patterns
registered
by
the
producer.
When
end­
use
product
data
call
in's
(
DCIs)
are
developed
(
e.
g.,
at
issuance
of
the
RED),
the
Registration
Division
(
RD)
should
require
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
SLNs,
and
products
subject
to
the
generic
data
exemption)
be
amended
such
that
they
are
consistent
with
the
basic
producer
labels.

Table
4.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Flumetsulam.

OPPTS
Guideline
Number
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.468]
Additional
Data
Needed?
MRID
Nos.

860.1200
Directions
for
Use
N/
A
=
Not
applicable
No
See
Appendix
A
860.1300
Nature
of
the
Residue
­
Plants
­
Field
Corn
N/
A
No
419317141,
419317151,
425738012,
425738022,
424890012,3,
424070014
­
Soybean
N/
A
No
419317121,
419317131,
425135012,
425135022,
424890012,3,
424070014
­
Dry
Bean
N/
A
No11
None
860.1300
Nature
of
the
Residue
­
Animals
­
Goat
N/
A
No
419317161
­
Hen
N/
A
No
419317171
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Table
4.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Flumetsulam.

OPPTS
Guideline
Number
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.468]
Additional
Data
Needed?
MRID
Nos.

6
of
32
860.1340
Residue
Analytical
Method
­
Plant
Commodities
N/
A
No12
425806072,
419521041,
419521051
­
Animal
Commodities
N/
A
No
None
860.1360
Multiresidue
Method
N/
A
No
419938021
860.1380
Storage
Stability
Data
­
Plant
Commodities
N/
A
No
426778015,
419317181,
425806082
­
Animal
Commodities
N/
A
No
None
860.1400
Magnitude
of
the
Residue
­
Water,
Fish,
and
Irrigated
Crops
None
established
No
None
860.1460
Magnitude
of
the
Residue
­
Food
Handling
None
established
No
None
860.1480
Magnitude
of
the
Residue
­
Meat,
Milk,
Poultry,
and
Eggs
None
established
No
None
860.1500
Crop
Field
Trials
­
Soybean
0.05
No
419521061,
419317191,
419317201
­
Field
Corn
0.05
No
426778035,
419317211
­
Dry
Bean
None
established14
No
443044026
860.1520
Processed
Food/
Feed
­
Field
Corn
None
established
No
426778025
860.1850
Confined
Accumulation
in
Rotational
Crops
N/
A
No
412632327,
419317388,
419317399,
4251250110
860.1900
Field
Accumulation
in
Rotational
Crops
None
established
No
None
1.
N.
Dodd,
PP#
1G4006,
3/
27/
92.
2.
N.
Dodd,
PP#
2F4036,
4/
14/
93.
3.
N.
Dodd,
D183546,
12/
23/
92.
4.
N.
Dodd,
D178112,
8/
20/
92.
5.
N.
Dodd,
D188957,
6/
28/
93.
6.
S.
Ary,
D301807,
8/
18/
04.
7.
G.
Maske,
DER
(
data
evaluation
record),
MRID
No.:
41263232,
1/
21/
90.
8.
G.
Maske,
DER,
MRID
No.:
41931738,
3/
12/
93.
9.
G.
Maske,
DER,
MRID
No.:
41931739,
ca.
1993.
10.
MRID
No.:
42512501
is
a
summary
of
MRID
Nos.:
41263232,
41931738,
and
41931739.
11.
A
plant
metabolism
study
has
not
been
submitted
for
dry
beans;
however,
metabolism
data
from
soybeans
may
be
translated
to
dry
beans
because
of
the
similarities
between
the
two
crops.
12.
The
submitted
GC/
MS
method
is
adequate
for
tolerance
enforcement
purposes
on
plant
commodities.
14.
The
registrant
has
petitioned
for
the
establishment
of
a
tolerance
of
flumetsulam
at
0.05
ppm
in/
on
dry
beans.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
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7
of
32
860.1300
Nature
of
the
Residue
­
Plants
The
nature
of
the
residue
in
corn
and
soybean
is
adequately
understood.
The
major
residues
in
corn
are
parent,
the
free
and
conjugated
5­
CH
2
OH
metabolite
(
N­(
2,6­
difluorophenyl)­
5­
hydroxymethyl­
1,2,4­
triazolo(
1,5a)
pyrimidine­
2­
sulfonamide),
and
the
free
and
conjugated
4­
OH
metabolite
(
N­(
2,6­
difluoro­
4­
hydroxyphenyl)­
5­
methyl­
1,2,4­
triazolo(
1,5a)
pyrimidine­
2­
sulfonamide).
The
major
residues
in
soybean
forage
are
parent
and
the
metabolite
hydroxybutyl­
DFATSA
(
N­(
2,6­
difluorophenyl)­
5­((
3­
hydroxy­
1­
methylpropyl)
amino)­
1,2,4­
triazole­
3­
sulfonamide)
and
its
conjugates.
The
major
residues
in
soybean
seed
are
parent
and
DFATSA
(
N­
(
2,6­
difluorophenyl)­
5­
amino­
1H­
1,2,4­
triazole­
3­
sulfonamide).
The
stability
of
the
sulfonamide
bond
was
demonstrated
in
both
field
corn
and
soybean.
Additionally,
the
absence
of
2,6­
difluoroaniline
(
2,6­
DFA)
as
a
metabolite
was
demonstrated
in
soybean.
In
field
corn,
if
any
2,6­
DFA
did
occur,
it
would
be
expected
to
be
found
in
an
organic
faction,
which
contained
low
percentages
of
the
residue
(
less
than
or
equal
to
3.6%
total
radioactive
residues;
N.
Dodd,
PP#
2F4036,
4/
14/
93).

On
April
21,
1993,
the
HED
Metabolism
Committee
concluded
that
the
residue
of
concern
resulting
from
the
uses
of
flumetsulam
on
field
corn
and
soybean
is
parent
per
se.
This
decision
was
based
on
the
low
levels
of
total
radioactive
residues
present
in
plant
metabolism
studies
and
the
lack
of
toxicological
concern
for
metabolites
which
have
the
sulfonamide
linkage
intact
(
N.
Dodd,
HED
Metabolism
Committee
Memo,
4/
26/
93).

Plant
metabolism
studies
for
dry
beans
have
not
been
submitted;
however,
metabolism
data
from
soybeans
may
be
translated
to
dry
beans
because
of
the
similarities
between
the
two
crops.

860.1300
Nature
of
the
Residue
­
Livestock
Nature
of
residue
studies
for
ruminant
(
goat)
and
poultry
(
hens)
have
been
submitted
and
reviewed
(
N.
Dodd,
PP#
1G4006,
3/
27/
92).
In
the
ruminant
study,
goats
were
fed
5­
14Cpyridine
labeled
flumetsulam
in
capsules
at
a
dose
of
21
mg/
day
(
10
ppm
in
feed)
for
5
consecutive
days.
Ninety­
two
percent
of
the
radioactive
residues
in
milk
and
88%
of
the
radioactive
residues
in
kidney
were
identified
as
parent.
Residues
in
muscle,
fat,
and
liver
were
not
characterized;
however,
14C­
residues
in
these
tissues
were
low
(
less
than
or
equal
to
0.1
ppm)
after
dosing
at
an
exaggerated
feeding
level.
In
the
poultry
study,
hens
were
fed
5­
14C­
pyridinelabeled
flumetsulam
in
capsules
at
a
dose
of
2.1
mg/
day
(
15
ppm
in
feed)
for
10
consecutive
days.
Seventy
percent
of
the
radioactive
residues
in
kidney
were
identified
as
parent
and
24%
were
identified
as
5­
hydroxymethyl
metabolite.
Residues
in
muscle,
fat,
liver,
and
eggs
were
not
characterized;
however,
14C­
residues
in
the
muscle,
fat,
liver,
and
eggs
were
low
(
less
than
or
equal
to
0.1
ppm)
after
dosing
at
an
exaggerated
feeding
level
(
N.
Dodd,
PP#
1G4006,
3/
27/
92).

The
nature
of
the
residue
in
animals
is
adequately
defined
for
the
current
and
proposed
uses
because
no
detectable
or
very
low
concentrations
of
residues
of
flumetsulam
per
se
were
found
in
feed
items.
However,
for
uses
which
may
result
in
detectable
residues
in
feed
items,
additional
animal
metabolism
data
on
ruminants
and
poultry
may
be
required.
Flumetsulam
Summary
of
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and
Residue
Data
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8
of
32
860.1340
Residue
Analytical
Methods
DowElanco's
methods
ACR
91.6
(
GC/
MS)
on
soybean
and
ACR
91.61S
(
GC/
MS)
on
corn
grain
and
fodder
were
submitted
by
the
petitioner
for
purposes
of
data
collection
and
enforcement
of
tolerances.
In
these
methods,
flumetsulam
is
extracted
from
the
crop
material
with
a
90%
acetone/
10%
0.1
N
HCl
solution.
The
acetone
is
evaporated
from
an
aliquot
of
the
extract
and
the
residue
is
diluted
with
0.005
N
HCl
and
washed
with
hexane.
The
sample
is
cleaned
up
on
C
18
and
alumina
SPE
cartridges
and
derivatized
with
methyl
iodide.
The
resulting
N­
methyl
derivative
is
dissolved
in
N­
d
3­
methyl
flumetsulam
internal
standard
solution
and
quantitated
by
gas
chromatography.
Average
recoveries
of
soybeans
fortified
between
5
and
50
ppb
ranged
from
88
to
99%.
An
independent
laboratory
evaluation
for
Method
ACR
91.6
on
soybeans
was
conducted
by
A&
L
Great
Lakes
Laboratories,
Inc.
Average
recoveries
of
flumetsulam
from
soybean
samples
fortified
at
5
and
25
ppb
by
the
independent
laboratory
were
90
and
121%,
respectively
(
N.
Dodd,
PP#
1G4006,
3/
27/
92).
An
independent
laboratory
validation
for
Method
ACR
91.61S
on
corn
was
not
conducted;
however,
it
is
not
needed
because
only
minor
modifications
were
made
from
Method
ACR
91.6
on
soybeans
for
use
on
corn
(
N.
Dodd,
D183546,
12/
23/
92).
Additionally,
a
confirmatory
method
is
not
needed
because
the
methods
combine
gas
chromatography
with
mass
spectroscopy.
The
stated
LOQ
of
the
method
was
0.005
ppm
and
the
estimated
LOD
was
0.0025
ppm,
however,
BEAD's
Analytical
Chemistry
Branch
(
ACB)
estimated
the
LOQ
at
0.01
ppm
and
the
LOD
at
0.005
ppm
in/
on
soybean
and
corn
grain
and
fodder
(
N.
Dodd,
D189444,
3/
29/
93).

ACB
validated
DowElanco's
Method
ACR
91.6
(
Method
I)
on
soybean
grain
and
DowElanco's
Method
ACR
91.61S
(
Method
II)
on
corn
grain
and
corn
fodder
at
0.05
ppm
(
N.
Dodd,
D189444,
3/
29/
93).
The
methods
were
approved
by
EPA
for
enforcement
of
tolerances
and
the
results
were
forwarded
to
Food
and
Drug
Administration
(
FDA)
on
December
6,
1992
for
inclusion
in
the
Pesticide
Analytical
Manual
(
PAM),
Volume
II
(
memo
from
N.
Dodd).
FDA
has
received
a
submission
for
flumetsulam;
however,
the
method
has
not
yet
been
compiled
in
PAM
Volume
II.

860.1360
Multiresidue
Methods
The
registrant
has
submitted
data
for
Protocol
B
(
Section
402,
Hopper
method
for
acids
and
phenols)
and
Protocol
C
(
Section
302
DG,
GLC
Data
only)
on
soybeans
and
wheat
grain
and
the
results
were
forwarded
by
EPA
to
the
Food
and
Drug
Administration
(
FDA)
to
determine
sufficiency
(
N.
Dodd,
PP#
1G4006,
3/
27/
92;
N.
Dodd,
PP#
1G4006,
11/
24/
92).
The
FDA
PESTDATA
database
dated
11/
01
(
PAM
Volume
I,
Appendix
I)
indicates
that
flumetsulam
was
not
recovered
using
Protocol
B
and
extraction
methods
E1
(
extraction
with
solvents
from
acidified
denatured
products)
and
E2
(
extraction
with
acidified
methylene
chloride).
According
to
the
PESTDATA
database,
the
retention
time
of
methylated
flumetsulam
using
an
OV­
101
GLC
column
is
12.4
(
relative
to
chlorpyrifos).

Testing
through
Protocol
A
is
not
required
because
flumetsulam
does
not
contain
the
Nmethylcarbamate
structure
(
N.
Dodd,
PP#
1G4006,
3/
27/
92)
and
testing
through
Protocol
G
is
not
required
because
flumetsulam
is
not
a
substituted
urea.
Protocols
D,
E,
and
F
are
not
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
9
of
32
appropriate
because
the
protocols
do
not
include
a
methylation
step,
which
is
necessary
for
flumetsulam
to
be
chromatographed
(
N.
Dodd,
D178112,
8/
20/
93).

860.1380
Storage
Stability
Storage
stability
studies
have
been
conducted
using
fortified
samples
of
field
corn
and
soybean.
The
results
indicate
that
residues
of
flumetsulam
are
stable
in
corn
grain,
forage,
and
fodder
stored
for
at
least
555
days
at
­
15

C.
Based
on
the
corrected
average
residues
at
0
and
555
days,
flumetsulam
losses
were
4%
for
grain,
5%
for
forage,
and
13%
for
fodder
(
N.
Dodd,
PP#
3F4185,
6/
28/
93).
In
soybeans,
residues
of
flumetsulam
are
stable
for
up
to
thirty
months
(
908
days)
at
­
15

C.
At
thirty
months,
flumetsulam
recoveries
corrected
for
percent
recovery
from
method
spikes
ranged
from
93
to
99%
(
average
97%;
N.
Dodd,
PP#
2F4036,
4/
14/
93).

A
storage
stability
study
for
dry
beans
was
not
conducted;
however,
the
storage
intervals
and
conditions
from
the
dry
bean
magnitude
of
residue
study
(­
20

C
for
a
maximum
of
ninety­
seven
days)
are
adequately
supported
by
the
storage
stability
data
from
the
studies
conducted
with
soybeans
and
corn.
Therefore,
the
submitted
information
from
the
corn
and
soybean
storage
stability
studies
is
adequate
to
support
the
residue
data
on
dry
beans.

860.1400
Water,
Fish,
and
Irrigated
Crops
Flumetsulam
is
not
presently
registered
for
direct
use
on
water
and
aquatic
food
and
feed
crops;
therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

860.1460
Food
Handling
Flumetsulam
is
not
presently
registered
for
use
in
food­
handling
establishments;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

860.1480
Meat,
Milk,
Poultry,
and
Eggs
The
dietary
burdens
of
beef
cattle,
dairy
cattle,
and
poultry
are
presented
in
Table
5.
Using
a
diet
containing
field
corn
forage,
field
corn
grain,
and
field
corn
milled
byproducts,
the
maximum
theoretical
dietary
burden
for
beef
cattle
is
0.07
ppm,
0.09
ppm
for
dairy
cattle,
and
0.05
ppm
for
poultry.

Table
5.
Calculation
of
Theoretical
Dietary
Burdens
of
Flumetsulam
to
Livestock.

Feedstuff
%
Dry
Matter1
Residue
(
ppm)
2
Beef
Cattle
Dairy
Cattle
Poultry
%
in
Diet
Dietary
Burden
(
ppm)
3
%
in
Diet
Dietary
Burden
(
ppm)
2
%
in
Diet
Dietary
Burden
(
ppm)
2
Corn,
field,
forage
40
0.05
30
0.04
50
0.06
0
0
Corn,
field,
grain
88
0.05
60
0.03
40
0.02
80
0.04
Flumetsulam
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Table
5.
Calculation
of
Theoretical
Dietary
Burdens
of
Flumetsulam
to
Livestock.

Feedstuff
%
Dry
Matter1
Residue
(
ppm)
2
Beef
Cattle
Dairy
Cattle
Poultry
%
in
Diet
Dietary
Burden
(
ppm)
3
%
in
Diet
Dietary
Burden
(
ppm)
2
%
in
Diet
Dietary
Burden
(
ppm)
2
10
of
32
Corn,
field,
milled
byproducts
85
0.05
10
0.01
10
0.01
20
0.01
Total
100
0.07
100
0.09
100
0.05
1.
OPPTS
Guideline
860.1000,
Table
1.
2.
Established
tolerance
levels
of
0.05
ppm
on
field
corn
were
used.
3.
Dietary
Burden
=
%
in
diet
x
(
residue
/
percent
dry
matter).

MRID
Number:
41931716
(
N.
Dodd,
PP#
1G4006,
3/
27/
92):
Nature
of
residue
studies
for
ruminant
(
goat)
and
poultry
(
hens)
have
been
submitted
and
reviewed.
In
the
ruminant
study,
goats
were
fed
5­
14C­
pyridine­
labeled
flumetsulam
in
capsules
at
a
dose
of
21
mg/
day
(
10
ppm
in
feed,
ca.
200x
dosing
level)
for
5
consecutive
days.
Ninety­
two
percent
of
the
radioactive
residues
in
milk
and
eighty­
eight
percent
of
the
radioactive
residues
in
kidney
were
identified
as
parent.
Residues
in
muscle,
fat,
and
liver
were
not
characterized;
however,
14C­
residues
in
these
tissues
were
low
(
less
than
or
equal
to
0.10
ppm)
after
dosing
at
the
exaggerated
feeding
level
(
10
ppm,
ca.
200x).
The
maximum
residues
of
flumetsulam
observed
in
any
matrix
in
the
goat
metabolism
study
were
less
than
or
equal
to
0.10
ppm
after
dosing
at
an
exaggerated
feeding
level
(
10
ppm,
ca.
200x
dosing
level).
Based
on
a
200x
dosing
level
for
goats,
the
expected
residues
of
flumetsulam
at
a
10x
level
are
0.005
ppm,
which
is
equal
to
the
plant
method
LOD
of
0.005
ppm.

In
the
poultry
study,
hens
were
fed
5­
14C­
pyridine­
labeled
flumetsulam
in
capsules
at
a
dose
of
2.1
mg/
day
(
15
ppm
in
feed,
ca.
300x
dosing
level)
for
10
consecutive
days.
Seventy
percent
of
the
radioactive
residues
in
kidney
were
identified
as
parent
and
twenty­
four
percent
were
identified
as
5­
hydroxymethyl
metabolite.
Residues
in
muscle,
fat,
liver,
and
eggs
were
not
characterized;
however,
14C­
residues
in
the
muscle,
fat,
liver,
and
eggs
were
low
(
less
than
or
equal
to
0.10
ppm)
after
dosing
at
the
exaggerated
feeding
level
(
15
ppm,
ca.
300x).
The
maximum
residues
of
flumetsulam
observed
in
any
matrix
in
the
poultry
metabolism
study
were
less
than
or
equal
to
0.10
ppm
after
dosing
at
an
exaggerated
feeding
level
(
15
ppm,
ca.
300x
the
dosing
level).
Based
on
a
300x
dosing
level
for
poultry,
the
expected
residues
of
flumetsulam
at
a
10x
level
are
0.0033
ppm,
which
is
less
than
the
plant
method
LOD
of
0.005
ppm.

Flumetsulam
is
not
presently
registered
for
use
as
a
direct
livestock
treatment
and
residues
of
flumetsulam
were
not
detected
in
the
feed
items.
The
nature
of
the
residue
in
animals
is
adequately
defined
for
the
current
and
proposed
uses.
HED
concludes
that
the
registered
uses
on
corn
and
soybeans
and
the
proposed
use
on
dry
beans
results
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
and
poultry
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
ruminant
and
poultry
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
and
poultry
are
not
required.
However,
for
uses
which
may
result
in
detectable
residues
in
feed
items,
additional
animal
metabolism
data
on
ruminants
and
poultry
may
be
required.
Such
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
11
of
32
data
may,
in
turn,
trigger
the
need
for
magnitude
of
the
residue
(
feeding)
studies
in
livestock.

860.1500
Crop
Field
Trials
Crop
field
trials
were
conducted
on
field
corn,
soybean,
and
dry
beans.
Detailed
summaries
of
these
studies
are
presented
below.
Briefly,
flumetsulam
residues
were
not
detected
at
a
concentration
above
the
stated
method
(
ACR
91.6)
LOQ
of
0.005
ppm
in/
on
corn
(
forage,
grain,
and
fodder)
and
soybeans.
However,
ACB
estimated
the
LOQ
of
analytical
method
ACR
91.6
at
0.01
ppm
and
the
LOD
at
0.005
ppm
in/
on
soybean
and
corn
grain
and
fodder
(
N.
Dodd,
D189444,
3/
29/
93).
Flumetsulam
residues
were
not
detected
above
the
method
(
GRM
96.21)
LOQ
of
0.017
ppm
in/
on
dry
beans.
Corn,
soybean,
and
dry
bean
samples
were
collected
from
plots
which
received
applications
of
flumetsulam
at
approximately
the
maximum
label
rate
(
Table
6).
The
applications
were
made
using
a
75%
WDG
formulation
(
corn
and
soybeans),
80.8%
WDG
formulation
(
dry
beans),
or
an
aqueous
soluble
concentrate
formulation
(
soybeans).
The
corn
and
soybean
crop
field
trials
were
conducted
using
two
separate
plots
which
each
received
either
a
single
preplant
incorporated
application
or
postemergence
application
of
the
test
substance.
A
limited
number
of
field
trials
with
corn
were
also
conducted
using
a
single
preemergence
application
of
the
test
substance.
The
dry
bean
crop
field
trials
were
conducted
using
only
plots
which
received
a
single
preplant
incorporated
application.
These
use
patterns
reflect
the
current
and
proposed
use
patterns
of
flumetsulm,
except
that
no
preplant
studies
without
soil
incorporation
were
conducted
on
all
crops
and
no
preemergence
studies
were
conducted
on
soybeans
and
dry
beans.

As
discussed
in
the
storage
stability
section,
EPA
has
accepted
the
storage
stability
data
submitted
for
corn
and
soybeans
to
support
the
residue
data
from
the
crop
field
trials
conducted
on
corn,
soybeans,
and
dry
beans.
Additionally,
the
analytical
methods
(
ACR
91.6
and
ACR
91.6S)
used
in
the
soybean
and
corn
crop
field
trial
studies
are
adequate
for
the
analysis
of
flumetsulam.
These
methods
have
been
validated
by
EPA
at
0.05
ppm
and
approved
for
use
as
enforcement
methods.
The
analytical
method
used
for
the
analysis
of
flumetsulam
in/
on
dry
beans
was
GRM
96.21.
The
stated
LOQ
of
GRM
96.21
was
0.017
ppm
and
the
stated
LOD
was
0.005
ppm
(
S.
Ary,
D301807,
8/
30/
04).
This
method
has
not
been
reviewed
by
EPA;
however,
based
on
concurrent
recoveries,
the
method
appears
acceptable
for
data
collection.
Flumetsulam
per
se
was
determined
to
be
the
residue
of
concern
in
field
corn
and
soybeans
by
HED
Metabolism
Committee.
Tolerance
levels
of
0.05
ppm
are
supported
by
the
available
residue
data.

Field
Corn
MRID
Number:
41931721
(
N.
Dodd,
PP#
1G4006,
3/
27/
92):
Studies
were
conducted
on
field
corn
at
sixteen
locations
in
thirteen
states:
GA
(
one),
IL
(
two),
IN
(
one),
IA
(
two),
KY
(
one),
MI
(
one),
MN
(
two),
MO
(
one),
NE
(
one),
NC
(
one),
OH
(
one),
WI
(
one),
and
MS
(
one).
At
each
location,
one
preplant
incorporated
soil
application
was
made
on
a
plot,
and
one
postemergence
application
was
made
on
a
different
plot.
A
75%
WDG
formulation
(
EPA
Reg.
No.:
62719­
224,
XRM­
5019)
was
applied
at
the
rate
0.06
lb
ai/
A.
At
three
locations
(
IL,
IA,
and
MS)
on
additional
plots,
a
rate
of
0.18
lb
ai/
A
was
applied
postemergent.
Applications
were
made
with
ground
equipment.
Most
applications
were
made
in
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
12
of
32
approximately
twenty
gallons
of
spray
per
acre.
All
postemergence
sprays
included
0.25%
(
v/
v)
Ortho
X­
77,
a
non­
ionic
surfactant.
Forage,
grain,
and
fodder
were
sampled
at
harvest
and
frozen
in
polyethylene
bags.
Grain
was
not
ground
before
storage.
Forage
and
fodder
were
cut
but
not
ground.
Samples
were
analyzed
within
eleven
months.
The
analytical
method
used
was
ACR
91.6
(
GC/
MS),
with
minor
modifications.
The
LOQ
of
the
method
was
0.005
ppm
and
the
estimated
LOD
was
0.0025
ppm.
All
control
values
for
forage,
fodder,
and
grain
were
less
than
the
method
LOD
of
0.002.
Average
recoveries
from
control
samples
of
field
corn
fortified
with
0.005
to
0.05
ppm
were
92%
for
forage,
97%
for
grain,
and
91%
for
fodder.
No
detectable
residues
(
less
than
0.002
ppm)
were
found
in
field
corn
grain,
forage,
and
fodder.

MRID
Number:
42677803
(
N.
Dodd,
D188957,
6/
28/
93):
Four
residue
studies
on
field
corn
were
conducted
in
the
states
of
CA,
WA,
TX,
and
MD
(
one
study
in
each
state).
A
75%
WDG
formulation
(
EPA
Reg.
No.:
62719­
224,
XRM­
5019)
was
mixed
with
water
and
applied
preemergence
as
a
broadcast
spray
or
postemergence
to
12­
inch
corn.
Postemergence
applications
included
the
additive
Ortho
X­
77.
Only
one
application
was
made
to
each
plot.
The
preemergence
application
rates
were
0.07,
0.11,
and
0.20
lb
ai/
A.
The
postemergence
application
rates
were
0.06,
0.09,
and
0.18
lb
ai/
A.
For
both
the
preemergence
and
postemergence
applications,
the
application
rates
were
1x,
1.5x,
and
3x
the
maximum
use
rate
of
0.07
lb
ai/
A.
The
samples
were
frozen
after
analysis,
shipped
frozen,
and
stored
at
­
20

C
until
analysis.
The
samples
were
analyzed
within
six
months
of
sampling.
The
samples
were
analyzed
by
method
ACR
91.6.
S1
(
GC/
MSD),
with
slight
modifications
to
allow
use
of
a
laboratory
robot.
The
method
was
validated
by
EPA
at
0.05
ppm,
the
current
tolerance
level.
The
petitioner
indicated
that
the
LOQ
of
the
analytical
method
was
0.007
ppm
and
the
LOD
was
0.0025
ppm.
Recoveries
were
71
to
104%
for
forage,
76
to
94%
for
grain,
and
71
to
90%
for
fodder.
All
forage,
grain,
and
fodder
controls
were
less
than
0.05
ppm.
All
residues
on
forage,
grain,
and
fodder
were
less
than
0.05
ppm
except
for
the
residue
data
on
forage
in
CA,
reflecting
postharvest
application
at
a
3x
rate.
The
petitioner
indicated
that
the
higher
residues
in
CA
may
be
due
to
furrow
irrigation
only.
The
corn
received
little
or
no
overhead
irrigation
after
application
of
the
herbicide
and
minimal
rainfall
during
the
1992
growing
season.

Soybean
MRID
Number
41952106
(
N.
Dodd,
PP#
1G4006,
3/
27/
92):
Residue
studies
on
soybeans
were
conducted
in
1988.
Studies
were
conducted
at
eighteen
locations
in
thirteen
states:
AR
(
two),
GA
(
one),
IL
(
two),
IN
(
two),
IA
(
two),
LA
(
one),
MI
(
one),
MN
(
two),
MS
(
one),
MO
(
one),
NE
(
one),
NC
(
one),
and
OH
(
one).
The
flumetsulam
formulation
used
was
an
aqueous
suspension
concentrate
containing
1
lb
ai/
gallon.
At
each
location,
one
preplant
incorporated
application
was
made
on
a
plot,
and
one
postemergence
application
was
made
on
a
different
plot.
The
preplant
application
was
made
at
the
rate
of
0.09
lb
ai/
A
(
ca.
1.3x
the
maximum
preemergence
application
rate).
The
postemergence
application
was
made
at
the
fifth
to
seventh
trifolate
stage
at
the
rate
of
0.03
lb
ai/
A
(
1x
the
maximum
postemergence
application
rate).
At
three
locations
(
MI,
IL,
and
MS)
on
additional
plots,
one
postemergence
application
was
made
at
the
rate
of
0.09
lb
ai/
A
(
3x
the
maximum
postemergence
application
rate).
Applications
were
made
with
ground
equipment.
Most
applications
were
made
in
approximately
twenty
gallons
of
spray
per
acre.
An
adjuvant
was
not
added
to
the
spray
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
13
of
32
solutions
in
any
of
the
trials.
Threshed
seeds
were
harvested
at
maturity
(
114­
166
days
after
preplant
incorporated
application;
79­
132
days
after
postemergence
application
at
the
rate
of
0.03
lb
ai/
A
and
104­
132
days
after
postemergence
application
at
the
rate
of
0.09
lb
ai/
A).
Samples
of
soybeans
were
stored
frozen
in
polyethylene
bags.
The
samples
were
analyzed
4.5
to
32.5
months
after
sampling
using
either
method
ACR
91.6
with
a
LOQ
of
0.005
ppm
and
an
estimated
LOD
of
0.0025
ppm)
or
an
earlier
version
of
this
method
with
a
LOQ
of
0.01
ppm
and
an
estimated
LOD
of
0.005
(
N.
Dodd,
D178112,
8/
20/
93).
All
control
values
were
less
than
the
LOD
for
both
methods.
Recoveries
from
controls
fortified
with
flumetsulam
at
0.005
to
0.10
ppm
were
79
to113%;
however,
the
method
used
to
obtain
this
data
was
not
specified.
No
detectable
residues
of
flumetsulam
(
i.
e.,
less
than
one­
half
the
lower
limits
of
quantitation
of
the
methods)
were
found.

MRID
Number:
41931719
(
N.
Dodd,
PP#
1G4006,
3/
27/
93):
In
this
study,
flumetsulam
was
applied
preplant
incorporated
to
soybeans
at
the
rate
of
0.28
lb
ai/
A
(
4x
the
maximum
preemergence
rate)
in
IL,
MI,
and
MS.
Applications
were
made
with
ground
equipment.
Threshed
mature
soybean
seeds
were
collected
at
harvest
(
124
to
146
days
after
application).
Samples
were
stored
frozen
in
polyethylene
bags
until
analysis.
Samples
were
analyzed
within
six
to
twenty
months
using
method
ACR
91.6,
modified
by
substituting
a
liquid/
liquid
extraction
using
diethyl
ether
for
the
dual
solid
phase
extraction
purification
before
methylation.
The
validated
LOQ
of
the
method
was
0.005
ppm.
All
control
values
were
less
than
the
method
LOD.
Recoveries
from
controls
fortified
with
flumetsulam
at
0.005
to
0.10
ppm
were
77
to
101%.
No
detectable
residues
of
flumetsulam
(
i.
e.,
less
than
one­
half
the
LOQ
of
the
method)
were
found.

MRID
Number:
41931720
(
N.
Dodd,
PP#
1G4006,
3/
27/
93):
A
formulation
comparison
study
was
conducted
on
soybeans
in
IL
and
MS
to
compare
residues
from
postemergence
applications
of
two
different
sprayable
formulations
of
flumetsulam,
XRM­
5019
and
XRM­
4950R.
XRM­
5019,
a
75%
WDG
formulation,
was
applied
with
ground
equipment
at
the
rate
of
0.03
lb
ai/
A
in
both
states.
XRM­
4950R,
an
aqueous
suspension
concentrate,
was
applied
at
the
rate
of
0.03
lb
ai/
A
in
IL,
and
at
the
rate
of
0.0032
lb
ai/
A
in
MS
due
to
error.
Both
formulations
were
applied
to
soybeans
at
the
third
or
fourth
trifoliate
stage.
Mature
threshed
soybeans
were
collected
at
PHIs
of
89
days
in
IL
and
108
days
in
MS.
Samples
were
stored
frozen.
The
analytical
method
used
was
ACR
91.6
with
a
LOQ
of
0.005
ppm
and
an
estimated
LOD
of
0.002
ppm.
Recoveries
of
flumetsulam
at
fortification
levels
of
0.005
to
0.05
ppm
were
75
to107%.
No
detectable
residues
were
found
in
soybean
seeds
from
application
of
either
formulation.

Dry
Bean
MRID
Number:
44304402
(
S.
Ary,
D301807,
8/
24/
04):
DowElanco
has
submitted
field
trial
data
for
flumetsulam
on
dry
beans.
Ten
field
trials
were
conducted
encompassing
EPA
Regions
5
(
ND,
MI,
and
MN;
five
trials),
7
(
NE;
one
trial),
8
(
KS;
one
trial),
9
(
CO;
one
trial),
10
(
CA;
one
trial),
and
11
(
ID;
one
trial)
during
the
1996
growing
season.
The
number
and
locations
of
field
trials
are
in
accordance
with
Office
of
Prevention,
Pesticides,
and
Toxic
Substances
(
OPPTS)
Guideline
860.1500.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
14
of
32
At
each
test
location,
the
treated
plot
received
a
single
application
of
an
80.8%
water
dispersible
granular
(
WDG)
formulation
as
a
preplant
incorporated
spray.
The
test
substance
was
incorporated
to
a
depth
of
two
to
three
inches
on
the
same
day
as
the
application
and
the
plots
were
planted
with
bean
seed
between
zero
and
three
days
after
application.
All
applications
were
made
at
a
target
rate
of
0.07
lb
ai/
A
and
a
spray
volume
of
20
gal/
A.
Actual
application
rates
ranged
from
0.086
to
0.089
lb
ai/
A.
An
adjuvant
was
not
added
to
the
spray
mixtures.
Mature
bean
samples
were
collected
at
PHIs
between
92
and
131
days.

Residues
of
flumetsulam
in
the
bean
samples
were
quantitated
by
GC/
MS
using
DowElanco
method
GRM
96.21.
The
stated
LOQ
was
0.017
ppm
and
the
stated
LOD
was
0.005
ppm.
This
method
is
adequate
for
data
collection
based
on
acceptable
concurrent
method
recovery
data.

The
maximum
storage
interval
of
bean
samples
from
harvest
to
analysis
was
ninety­
seven
days
(
3.2
months).
Sample
extracts
were
stored
for
a
maximum
of
two
months
prior
to
analysis.
Flumetsulam
has
been
shown
to
be
stable
in
soybeans
after
a
period
of
908
days
in
frozen
storage
(
97%
recovery;
N.
Dodd,
PP#
2F4036,
MRID
No.:
42580608,
4/
14/
93)
and
in
corn
grain,
forage,
and
fodder
after
a
period
of
555
days
in
frozen
storage
(
83
to
110%
recovery;
N.
Dodd,
PP#
3F4185,
MRID
No.:
42677801,
6/
28/
93).
In
the
absence
of
specific
storage
stability
data
for
bean
samples,
it
is
assumed
that
residues
will
behave
similarly
in
beans
as
in
the
tested
commodities.

The
results
of
the
preplant
incorporated
spray
field
trials
showed
that
flumetsulam
residues
were
less
than
the
LOD
(
0.005
ppm)
in
all
dry
bean
samples
analyzed.
In
the
decline
study,
residues
of
flumetsulam
were
below
the
method
LOD
(
0.005
ppm)
at
all
sampling
intervals
(­
7,
­
3,
+
3,
and
+
7
days
from
normal
harvesting).

Table
6.
Summary
of
Residues
from
the
Crop
Field
Trials
with
Flumetsulam.

MRID
No.
EP1
Crop
Matrix
Applic.
Rate
(
lb
ai/
A)
PHI
(
days)
Flumetsulam
Residues
(
ppm)
2
Mean
Std.
Dev.
HAFT
Min.
Max.

Field
Corn
Preplant
Incorporated
(
current
maximum
application
rate
=
0.07
lb
ai/
A;
PHI
=
85
days)

41931721
75%
WDG
forage
0.06
72­
121
<
0.05
0
<
0.05
<
0.05
<
0.05
grain
0.06
120­
169
<
0.05
0
<
0.05
<
0.05
<
0.05
fodder
0.06
102­
127
<
0.05
0
<
0.05
<
0.05
<
0.05
Preemergence
(
current
maximum
application
rate
=
0.07
lb
ai/
A;
PHI
=
85
days)

42677803
75%
WDG
forage
0.07
NP3
<
0.05
0
<
0.05
<
0.05
<
0.05
0.11
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.20
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
grain
0.07
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.11
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.20
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
fodder
0.07
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Table
6.
Summary
of
Residues
from
the
Crop
Field
Trials
with
Flumetsulam.

MRID
No.
EP1
Crop
Matrix
Applic.
Rate
(
lb
ai/
A)
PHI
(
days)
Flumetsulam
Residues
(
ppm)
2
Mean
Std.
Dev.
HAFT
Min.
Max.

15
of
32
0.11
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.20
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
Postemergence
(
current
maximum
application
rate
=
0.07
lb
ai/
A;
PHI
=
85
days)

41931721
75%
WDG
forage
0.06
43­
80
<
0.05
0
<
0.05
<
0.05
<
0.05
grain
0.06
88­
134
<
0.05
0
<
0.05
<
0.05
<
0.05
0.18
102­
127
<
0.05
0
<
0.05
<
0.05
<
0.05
fodder
0.06
88­
134
<
0.05
0
<
0.05
<
0.05
<
0.05
42677803
75%
WDG
forage
0.06
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.09
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.18
14
NP
NP
NP
0.1764
(
0.2025)
4
0.2184
(
0.2318)
4
0.18
28
NP
NP
NP
0.0538
(
0.0571)
4
0.0860
(
0.0987)
4
grain
0.06
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.09
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.18
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
fodder
0.06
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.09
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
0.18
NP
<
0.05
0
<
0.05
<
0.05
<
0.05
Soybean
Preplant
Incorporated
(
current
maximum
application
rate
=
0.07
lb
ai/
A;
PHI
=
70­
85
days)

41952106
Aqueous
Suspension
Concentrate
(
1
lb
ai/
gal)
Soybean
0.09
114­
166
<
0.05
0
<
0.05
<
0.05
<
0.05
41931719
75%
WDG
Soybean
0.28
124­
146
<
0.05
0
<
0.05
<
0.05
<
0.05
Postemergence
(
current
maximum
application
rate
=
0.021
lb
ai/
A
total
application
rate;
PHI
=
85
days)

41952106
Aqueous
Suspension
Concentrate
(
1
lb
ai/
gal)
Soybean
0.03
79­
132
<
0.05
0
<
0.05
<
0.05
<
0.05
75%
WDG
Soybean
0.09
104­
132
<
0.05
0
<
0.05
<
0.05
<
0.05
41931720
Aqueous
Suspension
Concentrate
(
1
lb
ai/
gal)
Soybean
0.03
89­
108
<
0.05
0
<
0.05
<
0.05
<
0.05
75%
WDG
Soybean
0.03
89­
108
<
0.05
0
<
0.05
<
0.05
<
0.05
Dry
Bean
Preplant
Incorporated
(
current
maximum
application
rate
=
0.07
lb
ai/
A
total
application
rate;
PHI
=
85
days)
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Table
6.
Summary
of
Residues
from
the
Crop
Field
Trials
with
Flumetsulam.

MRID
No.
EP1
Crop
Matrix
Applic.
Rate
(
lb
ai/
A)
PHI
(
days)
Flumetsulam
Residues
(
ppm)
2
Mean
Std.
Dev.
HAFT
Min.
Max.

16
of
32
44304402
80.8%
WDG
Dry
bean
0.086
­
0.089
94
­
131
<
0.05
0
<
0.05
<
0.05
<
0.05
1.
EP
=
End­
use
product.
2.
The
method
was
validated
by
EPA
at
0.05
ppm.
3.
NP
=
Not
provided.
4.
These
values
are
corrected
for
concurrent
recovery.
The
petitioner
indicated
that
the
higher
residues
in
CA
may
be
due
to
furrow
irrigation
only.
The
corn
received
little
or
no
overhead
irrigation
after
application
of
the
herbicide
and
minimal
rainfall
during
the
1992
growing
season.
Also,
the
application
rate
was
ca.
3x
(
0.18
lb
ai/
A)
the
current
use
rate
of
0.07
lb
ai/
A.

860.1520
Processed
Food
and
Feed
A
processed
food
and
feed
study
was
conducted
using
field
corn
that
was
treated
postemergence
at
0.18
lb
ai/
A
(
ca.
3x
the
application
use
rate).
The
corn
was
processed
into
crude
oil,
refined
oil,
grits,
meal,
flour,
and
starch
using
either
dry
or
wet
processing
techniques
that
were
intended
to
produce
commercially
representative
fractions.
The
solid
by­
product
samples
(
grits,
meal,
flour,
and
starch)
were
stored
for
up
to
3.5
months
prior
to
analysis
and
the
oil
samples
were
stored
up
to
four
weeks
prior
to
analysis.
Storage
stability
data
was
not
submitted
for
the
solid
by­
product
processed
fractions;
however,
because
the
solid
by­
product
processed
fractions
closely
resemble
corn
grain,
the
demonstrated
stability
of
flumetsulam
in
corn
grain
(
555
days
at
­
15

C)
is
acceptable
for
the
storage
conditions
and
intervals
of
the
solid
by­
product
processed
fractions.
Storage
stability
data
were
also
not
submitted
for
the
oil
samples;
however,
data
are
not
required
because
the
oil
samples
were
stored
for
less
than
or
equal
to
thirty
days
and
flutmetsulam
is
not
known
to
be
volatile
or
labile.
The
raw
agricultural
commodity
(
RAC)
and
processing
samples
were
analyzed
for
flumetsulam
using
method
ACS
91.6S,
which
was
validated
with
corn
grain,
corn
fodder,
and
soybeans
by
EPA
at
0.05
ppm.
The
HED
Metabolism
committee
determined
that
the
residue
of
concern
in
field
corn
is
flumetsulam
per
se.
Flumetsulam
residues
in
the
RAC
and
the
processing
fractions
were
not
detected
above
the
estimated
method
LOD
of
0.002
ppm
(
D188957,
N.
Dodd,
6/
28/
93).

The
application
rate
for
the
study
was
3x.
Unless
the
3x
application
rate
was
chosen
because
of
phytotoxicity
concerns,
the
application
rate
for
the
processing
study
should
have
been
5x
the
maximum
application
rate.
Considering
the
absence
of
detectable
residues
in
all
the
processed
fractions
at
3x
and
the
properties
of
flumetsulam
(
low
octanol/
water
partition
coefficient
[
log
P
=
0.21]
and
greater
solubility
in
water
than
in
hexane),
HED
concludes
that
concentration
of
residues
in
oil
is
highly
unlikely.
Therefore,
the
processing
study
is
adequate
to
show
that
food
or
feed
additive
tolerances
are
unnecessary
(
N.
Dodd,
D188957,
6/
28/
93).

A
processing
study
and
food
additive
tolerances
are
not
required
for
soybeans
because
no
detectable
residues
(
less
than
0.005
ppm)
were
found
in
soybeans
resulting
from
postemergence
treatment
at
6x
the
maximum
application
rate,
which
is
the
theoretical
concentration
factor
for
soybean
oil.
Additionally,
no
detectable
residues
were
found
in
soybeans
from
preplant
incorporated
treatment
at
4x
the
maximum
application
rate
(
N.
Dodd,
PP#
1G4006,
3/
27/
93).

A
processing
study
for
dry
beans
is
not
required
because
dry
beans
are
not
processed
into
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
17
of
32
food/
feed
items.

860.1650
Submittal
of
Analytical
Reference
Standards
An
analytical
reference
standard
for
flumetsulam
was
submitted
by
Dow
in
July
of
1999
and
expires
May
of
2007.
The
standard
is
available
at
the
EPA
National
Pesticide
Standards
Repository.

860.1850
Confined
Accumulation
in
Rotational
Crops
MRID
Numbers:
41263232,
41931738,
41931739,
and
42512502:
An
accumulation
in
confined
rotational
crops
study
was
initiated
in
May
of
1997
with
plant
back
intervals
of
30,
120,
and
365
days
after
soil
treatment.
The
application
rate
for
this
study
was
0.12
lb
ai/
A
(
ca.
2x
the
recommended
use
rate).
The
study
was
reported
in
two
parts.
The
30­
day
and
120­
day
plant
back
interval
study
was
submitted
and
reviewed
first
(
G.
Maske,
MRID
No.:
41263232,
1/
21/
90),
followed
by
the
365­
day
study
(
G.
Maske,
MRID
No.:
41931738,
3/
12/
93).
The
review
of
the
30­
day
and
120­
day
study
listed
the
following
deficiencies:
incomplete
residue
characterization,
storage
stability
questions,
and
lack
of
confirmation
of
the
application
rate.
A
33­
day
study
was
conducted
at
0.13
lb
ai/
A
(
ca.
2x
the
recommended
use
rate)
and
was
submitted
and
reviewed
to
satisfy
the
30­
day
and
120­
day
study
deficiencies
(
G.
Maske,
MRID
No.:
41931739,
ca.
1993).
The
registrant
was
instructed
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
to
submit
an
overview
(
MRID
No.:
42512502)
to
summarize
the
results
of
the
confined
rotational
crop
studies.

For
all
phases
of
the
original
confined
rotational
crop
studies
(
MRID
Nos.:
41263232
and
41931738)
and
the
supporting
study
(
MRID
No.:
41931739),
the
14C
residues
in
lettuce,
carrot
tops
and
roots,
wheat
grain,
and
soybeans
were
reported
to
be
less
than
or
equal
to
0.01
ppm.
Wheat
forage
and
soybean
forage
had
reported
total
14C
residues
of
0.039
and
0.056
ppm,
respectively.
The
highest
total
14C
residues
were
reportedly
found
in
wheat
straw/
chaff
and
soybean
trash
at
0.060
and
0.082
ppm,
respectively.
These
residues
were
characterized
by
solvent
extractability,
acid
extractability,
and/
or
lignin
and
cellulose
isolation.
The
neutral
solvent
extractable
14C
residues
were
further
characterized
by
chromatographic
comparison
of
the
extractable
residue
components
to
reference
standards.
Four
degradates
were
shown
to
be
present
which
had
concentrations
ranging
from
less
than
0.001
to
0.031
ppm.
These
were
reported
as
Components
A,
B,
C,
and
D.
Component
D,
which
had
a
retention
time
similar
to
flumetsulam,
was
present
at
less
than
0.001
ppm
for
all
tissues
analyzed.
Component
C
occurred
at
a
retention
time
similar
to
both
the
5­
hydroxymethyl
and
7­
hydroxymethyl
metabolites
of
flumetsulam.
With
the
exception
of
soybean
forage
(
0.020
ppm),
the
concentration
of
Component
C
was
less
than
or
equal
to
0.007
ppm.
Component
B
was
determined
to
be
more
polar
than
Component
C
and
was
present
at
less
than
or
equal
to
0.005
ppm,
with
the
exception
of
soybean
forage
(
0.031
ppm).
The
concentration
of
Component
A
was
less
than
or
equal
to
0.009
ppm,
with
the
exception
of
soybean
forage
(
0.019
ppm).
Component
A
is
likely
composed
of
two
degradates.
The
registrant
indicated
that
the
total
radioactive
residues
were
present
at
such
low
levels
that
only
characterization
and
not
identification
of
specific
degradates
was
possible.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
18
of
32
The
current
use
labels
for
flumetsulam
restricts
crop
rotation
after
treatment
to
four
months
or
greater
for
all
crops
except
soybean.
Feeding
of
soybean
forage,
hay,
or
straw
to
livestock
is
restricted.
Under
these
restrictions,
the
total
quantifiable
14C
residues
accumulated
in
crop
fractions
is
less
than
0.006
ppm
with
the
exception
of
wheat
straw/
chaff.
The
highest
wheat
straw/
chaff
residue
occurred
for
the
30­
day
planting
at
0.060
ppm.
The
total
14C
residue
levels
in
wheat
straw/
chaff
samples
were
0.029
ppm
in
the
120­
day
study
and
0.010
ppm
in
the
365­
day
study.

The
results
of
the
30­
day,
120­
day,
and
365­
day
rotational
crop
studies
indicate
that
the
total
14C
residue
accumulation
in
lettuce,
carrot
roots
and
tops,
turnip
roots
and
tops,
wheat
grain,
and
soybeans
was
less
than
or
equal
to
0.01
ppm.
However,
total
14C
residues
reported
in
wheat
straw/
chaff
ranged
from
0.010
to
0.047
ppm
(
MRID
Nos.:
41263232
and
41931738).
In
a
separate
study
(
MRID
No.:
41931739),
wheat
forage,
soybean
forage,
soybean
trash,
and
wheat
straw/
chaff
had
reported
total
14C
residues
of
0.039,
0.056,
0.082,
0.060
ppm,
respectively.
Therefore,
for
leafy
and
root
crops,
a
30­
day
rotational
crop
interval
is
satisfactory.
For
cereal
grains,
a
120­
day
rotational
crop
interval
is
satisfactory.
A
restriction
against
feeding
soybean
forage,
hay,
or
straw
to
livestock
should
be
added
to
all
labels.

860.1900
Field
Accumulation
in
Rotational
Crops
Studies
for
field
accumulation
in
rotational
crops
studies
have
not
been
submitted;
however,
review
of
the
confined
studies
(
MRID
Numbers:
41263232,
41931738,
and
41931739)
indicate
that
residues
of
concern
in
these
studies
are
less
than
0.01
ppm
at
the
appropriate
rotational
intervals.
Trials
for
field
accumulation
in
rotational
crops
are
not
required
at
this
time.
However,
if
the
registrant
wishes
to
have
shorter
plant­
back
intervals
(
PBI),
field
accumulation
studies
will
be
needed
to
set
tolerance
levels
for
rotational
crops.

860.1550
Proposed
Tolerances
Tolerances
have
been
established
under
40
CFR
§
180.468
for
residues
of
flumetsulam
in/
on
field
corn
(
forage,
grain,
and
stover)
and
soybean
at
0.05
ppm.
Available
residue
data
indicate
that
the
established
tolerances
for
these
commodities
are
adequate.
Dow
has
petitioned
for
the
establishment
of
a
tolerance
for
residues
of
flumetsulam
in/
on
dry
beans
at
0.05
ppm.
HED
recommends
that
the
tolerance
level
in/
on
dry
beans
be
established
at
the
proposed
rate.
Table
7
presents
the
established/
proposed
and
recommended
tolerance
levels
for
all
commodities.

There
are
no
Codex,
Canadian,
or
Mexican
maximum
residue
limits
(
MRLs)
for
flumetsulam;
therefore,
no
questions
of
compatibility
with
U.
S.
tolerances
exist.

Table
7.
Tolerance
Summary
for
Flumetsulam.

Commodity
Established/
Proposed
Tolerance
(
ppm)
Recommended
Tolerance
(
ppm)
Comments
(
correct
commodity
definition)

Corn,
field,
forage
0.05
(
established)
0.05
None
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Commodity
Established/
Proposed
Tolerance
(
ppm)
Recommended
Tolerance
(
ppm)
Comments
(
correct
commodity
definition)

19
of
32
Corn,
field,
grain
0.05
(
established)
0.05
None
Corn,
field,
stover
0.05
(
established)
0.05
None
Soybean
0.05
(
established)
0.05
None
Dry
bean
0.05
(
proposed)
0.05
Bean,
dry
BIBLIOGRAPHY
Study
Citations
41263232.
Hamburg,
A.;
Miller,
J.;
Lardie,
T.;
et
al.
(
1989)
[
carbon
14]­
XRD­
498:
Confined
Accumulation
Study
on
Rotational
Crops
Planted
at
30
and
120
Days
After
Soil
Treatment:
Project
ID
GH­
C
2170.
Un­
published
study
prepared
by
Dow
Chemical
Co.
75
p.

41931712.
Stafford,
L.;
Lardie,
T.
(
1990)
A
Study
of
the
Nature
of
the
Residue
in
Soybeans
Following
a
Postemergent
Application
of
[
carbon
14]­
Labelled
XRD­
498:
Protocol
No.
87077:
Lab
Project
No.
GH­
C
2437.
Unpublished
study
prepared
by
DowElanco.
64
p.

41931713.
Chang,
M.;
Lardie,
T.;
Becker,
G.;
et
al.
(
1991)
A
Study
of
the
Nature
of
the
Residue
in
Soybean
Following
a
Post­
emergent
Application
of
[
carbon
14]­
Phenyl
DE­
498:
Lab
Project
No:
90046.
Unpublished
study
prepared
by
DowElanco.
114
p.

41931713.
Chang,
M.;
Lardie,
T.;
Becker,
G.;
et
al.
(
1991)
A
Study
of
the
Nature
of
the
Residue
in
Soybean
Following
a
Post­
emergent
Application
of
[
carbon
14]­
Phenyl
DE­
498:
Lab
Project
No:
90046.
Unpublished
study
prepared
by
DowElanco.
114
p.

41931714.
Stafford,
L.;
Lardie,
T.
(
1990)
A
Study
of
the
Nature
of
the
Resi­
due
in
Corn
Following
a
Postemergent
Application
of
[
carbon
14]
Labeled
XRD­
498:
Lab
Project
Number:
GH­
C
2436:
Protocol
Number:
87076.
Unpublished
study
prepared
by
DowElanco.
67
p.

41931715.
Stafford,
L.;
Lardie,
T.;
Becker,
G.
(
1991)
A
Study
of
the
Nature
of
the
Residue
in
Corn
Following
a
Postemergent
Application
of
[
carbon
14]­
Phenyl
DE­
498:
Lab
Project
Number:
MET90045.
Unpub­
lished
study
prepared
by
DowElanco.
75
p.

41931717.
Hamburg,
A.;
Baldwin,
W.
(
1989)
Nature
of
the
Residue
in
Tissues
and
Eggs
from
Laying
Hens
Fed
[
carbon
14]­
XRD­
498:
Lab
Project
No:
GH­
C
2216.
Unpublished
study
prepared
by
Dow
Chemical
Co.
107
p.

41931718.
Olberding,
E.;
Harnick,
B.
(
1990)
Frozen
Storage
Stability
of
DE­
498
Herbicide
in
Soybeans:
Lab
Project
Number:
90002.00.
Un­
published
study
prepared
by
DowElanco.
22
p.

41931719.
Olberding,
E.;
Harnick,
B.;
Balcer,
J.
(
1991)
DE­
498
Herbicide
Applied
Preplant
to
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
20
of
32
Soybeans­­
Residue
Study
to
Provide
Data
for
Tolerance
and
Registration:
Lab
Project
Number:
89010.
Unpub­
lished
study
prepared
by
DowElanco.
31
p.

41931720.
Olberding,
E.;
Duebelbeis,
D.;
Harnick,
B.;
et
al.
(
1991)
DE­
498
Herbicide
Applied
Postemergence
to
Soybeans­­
Comparison
of
Resi­
dues
from
Two
Different
Formulations:
Lab
Project
Number:
90041.
Unpublished
study
prepared
by
DowElanco.
34
p.

41931721.
Duebelbeis,
D.;
Olberding,
E.;
Harnick,
B.
(
1991)
DE­
498
Herbicide
Applied
Preplant
or
Postemergence
to
Field
Corn­­
Residue
Study
to
Provide
Data
for
Tolerance
and
Registration:
Lab
Project
Num­
ber:
90031.
Unpublished
study
prepared
by
DowElanco.
123
p.

41931738.
Hamburg,
A.
(
1989)
[
carbon
14]­
XRD­
498:
Confined
Accumulation
Study
on
Rotational
Crops
Planted
at
365
Days
after
Soil
Treatment:
Lab
Project
Number:
87058:
GH­
C
2244.
Unpublished
study
prepared
by
Dow
Chemical
Co.
56
p.

41931739.
Hamburg,
A.;
Byrne,
S.;
Harding,
R.
(
1991)
[
carbon
14]­
5­
DE­
498
Con­
fined
Accumulation
Study
in
Rotational
Crops:
Confirmation
of
the
Validity
of
the
Results
fron
the
Original
Study
Started
on
May
5,
1987,
and
Reported
in
GH­
C
2170
(
30­
and
120­
Day
Phases)
and
GH­
C
2244
(
365­
Day
Phase):
Supplement
to:
Lab
Project
No:
90069.
Unpublished
study
prepared
by
DowElanco.
71
p.

41952104.
Olberding,
E.;
Duelbelbeis,
D.;
Harnick,
B.;
et
al.
(
1991)
Determi­
nation
of
Residues
of
DE­
498
in
Soybean
Capillary
Gas
Chromatog­
raphy/
Mass
Spectrometry:
Lab
Project
Number:
ACR
91.6.
Unpub­
lished
study
prepared
by
DowElanco.
23
p.

41952105.
Duebelbeis,
D.
(
1991)
Validation
of
Method
ACR
91.6:
Determination
of
Residues
of
DE­
498
in
Soybeans
by
Capillary
Gas
Chromatograpy
/
Mass
Spectrometry:
Lab
Project
Number:
MV000036.
Unpublished
study
prepared
by
A&
L
Great
Lakes
Labs,
Inc.
17
p.

41952106.
Olberding,
E.;
Harnick,
B.;
Balcer,
J.
(
1991)
DE­
498
Herbicide
App­
lied
Preplant
or
Postemergence
to
Soybeans:
Residue
Study
to
Pr­
ovide
Data
for
Tolerance
and
Registration:
Lab
Project
Number:
88050.
Unpublished
study
prepared
by
DowElanco.
195
p.

42489001.
Lade,
D.;
Olberding,
E.;
Stafford,
L.
(
1992)
Response
to
EPA
Reviews
on
DE­
498
(
Flumetsulam)
Pertaining
to
Residue
Chemistry
Concerns
on
Corn
in
the
CB­
TS
Review
of
March
27,
1992:
Lab
Project
Number:
DHL
92­
1.
Unpublished
study
prepared
by
DowElanco.
113
p.

42512502.
Hamburg,
A.;
Byrne,
S.
(
1992)
Overview
for
the
Studies
on
the
Accumulation
in
Confined
Rotational
Crops
Submitted
for
Flumetsulam
(
MRIDs
41263232,
41931738
and
41931739):
Lab
Project
Number:
MET90069.01.
Unpublished
study
prepared
by
DowElanco.
39
p.

42513501.
Chang,
M.;
Brown,
S.;
Lyons,
W.
(
1992)
A
Study
of
the
Nature
of
the
Residue
in
Soybean
Following
a
Postemergence
Application
of
[
carbon­
14]­
Phenyl­
DE­
498:
Supplimental
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
21
of
32
Data
to
GH­
C
2532,
MRID
41931713:
Lab
Project
Number:
90046.01.
Unpublished
study
prepared
by
DowElanco.
79
p.

42513502.
Chang,
M.;
Brown,
S.;
Lyons,
W.
(
1992)
A
Study
of
the
Nature
of
the
Residue
in
Soybeans
Following
Separate
Preplant­
Soil­
Incorporated
Applications
of
[
carbon­
14]­
Phenyl­
DE­
498
and
[
Carbon­
14]­
5­
DE­
498:
Lab
Project
Number:
MET91064.
Unpublished
study
prepared
by
DowElanco.
136
p.

42580607.
Harnick,
B.;
Olberding,
E.
(
1992)
A
Study
to
Determine
the
Interference
of
Pesticides
with
the
Performance
of
Analytical
Methods
ACR
91.3
and
ACR
91.6:
Lab
Project
Number:
RES92074.
Unpublished
study
prepared
by
DowElanco.
100
p.

42580608.
Harnick,
B.;
Olberding,
E.
(
1992)
Frozen
Storage
Stability
of
DE­
498
Herbicide
in
Soybeans:
A
Supplement:
Lab
Project
Number:
90002.01.
Unpublished
study
prepared
by
DowElanco.
24
p.

42573801.
Stafford,
L.;
Lardie,
T.;
Brink,
D.;
et
al.
(
1992)
A
Study
of
the
Nature
of
the
Residue
in
Corn
following
a
Postemergence
Application
of
[
carbon
14]­
Phenyl­
DE­
498:
Supplemental
Data
to
GH­
C
2533:
Lab
Project
Number:
MET90045.01.
Unpublished
study
prepared
by
DowElanco.
63
p.

42573802.
Stafford,
L.;
Lardie,
T.;
Brink,
D.;
et
al.
(
1992)
A
Study
of
the
Nature
of
the
Residue
in
Early
Corn
Forage
Comparing
[
carbon
14]­
Phenyl
and
[
carbon
14]­
2­
DE­
498:
Lab
Project
Number:
MET92013.
Unpublished
study
prepared
by
DowElanco.
57
p.

42677801.
Olberding,
E.;
Duebelbeis,
D.;
Harnick,
B.
(
1993)
Frozen
Storage
Stability
of
DE­
498
Herbicide
in
Corn
Grain,
Forage,
and
Fodder:
Lab
Project
Number:
RES91022.
Unpublished
study
prepared
by
DowElanco.
35
p.

42677802.
Moore,
M.
(
1993)
Process
Fraction
Study
for
Field
Corn
Receiving
DE­
498
Herbicide
Applied
Preemergent
Surface
or
Postemergent:
Lab
Project
Number:
RES92039.01.
Unpublished
study
prepared
by
DowElanco.
98
p.

42677803.
Moore,
M.
(
1993)
DE­
498
Herbicide
Applied
Preemergent
Surface
or
Postemergent
to
Field
Corn­
residue
Study
to
Provide
Data
for
Tolerance
and
Registration:
Lab
Project
Number:
RES92039.
Unpublished
study
prepared
by
DowElanco.
59
p.

43292103.
Rutherford,
B.;
Foster,
D.
(
1994)
Magnitude
of
Residues
in
Corn
Treated
Postemergence
with
NAF­
73
Herbicide:
Lab
Project
Number:
RES93050.
Unpublished
study
prepared
by
North
American
Environmental
Chemistry
Lab.,
DowElanco
and
A&
L
Great
Lakes
Lab.,
Inc.
229
p.

43805401.
Bargar,
E.;
Gehring,
H.;
Foster,
D.
(
1995)
Magnitude
of
the
Residue
in
Soybeans
Treated
Postemergence
with
Flumetsulam:
Bridging
Study
of
XRM­
5019
and
BF­
308
Formulations:
Lab
Project
Number:
RES94037.
Unpublished
study
prepared
by
DowElanco
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
22
of
32
North
American
Environmental
Chemistry
Lab.
84
p.

44304402.
Gardner,
R.;
Robb,
C.
(
1997)
Magnitude
of
Residue
of
Flumetsulam
in
Dry
Beans
After
Use
of
an
80%
WDG:
Lab
Project
Number:
RES96035.
Unpublished
study
prepared
by
DowElanco.
84
p.

Agency
Memoranda
Citations
Agency
Memoranda
Citations.

Date
Barcode
CBTS
No.
Petition
or
ID
Number
From
To
MRID
Nos.
Subject
1/
21/
90
None
None
None
G.
Maske
EFED
Files
41263232
DER:
Confined
Accumulation
of
Rotational
Crops;
MRID
No.:
41233232.

3/
10/
92
D168583
8560
1G4006
N.
Dodd
J.
Miller
None
PP#
1G4006
(
CBTS
#
8560;
Barcode
#
D168583).
DE­
498
and
Trifluralin
on
Soybeans.
Formulation
XRM­
5313.

3/
27/
92
D167462
D168563
8400
8646
1G4006
N.
Dodd
J.
Miller
and
Toxicology
Branch
41931701
41931702
41931712­
41931721
41952101
41952104­
41952106
41993802
PP#
1G4006
(
CB#'
s
8400
and
8646;
Barcode
#'
s
D167462
and
D168563,
respectively).
DE­
498
on
Soybeans
and
Field
Corn.
(
MRID
#'
s
419317­
01,
­
02;
419317­
12
through
­
21;
419521­
01,
­
04,
­
05,
­
06;
and
419938­
02.

8/
20/
92
D178112
9845
1G4006
N.
Dodd
J.
Miller
and
Toxicology
Branch
42407000­
42407004
PP#
1G4006
(
CBTS
#
9845;
Barcode
#
D178112).
DE­
498
and
DE­
498/
Trifluralin
on
Soybeans.
Amendment
dated
7/
24/
92.
(
MRID
#
s
424070­
00,
424070­
01,
424070­
02,
424070­
03,
424070­
04).

11/
24/
92
None
None
1G4006
N.
Dodd
Leon
Sawyer
(
FDA)
41993802
Multiresidue
Test
Information
for
the
Updating
of
PAM
I.

12/
23/
92
D183546
10738
2G4149
N.
Dodd
J.
Miller
and
Toxicology
Branch
42489001
PP#
2G4149
(
CBTS
#
10738;
Barcode
#
D183546).
DE­
498
on
Field
Corn.
Amendment
dated
9/
24/
92.
(
MRID
#'
s
424890­
01).

3/
12/
93
None
None
None
G.
Maske
EFED
Files
41931738
DER:
Confined
Accumulation
of
Rotational
Crops;
MRID
No.:
41931738.

Ca.
1993
None
None
None
G.
Maske
EFED
Files
41931739
DER:
Confined
Accumulation
of
Rotational
Crops;
MRID
No.:
41931739.

3/
29/
93
D189444
11610
062719­
EEG
N.
Dodd
J.
Miller
None
ID
#
062719­
EEF
(
CBTS
#
11610;
Barcode
#
D189444).
Flumetsulam
(
DE­
498)
on
Soybeans
and
Corn.
Evaluation
of
Method
Trial
Report
dated
3/
19/
93.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Agency
Memoranda
Citations.

Date
Barcode
CBTS
No.
Petition
or
ID
Number
From
To
MRID
Nos.
Subject
23
of
32
4/
14/
93
D183274
D184405
D184530
D185716
D185720
10708
10846
10914
11054
11055
2F4036
N.
Dodd
J.
Miller
A.
Kocialski
42489001
42513501
42513502
42580601­
42580608
TASK
4.
PP#
2F4036.
Flumetsulam
(
DE­
498)
on
Soybeans
and
Corn.
Amendments
dated
9/
25/
92,
10/
8/
92,
11/
30/
92,
and
12/
7/
92.

4/
26/
93
None
None
None
N.
Dodd
HED
Metabolism
Committee
None
Flumetsulam
Metabolism
in
Soybeans
and
Field
Corn.
The
HED
Metabolism
Committee
Meeting
Held
on
4/
21/
93.

6/
28/
93
None
None
2F4036
N.
Dodd
J.
Miller
A.
Kocialski
None
PP#
2F4036.
Flumetsulam
(
DE­
498)
on
Soybeans.
Addendum
to
Review
dated
5/
3/
93
regarding
Section
409.

6/
28/
93
D188957
11516
11799
3F4185
062719­
EEG
N.
Dodd
J.
Miller
426778­
00
through
­
03
PP#
3F4185
and
ID#
062719­
EEG.
(
CBTS
#'
s
11516
and
11799;
Barcode
#'
s
D188957
and
D190750).
DE­
498
(
Flumetsulam)
on
Field
Corn
(
MRID
#'
s
426778­
00,
­
01,
­
02,
and
­
03).

12/
6/
93
None
None
2F4036
3F4185
N.
Dodd
A.
Marcotte
(
FDA)
None
Materials
for
a
new
entry
in
PAM
II.

9/
24/
04
D301807
None
7F4851
S.
Ary
A.
Nielsen
44304402
DER:
Flumetsulam
Crop
Field
Trial
­
Dry
Bean
RDI:
S.
Ary
(
8/
25/
04);
S.
Kinard
(
8/
27/
04);
W.
Hazel
(
8/
31/
04).
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
24
of
32
Appendix
A.
Food/
Feed
Use
Patterns
of
Flumetsulam.

Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
CORN
Early
preplant
S
Conservation
tillage/
Soil
broadcast
treatment
S
Granule
applicator/
Ground/
Low
pressure
ground
sprayer
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Geographic
allowable:

CO
CT
DE
IA
IL
IN
KS
KY
MA
MD
ME
MI
MN
MO
MT
ND
NE
NH
NJ
NY
OH
PA
RI
SD
TN
VA
VT
WI
WV
WY
Preemergence
S
Broadcast/
Soil
band
treatment/
Soil
broadcast
treatment
S
Band
sprayer/
Granule
applicator/
Ground/
Low
pressure
ground
sprayer
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Preplant
S
Soil
band
treatment/
Soil
incorporated
treatment
S
Granule
applicator/
Ground/
Low
pressure
ground
sprayer/
Soil
incorporation
equipment
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
14
days
REI:
12
h
Incorporate
to
a
depth
of
2
inches.

Limitations:
85
day(
s)
preharvest
interval.

85
day(
s)
preharvest
interval.

Do
not
apply
by
aircraft.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
to
muck
soils.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
feed
straw
to
livestock.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
25
of
32
Do
not
graze
or
feed
forage
or
hay.

Groundwater
restriction.

Rotational/
plant
back
crop
restriction.

Treated
pulp
may
be
fed
to
animals
being
finished
for
slaughter.

Geographic
disallowable:
Other
CORN
(
UNSPECIFIED)

Early
preplant
S
Soil
broadcast
treatment
S
Granule
applicator/
Ground/
Low
pressure
ground
sprayer
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Geographic
allowable:

CO
CT
DE
IA
IL
IN
KS
KY
MA
MD
ME
MI
MN
MO
MT
ND
NE
NH
NJ
NY
OH
PA
RI
SD
TN
VA
VT
WI
WV
WY
Preemergence
S
Soil
band
treatment/
Soil
broadcast
treatment
S
Band
sprayer/
Granule
applicator/
Low
pressure
ground
sprayer
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Preplant
S
Soil
band
treatment/
Soil
incorporated
treatment
S
Granule
applicator/
Ground/
Low
pressure
ground
sprayer/
Soil
incorporation
equipment
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
14
days
REI:
12
h
Incorporate
to
a
depth
of
2
inches.

Limitations:
85
day(
s)
preharvest
interval.

Do
not
apply
by
aircraft.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
to
muck
soils.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
26
of
32
Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
feed
straw
to
livestock.

Do
not
graze
or
feed
forage
or
hay.

Groundwater
restriction.

Rotational/
plant
back
crop
restriction.

Treated
pulp
may
be
fed
to
animals
being
finished
for
slaughter.

CORN,
FIELD
Early
preplant
S
Conservation
tillage/
Soil
broadcast
treatment
S
Granule
applicator/
Ground/
Low
pressure
ground
sprayer
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Geographic
allowable:

CO
CT
DE
IA
IL
IN
KS
KY
MA
MD
ME
MI
MN
MO
MT
ND
NE
NH
NJ
NY
OH
PA
RI
SD
TN
VA
VT
WI
WV
WY
Foliar
S
Band
treatment/
Ground
spray/
Low
volume
spray
(
concentrate)

S
Band
sprayer/
Fixed­
wing
aircraft/
Helicopter/
Sprayer
0.03478
lb
ai/
A
0.03478
lb/
cc
NS
NS
REI:
48
h
Geographic
allowable:

CO
IA
KS
MN
NE
OK
SD
TX
Postemergence
S
Soil
band
treatment/
Soil
broadcast
treatment
S
Band
sprayer/
Ground/
Low
pressure
ground
sprayer
(
L)
0.05781
lb
ai/
A
0.06938
lb/
A/
yr
NS
NS
REI:
48
h
Preemergence
S
Broadcast/
Soil
band
treatment/
Soil
broadcast
treatment/
Soil
incorporated
treatment
S
Band
sprayer/
Granule
applicator/
Ground/
Low
pressure
ground
0.0693
lb
ai/
A
0.07031
lb/
A/
yr
NS
14
days
REI:
12
h
Incorporate
to
a
depth
of
3
inches.

Incorporate
to
a
minimum
depth
of
2
inches.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
27
of
32
sprayer
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
28
of
32
Preplant
S
Soil
band
treatment/
Soil
broadcast
treatment/
Soil
incorporated
treatment/
Soil
treatment
(
surface)

S
Band
sprayer/
Granule
applicator/
Ground/
Low
pressure
ground
sprayer/
Soil
incorporation
equipment
0.0693
lb
ai/
A
0.07
lb/
cc
0.07031
lb/
yr
NS
14
days
REI:
12
h
Incorporate
to
a
depth
of
2
inches.

Incorporate
to
a
depth
of
3
inches.

Incorporate
to
a
maximum
depth
of
3
inches.

Incorporate
to
a
minimum
depth
of
2
inches.

Limitations:
85
day(
s)
preharvest
interval.

85
day(
s)
prefeeding
interval.

85
day(
s)
pregrazing
interval.

85
day(
s)
preharvest
interval.

Do
not
apply
by
aircraft.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
to
any
body
of
water.

Do
not
apply
to
muck
soils.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
apply
where
runoff
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
feed
straw
to
livestock.

Do
not
graze
or
feed
forage
or
hay.

Do
not
make
more
than
1
applications
per
crop
cycle.

Groundwater
restriction.

Rotational/
plant
back
crop
restriction.

Treated
pulp
may
be
fed
to
animals
being
finished
for
slaughter.

Geographic
disallowable:
Other
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
29
of
32
SOYBEANS
(
UNSPECIFIED)

Early
preplant
S
Conservation
tillage/
Soil
band
treatment/
Soil
broadcast
treatment
S
Band
sprayer/
Granule
applicator/
Ground/
Low
pressure
ground
sprayer
1
(
L)

and
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Geographic
allowable:
CO
CT
DE
IA
IL
IN
KS
KY
MA
MD
ME
MI
MN
MO
MT
ND
NE
NH
NJ
NY
OH
PA
RI
SD
TN
VA
VT
WI
WV
WY
Postemergence
S
Broadcast
S
Low
pressure
ground
sprayer
0.021
lb
ai/
A
0.012lb
ai/
A/
cc
2/
1
yr
14
days
REI:
12
h
Preemergence
S
Soil
band
treatment/
Soil
broadcast
treatment
S
Band
sprayer/
Granule
applicator/
Ground/
Low
pressure
ground
sprayer
1
(
L)

and
0.06875
lb
ai/
A
0.07031
lb
ai/
A/
yr
NS
NS
REI:
12
h
Preplant
S
Soil
band
treatment/
Soil
broadcast
treatment/
Soil
incorporated
treatment
S
Band
sprayer/
Granule
applicator/
Ground/
Low
pressure
ground
sprayer/
Soil
incorporation
equipment
0.07031
lb
ai/
A
0.07
lb
ai/
A/
cc
0.07031
lb
ai/
A/
yr
NS
14
days
REI:
12
h
Incorporate
to
a
depth
of
2
inches.

Incorporate
to
a
maximum
depth
of
3
inches.

Incorporate
to
a
minimum
depth
of
2
inches.

Limitations:
85
day(
s)
preharvest
interval.

70
day(
s)
preharvest
interval.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
30
of
32
85
day(
s)
preharvest
interval.

Do
not
apply
by
aircraft.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
to
muck
soils.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
apply
when
wind
velocity
is
10
mph
or
greater.

Do
not
apply
where
runoff
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
feed
green
forage,
hay,
or
straw
to
livestock.

Do
not
feed
straw
to
livestock.

Do
not
graze
or
feed
forage
or
hay
from
treated
areas
to
livestock.

Do
not
graze
or
feed
forage
or
hay.

Do
not
harvest
treated
crop
for
livestock
forage,
fodder
or
hay.

Groundwater
restriction.

Rotational/
plant
back
crop
restriction.

This
pesticide
is
toxic
to
aquatic
invertebrates.

This
product
is
toxic
to
fish.

Treated
pulp
may
be
fed
to
animals
being
finished
for
slaughter.

Geographic
disallowable:
Other
DRY
BEANS1
Preplant2
S
Soil
broadcast
treatment/
Soil
incorporated
treatment
S
Ground
equipment
0.07031
lb
ai/
A
0.07031
lb
ai/
A
NS
NS
REI:
Geographic
allowable
(
Surface
treatment):

CO
CT
DE
IA
IL
IN
KS
KY
MA
MD
ME
MI
MN
MO
MT
ND
NE
NH
NJ
NY
OH
PA
RI
SD
TN
VA
VT
WI
WV
WY
Incorporate
to
a
depth
of
2
to
3
inches.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
31
of
32
Preemergence3
S
Broadcast/
Soil
band
treatment/
Soil
broadcast
treatment
S
Ground
equipment
0.0665
lb
ai/
A
0.0665
lb
ai/
A
NS
NS
REI:

Limitations:
85
day(
s)
preharvest
interval.

Do
not
apply
by
aircraft.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
to
muck
soils.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
apply
when
wind
velocity
is
10
mph
or
greater.

Do
not
apply
where
runoff
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
graze
or
feed
forage,
hay,
or
straw
from
treated
areas
to
livestock.

Groundwater
restriction.

Rotational/
plant
back
crop
restriction.

PRODUCT
NUMBERS
CONTAINED
IN
THIS
REPORT4
000352­
00593,
000352­
00612,
062719­
00222,
062719­
00239,
062719­
00240,
062719­
00253,
062719­
00264,
062719­
00277,
062719­
00299,
062719­
00315
HOMEOWNER
PRODUCTS
CONTAINED
IN
THIS
REPORT
None
HEADER
ABBREVIATIONS
Site
Name
­
The
site
name
refers
to
the
entity
(
crop,
building,
surface
or
article)
where
a
pesticide
is
applied
and/
or
which
is
being
protected.

Limitations
­
Precautionary
statements
related
to
the
use
of
the
product(
s).

Application
Timing
­
The
timing
of
pesticide
application
and
is
the
primary
application
sort
(
not
aggregated).

Application
Type
­
The
type
of
pesticide
application
(
aggregated).

Application
Equipment
­
The
equipment
used
to
apply
pesticide
(
aggregated).

Max.
Single
Appl.
Rate
to
a
Single
Site
­
Maximum
Dose
for
a
single
application
to
a
single
site.
System
calculated.

Max
Seasonal
Rate
­
The
maximum
amount
of
pesticide
that
can
be
applied
to
a
site
in
one
growing
season
(/
cc)
and
during
the
span
of
one
year
(/
yr).

Max.
#
Apps/
cc
&
yr
­
Maximum
Number
of
Applications
per
crop
cycle
and
per
year.
Flumetsulam
Summary
of
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
306242
Food/
Feed
Use
Patterns
of
Flumetsulam.

Application
Timing
S
Application
Type
S
Application
Equipment
Max.
Single
Application
Rate
Max.
Seasonal
Rate
Max.
No.
Applications/

cc
&
yr
MRI
Use
Limitations
32
of
32
M
R
I
­
Minimum
Retreatment
Interval
(
days)
(
at
any
rate).
The
minimum
interval
between
pesticide
application
(
days).

R
E
I
­
ReEntry
Interval
­
The
minimum
amount
of
time
that
must
elapse
before
workers
can
reenter
a
treated
area.

PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.#
s)
­
Preharvest/
Pregrazing/
Preslaughter
Interval
use
limitations
pertinent
to
the
application.

Current
As
Of:
­
The
label
data
for
the
listed
products
in
this
report
is
current
of
this
date.

ABBREVIATIONS
AN
­
As
needed
NA
­
Not
Applicable
NS
­
Not
Specified
(
on
label)

(
L)
­
The
dosage
information
provided
is
from
the
label
in
terms
of
product
(
e.
g.,
ounces,
gallons,
or
pounds
of
the
product)
because
there
was
insufficient
information
(
e.
g.,
missing
density,
area,
or
active
ingredient
percentages)
to
provide
converted
dosage
information.
This
report
provides
active
ingredient
percentage
in
the
product
for
the
reported
chemical
for
all
unconverted
label
dosage
information
if
this
information
is
available.
This
active
ingredient
percentage
information
is
displayed
next
to
the
form
code
abbreviations
(
e.
g.,
80%
WP).

APPLICATION
RATE
cwt
:
Hundred
Weight
nnE­
xx
:
nn
times
(
10
power
­
xx),
for
instance,
"
1.234E­
04"
is
equivalent
to
".
0001234"

End
of
Report
For
questions
and
comments
please
contact
the
OPP
Label
Data
Team
through
e­
mail.

1.
Use
patterns
for
beans
were
not
included
in
the
table
by
BEAD
because
it
is
a
proposed
new
use.

2.
Preplant
incorporated
applications
for
dry
beans
are
applicable
for
EPA
Registration
Nos.
062719­
222,
062719­
239,
and
062719­
277.
Preplant
surface
applications
are
applicable
for
Registration
Nos.
062719­
239
and
062719­
277.

3.
Preemergence
applications
for
dry
beans
are
applicable
for
EPA
Registrations
Nos.
062719­
239
and
062719­
277.

4.
The
following
registration
numbers
were
not
included
in
the
BEAD
table
for
unknown
reasons:
62719­
224,
62719­
278,
and
62719­
279.
