Jan
21,
2004
MEMORANDUM
SUBJECT:
Product
Chemistry
Science
Chapter
on
Pine
Oil
for
the
Reregistration
Eligibility
Decision
(
RED)

From:
A.
Najm
Shamim,
Ph.
D.,
Chemist
Regulatory
Management
Branch
II
Antimicrobials
Division
(
7510C)

To:
Ben
Chambliss,
Team
Leader
Regulatory
Management
Branch
II
Antimicrobials
Division
(
7510C)

Thru:
Tim
McMahon,
Senior
Toxicologist
and
Chair:
ADTC
Antimicrobials
Division
(
7510C)

And
Michelle
Centra,
Member
ADTC
Regulatory
Management
Branch
II
Antimicrobials
Division
(
7510C)

And
Connie
Welch,
Chief,
Regulatory
Management
Branch
II
Antimicrobials
Division
(
7510C)

Enclosed
is
the
Science
Chapter
of
Product
Chemistry
of
Pine
Oil
for
Reregistration
Eligibility
Decision
(
RED)
process
PRODUCT
CHEMISTRY
CHAPTER
A.
Chemical
Overview
Pine
oil
is
generally
used
as
a
disinfectant
fluid.
Because
Pine
oil
is
a
mixture,
Pine
Oil
Blend
110990
(
November
9,
1990)
was
made
by
the
Pine
oil
industry
as
a
distinct
entity
for
testing
purposes
(
physical/
chemical,
toxicological
etc)
only.
Registered
Manufacturing
Use
products
(
MUPs)
contain
pine
oil
at
concentrations
between
99
to
100%,
in
all
these
products
alpha
terpineol
is
the
major
constituent
(
80%).
Pine
Oil
Blend
110990
was
made
using:
Glidco
Organics
Pine
Oil
(
EPA
Reg
#
13648­
8),
Unipine
80
(
EPA
Reg#:
9886­
4),
Herco
Pine
Oil
(
Reg#:
891­
175),
Sentesis
Pine
Oil
80
(
Reg#:
49547­
3),
Arizole
Pine
Oil
80
(
Reg#:
39055­
1)
(
currently
known
as
Sylvapine
Pine
Oil),
Arizole
Pine
Oil
(
39055­
2),
and
El­
Pinol
(
Reg#:
11688­
3).
Glidco
Pine
Oil
80,
Sentesis
Pine
Oil
80
and
Arizole
Pine
Oil
are
no
longer
registered
as
active
products.

According
to
the
Agency's
database,
there
are
17
MUP
registrations
and
81
end­
use
products
(
EUPs)
registered
as
actives.

B.
Chemical
Identification
°
Name:
Pine
Oil
°
Chemical
Family:
alpha­
Terpineol
and
Terpinolene
(
Terpene
alcohol)
°
Chemical
Name:
1­
Methyl­
4­
isopropyl­
1­
cyclo­
hexen­
8­
ol
°
Common/
Trade
Names:
Pine
Oil
80
°
CAS
Number:
8002­
09­
3
°
Molecular
Formula:
C
10
H
18
O
°
Molecular
Structure:
CH
3­
C
6
H
9­(
OH)­
C
3
H
5
C.
Physical/
Chemical
Properties
The
following
characteristics
have
been
reported
for
pine
oil:
Technical
Grade
Active
Ingredient
(
TGAI):

°
Molecular
Weight:
154.0
°
Color:
Colorless
to
pale
yellow
°
Physical
State:
liquid
°
Specific
gravity:
0.952
at
20oC
°
b.
p.:
~
210
o
C
at
750
mm
Hg
°
Dissociation
Constant:
NA
(
insoluble
in
water)
°
pH:
NA
(
insoluble
in
water)
°
Stability:
30day­
accelerated
storage
study
showed
the
substance
is
stable
°
Melting
point:
N/
A
°
Water
Solubility:
insoluble
in
water
(
immiscible)
°
Solubility
in
organic
solvents:
Isopropyl
alcohol
>
90%
Toluene
>
90%
°
Octanol­
water
Partition
Coefficient:
Can
not
be
determined
(
insoluble
in
water)
°
Vapor
Pressure:
0.2
mm
Hg
at
20

C
°
Corrosion
Characteristics:
N/
A
