2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
1
of
13
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
7/
13/
2004
SUBJECT:
2,4­
DB
Acute
and
Chronic
Dietary
Exposure
Assessments
for
the
Reregistration
Eligibility
Decision
PC
Code:
030801,
030819
DP
Barcode:
D291221
REVIEWER:
Felecia
Fort,
Chemist
RRB1/
Health
Effects
Division
(
7509C)

THROUGH:
Thomas
Bloem,
Chemist
Kent
Carlson,
Ph.
D,
Biologist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

and
Whang
Phang,
Ph.
D.,
Branch
Senior
Scientist
RRB1/
Health
Effects
Division
(
7509C)

TO:
Kit
Farwell,
D.
V.
M.
RRB1/
Health
Effects
Division
(
7509C)

and
Mika
Hunter
Special
Review
and
Reregistration
Branch
(
7508C)

This
document
was
revised
to
correct
grammatical
and
typographical
errors
found
by
the
2,4­
DB
Task
Force
as
part
of
the
Phase
2
Error
Correction
period.
No
other
changes
have
been
made
to
this
document.
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
2
of
13
Executive
Summary
Acute
and
chronic
dietary
risk
assessments
were
conducted
for
2,4­
DB
[
4­(
2,4­
dichlorophenoxy)
butyrate]
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID
 
)
Version
1.30,
and
the
Lifeline
Model
Version
2.0
which
use
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analyses
were
performed
to
support
the
reregistration
eligibility
decision.
2,4­
DB
is
a
plant
growth
regulator
and
herbicide
registered
for
use
on
alfalfa,
clover,
peanuts,
soybean,
peppermint,
spearmint,
and
trefoil.

Acute
Dietary
Exposure
Results
and
Characterization
An
unrefined
(
tolerance
level
and
100%
crop
treated
(%
CT))
acute
dietary
risk
assessment
was
conducted
for
all
supported
2,4­
DB
food
uses.
Dietary
risk
estimates
are
provided
for
females
13
to
49
years
old,
the
population
subgroup
of
concern.
The
results
using
the
DEEM­
FCID
and
Lifeline
models
showed
risk
estimates
at
the
95th
percentile
of
exposure
to
be
<
1%
of
the
aPAD
regardless
of
the
model
used
and
were
therefore
not
of
concern.

Chronic
Dietary
Exposure
Results
and
Characterization
Tolerance
level
residues
and
100%
CT
information
were
also
used
to
determine
the
chronic
dietary
exposure
and
risk
estimates.
This
assessment
concluded
that
for
all
included
commodities,
the
chronic
risk
estimates
are
below
the
Agency's
level
of
concern
for
the
general
U.
S.
population
(<
1%
of
the
cPAD)
and
all
population
subgroups
(<
2.2%
cPAD)
when
using
DEEM_
FCID
or
Lifeline
models.
The
most
highly
exposed
population
subgroup
was
All
Infants
(<
1
years
old).

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor.

For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
References
which
discuss
the
acute
and
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
3
of
13
This
is
the
first
dietary
risk
assessment
that
has
been
conducted
for
2,4­
DB.

II.
Residue
Information
2,4­
DB
is
currently
registered
for
use
on
on
alfalfa,
clover,
peanuts,
soybean,
peppermint,
spearmint,
and
trefoil.
It
is
currently
manufactured
as
the
acid
(
030801)
and
the
dimethylamine
salt
(
030819);
no
other
salt
or
ester
products
are
currently
registered.

Tolerances
for
residues
of
2,4­
DB
in
plant
commodities
are
currently
expressed
as
the
combined
residues
of
the
herbicide
4­(
2,4­
dichlorophenoxy)
butyric
acid
and
its
metabolite
2,4­
dichlorophenoxyacetic
acid
(
2,4­
D)
which
is
also
a
registered
active
ingredient.
Current
tolerance
levels
are
set
at
0.2
ppm
(
based
on
negligible
residues)
in
alfalfa;
clover;
mint,
hay;
peanut;
trefoil,
birdsfoot;
soybean;
and
soybean,
hay.
No
tolerances
in
livestock
commodities
or
food/
feed
processed
commodities
have
been
established.

The
qualitative
nature
of
the
2,4­
DB
residue
in
plant
and
livestock
commodities
is
adequately
understood
based
on
acceptable
metabolism
studies
in
alfalfa,
peanuts,
soybeans,
dairy
cows
and
laying
hens.
The
HED
Metabolism
Committee
concluded
that
the
residue
to
be
regulated
in
plant
and
livestock
commodities
is
2,4­
DB
per
se
(
D.
Miller,
1/
29/
96).

The
reassessed
tolerances
for
plants
are
listed
as
follows:
alfalfa,
forage
(
0.70
ppm);
alfalfa,
hay
(
2.0
ppm);
clover,
forage
and
clover,
hay
(
insufficient
data
available);
peppermint,
tops
and
spearmint,
tops
(
0.20
ppm);
soybean,
seed
(
0.50
ppm),
soybean,
forage
(
0.70
ppm),
soybean,
hay
(
2.0
ppm);
peanut
(
0.05
ppm);
trefoil,
forage
(
0.70
ppm)
and
trefoil,
hay
(
2.0
ppm).
For
livestock,
the
appropriate
tolerance
for
2,4­
DB
is
0.05
ppm
(
LOQ)
in
the
meat
byproducts
of
cattle,
goats,
hogs,
horses,
and
sheep.
There
is
no
reasonable
expectation
of
the
transfer
of
residues
of
2,4­
DB
from
feedstuffs
to
livestock
meat,
fat
or
milk;
therefore,
the
current
use
of
2,4­
DB
with
respect
to
these
commodities
should
be
classified
as
Category
3
under
40
CFR
180.6(
a),
and
tolerances
for
residues
of
2,4­
DB
in
milk
and
in
meat
and
fat
of
cattle,
goats,
hogs,
horses,
and
sheep
are
not
required.

Processing
Factors
The
magnitude
of
the
residue
data
for
processed
commodities
of
food/
feed
crops
that
are
presently
registered
have
been
evaluated
and
deemed
adequate.
Residues
of
2,4­
DB
do
not
significantly
concentrate
upon
processing.
Based
on
the
submitted
studies,
a
processing
factor
of
0.72x
was
used
for
peanut
oil
in
the
dietary
assessment
and
a
1x
processing
factor
was
used
for
mint
oil
and
soybean
oil.

Table
1.
Tolerances
Used
in
the
Dietary
Assessment
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
4
of
13
Commodity
Tolerance
Reassessment
Peanut
0.05
Peppermint,
tops
0.20
Soybean
0.50
Spearmint,
tops
0.20
Cattle,
meat
byproducts
0.05
Goat,
meat
byproducts
0.05
Hog,
meat
byproducts
0.05
Sheep,
meat
byproducts
0.05
III
Program
and
Consumption
Information
Several
peer­
reviewed
programs
have
recently
been
emerging
for
modeling
dietary
exposure
to
pesticides.
For
technical
and
historical
reasons,
DEEM
 
was
the
preferred
program
for
EPA
through
2003.
Lifeline
 
,
which
is
capable
of
performing
a
probabilistic
aggregate
assessment
(
food,
water,
and
residential
exposure),
is
currently
being
evaluated
by
EPA.
This
evaluation
includes
the
comparison
of
dietary
exposure
estimates
for
a
given
chemical
using
both
DEEM
 
and
Lifeline
 
.
Once
this
evaluation
period
is
completed,
Lifeline
 
is
expected
to
become
the
default
dietary
exposure
assessment
program
for
EPA.
Dietary
Exposure
assessments
may
also
be
performed
with
other,
similar
programs,
and
if
submitted,
such
results
will
be
reviewed
by
EPA
for
acceptability
and
comparability
to
Lifeline
 
and/
or
DEEM
 
.
The
following
paragraphs
are
summaries
of
each
program.

IIIa.
DEEM­
FCID
 
Program
and
Consumption
Information
2,4­
DB
acute
and
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
1.30),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
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PC
Code:
030801,
030819
Page:
5
of
13
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
food­
form
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form.
The
resulting
residue
consumption
estimate
for
each
food/
food
form
is
summed
with
the
residue
consumption
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

For
acute
exposure
assessments,
individual
one­
day
food
consumption
data
are
used
on
an
individual­
by­
individual
basis.
The
reported
consumption
amounts
of
each
food
item
can
be
multiplied
by
a
residue
point
estimate
and
summed
to
obtain
a
total
daily
pesticide
exposure
for
a
deterministic
exposure
assessment,
or
"
matched"
in
multiple
random
pairings
with
residue
values
and
then
summed
in
a
probabilistic
assessment.
The
resulting
distribution
of
exposures
is
expressed
as
a
percentage
of
the
aPAD
on
both
a
user
(
i.
e.,
those
who
reported
eating
relevant
commodities/
food
forms)
and
a
per­
capita
(
i.
e.,
those
who
reported
eating
the
relevant
commodities
as
well
as
those
who
did
not)
basis.
In
accordance
with
HED
policy,
per
capita
exposure
and
risk
are
reported
for
all
tiers
of
analysis.
However,
for
tiers
1
and
2,
significant
differences
in
user
vs.
per
capita
exposure
and
risk
are
identified
and
noted
in
the
risk
assessment.

III
b.
Lifeline
 
Program
and
Consumption
Information
Acute
and
chronic
dietary
exposure
estimates
were
also
conducted
using
the
Lifeline
 
model
(
Version
2.0).
These
Lifeline
 
assessments
were
also
conducted
using
the
same
consumption
data
as
the
DEEM­
FCID
 
(
CSFII,
1994­
1996
and
1998
consumption
data
with
FCID).
Lifeline
 
uses
the
recipe
file
to
relate
RACs
to
foods
"
as­
eaten."
Lifeline
 
converts
the
RAC
residues
into
food
residues
by
randomly
selecting
a
RAC
residue
value
from
the
"
user
defined"
residue
distribution
(
created
from
the
residue,
percent
crop
treated,
and
processing
factors
data),
and
calculating
a
net
residue
for
that
food
based
on
the
ingredients'
mass
contribution
to
that
food
item.
For
example,
`
apple
pie'
will
have
a
residue
distribution
based
on
the
residues
provided
for
apples
(
adjusted
by
the
appropriate
processing
factors
and
percent
crop
treated),
as
well
as
the
residues
for
each
of
the
other
ingredients
in
the
apple
pie
recipe
for
which
there
may
be
tolerances.
Lifeline
 
calculates
dietary
exposure
from
`
apple
pie'
based
on
the
amount
eaten,
and
the
residue
drawn
from
the
`
apple
pie'
residue
distribution
for
that
eating
occasion.

Lifeline
 
models
the
individual's
dietary
exposures
over
a
season
by
selecting
a
new
CSFII
diary
each
day
from
a
set
of
similar
individuals
based
on
age,
season
and
socioeconomic
attributes
Lifeline
 
groups
CSFII
diaries
based
on
the
respondents'
age
and
the
season
during
which
the
food
diary
was
recorded.
Further
information
regarding
the
Lifeline
 
model
can
be
found
at
the
following
web
site:
www.
theLifeline
 
group.
org.

IV.
Toxicological
Information
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
6
of
13
The
doses
and
endpoints
for
dietary
risk
assessment
selected
by
the
HED
Hazard
Identification
Assessment
Review
Committee
(
HIARC)
were
discussed
in
detail
in
the
K.
Farwell
memorandum
dated
6/
13/
03.
A
summary
of
this
information
is
presented
in
Table
2.

The
HIARC
determined
that
the
special
FQPA
Safety
Factor
can
be
removed
(
1X)
since
there
are
no
residual
uncertainties
for
pre­
and/
or
postnatal
toxicity.

2,4­
DB
has
been
classified
as
a
"
not
likely"
carcinogen;
therefore,
no
carcinogenic
dietary
analysis
is
required.

Table
2.
Summary
of
Toxicological
Dose
and
Endpoints
for
2,4­
DB
Exposure
Scenario
Dose
for
Risk
Assessment
and
Uncertainty
Factor
Special
FQPA
Safety
Factor
and
Level
of
Concern
Study
and
Toxicological
Effects
Acute
Dietary
(
Females
13­
50
years
of
age)
NOAEL
=
62.5
mg/
kg/
day
UF
=
100
Acute
RfD
=
0.6
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
=
0.6
mg/
kg/
day
Rat
developmental
toxicity.
LOAEL
=
125
mg/
kg/
day
based
on
skeletal
variations/
malformations,
microphthalmia,
post­
implantation
loss
Acute
Dietary
(
General
population
including
infants
and
children)
None
N/
A
No
appropriate
endpoint
attributable
to
a
single
dose
from
oral
toxicity
studies.

Chronic
Dietary
(
All
populations)
NOAEL=
3
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.03
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.03
mg/
kg/
day
Chronic/
carcinogenicity
study
in
rats.
LOAEL
=
30
mg/
kg/
day
based
on
decreased
body
weight
gain
and
food
consumption
in
females.

Cancer
None
N/
A
Classified
"
not
likely
to
be
a
human
carcinogen".

1
UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose,
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose,
NA
=
Not
Applicable
V.
Results/
Discussion/
Conclusions
As
stated
above,
for
acute
and
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
results
reported
in
Table
3
for
the
chronic
assessment
is
for
the
general
U.
S.
Population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
7
of
13
13­
49,
adults
20­
49,
and
adults
50+
years.
Females
13­
49
years
old,
the
population
subgroup
of
concern,
is
reported
for
the
acute
assessment.
No
appropriate
acute
toxicity
endpoint
was
identified
for
the
general
population
including
infants
and
children;
therefore,
no
risk
was
assessed
(
see
Table
3).
Risk
estimates
were
below
HED's
level
of
concern
for
both
the
chronic
and
acute
assessments.
The
resulting
acute
dietary
exposure
estimates
were
less
than
1%
of
the
aPAD
for
Females
13
to
49
years
old
at
the
95th
percentile
of
exposure.
In
the
chronic
assessments,
the
highest
exposed
population
subgroup
was
All
Infants
(<
1
years
old).
DEEM­
FCID
and
Lifeline
risk
estimates
were
2.2%
and
1.8%
of
the
cPAD,
respectively
for
All
Infants
(<
1
years
old).

These
assessment
were
based
on
conservative
residue
estimates.
The
dietary
risk
estimates
could
be
further
refined
with
the
incorporation
of
anticipated
residues,
percent
crop
treated
data,
and
cooking/
processing
factors.
Based
on
the
results
of
the
assessment,
further
refinements
are
not
warranted.

Table
3.
Summary
of
Dietary
Exposure
and
Risk
for
2,4­
DB
Population
Subgroup*
Acute
Dietary
(
95th
Percentile)
Chronic
Dietary
DEEM­
FCID
Lifeline
DEEM­
FCID
Lifeline
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD*
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD
Dietary
Exposure
(
mg/
kg/
day)
%
cPAD
Dietary
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.000242
0.8
0.000232
0.8
All
Infants
(<
1
year
old)
0.000661
2.2
0.000554
1.8
Children
1­
2
years
old
0.000548
1.8
0.000539
1.8
Children
3­
5
years
old
0.000535
1.8
0.000505
1.7
Children
6­
12
years
old
0.000373
1.2
0.000346
1.2
Youth
13­
19
years
old
0.000238
0.8
0.000224
0.7
Adults
20­
49
years
old
0.000197
0.7
0.000198
0.7
Adults
50+
years
old
0.000153
0.5
0.000191
0.6
Females
13­
49
years
old
0.000467
0.08
0.000614
0.102
0.000185
0.6
0.000228
0.8
*
*
The
values
for
the
highest
exposed
population
for
each
type
of
risk
assessment
are
bolded.
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
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PC
Code:
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of
13
VIII.
List
of
Attachments
Attachment
1.
DEEM­
FCID
Residue
File
Attachment
2.
Acute
DEEM­
FCID
Analysis
Attachment
3
Chronic
DEEM­
FCID
Analysis
Attachment
4
Lifeline
Residue
File
Attachment
5.
Lifeline
Acute
and
Chronic
Results
cc:
FFort,
Reg.
Std.
File,
RF
7509C:
RRB1:
FAFORT:
faf:
CM#
2:
Rm
722H:
305­
7478:
4/
20/
04
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
9
of
13
Attachment
1.
DEEM­
FCID
Residue
File
U.
S.
Environmental
Protection
Agency
Ver.
1.33
DEEM­
FCID
Acute
analysis
for
24DB
Residue
file
name:
C:\$
MyFiles\
24db.
R98
Analysis
Date
02­
18­
2004
Residue
file
dated:
02­
18­
2004/
16:
24:
46/
8
Reference
dose
(
aRfD)
=
0.6
mg/
kg
bw/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
21000460
M
Beef,
meat
byproducts
0.050000
1.000
1.000
21000461
M
Beef,
meat
byproducts­
babyfood
0.050000
1.000
1.000
21000480
M
Beef,
kidney
0.050000
1.000
1.000
21000490
M
Beef,
liver
0.050000
1.000
1.000
21000491
M
Beef,
liver­
babyfood
0.050000
1.000
1.000
23001700
M
Goat,
meat
byproducts
0.050000
1.000
1.000
23001720
M
Goat,
kidney
0.050000
1.000
1.000
23001730
M
Goat,
liver
0.050000
1.000
1.000
95002630
O
Peanut
0.050000
1.000
1.000
95002640
O
Peanut,
butter
0.050000
1.000
1.000
95002650
O
Peanut,
oil
0.050000
0.720
1.000
95002750
O
Peppermint
0.200000
1.000
1.000
95002760
O
Peppermint,
oil
0.200000
1.000
1.000
25002920
M
Pork,
meat
byproducts
0.050000
1.000
1.000
25002921
M
Pork,
meat
byproducts­
babyfood
0.050000
1.000
1.000
25002940
M
Pork,
kidney
0.050000
1.000
1.000
25002950
M
Pork,
liver
0.050000
1.000
1.000
26003400
M
Sheep,
meat
byproducts
0.050000
1.000
1.000
26003420
M
Sheep,
kidney
0.050000
1.000
1.000
26003430
M
Sheep,
liver
0.050000
1.000
1.000
06003470
6
Soybean,
seed
0.500000
1.000
1.000
06003480
6
Soybean,
flour
0.500000
1.000
1.000
06003481
6
Soybean,
flour­
babyfood
0.500000
1.000
1.000
06003490
6
Soybean,
soy
milk
0.500000
1.000
1.000
06003491
6
Soybean,
soy
milk­
babyfood
or
in
0.500000
1.000
1.000
06003500
6
Soybean,
oil
0.500000
1.000
1.000
06003501
6
Soybean,
oil­
babyfood
0.500000
1.000
1.000
95003520
O
Spearmint
0.200000
1.000
1.000
95003530
O
Spearmint,
oil
0.200000
1.000
1.000
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
10
of
13
Attachment
2.
Acute
DEEM­
FCID
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
1.33
DEEM­
FCID
ACUTE
Analysis
for
24DB
(
1994­
98
data)
Residue
file:
24db.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date:
02­
18­
2004/
16:
27:
08
Residue
file
dated:
02­
18­
2004/
16:
24:
46/
8
Daily
totals
for
food
and
foodform
consumption
used.
Run
Comment:
""
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
Females
13­
49
yrs:
0.000467
0.08
0.000769
0.13
0.002699
0.45
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
11
of
13
Attachment
3.
Chronic
DEEM­
FCID
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
1.30
DEEM­
FCID
Chronic
analysis
for
24DB
(
1994­
98
data)
Residue
file
name:
C:\$
MyFiles\
24db.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
02­
18­
2004/
16:
25:
47
Residue
file
dated:
02­
18­
2004/
16:
24:
46/
8
Reference
dose
(
RfD,
Chronic)
=
.03
mg/
kg
bw/
day
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000242
0.8%

U.
S.
Population
(
spring
season)
0.000243
0.8%
U.
S.
Population
(
summer
season)
0.000236
0.8%
U.
S.
Population
(
autumn
season)
0.000243
0.8%
U.
S.
Population
(
winter
season)
0.000246
0.8%

Northeast
region
0.000223
0.7%
Midwest
region
0.000250
0.8%
Southern
region
0.000238
0.8%
Western
region
0.000255
0.9%

Hispanics
0.000244
0.8%
Non­
hispanic
whites
0.000234
0.8%
Non­
hispanic
blacks
0.000259
0.9%
Non­
hisp/
non­
white/
non­
black
0.000314
1.0%

All
infants
(<
1
year)
0.000661
2.2%
Nursing
infants
0.000210
0.7%
Non­
nursing
infants
0.000833
2.8%
Children
1­
6
yrs
0.000525
1.8%
Children
7­
12
yrs
0.000359
1.2%

Females
13­
19
(
not
preg
or
nursing)
0.000208
0.7%
Females
20+
(
not
preg
or
nursing)
0.000164
0.5%
Females
13­
50
yrs
0.000196
0.7%
Females
13+
(
preg/
not
nursing)
0.000221
0.7%
Females
13+
(
nursing)
0.000219
0.7%

Males
13­
19
yrs
0.000267
0.9%
Males
20+
yrs
0.000198
0.7%
Seniors
55+
0.000149
0.5%

Children
1­
2
yrs
0.000548
1.8%
Children
3­
5
yrs
0.000535
1.8%
Children
6­
12
yrs
0.000373
1.2%
Youth
13­
19
yrs
0.000238
0.8%
Adults
20­
49
yrs
0.000197
0.7%
Adults
50+
yrs
0.000153
0.5%
Females
13­
49
yrs
0.000185
0.6%

Attachment
4.
Lifeline
Residue
File
CROPGROUP
RACCODE
RESIDUE
Processing
Factor
%
Crop
Treated
Beef
meat
by­
products
0.050000
1.000000
1.000000
Beef
meat
by­
products
­
babyfood
0.050000
1.000000
1.000000
Beef
kidney
0.050000
1.000000
1.000000
Beef
liver
0.050000
1.000000
1.000000
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
12
of
13
Beef
liver­
babyfood
0.050000
1.000000
1.000000
Goat
All
0.050000
1.000000
1.000000
Pork
meat
byproducts
0.050000
1.000000
1.000000
Pork
meat
byproducts­
babyfood
0.050000
1.000000
1.000000
Pork
kidney
0.050000
1.000000
1.000000
Pork
liver
0.050000
1.000000
1.000000
Sheep
meat
byproducts
0.050000
1.000000
1.000000
Sheep
kidney
0.050000
1.000000
1.000000
Sheep
liver
0.050000
1.000000
1.000000
Soybean
flour
0.500000
1.000000
1.000000
Soybean
flour­
babyfood
0.500000
1.000000
1.000000
Soybean
soy
milk
0.500000
1.000000
1.000000
Soybean
soy
milk
­
babyfood
0.500000
1.000000
1.000000
Soybean
oil
0.500000
1.000000
1.000000
Soybean
oil­
babyfood
0.500000
1.000000
1.000000
Soybean
seed
0.500000
1.000000
1.000000
Peanut
0.050000
1.000000
1.000000
Peanut
butter
0.050000
1.000000
1.000000
Peanut
oil
0.050000
0.72
1.000000
Peppermint
0.200000
1.000000
1.000000
Peppermint
oil
0.200000
1.000000
1.000000
Spearmint
0.200000
1.000000
1.000000
Spearmint
oil
0.200000
1.000000
1.000000
2,4­
DB
Dietary
Exposure
Assessment
DP
Barcode:
D291221
PC
Code:
030801,
030819
Page:
13
of
13
Attachment
5.
Lifeline
Acute
and
Chronic
Results
Acute
age_
group
P_
95
aPad_
95
P_
99
aPad_
99
P_
99_
9
aPad_
999
Females
13­
49
years
old
0.000614
0.10238
0.001022
0.170392
0.002478
0.41296
Chronic
age_
group
mean
cPAD_
mean
General
U.
S.
Population
0.000231793
0.772643298
All
Infants
(<
1
year
old)
0.000554062
1.846872075
Children
1­
2
years
old
0.000539485
1.798283983
Children
3­
5
years
old
0.000504561
1.681868922
Children
6­
12
years
old
0.000346067
1.153556182
Youth
13­
19
years
old
0.000224081
0.746937668
Adults
20­
49
years
old
0.000197946
0.659820733
Adults
50+
years
old
0.000190502
0.635005496
Females
13­
49
years
old
0.000228173
0.760577786
