UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
July
21st,
2004
MEMORANDUM:

SUBJECT:
Revised
Reregistration
Eligibility
Decision
Document
(
RED)
of
Pentachloronitrobenzene
(
PCNB,
PC
Code
056502):
Product
and
Residue
Chemistry
Considerations.
Reregistration
Case
0128.
DP
Barcode.
D305653.
MRID
No.
None.

FROM:
Mohsen
Sahafeyan,
Residue
Chemist
Kenneth
W.
Dockter,
Product
Chemist
Reregistration
Branch
2
Health
Effects
Division
(
7509C)

THROUGH:
Alan
Nielsen,
Branch
Senior
Scientist
Reregistration
Branch
2
Health
Effects
Division
(
7509C)

TO:
Jill
Bloom,
CRM
Reregistration
Branch
2
Special
Review
and
Reregistration
Division
(
7508C)

Attached
are
the
product
chemistry
and
residue
chemistry
considerations
for
the
tolerance
reassessment
of
the
fungicide,
pentachloronitrobenzene
(
PCNB).
The
chapters
were
assembled
by
Dynamac
Corporation
under
supervision
of
HED.
The
data
assessment
has
undergone
secondary
review
in
the
branch
and
has
been
revised
to
reflect
branch
policies.

EXECUTIVE
SUMMARY:

Several
product
chemistry
data
requirements
remain
outstanding.


All
labels
should
restrict
use
on
collards,
kale,
mustard
greens
to
the
state
of
GA.


All
the
current
tolerance
expressions
which
include
PCNB
per
se
should
be
changed
to
include
PCNB,
PCA,
and
PCTA.


Tolerances
listed
under
§
180.319
should
be
reassigned
to
§
180.291(
a)
as
timelimited
or
permanent
tolerances.


All
labels
must
specify
that
the
treated
crops
can
only
be
rotated
to
the
registered
crops.


Field
accumulation
in
rotational
crop
studies
on
registered
crops
are
required.


Additional
residue
data
are
required
for
cotton
gin
byproducts,
seed
treated
crops,
soybean
(
forage,
hay,
seeds),
wheat(
forage,
hay,
straw,
grain),
peppers,
tomatoes,
peanuts,
potatoes,
garlic,
beans,
cottonseed
and
broccoli.


Development
of
a
radiolabeled
common
moiety
method
for
plants
and
animal
commodities
is
recommended.


An
enforcement
method
for
animal
commodities
is
required.


New
/
additional
data
on
plant
and
animal
metabolism
studies
are
required.


Tolerances
on
livestock
commodities
must
be
established.


Residue
data
for
ginseng
should
be
generated
in
the
representative
countries
and
tolerance
should
be
proposed.


Analytical
reference
standards
for
PCNB,
and
metabolites
must
be
supplied
as
requested
by
the
EPA
National
Pesticide
Standards
Repository.

cc
:
Chem
F,
M.
Sahafeyan,
K.
Dockter,
D.
Locke
RDI:
ChemSAC:
5/
5/
04;
A.
Nielsen
:
5/
13/
04
M.
Sahafeyan,
Rm.
712D
CM2,
305­
6872,
mail
code
7509C
K.
Dockter,
Rm.
712G,
CM2,
305­
7886,
mail
code
7509C
2
Cl
Cl
Cl
Cl
Cl
NO
2
PENTACHLORONITROBENZENE
(
PCNB)

REREGISTRATION
ELIGIBILITY
DECISION:

PRODUCT
CHEMISTRY
CONSIDERATIONS
PC
Code
056502;
Case
No.
0128
DP
Barcode
D266923
DESCRIPTION
OF
CHEMICAL
PCNB
[
pentachloronitrobenzene]
is
a
soil
fungicide
registered
for
use
on
beans,
Brassica
vegetables,
cotton,
garlic,
peppers,
peanuts,
potatoes
and
tomatoes.

Empirical
Formula:
C
6
Cl
5
NO
2
Molecular
Weight:
295.3
CAS
Registry
No.:
82­
68­
8
PC
Code:
056502
IDENTIFICATION
OF
ACTIVE
INGREDIENT
PCNB
is
a
white
to
off­
white
crystalline
solid
with
a
melting
point
of
141­
146
C,
density
of
1.72
g/
cc,
octanol/
water
partition
coefficient
(
log
P
ow)
of
5.0,
and
vapor
pressure
of
5
x
10­
5
mm
Hg
at
20
C.
PCNB
is
practically
insoluble
in
water
(
0.44
mg/
L
at
20
C),
and
is
soluble
in
ethanol
(
2
g/
100
mL),
dichloroethane
(
20%
w/
w),
and
toluene
(
50%
w/
w).
PCNB
is
generally
soluble
in
carbon
disulfide,
benzene,
chloroform,
ketones,
and
aromatic
and
chlorinated
hydrocarbons.

MANUFACTURING­
USE
PRODUCTS
According
to
a
search
of
the
Reference
Files
System
(
REFS)
conducted
2/
8/
01,
there
are
seven
manufacturing­
use
products
(
MPs)
registered
under
PC
Code
056502;
these
are
presented
in
Table
1.
[
Note,
these
products
were
confirmed
to
still
be
active
as
of
8/
23/
02.
No
new
actions
are
pending;
personal
communication
M.
Waller
8/
23/
02]
The
seven
registered
PCNB
MPs
are
4
subject
to
a
reregistration
eligibility
decision.

Table
1.
Registered
PCNB
manufacturing­
use
products.

Formulation
EPA
Reg.
No.
Registrant
99.7%
T
400­
401
Uniroyal
Chemical
Company,
Inc.
96.2%
T
400­
504
1
99.4%
T
400­
459
2
90%
FI
400­
414
96.2%
T
5481­
197
Amvac
Chemical
Corporation
80%
FI
5481­
438
80%
FI
7501­
45
Gustafson,
Inc.

1
Repackaged
from
an
EPA­
registered
product;
registered
9/
00.
2
Transferred
from
Quimica
Organica
de
Mexico
(
EPA
Reg.
No.
10820­
1)
on
8/
12/
94.

REGULATORY
BACKGROUND
The
PCNB
Reregistration
Standard
was
issued
6/
30/
86
and
required
additional
product
chemistry
data
concerning
PCNB.
The
PCNB
Guidance
Document
dated
1/
87
required
that
all
new
product
chemistry
data
be
submitted
for
the
reregistration
of
PCNB
because
new
requirements
had
been
introduced
and
previously
submitted
data
needed
to
be
updated.
Data
submitted
in
response
to
the
Guidance
Document
for
the
MPs
were
evaluated
in
Agency
reviews
and
in
the
PCNB
Reregistration
Standard
Update
dated
6/
19/
90
with
regard
to
adequacy
in
fulfilling
product
chemistry
requirements.
The
PCNB
Update
summarized
the
available
product
chemistry
database
and
required
additional
data
for
the
Uniroyal,
Amvac,
and
Gustafson
PCNB
MPs.

Additional
data
were
required
for
PCNB
concerning
potential
impurities
of
concern,
including
chlorinated
dibenzofurans/
dibenzodioxins
and
hexachlorobenzene
(
HCB).
The
available
dioxin
data
indicate
that
dioxins
are
not
expected
to
form
in
technical
PCNB
at
levels
at
or
above
the
EPA­
specified
Limits
of
Quantitation
[
LOQs].
In
conjunction
with
an
Rebuttable
Presumption
Against
Registration
[
RPAR]
Termination
Notice
dated
3/
23/
82,
the
Guidance
Document
required
that
the
registrants
submit
annual
progress
reports
summarizing
efforts
to
implement
measures
to
reduce
levels
of
HCB
in
the
TGAI
to
<
0.1%.
Subsequent
to
the
Guidance
Document,
the
manufacturing
processes
for
the
technical
PCNB
products
were
refined
to
maintain
HCB
levels
at
less
than
0.1%;
quality
control
measures
were
also
initiated
to
monitor
HCB
levels.

The
current
status
of
the
product
chemistry
data
requirements
for
the
PCNB
MPs
is
presented
in
the
attached
data
summary
tables.
Refer
to
these
tables
for
a
listing
of
the
outstanding
product
chemistry
data
requirements.
5
CONCLUSIONS
Most
pertinent
product
chemistry
data
requirements
have
been
satisfied
for
the
Uniroyal
99.7%
and
Amvac
95%
T/
TGAIs.
Additional
data
are
required
concerning
UV/
visible
absorption
(
OPPTS
830.7050)
for
both
technical
products,
and
additional
data
are
required
for
the
Amvac
95%
T
only
concerning
preliminary
analysis
(
OPPTS
830.1700).
The
Uniroyal
96.2%
T
(
EPA
Reg.
No.
400­
504)
is
repackaged
from
an
EPA­
registered
product;
therefore,
all
product
chemistry
data
requirements
for
this
product
will
be
satisfied
by
data
for
the
source
product.
Additional
data
are
required
for
the
Uniroyal
96%
T
concerning
description
of
the
production
process,
oxidation/
reduction,
explodability,
storage
stability,
corrosion
characteristics,
and
UV/
visible
absorption
(
OPPTS
830.1620,
6314,
6316,
6317,
6320,
and
7050).
TGAI
data
requirements
for
the
Uniroyal,
Amvac,
and
Gustafson
FIs
will
be
fulfilled
by
data
for
the
technical
source
products;
however,
the
following
product­
specific
data
are
required:
(
i)
for
the
Uniroyal
90%
FI,
all
product­
specific
data
are
outstanding
except
for
description
of
materials
used
to
produce
the
product
and
the
formulation
process
and
discussion
of
formation
of
impurities
(
OPPTS
830.1600,
1650,
and
1670);
(
ii)
for
the
Amvac
80%
FI,
data
concerning
certified
limits,
color,
physical
state,
odor,
and
storage
stability
(
OPPTS
830.6302,
6303,
6304,
and
6317);
and
(
iii)
for
the
Gustafson
80%
FI,
data
concerning
enforcement
methods,
color,
physical
state,
odor,
oxidation/
reduction,
explodability,
storage
stability,
corrosion
characteristics,
pH,
and
density
(
OPPTS
830.1800,
6302,
6303,
6304,
6314,
6316,
6317,
6320,
7000,
and
7300).
Provided
that
the
registrants
submit
the
data
required
in
the
attached
data
summary
tables
for
the
PCNB
T/
TGAIs,
and
either
certify
that
the
suppliers
of
beginning
materials
and
the
manufacturing
processes
have
not
changed
since
the
last
comprehensive
product
chemistry
reviews
or
submit
complete
updated
product
chemistry
data
packages,
the
Agency
has
no
objections
to
the
reregistration
of
PCNB
with
respect
to
product
chemistry
data
requirements.
6
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Uniroyal
Chemical
Company,
Inc.
Product(
s):
99.7%
T
(
EPA
Reg.
No.
400­
401)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
CSF
4/
19/
88,
41355401
3,
42890401
4,
CSF
12/
22/
94
5
830.1600
Description
of
materials
used
to
produce
the
product
Y
41355401
3,
42890401
4
830.1620
Description
of
production
process
Y
41355401
3,
42890401
4
830.1670
Discussion
of
formation
of
impurities
Y
41355401
3
830.1700
Preliminary
analysis
Y
41355402
3,
42890401
4
830.1750
Certified
limits
Y
CSF
4/
19/
88,
41355402
3,
42890402
4,
CSF
12/
22/
94
5
830.1800
Enforcement
analytical
method
Y
40506101,
41355402
3,
42890403
4
830.6302
Color
Y
41355403
3
830.6303
Physical
state
Y
41355403
3
830.6304
Odor
Y
41355403
3
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
Y
41355403
3
830.6314
Oxidation/
reduction:
chemical
incompatibility
Y
41355403
3
830.6315
Flammability
N/
A
6
41355403
3
830.6316
Explodability
Y
41355403
3
830.6317
Storage
stability
Y
41355403
3
830.6319
Miscibility
N/
A
6
830.6320
Corrosion
characteristics
Y
41355403
3
830.7000
pH
Y
41355403
3
830.7050
UV/
Visible
absorption
N
7
830.7100
Viscosity
N/
A
6
830.7200
Melting
point/
melting
range
Y
41355403
3
830.7220
Boiling
point/
boiling
range
N/
A
6
830.7300
Density/
relative
density/
bulk
density
Y
41355403
3,
42890404
4
830.7370
Dissociation
constants
in
water
N/
A
8
41355403
3
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
41355403
3,
42890404
4,
40609603
4,
9
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
Y
41355403
3,
42890404
4
830.7950
Vapor
pressure
Y
41355403
3,
42890404
4
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
We
note
that
the
data
cited
above
were
initially
submitted
in
support
of
an
alternate
formulation
source;
based
on
the
current
CSF,
this
source
is
now
the
basic
and
only
source
product
for
the
99.7%
T.

2
Bolded
references
were
reviewed
in
the
PCNB
Reregistration
Standard
Update
dated
6/
19/
90;
and
all
other
references
were
reviewed
as
noted.
7
3
DEB
No.
6290,
2/
15/
90,
S.
Funk.
We
note
that
although
Amvac
was
identified
as
the
registrant
in
the
review
document,
the
data
reviewed
pertain
to
the
Uniroyal
registration.

4
RD
Memorandum
D194583,
9/
16/
93,
A.
Smith.

5
RD
Memorandum
D239579,
10/
27/
97,
A.
Smith
reviewed
the
label
claim
in
connection
with
the
CSF;
the
CSF
dated
12/
22/
94
was
obtained
from
the
product
jacket.

6
Data
are
not
required
because
the
TGAI/
MP
is
a
solid
at
room
temperature.

7
The
OPPTS
Series
830,
Product
Properties
Test
Guidelines
require
data
pertaining
to
UV/
visible
absorption
for
the
PAI.

8
Data
are
not
required
because
PCNB
does
not
dissociate
in
water.

9
RCB
No.
3880,
8/
19/
88,
N.
Gray.
8
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Uniroyal
Chemical
Company,
Inc.
Product(
s):
96.2%
T
(
EPA
Reg.
No.
400­
504)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
3
CSF
7/
20/
00
830.1600
Description
of
materials
used
to
produce
the
product
N/
A
830.1620
Description
of
production
process
N/
A
830.1670
Discussion
of
formation
of
impurities
N/
A
830.1700
Preliminary
analysis
N/
A
830.1750
Certified
limits
Y
3
CSF
7/
20/
00
830.1800
Enforcement
analytical
method
N/
A
830.6302
Color
N/
A
830.6303
Physical
state
N/
A
830.6304
Odor
N/
A
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N/
A
830.6314
Oxidation/
reduction:
chemical
incompatibility
N/
A
830.6315
Flammability
N/
A
830.6316
Explodability
N/
A
830.6317
Storage
stability
N/
A
830.6319
Miscibility
N/
A
830.6320
Corrosion
characteristics
N/
A
830.7000
pH
N/
A
830.7050
UV/
Visible
absorption
N/
A
830.7100
Viscosity
N/
A
830.7200
Melting
point/
melting
range
N/
A
830.7220
Boiling
point/
boiling
range
N/
A
830.7300
Density/
relative
density/
bulk
density
N/
A
830.7370
Dissociation
constants
in
water
N/
A
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
830.7950
Vapor
pressure
N/
A
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
96.2%
T
is
repackaged
from
an
EPA­
registered
product;
therefore,
all
product
chemistry
data
requirements
will
be
fulfilled
by
data
for
the
source
product.

2
The
CSF
was
obtained
from
the
product
jacket.

3
We
note
that,
although
the
product
is
100%
repackaged
from
an
EPA­
registered
product,
the
nominal
concentration
and
certified
limits
on
the
CSF
should
reflect
the
actual
levels
of
the
ai
in
the
product.
9
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Uniroyal
Chemical
Company,
Inc.
Product(
s):
99.4%
T
(
EPA
Reg.
No.
400­
459)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
3
40609601,
40609602
830.1600
Description
of
materials
used
to
produce
the
product
Y
40609601,
40609602
830.1620
Description
of
production
process
N
4
40609601,
40609602
830.1670
Discussion
of
formation
of
impurities
Y
40609601,
40609602
830.1700
Preliminary
analysis
Y
40609601,
40609602
830.1750
Certified
limits
Y
3
40609601,
40609602
830.1800
Enforcement
analytical
method
Y
40609602
830.6302
Color
Y
40609603
830.6303
Physical
state
Y
40609603
830.6304
Odor
Y
40609603
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
Y
40609603
830.6314
Oxidation/
reduction:
chemical
incompatability
N
830.6315
Flammability
N/
A
5
830.6316
Explodability
N
830.6317
Storage
stability
N
830.6319
Miscibility
N/
A
5
830.6320
Corrosion
characteristics
N
830.7000
pH
Y
40609603
830.7050
UV/
Visible
absorption
N
6
830.7100
Viscosity
N/
A
5
830.7200
Melting
point/
melting
range
Y
40609603
830.7220
Boiling
point/
boiling
range
N/
A
5
830.7300
Density/
relative
density/
bulk
density
Y
40609603
830.7370
Dissociation
constants
in
water
N/
A
7
40609603
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
40609603
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
Y
40609603
830.7950
Vapor
pressure
Y
40609603
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
Uniroyal
96%
T
was
transferred
from
Quimica
Organica
de
Mexico
(
EPA
Reg.
No.
10820­
1;
8/
12/
94),
and
the
data
cited
above
are
based
on
data
submitted
by
Quimica.
The
registrant
must
confirm
that
the
manufacturing
site
and
process
have
not
changed
since
the
product
transfer;
otherwise
additional
product
chemistry
data
will
be
required.

2
All
references
were
reviewed
under
RCB
No.
3880,
8/
19/
88,
N.
Gray.

3
The
current
CSF
dated
5/
29/
88
must
be
revised
to
reflect
the
product
transfer,
including
the
current
registrant,
registration
number,
and
production
site.
In
addition,
we
note
that
the
label
claim
must
be
revised
as
required
10
under
PR
Notice
91­
2
to
reflect
the
nominal
concentration
of
the
active
ingredient
in
the
product
(
99.4%).

4
Because
a
purer
TGAI
is
being
produced
which
contains

0.1%
HCB,
an
explanation
is
required
regarding
any
changes
that
have
been
made
in
the
manufacturing
process
for
crude
PCNB
since
the
original
submissions
(
1983
and
1985).

5
Data
are
not
required
because
the
TGAI/
MP
is
a
solid
at
room
temperature.

6
The
OPPTS
Series
830,
Product
Properties
Test
Guidelines
require
data
pertaining
to
UV/
visible
absorption
for
the
PAI.

7
Data
are
not
required
because
PCNB
does
not
dissociate
in
water.
11
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Uniroyal
Chemical
Company,
Inc.
Product(
s):
90%
FI
(
EPA
Reg.
No.
400­
414)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
N
3
40287901,
40506101,
CSF
11/
29/
89
4
830.1600
Description
of
materials
used
to
produce
the
product
Y
40287901
830.1650
Description
of
formulation
process
Y
40287901
830.1670
Discussion
of
formation
of
impurities
Y
40287901
830.1700
Preliminary
analysis
N/
A
5
40506101
830.1750
Certified
limits
N
3
40506101,
CSF
11/
29/
89
4
830.1800
Enforcement
analytical
method
N
6
40506101
830.6302
Color
N
830.6303
Physical
state
N
830.6304
Odor
N
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N/
A
5
830.6314
Oxidation/
reduction:
chemical
incompatibility
N
830.6315
Flammability
N
830.6316
Explodability
N
830.6317
Storage
stability
N
830.6319
Miscibility
N
830.6320
Corrosion
characteristics
N
830.7000
pH
N
830.7050
UV/
Visible
absorption
N/
A
5
830.7100
Viscosity
N
830.7200
Melting
point/
melting
range
N/
A
5
830.7220
Boiling
point/
boiling
range
N/
A
5
830.7300
Density/
relative
density/
bulk
density
N
830.7370
Dissociation
constants
in
water
N/
A
5
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
5
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
5
830.7950
Vapor
pressure
N/
A
5
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
90%
FI
is
manufactured
from
EPA­
registered
products.

2
Bolded
references
were
reviewed
in
the
PCNB
Reregistration
Standard
Update
dated
6/
19/
90;
and
all
other
references
were
reviewed
as
noted.

3
The
CSF
must
be
revised
to
indicate
that
the
product
contains
HCB
at
0.05%
or
less.
In
addition
the
technical
sources
listed
on
the
CSF
must
be
amended
because
one
of
the
products
has
been
transferred.
12
4
RD
Letter
dated
7/
27/
00,
from
M.
Waller,
RD,
to
B.
Katzman.

5
TGAI
data
requirements
will
be
fulfilled
by
data
for
the
technical
source
products.

6
Supporting
validation
data
generated
using
the
90%
FI
are
required
for
the
enforcement
methods.
13
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Amvac
Chemical
Corporation
Product(
s):
96.2%
T
(
EPA
Reg.
No.
5481­
197)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
3
40668601,
40668602
4,
CSF
2/
12/
98
5
830.1600
Description
of
materials
used
to
produce
the
product
Y
40668601
830.1620
Description
of
production
process
Y
40668601
830.1670
Discussion
of
formation
of
impurities
Y
40668601
830.1700
Preliminary
analysis
N
6
40668602
4
830.1750
Certified
limits
Y
40668602
4,
CSF
2/
12/
98
5
830.1800
Enforcement
analytical
method
Y
40668602
4
830.6302
Color
Y
40668602,
41795702
4
830.6303
Physical
state
Y
40668602,
41795702
4
830.6304
Odor
Y
40668602,
41795702
4
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
Y
40668602,
41795702
4
830.6314
Oxidation/
reduction:
chemical
incompatibility
N
830.6315
Flammability
N/
A7
830.6316
Explodability
N
830.6317
Storage
stability
N
830.6319
Miscibility
N/
A
7
830.6320
Corrosion
characteristics
N
830.7000
pH
Y
40668602,
41795702
4
830.7050
UV/
Visible
absorption
N
8
830.7100
Viscosity
N/
A7
830.7200
Melting
point/
melting
range
Y
40668602,
41795702
4
830.7220
Boiling
point/
boiling
range
N/
A
7
830.7300
Density/
relative
density/
bulk
density
Y
40668602,
41795702
4
830.7370
Dissociation
constants
in
water
N/
A
9
40668602,
41795702
4
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
40668602,
41795702
4
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
Y
40668602,
41795702
4
830.7950
Vapor
pressure
Y
40668602,
41795702
4
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.

2
Bolded
references
were
reviewed
in
the
PCNB
Reregistration
Standard
Update
dated
6/
19/
90;
and
all
other
references
were
reviewed
as
noted.

3
The
label
claim
reflects
the
lower
certified
limit.
As
required
under
PR
Notice
91­
2,
the
registrant
must
revise
the
label
claim
to
reflect
the
nominal
concentration
of
96.2%.
14
4
RD
Memorandum,
8/
21/
91,
H.
Roldan.
We
note
that
this
memorandum
reviewed
MRID
40668602,
which
was
previously
reviewed
in
the
Update,
and
reviewed
MRID
41795702
for
physical/
chemical
characteristics.

5
RD
Memorandum
D252703,
1/
11/
99,
S.
Mathur.

6
Additional
data
are
required
reflecting
analysis
of
five
current
batches
of
the
PCNB
TGAI
to
confirm
the
levels
of
two
impurities
in
current
production
lots.

7
Data
are
not
required
because
the
T/
TGAI
is
a
solid
at
room
temperature.

8
The
OPPTS
Series
830,
Product
Properties
Test
Guidelines
require
data
pertaining
to
UV/
visible
absorption
for
the
PAI.

9
Data
are
not
required
because
PCNB
does
not
dissociate
in
water.
15
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Amvac
Chemical
Corporation
Product(
s):
80%
FI
(
EPA
Reg.
No.
5481­
438)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
42232401,
CSF
1/
10/
92
830.1600
Description
of
materials
used
to
produce
the
product
Y
42232401
830.1650
Description
of
formulation
process
Y
42232401
830.1670
Discussion
of
formation
of
impurities
Y
42232401
830.1700
Preliminary
analysis
N/
A
3
830.1750
Certified
limits
N
4
42232401,
CSF
1/
10/
92
830.1800
Enforcement
analytical
method
Y
42232401
830.6302
Color
N
5
42232401
830.6303
Physical
state
N
5
42232401
830.6304
Odor
N
5
42232401
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
830.6314
Oxidation/
reduction:
chemical
incompatibility
Y
42232401
830.6315
Flammability
N/
A
6
830.6316
Explodability
Y
42232401
830.6317
Storage
stability
N
5
42232401
830.6319
Miscibility
N/
A
6
830.6320
Corrosion
characteristics
Y
42232401
830.7000
pH
Y
42232401
830.7050
UV/
Visible
absorption
N/
A
3
830.7100
Viscosity
N/
A
6
830.7200
Melting
point/
melting
range
N/
A
3
830.7220
Boiling
point/
boiling
range
N/
A
3
830.7300
Density/
relative
density/
bulk
density
N
5
42232401
830.7370
Dissociation
constants
in
water
N/
A
3
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
3
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
3
830.7950
Vapor
pressure
N/
A
3
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
80%
FI
is
manufactured
from
an
EPA­
registered
product.

2
All
references
were
reviewed
under
RD
Memorandum
D1782827,
dated
6/
12/
92,
A.
Smith.

3
TGAI
data
requirements
will
be
fulfilled
by
data
for
the
technical
source
product.

4
Lower
certified
limits
must
be
proposed
for
the
inert
ingredients.
16
5
Data
referenced
by
the
registrant
were
for
the
technical
source
product
and
do
not
apply
to
product­
specific
requirements
for
the
FI.

6
Data
are
not
required
because
the
MP
is
a
solid
at
room
temperature.
17
Case
No.
0128
PC
Code
056502
Case
Name:
PCNB
Registrant:
Gustafson,
Inc.
Product(
s):
80%
FI
(
EPA
Reg.
No.
7501­
45)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
42624201,
Letter
9/
14/
93
3,
CSF
6/
23/
97
4
830.1600
Description
of
materials
used
to
produce
the
product
Y
42624201,
Letter
9/
14/
93
3
830.1650
Description
of
formulation
process
Y
42624201,
Letter
9/
14/
93
3
830.1670
Discussion
of
formation
of
impurities
Y
42624201
830.1700
Preliminary
analysis
N/
A
5
830.1750
Certified
limits
Y
42624201,
CSF
6/
23/
97
4
830.1800
Enforcement
analytical
method
N
6
42624201,
Letter
9/
14/
93
3
830.6302
Color
N
830.6303
Physical
state
N
830.6304
Odor
N
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N/
A
5
830.6314
Oxidation/
reduction:
chemical
incompatibility
N
830.6315
Flammability
N/
A
7
830.6316
Explodability
N
830.6317
Storage
stability
N
830.6319
Miscibility
N/
A
7
830.6320
Corrosion
characteristics
N
830.7000
pH
N
830.7050
UV/
Visible
absorption
N/
A
5
830.7100
Viscosity
N/
A
7
830.7200
Melting
point/
melting
range
N/
A
5
830.7220
Boiling
point/
boiling
range
N/
A
5
830.7300
Density/
relative
density/
bulk
density
N
830.7370
Dissociation
constants
in
water
N/
A
5
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
5
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
5
830.7950
Vapor
pressure
N/
A
5
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
80%
FI
is
manufactured
from
an
EPA­
registered
product.

2
All
references
were
reviewed
under
D187966,
4/
23/
93,
D.
McNeilly,
unless
otherwise
noted.

3
D195328,
12/
13/
93,
F.
Toghrol.

4
RD
Memorandum
D237246,
9/
17/
97,
H.
Podall.
18
5
TGAI
data
requirements
will
be
fulfilled
by
data
for
the
technical
source
product.

6
Additional
validation
data
are
required.

7
Data
are
not
required
because
the
MP
is
a
solid
at
room
temperature.
19
AGENCY
MEMORANDA
CITED
IN
THIS
DOCUMENT
CBRS
No(
s).:
3880
Subject:
Product
Chemistry
Data
Submission
on
PCNB.
From:
N.
Gray
To:
L.
Rossi/
H.
Toma
Dated:
8/
19/
88
MRID(
s):
40609601­
40609603
DEB
No(
s).:
6290
Subject:
Product
Chemistry
Data
Submission
on
PCNB
for
Registration
Request.
ID
No.
5481­
URT.
Record
No.
258324.
From:
S.
Funk
To:
S.
Lewis
Dated:
2/
15/
90
MRID(
s):
41355401­
41355403
DP
Barcode:
RD
Memorandum
Subject:
Product
Chemistry
Review
on
Technical
Grade
PCNB
96.2%
EPA
Reg.
No.
5481­
197.
From:
H.
Roldan
To:
S.
Lewis
Dated:
8/
28/
91
MRID(
s):
40668602
and
41795702
DP
Barcode:
RD
MemorandumD178272
Subject:
Product
Chemistry
Review;
EPA
Reg.
No.:
5481­
UGI;
Product
Name:
80%
PCNB
Manufacturing
Concentrate.
From:
A.
Smith
To:
PM
25
Dated:
6/
12/
92
MRID(
s):
42232401
CBRS
No(
s).:
11340
DP
Barcode:
D187966
Subject:
Pentachloronitrobenzene
(
PCNB):
Product
Chemistry
Data
{
Case
818950}.
From:
D.
McNeilly
To:
S.
Cerrelli
Dated:
4/
23/
93
MRID(
s):
42624201
20
DP
Barcode:
RD
Memorandum
D194583
Subject:
Product
Chemistry
Review
of
Pentachloronitrobenzene
Technical
(
EPA
Reg.
No.
400­
401).
From:
A.
Smith
To:
E.
Allen
Dated:
9/
16/
93
MRID(
s):
42890401­
42890404
CBRS
No(
s).:
12606
DP
Barcode:
D195328
Subject:
Pentachloronitrobenzene
(
PCNB)
Reregistration:
List
A
Chemical
No.
056502.
Case
No.
0128.
Gustafson
Response
(
Letter
dated
9/
14/
93)
to
Product
Chemistry
Data
Requirements
(
GLN
61­
1,
61­
2,
and
62­
3)
for
PCNB
80%
FI
(
EPA
Reg.
No.
7501­
45)
From:
F.
Toghrol
To:
L.
Rossi/
L.
Propst
Dated:
12/
13/
93
MRID(
s):
None
DP
Barcode:
RD
Memorandum
D237246
Subject:
Product
Chemistry
Review
of
MP;
EPA
Reg./
File
Symbol
No.:
7501­
45;
Product
Name:
Gustafson
Terraclor
80%
Dust
Concentrate;
Company:
Gustafson,
Inc.
From:
H.
Podall
To:
C.
Welch/
T.
Stowe
Dated:
9/
17/
97
MRID(
s):
None
DP
Barcode:
RD
Memorandum
D239579
Subject:
Product
Chemistry
Review;
EPA
Reg./
File
Symbol
No.:
400­
401;
Product
Name:
Terraclor
Technical;
Company:
Uniroyal
Chemical
Co.,
Inc.
From:
A.
Smith
To:
S.
Gardner­
Jenkins
Dated:
10/
27/
97
MRID(
s):
None
21
DP
Barcode:
RD
Memorandum
D252703
Subject:
Product
Chemistry
Review
of
TGAI;
EPA
Reg./
File
Symbol
No.:
5481­
197;
Product
Name:
Technical
Grade
PCNB
96.2%;
Company:
Amvac
Chemical
Corporation
From:
S.
Mathur
To:
M.
Waller
Dated:
1/
11/
99
MRID(
s):
None
DP
Barcode:
RD
Letter
Subject:
Terraclor
90%
Concentrate;
EPA
Reg.
No.
400­
414;
Your
Letter
Dated
February
24,
2000.
From:
M.
Waller
To:
B.
Katzman,
Uniroyal
Chemical
Company
Dated:
7/
27/
00
MRID(
s):
None
PRODUCT
CHEMISTRY
CITATIONS
Bibliographic
citations
include
only
MRIDs
containing
data
which
fulfill
data
requirements.

References
(
cited):

40287901
Drozdick,
M.
(
1987)
Product
Specific
Data
for
Terraclor
90%
Dust
Concentrate,
Part
1.
Unpublished
compilation
prepared
by
Uniroyal
Chemical
Co.,
Inc.
16
p.

40506101
Drozdick,
M.
(
1988)
Preliminary
Analysis,
Certification
Statement
and
Analytical
Method
for
Terraclor
90%
Dust
Concentrate:
Laboratory
Project
ID:
MDD071687
1
thru
5.
Unpublished
compilation
prepared
by
Uniroyal
Chemical
Co.,
Inc.
10
p.

40609601
Carrilo,
F.;
Mertz,
J.
(
1988)
Terrazan
PCNB
Technical
99%:
Product
Chemistry
Data­­
Product
Identity
and
Composition.
Unpublished
compilation
prepared
by
Quimica
Organica
de
Mexico,
S.
A.
de
C.
V.
in
cooperation
with
Uniroyal
Chemical
Co.,
Inc.
9
p.

40609602
Carrilo,
F.;
Blaszczynski,
E.
(
1988)
Terrazan
PCNB
Technical
99%:
Product
Chemistry
Data­­
Analysis
and
Certification
of
Product
Ingredients:
Project
No.
8825.
Unpublished
compilation
prepared
by
Quimica
Organica
de
Mexico,
S.
A.
de
C.
V.
in
cooperation
with
Uniroyal
Chemical
Co.,
Inc.
22
p.

40609603
Carrilo,
F.;
Batorewicz,
W.;
Woolson,
E.
(
1988)
Terrazan
PCNB
Technical
99%:
Product
Chemistry
Data
­
A
Compilation
of
Physical
and
Chemical
Characteristics:
Project
No.
8817.
Unpublished
study
prepared
by
Quimica
Organica
de
Mexico,
S.
A.
de
C.
V.,
and
Uniroyal
Chemical
Co.,
Inc.
in
cooperation
with
EPL
Bio­
Analytical
Services,
Inc.
17
p.
22
40668601
Feiler,
W.
(
1988)
PCNB:
Product
Identity
and
Composition.
Unpublished
compilation
prepared
by
Amvac
Chemical
Corp.
42
p
40668602
Feiler,
W.
(
1988)
PCNB:
Analysis
and
Certification
of
Product
Ingredients.
Unpublished
study
prepared
by
Amvac
Chemical
Corp.
23
p.

41355401
Yoshioka,
T.
(
1989)
PCNB:
Product
Identity
and
Composition.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.
14
p.

41355402
Yoshioka,
T.
(
1989)
PCNB:
Analysis
and
Certification
of
Product
Ingredients.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.
21
p.

41355403
Yoshioka,
T.
(
1989)
PCNB:
Physical
and
Chemical
Characteristics.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.
5
p.

41795701
Feiler,
W.
(
1991)
PCNB:
Product
Identity
And
Composition.
Unpublished
study
prepared
by
Amvac
Chemical
Corp.
10
p.

41795702
Feiler,
W.
(
1991)
PCNB:
Physical
And
Chemical
Characteristics:
Unpublished
study
prepared
by
Amvac
Chemical
Co.
76
p.

41838101
Braden,
G.;
Feiler,
W.
(
1991)
PCNB:
Analysis
and
Certification
of
Product
Ingredients.
Unpublished
study
prepared
by
Amvac
Chemical
Corp.
25
p.

42232401
McClane,
H.
(
1991)
Product
Specific
Data:
80
Percent
PCNB
Manufacturing
Concentrate:
Lab
Project
Number:
D:
EPA/
AMVAC/
54PCNB80.
Unpublished
study
prepared
by
AmVac
Chemical
Corp.
6
p.

42293601
Feiler,
W.
(
1992)
PCNB:
Product
Identity
and
Composition;
PCNB:
Physical
and
Chemical
Characteristics:
Supplement
to....
Unpublished
study
prepared
by
AMVAC
Chemical
Corp.
16
p.

42624201
Rockwell,
J.
(
1991)
Product
Chemistry
Information;
Terracolor
80%
Dust
Concentrate.
Unpublished
study
prepared
by
Gustafson
Inc.
and
Uniroyal
Chemical
Corp.
10
p.

42890401
Stewart,
R.
(
1993)
PCNB:
Product
Identity
and
Composition:
Supplement
to
MRID
41355401.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.,
c/
o
Technology
Sciences
Group,
Inc.
92
p.

42890402
Stewart,
R.
(
1993)
PCNB:
Analysis
and
Certification
of
Product
Ingredients:
Supplement
to
MRID
41355402.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.,
c/
o
Technology
Sciences
Group
Inc.
13
p.
23
42890403
Stewart,
R.
(
1993)
PCNB:
Analytical
Method
for
Enforcement
of
Limits:
Supplement
to
MRID
41355402.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.
23
p.

42890404
Stewart,
R.
(
1993)
PCNB:
Physical
and
Chemical
Characteristics:
Supplement
to
41355403.
Unpublished
study
prepared
by
Mitsui
Toatsu
Chemicals,
Inc.,
c/
o
Technology
Sciences
Group
Inc.
5
p.
24
PENTACHLORONITROBENZENE
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
056502;
Case
0128
DP
Barcode
D266923
TABLE
OF
CONTENTS
page
INTRODUCTION
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
24
REGULATORY
BACKGROUND
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
24
SUMMARY
OF
SCIENCE
FINDINGS
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
28
OPPTS
GLN
860.1200:
Directions
for
Use
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
28
OPPTS
GLN
860.1300:
Nature
of
the
Residue
in
Plants
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
30
OPPTS
GLN
860.1300:
Nature
of
the
Residue
in
Livestock
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
33
OPPTS
GLN
860.1340:
Residue
Analytical
Methods
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
35
OPPTS
GLN
860.1360:
Multiresidue
Method
Testing
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
36
OPPTS
GLN
860.1380:
Storage
Stability
Data
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
36
OPPTS
GLN
860.1500:
Magnitude
of
the
Residue
in
Crop
Plants
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
36
OPPTS
GLN
860.1520:
Magnitude
of
the
Residue
in
Processed
Food/
Feed
.
.
.
.
.
.
.
.
.
45
OPPTS
GLN
860.1480:
Magnitude
of
the
Residue
in
Meat,
Milk,
Poultry,
and
Eggs
.
.
.
47
OPPTS
GLN
860.1400:
Magnitude
of
the
Residue
in
Water,
Fish,
Irrigated
Crops
.
.
.
.
50
OPPTS
GLN
860.1460:
Magnitude
of
the
Residue
in
Food­
handling
Establishments
.
.
.
51
OPPTS
GLN
860.1650:
Submittal
of
Analytical
Reference
Standards
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
51
OPPTS
GLN
860.1850:
Confined
Accumulation
in
Rotational
Crops
.
.
.
.
.
.
.
.
.
.
.
.
.
.
52
OPPTS
GLN
860.1900:
Field
Accumulation
in
Rotational
Crops
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
52
TOLERANCE
REASSESSMENT
SUMMARY
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
79
Tolerances
Listed
Under
40
CFR
§
180.291(
a):
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
79
Tolerances
Listed
Under
40
CFR
§
180.291(
b):
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
79
Tolerances
Listed
Under
40
CFR
§
180.319:
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
79
Tolerances
Needed
Under
40
CFR
§
180.291(
a)
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
80
DIETARY
EXPOSURE
ASSESSMENT
SUMMARY
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
84
CODEX
HARMONIZATION
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
85
AGENCY
MEMORANDA
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
86
RESIDUE
CHEMISTRY
CITATIONS
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
91
25
NO
2
Cl
Cl
Cl
Cl
Cl
PENTACHLORONITROBENZENE
(
PCNB)

REREGISTRATION
ELIGIBILITY
DOCUMENT
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
056502;
DP
Barcode
D266923
INTRODUCTION
Pentachloronitrobenzene
(
PCNB)
is
an
organochlorine
fungicide
registered
for
direct
field
use
on
beans,
Brassica
vegetables,
cotton,
garlic,
peppers,
peanuts,
potatoes
and
tomatoes,
and
for
use
as
a
seed
treatment
on
a
variety
of
crops.
PCNB
formulations
registered
to
the
basic
producers,
Uniroyal
Chemical
Company
and
Amvac
Chemical
Corporation,
for
use
on
food/
feed
crops
include
flowable
concentrate
(
FlC),
water
dispersible
granular
(
WDG),
wettable
powder
(
WP),
emulsifiable
concentrate
(
EC),
granular
(
G),
dust
(
D),
and
ready­
to­
use
(
RTU)
formulations.
These
products
may
be
applied
as
pre­
plant
incorporated
applications,
in­
furrow
applications,
broadcast
applications,
or
banded
applications
using
ground
equipment
or
as
seed
treatments.
Depending
on
the
producer
and
the
manufacturing
procedure,
PCNB
impurities
can
include
hexachlorobenzene
(
HCB),
pentachlorobenzene
(
PCB)
and
tetrachloronitrobenzene
(
TCNB).

REGULATORY
BACKGROUND
PCNB
is
a
List
A
reregistration
chemical
that
was
the
subject
of
a
Registration
Standard
dated
6/
30/
86
and
a
Reregistration
Standard
Update
dated
6/
19/
90.
These
documents
summarized
regulatory
conclusions
on
the
available
residue
chemistry
data
and
specified
that
additional
data
were
required
for
reregistration
purposes.
Several
submissions
of
data
have
been
received
since
the
Reregistration
Standard
Update
was
issued.
The
information
contained
in
this
document
outlines
the
current
Residue
Chemistry
Science
Assessments
with
respect
to
the
reregistration
of
PCNB.

After
examination
of
the
toxicology
and
chemistry
data
submitted
by
Uniroyal
and
Amvac,
the
Hazard
Identification
Assessment
Review
Committee
(
HIARC,
1992)
concluded
that
the
PCNB
technical
materials
from
both
of
these
registrants
are
so
dissimilar
they
needed
to
be
considered
as
separate
and
distinct
chemicals
based
on
differences
in
impurities
and
contaminants
associated
with
the
different
manufacturing
processes
of
the
two
registrants.
As
these
registrants
could
not
26
share
information,
separate
data
were
required
from
both
registrants
fulfilling
residue
chemistry
data
requirements.

Tolerances
limiting
the
amount
of
the
impurities
hexachlorobenzene
(
HCB)
and
pentachlorobenzene
(
PCB)
have
been
proposed
for
residues
of
PCNB
(
PP#
1F1083,
Amendment
of
1/
83).
Both
registrants,
Amvac
and
Uniroyal,
have
agreed
for
PCNB
formulations
to
reduce
the
maximum
level
of
HCB
to
0.05%,
and
of
PCB
to
0.01%.
The
Agency
has
determined
that
these
limits
will
reduce
dietary
risk
from
HCB
and
PCB
as
impurities
to
negligible
levels
for
PCNB
alone,
pending
a
comprehensive
risk
assessment
for
all
products
containing
HCB
and
PCB
(
Letters,
J.
E.
Housenger,
SRRD
to
J.
K.
Smith,
Amvac,
and
W.
F.
Cummings,
Uniroyal,
10/
4/
94).

In
a
cumulative
risk
assessment
for
HCB
and
PCB
from
all
sources,
HED
concluded
that
the
risk
due
to
these
chemicals
is
below
the
level
of
concern
(
William
Smith,
"
Assessment
of
the
Dietary
Cancer
Risk
of
Hexachlorobenzene
and
Pentachlorobenzene
as
impurities
in
Chlorothalonil,
PCNB,
Picloram,
and
several
other
pesticides.
DP
Barcode
D243499.
Chemical
codes
061001
(
Hexachlorobenzene)
&
081901
(
Chlorothalonil)",
2/
26/
98)

The
Metabolism
Assessment
Review
Committee
(
MARC)
met
on
October
4,
2001
to
determine
if
the
variability
in
the
level
of
active
ingredient
of
PCNB
and
its
contaminants
in
the
Uniroyal
and
Amvac
test
materials
used
for
toxicity
studies
is
significant
enough
to
call
into
question
current
registrations
for
the
Uniroyal
and
Amvac's
PCNB
technical
grade
of
active
ingredients.
The
(
MARC)
could
find
no
evidence
that
the
chemical
composition
(
i.
e.
impurity
levels)
differences
among
the
formulations
tested
in
the
toxicity
studies
affected
the
NOAELS/
LOAELS
and
endpoints
found.
Other
factors
likely
were
greater
contributors
to
the
differences
in
the
side­
byside
toxicity
studies
submitted
by
the
two
registrants.
Furthermore,
it
is
the
MARC's
opinion
that
the
contaminants
at
the
levels
found
in
the
tested
batches
and
the
levels
mandated
by
the
Agency
in
the
12/
94
letter
will
not
bias
the
results
of
the
toxicity
studies.

Permanent
tolerances
for
PCNB
residues
have
been
established
in/
on
plant
raw
agricultural
commodities
(
RACs)
under
40
CFR
§
180.291,
and
"
interim
tolerances"
for
PCNB
residues
have
been
established
under
40
CFR
§
180.319.
A
permanent
tolerance
of
0.1
ppm
for
residues
of
PCNB
per
se
in/
on
cottonseed
has
been
established
[
40
CFR
§
180.291(
a)].
Permanent
tolerances
for
a
regional
registration
have
also
been
established
for
the
combined
residues
of
PCNB
and
its
metabolites,
pentachloroaniline
(
PCA)
and
methyl
pentachlorophenyl
sulfide
(
MPCPS,
also
abbreviated
as
PCTA)
in/
on
collards,
kale
and
mustard
greens
at
0.2
ppm
[
40
CFR
§
180.291(
b)].
"
Interim"
tolerances
for
residues
of
PCNB
per
se
have
also
been
established
at
0.1
ppm
in/
on
beans,
broccoli,
Brussels
sprouts,
cabbage,
cauliflower,
garlic,
peppers,
potatoes
and
tomatoes
and
at
1.0
ppm
in/
on
peanuts
[
40
CFR
§
180.319].

The
MARC
met
on
April
16,
2003
to
determine
the
residues
of
concern
for
tolerance
expression
and
for
risk
assessment.
The
MARC
decided
that
as
all
the
metabolites
of
PCNB
are
polychlorinated
phenyl
compounds
and
thus
of
toxicological
concern,
PCNB
and
all
its
metabolites
(
including
minor
metabolites)
are
of
concern
in
plant
and
animal
commodities;
there
are
currently
more
than
80
identified
metabolites
of
concern.
However,
the
residues
of
concern
for
tolerance
setting
purposes
in
primary
and
rotational
crops
and
livestock
are
PCNB,
PCA,
and
27
PCTA
(
also
abbreviated
as
MPCPS).
The
MARC
also
determined
that
the
residues
of
concern
in
drinking
water
are
PCNB,
PCA,
and
PCP.
(
Sahafeyan,
M.,
"
The
Outcome
of
the
HED
Metabolism
Assessment
Review
Committee
Held
on
April
16th,
2003
to
discuss
residues
of
concern
in
risk
assessment
and
tolerance
expression
of
Pentachloronitrobenzene
(
PCNB)
Chemical
056502",
TXR
no.
0051921,
5/
27/
2003).

The
Food
Quality
Protection
Act
(
FQPA)
of
1996
has
amended
and
strengthened
the
standard
for
establishing
tolerances
under
the
Federal
Food,
Drug,
and
Cosmetic
Act
(
FFDCA).
All
future
tolerance
petitions
as
well
as
reassessment
of
established
tolerances
must
meet
the
requirements
of
the
FFDCA
as
amended
by
the
FQPA.
OPP
may
require
additional
data
to
determine
if
the
terms
of
the
amended
statute
are
met.

The
Agency
updated
the
list
of
raw
agricultural
and
processed
commodities
and
feedstuffs
derived
from
crops
(
Table
1,
OPPTS
860.1000).
As
a
result
of
changes
to
Table
1,
additional
PCNB
residue
data
are
now
required
for
some
commodities
(
e.
g.
cotton
gin
byproducts);
these
data
requirements
have
been
incorporated
into
this
document.
These
new
data
requirements
will
be
imposed
at
the
issuance
of
the
PCNB
RED
but
should
not
impinge
on
the
reregistration
eligibility
decisions
for
PCNB.

A
revised
chronic
dietary
risk
assessment
was
completed
on
March
31st,
2004.
The
results
for
food
alone
(
no
water)
indicates
that
the
chronic
dietary
risk
for
all
population
subgroups
are
below
the
level
of
concern
(
100%
cPAD);
the
highest
risk
was
for
the
population
subgroup
children
1­
2
years
old
at
34%
cPAD.
The
chronic
dietary
risk
for
general
U.
S.
population
was
at
12%
cPAD.
When
water
was
added
to
the
analysis,
%
cPAD
exceeded
100%
for
all
populations
except
youth
13­
19
with
%
cPAD
of
78%
and
adults
20­
49
with
%
cPAD
of
97%;
all
other
population
subgroups
exceeded
the
100%
cPAD
mark
and
thus
are
of
concern.
The
estimated
risk
including
water
for
general
U.
S.
population
is
105%
cPAD
and
the
highest
estimated
risk
is
for
population
subgroup
all
infants
at
313%
cPAD.

A
semi­
quantitative
dietary
risk
assessment
of
PCP
based
on
the
available
information
was
also
estimated
since
PCP
has
a
different
(
carcinogenic)
end
point.
In
this
worst
case
analysis
with
the
assumption
of
potential
residues
of
PCP
in
all
tuber
crops
and
using
the
recently
revised
Q
1*
(
3/
4
scaling
factor)
of
0.07
x
10­
1
mg/
kg­
day,
the
potential
risk
may
be
5
x
10­
8
(
general
population),
which
is
not
of
concern.
28
NO
2
Cl
Cl
Cl
Cl
Cl
NH
2
Cl
Cl
Cl
Cl
Cl
S
CH
3
Cl
Cl
Cl
Cl
Cl
Figure
A.
Chemical
name
and
structure
of
PCNB
and
its
residues
of
concern
for
tolerance
expression.

Common
Name/
Chemical
Name
Chemical
Structure
PCNB
Pentachloronitrobenzene
PCA
Pentachloroaniline
MPCPS
(
PCTA)

Methyl
pentachlorophenyl
sulfide
29
SUMMARY
OF
SCIENCE
FINDINGS
OPPTS
GLN
860.1200:
Directions
for
Use
A
search
of
the
Agency's
Reference
Files
System
(
REFS)
on
2/
8/
01
indicated
that
there
are
a
total
of
28
PCNB
end­
use
products
(
EPs)
with
uses
on
food/
feed
crops
registered
to
Uniroyal
and
Amvac.
These
EPs
are
presented
below
by
registrant.

PCNB
End­
Use
Products
with
Food/
Feed
Uses
Registered
to
Uniroyal
Chemical
Company.

EPA
Reg
No.
Label
Acceptance
Date
Formulation
Class
Product
Name
400­
399a
8/
13/
99
75%
WP
Terraclor
®
Wettable
Powder
400­
400
11/
10/
97
2
lb/
gal
EC
Terraclor
®
2
lb
Emulsifiable
400­
402
8/
13/
99
10%
G
Terraclor
®
10%
Granular
400­
406b
3/
13/
98
10%
G
Terraclor
Super
X
®
Granular
400­
408c
8/
31/
99
6.5%
G
Terraclor
Super
X
®
with
Di­
Syston
®
400­
411d
11/
29/
96
6.5%
G
Terraclor
®
6.5%
plus
Di­
Syston
®
6.5%

400­
412e
1/
2/
97
6.5%
G
Terraclor
®
6.5%
with
Thimet
®
6.5%

400­
453
8/
13/
99
4
lb/
gal
FlC
Terraclor
®
Flowable
Fungicide
400­
455f
6/
1/
95
2
lb/
gal
FlC
Terraclor
Super
X
®
Flowable
400­
456g
8/
24/
99
15%
G
Terraclor
Super
X
®
18.8
Granular
400­
457
12/
30/
99
15%
G
Turfcide
®
15G
Turf
&
Ornamental
Fungicide
400­
458
12/
30/
99
15%
G
Terraclor
®
15%
Granular
400­
460h
8/
15/
1983
24%
EC
Terrazan
24%
Emulsifiable
Concentrate
400­
475i
1/
8/
97
1.5
lb/
gal
EC
Terraclor
Super
X
®
plus
Di­
Syston
®
EC
400­
479
5/
13/
98
75%
WDG
Turfcide
®
WDG
Turf
&
Ornamental
Fungicide
a
Includes
SLN
No.
ME79000100
for
use
on
potatoes.
b
EPA
Reg.
No.
400­
406
is
a
MAI
formulation
that
also
contains
2.5%
5­
Ethoxy­
3­(
trichloromethyl)­
1,2,4­
thiadiazole
and
is
registered
for
use
only
on
cotton;
Uniroyal
has
recently
requested
cancellation
of
this
product
(
FR
Notice
Vol.
66,
44131,
8/
22/
01).
c
EPA
Reg.
No.
400­
408
is
a
MAI
formulation
that
also
contains
1.63%
5­
Ethoxy­
3­(
trichloromethyl)­
1,2,4­
thiadiazole
and
6.5%
disulfoton
and
is
registered
for
use
only
on
cotton.
d
EPA
Reg.
No.
400­
411
is
a
MAI
formulation
that
also
contains
6.5%
disulfoton
and
is
registered
for
use
only
on
cotton.
e
EPA
Reg.
No.
400­
412
is
a
MAI
formulation
that
also
contains
6.5%
phorate
and
is
registered
for
use
only
on
cotton.
f
EPA
Reg.
No.
400­
455
is
a
MAI
formulation
that
also
contains
0.5
lb/
gal
of
5­
Ethoxy­
3­
(
trichloromethyl)­
1,2,4­
thiadiazole
and
is
registered
for
use
only
on
cotton.
g
EPA
Reg.
No.
400­
456
is
a
MAI
formulation
that
also
contains
3.8%
5­
Ethoxy­
3­(
trichloromethyl)­
1,2,4­
thiadiazole
and
is
registered
for
use
only
on
cotton.
h
EPA
Reg.
No.
400­
460
is
registered
for
cotton,
beans,
beans,
beans
(
snap),
beans
(
dry),
and
garlic.
i
EPA
Reg.
No.
400­
475
is
a
MAI
formulation
that
also
contains
0.4
lb/
gal
5­
Ethoxy­
3­(
trichloromethyl)­
1,2,4­
thiadiazole
and
1.5
lb/
gal
disulfoton,
and
is
registered
for
use
only
on
cotton.
30
PCNB
End­
Use
Products
with
Food/
Feed
Uses
Registered
to
Amvac
Chemical
Corporation.

EPA
Reg
No.
Label
Acceptance
Date
Formulation
Class
Product
Name
5481­
211
1/
27/
00
10%
G
PCNB
10%
Granules
Soil
Fungicide
5481­
212a
12/
4/
96
2
lb/
gal
EC
PCNB
2­
E
Liquid
5481­
215
7/
22/
91
1.7
lb/
gal
FlC
PCNB
2LF
Seed
Treatment
Fungicide
5481­
279b
8/
29/
94
75%
WP
PCNB
75%
Wettable
Powder
5481­
308c
2/
23/
94
30%
D
PCNB­
Thiram
30­
30
Seed
Treat
5481­
311d
2/
23/
94
10%
D
PCNB­
Thiram
10­
10
Seed
Treat
5481­
415e
4/
4/
90
6.5%
G
PCNB
Disulfoton
Granules
6.5­
6.5
5481­
441
10/
4/
94
75%
WDG
PCNB
75
DG
5481­
442
10/
12/
94
2
lb/
gal
RTU
PCNB
Flowable
RTU
seed
Protectant
5481­
445
9/
2/
93
1.7
lb/
gal
FlC
PCNB
ST
Liquid
Flowable
Seed
Treatment
Fungicide
5481­
450
11/
2/
94
20%
WDG
PCNB
20%
WDG
Soil
Fungicide
5481­
453
8/
1/
95
75%
WP
PCNB
75
WSP
5481­
471
12/
2/
98
6
lb/
gal
FlC
Win­
Flo
®
6F
Flowable
Soil
Fungicide
5481­
472f
8/
31/
99
4
lb/
gal
FlC
BlockerJ
4F
Flowable
Fungicide
a
Includes
the
SLN
No.
TX90001000
for
use
on
cotton.
b
Includes
the
SLN
No.
TX92002400
for
use
on
cotton.
c
EPA
Reg.
No.
5481­
308
is
a
MAI
formulation
that
also
contains
30%
thiram
and
is
registered
for
use
only
on
cotton.
d
EPA
Reg.
No.
5481­
311
is
a
MAI
formulation
that
also
contains
10%
thiram
and
is
registered
for
use
only
on
cotton.
e
EPA
Reg.
No.
5481­
415
is
a
MAI
formulation
that
also
contains
6.5%
disulfoton
and
is
registered
for
use
only
on
cotton.
f
Includes
the
SLN
Nos.
ID
00000800,
OR00001900,
and
WA00003000
for
use
on
potatoes.

A
comprehensive
summary
of
the
registered
food/
feed
use
patterns
of
PCNB,
based
on
the
product
labels
registered
to
Uniroyal
and
Amvac,
are
presented
in
Tables
A1
and
A2.
A
tabular
summary
of
the
residue
chemistry
science
assessments
for
reregistration
of
PCNB
are
presented
for
each
registrant
in
Tables
B1
and
B2.
The
conclusions
listed
in
Tables
B1
and
B2
regarding
the
reregistration
eligibility
of
PCNB
food/
feed
uses
are
based
on
the
use
patterns
registered
by
Uniroyal
and
Amvac,
respectively.

Considering
the
current
label
directions
and
the
available
residue
data,
the
following
Uniroyal
label
changes
are
recommended:

$
Unless
the
registrants
are
intending
to
support
direct
field
applications
to
soybeans,
use
directions
for
"
Beans"
should
be
amended
to
prohibit
field
applications
to
soybeans.

$
All
labels
should
restrict
use
on
collards,
kale,
mustard
greens
to
the
state
of
GA.

$
All
labels
should
restrict
rotation
of
crops
only
to
the
registered
crops.
31
Considering
the
current
label
directions
and
the
available
residue
data,
the
following
Amvac
label
changes
are
recommended:

$
Use
directions
for
"
Beans"
should
be
amended
to
include
a
minimum
PHI
and
maximum
seasonal
use
rate.
Current
crop
field
trial
data
would
support
a
PHI
of
40
days
for
dry
and
lima
beans,
and
a
maximum
seasonal
use
rate
of
7.5
lb
ai/
A.
For
snap
beans,
Amvac
must
submit
new
trials
at
a
specified
PHI.

$
The
maximum
rate
for
in­
furrow
applications
to
cotton,
currently
expressed
in
lb
ai/
A,
should
be
expressed
in
lb
ai/
linear
feet
of
row.

$
All
labels
should
restrict
use
on
collards,
kale,
mustard
greens
to
the
state
of
GA.

$
All
labels
should
restrict
rotation
of
crops
only
to
the
registered
crops.

OPPTS
GLN
860.1300:
Nature
of
the
Residue
in
Plants
In
response
to
the
PCNB
Reregistration
Standard
Update
(
6/
90),
Uniroyal
submitted
plant
metabolism
studies
for
PCNB
on
cabbage,
potatoes
(
2
tests),
and
peanuts
(
2
tests).

In
Uniroyal's
cabbage
metabolism
study,
[
14C]
PCNB
was
applied
and
incorporated
into
the
soil
at
a
rate
of
48
lb
ai/
A
(
equivalent
to
1.6x
the
maximum
labeled
rate).
On
the
day
of
treatment,
27­
day
old
cabbage
plants
were
transplanted
into
the
soil.
Total
radioactive
residues
(
TRR)
were
4.1­
7.9
ppm
in
immature
plants
collected
55
and
76
days
post­
treatment.
At
maturity
(
160
days
post­
treatment),
TRR
were
0.7­
2.49
in
cabbage
heads
and
11.0­
17.9
ppm
in
wrapper
leaves.
Samples
of
wrapper
leaves
were
used
for
metabolite
analysis.
Seven
metabolites
were
tentatively
identified
in
cabbage
leaves,
for
a
total
of
57.5%
of
the
TRR.
The
major
metabolites
in
cabbage
leaves
were
tertachlorophenyl
methyl
sulfoxide
(
TCPM
sulfoxide,
20.8%
TRR)
and
tetrachlorophenyl
methyl
sulfone
(
TCPM
sulfone,
24.1%
TRR).
Other
minor
metabolites
included:
trichlorophenyl
methyl
sulfone
(
RCPM
sulfone,
5.1%
TRR),
trichlorophenol
methyl
sulfone
(
RCHM
sulfone,
2.1%
TRR),
N­
hydroxypentachloroaniline
(
NOHPCA,
2.3%
TRR),
PCTA
(
0.3%
TRR),
and
PCTA
sulfoxide
(
2.8%
TRR).
In
its
initial
review
of
the
cabbage
metabolism
study,
the
Agency
(
J.
Abbotts,
4/
24/
96)
concluded
that
the
study
was
not
adequate
and
required
additional
data
characterizing
14C­
residues
in
acetone
extracts
and
insoluble
fractions
that
accounted
for
>
10%
of
the
TRR.

In
Uniroyal's
initial
peanut
metabolism
study,
[
14C]
PCNB
was
applied
and
incorporated
into
the
soil
at
a
rate
of
7.5
lb
ai/
A
(
equivalent
to
3.8x
the
maximum
labeled
rate).
Peanut
seeds
were
immediately
planted
in
the
treated
soil
and
mature
plants
were
harvested
147
days
later.
At
maturity,
TRRs
were
1520.8
ppm
in
roots,
42.3
ppm
in
vines,
128.3
ppm
in
shells,
and
5.2
ppm
in
nutmeats.
All
four
matrices
were
extracted
and
analyzed,
but
the
extract
from
roots
was
used
for
metabolite
identification.
A
total
of
39.0­
63.3%
of
the
TRR
was
identified
in
roots,
vines,
and
32
shells,
and
5.8%
of
the
TRR
was
identified
in
nutmeats.
The
metabolites
identified
in
roots,
vines,
and
shells
included:
S­(
pentachlorophenyl)­
2­
N­
malonylcysteine
(
PCP­
MalCys,
16.3­
36.9%
TRR),
tetrachloroaniline
(
TCA,
11.6­
19.9%
TRR),
and
S­[(
methylthio)
tetrachlorophenyl]­
2­
thioacetic
acid
(
MTCP­
TAA,
5.6­
11.1%
TRR).
The
metabolite
PCP­
MalCys
also
accounted
for
5.8%
of
the
TRR
in
nutmeats.
In
its
initial
review
of
the
peanut
metabolism
study,
the
Agency
(
J.
Abbotts,
4/
24/
96)
concluded
that
the
study
was
not
adequate.

Uniroyal
subsequently
submitted
an
additional
peanut
metabolism
study.
Greenhouse
grown
peanut
plants
were
treated
with
[
14C­
U­
phenyl]
PCNB
as
either
a
preplant
incorporated
(
PPI)
application
at
15
lb
ai/
A
or
as
two
banded
applications
over
the
plants
at
pegging,
totaling
10
lb
ai/
A.
Samples
of
mature
peanut
and
hay
were
collected
from
the
different
applications
at
193
and
76
days
post­
treatment,
respectively.
TRR
were
13.0
and
2.14
ppm
in/
on
hay
and
nutmeats
from
the
PPI
application
and
16.3
and
1.72
ppm
in/
on
hay
and
nutmeats
from
the
post­
emergence
application.
Quantitative
HPLC
analyses
of
nutmeats
and
hay
from
the
post­
emergence
treatment
identified
96.6%
of
the
TRR
in
nutmeats
and
91.7%
of
the
TRR
in
hay.
Metabolite
identities
were
confirmed
using
GC/
ECD,
GC/
MS
and/
or
LC/
MS.
In
nutmeats,
the
major
14C­
residue
was
PCNB,
accounting
for
96.6%
of
the
TRR
(
1.7
ppm),
along
with
trace
levels
of
PCA.
In
hay,
the
main
14C­
residues
included:
PCNB
(
18.8%
TRR,
3.1
ppm),
PCP­
MalCys
(
53.1%
TRR,
8.7
ppm),
and
N­
malonyl­
S­(
tetrachloroaminophenyl)­
cysteine
(
Metabolite
VI,
19.8%
TRR,
3.2
ppm).
Trace
amounts
of
N­
malonyl­
S­(
tetrachloronitrophenyl)­
cysteine
(
Metabolite
IV)
and
tetrachloronitrophenyl
glutathione
(
Metabolite
VII)
were
also
identified
in
peanut
hay.
Although
quantitative
data
were
not
provided
from
the
analysis
of
shells,
the
principal
solvent­
extractable
14C­
residues
in
peanut
shells
were
PCNB
and
PCP­
MalCys,
along
with
smaller
quantities
of
Metabolite
IV
and
tetrachloroaminophenyl
sulphonic
acid
(
Metabolite
V).

These
data
indicate
that
the
metabolism
of
[
14C]
PCNB
in
peanuts
primarily
involves
displacement
of
the
nitro
group
with
reduced
glutathione,
and
the
subsequent
metabolism
of
the
glutathione
moiety.
Provided
the
registrant
submits
information
supporting
the
storage
stability
of
14C­
residues
over
the
course
of
the
study,
the
submitted
peanut
metabolism
study
is
acceptable.

In
Uniroyal's
initial
potato
metabolism
study,
[
14C]
PCNB
was
applied
and
incorporated
into
the
soil
at
a
rate
of
18.9
lb
ai/
A
(
Uniroyal
currently
has
no
registered
uses
on
potatoes).
Potato
seed
pieces
were
planted
in
the
treated
soil,
and
tubers
were
harvested
77
days
later.
TRRs
were
2.39
ppm
in/
on
whole
tubers,
11.26
in/
on
peel
and
0.76
ppm
in/
on
potato
flesh.
All
three
matrices
were
extracted
and
analyzed,
but
identification
work
focused
primarily
on
the
peel
fraction.
A
total
of
76.4%
of
the
TRR
was
identified
in
extracts
from
peel.
The
major
14C­
residues
in
peel
included:
PCNB
(
24.4%
TRR),
PCA
(
18.3%
TRR),
S­(
pentachlorophenyl)
cysteine
(
PCP­
Cys,
8.5%
TRR),
and
tetrachlorophenol
(
TCP,
5.9%
TRR).
Other
minor
metabolites
in
peel
included:
PCTA
(
2.9%
TRR),
tetrachloronitrophenol
(
TCNP,
3.6%
TRR),
NOHPCA
(
1.8%
TRR),
conjugates
of
pentachlorothiophenyl
(
PCTP
conjugates,
10.6%
TRR),
and
pentachlorophenol
glycoside
(
PCP­
Gly,
0.4%
TRR).
Another

28%
of
the
peel
TRR
was
released
by
acid
and
base
hydrolyses
and
identified
as
being
comprised
of
PCA,
PCP,
and
TCP.
In
whole
potatoes,
the
major
metabolites
included:
a
PCTP
conjugate
(
31.7%
TRR),
PCP­
Cys
(
17.5%
TRR),
and
PCTA
(
9.5%
TRR).
Minor
amounts
of
PCA
(
6.4%
TRR)
and
NOHPCA
(
1.6%
TRR)
were
also
33
detected
in
whole
tubers.
The
initial
review
of
the
potato
metabolism
study
cited
several
deficiencies
in
the
study,
but
the
study
was
later
upgraded
to
acceptable.

Uniroyal
submitted
an
additional
potato
metabolism
study,
in
which
[
14C­
UL­
phenyl]
PCNB
was
applied
to
potato
plants
growing
outdoors
as
a
preplant
incorporated
(
PPI)
application
to
the
soil
at
either
20
or
60
lb
ai/
A.
Treated
soil
was
hilled
around
the
plants
twice
during
the
growing
season,
as
per
standard
agricultural
practices.
Samples
of
mature
potato
tubers
were
collected
95
days
post­
treatment.
TRR
were
1.12
and
3.54
ppm
in/
on
tubers
from
the
20
and
60
lb
ai/
A
treatments,
respectively.
The
overall
recovery
of
radioactivity
from
tubers
accounted
for
100­
102%
of
the
TRR.
Detailed
quantitative
analyses
of
the
solubilized
14C­
residues
identified
parent
and
more
than
45
metabolites
in
potato
tubers.
The
metabolite
profile
was
similar
for
both
application
rates,
and
the
identified
components
together
accounted
for
60.1­
64.1%
of
the
TRR
Although
no
single
component
accounted
for
>
10%
of
the
TRR,
approximately
half
of
the
identified
radioactivity
(
27.0­
29.8%
TRR)
was
comprised
of
five
components.
The
two
most
abundant
14C­
residues
were
PCNB
(
7.5­
8.0%
TRR)
and
PCP­
MalCys
(
9.8­
10.1%
TRR),
followed
by
PCA
(
2.4­
4.3%
TRR),
PCTA
(
2.7­
3.5%
TRR),
and
aminotetrachlorobenzene
sulfonic
acid
(
AM
TCB
sulfonic
acid;
3.9­
4.8%
TRR).
The
remaining
44
metabolites
each
accounted
for

2.8%
of
the
TRR.
PCB
was
detected
at
1.0­
1.9%
of
the
TRR
(

0.014
ppm),
but
HCB
was
not
detected.
This
potato
metabolism
study
was
deemed
adequate.

Based
on
Uniroyal's
two
potato
studies,
the
major
routes
of
metabolism
of
[
14C]
PCNB
in
potatoes
involve:
the
displacement
of
a
chlorine
atom
by
glutathione;
displacement
of
the
nitro
group
with
reduced
glutathione
with
the
subsequent
metabolism
of
the
glutathione
moiety;
reduction
of
the
nitro
group;
and
reductive
and
oxidative
dechlorination.

Amvac
has
also
submitted
metabolism
studies
on
peanuts,
potatoes,
and
cabbage.
Each
of
these
studies
were
deemed
inadequate,
but
upgradable.
In
the
peanut
metabolism
study,
[
14C]
PCNB
was
applied
at
33.8
lb
ai/
A
(
3.3x
the
maximum
rate)
to
the
soil
and
incorporated
immediately
prior
to
planting.
Immature
vines
were
collected
at
92
day
after
treatment
(
DAT)
and
mature
vines,
hulls,
and
nutmeats
were
collected
at
185
DAT.
TRRs
were
3.5­
3.97
ppm
in
vines,
26.3
ppm
in
hulls,
and
1.99
ppm
in
nutmeats.
Approximately
29%
of
the
TRR
was
identified
in
mature
vines,
40%
of
the
TRR
was
identified
in
hulls,
and
65%
of
the
TRR
was
identified
in
nutmeats.
In
addition
to
PCNB,
the
following
metabolites
were
identified
in
peanuts:
PCA,
PCB,
2,3,5,6­
tetrachloronitrobenzene
(
4­
TCNB),
2,3,4,5­
tetrachloronitrobenzene
(
6­
TCNB),
PCP­
MalCys,
and
S­
tetrachloronitrophenyl­
N­
malonylcysteine.
However,
the
Agency
has
requested
additional
data
characterizing
Unknowns
D
and
H.

In
Amvac's
potato
metabolism
study,
[
14C]
PCNB
was
applied
at
33.8
lb
ai/
A
(
1.4x
the
maximum
rate)
to
the
soil
and
incorporated
immediately
prior
to
planting.
Samples
of
foliage
were
collected
at
92
DAT
and
samples
of
tubers
and
foliage
were
collected
at
122
and
154
DAT.
TRRs
were
4.9­
7.95
ppm
in
foliage
and
0.96­
18.0
ppm
in
tubers
at
maturity.
Approximately
13­
31%
of
the
TRR
was
identified
in
tubers
and
2­
4%
of
the
TRR
was
identified
in
mature
foliage.
In
addition
to
PCNB,
the
following
metabolites
were
identified
in
potatoes:
PCA,
PCTA,
PCB,
4­
TCNB,
6­
TCNB,
and
HCB.
To
upgrade
the
study,
the
Agency
requested
additional
data
characterizing
Unknowns
D
and
H.
1
These
TRR
values
(
24.0
and
58.5)
can
be
found
in
the
previous
Agency
document
(
J.
Abbotts,
D158943,
4/
24/
1996).
However,
the
original
studies
(
MRIDs
41341205
and
41303301)
do
not
contain
these
information.
Calculated
TRR
for
milk
based
on
%
TRR
(
by
Dynamac)
suggests
lower
TRR
values
for
milk
(~
8
ppm).
Uniroyal
is
asked
for
further
clarification.

34
In
Amvac's
cabbage
metabolism
study,
[
14C]
PCNB
was
applied
at
30.1
lb
ai/
A
(
1x
the
maximum
rate)
to
the
soil
and
incorporated
immediately
prior
to
planting.
Samples
of
cabbage
were
collected
at
120
and
206
DAT.
TRRs
in/
on
whole
cabbage
were
3.52
ppm
at
120
DAT
and
0.285­
0.359
ppm
in/
on
cabbage
from
206
DAT.
Approximately
20%
of
the
TRR
was
identified
in
immature
cabbage
and
6­
7%
of
the
TRR
was
identified
in
mature
cabbage.
In
addition
to
PCNB,
the
following
metabolites
were
identified
in
cabbage:
PCA,
PCB,
PCTA,
6­
TCNB,
HCB
and
PCP­
MalCys,
and
S­
tetrachloronitrophenyl­
N­
malonylcysteine.
As
in
the
other
two
metabolism
studies,
the
Agency
requested
additional
data
characterizing
Unknowns
D
and
H.

In
considering
all
three
of
Amvacs'
plant
metabolism
studies,
the
Agency
(
D184350
and
D181195,
J.
Abbotts,
4/
16/
96)
noted
that
early
metabolites
in
the
peanut,
potato,
and
cabbage
studies
are
similar,
and
that
the
HPLC
profiles
of
polar
metabolites
are
also
similar
for
these
crops.
Provided
a
new
acceptable
metabolism
study
were
completed
on
potato
or
cabbage,
including
identification
of
metabolites
D
and
H,
the
Agency
would
be
willing
to
conclude
that
the
nature
of
the
residue
in
plants
was
adequately
understood.

OPPTS
GLN
860.1300:
Nature
of
the
Residue
in
Livestock
In
response
to
the
PCNB
Reregistration
Standard
Update
(
6/
90),
Uniroyal
submitted
both
a
ruminant
and
poultry
metabolism
study;
these
studies
were
recently
upgraded
to
adequate.

In
Uniroyal's
ruminant
metabolism
study,
two
goats
were
dosed
orally
with
[
14C]
PCNB
for
five
consecutive
days
at
levels
equivalent
to
770
or
1,400
ppm
in
the
diet.
Based
on
Uniroyal's
currently
registered
uses
for
PCNB,
these
dietary
levels
are
equivalent
to
3850x
and
7000x
the
maximum
dietary
burden.
TRR
in
milk
were
24.0
and
58.5
ppm
from
the
low­
and
high­
dose
goats,
respectively1.
For
the
low­
dose
goat,
TRR
in
tissues
were
32.1
ppm
in
kidney,
25.9
ppm
in
liver,
1.1
ppm
in
muscle,
and
17.4­
18.3
ppm
in
fat.
For
the
high­
dose
goat,
TRR
in
tissues
were
49.1
ppm
in
kidney,
45.5
ppm
in
liver,
2.3
ppm
in
muscle,
and
21.8
ppm
in
fat.
Analysis
of
milk
and
tissues
from
the
high­
dose
goat
indicated
that
PCA
was
the
major
residue
in
milk
(
72%
TRR)
and
fat
(
83­
90%
TRR).
PCA
also
accounted
for
16
and
26%
of
the
TRR
in
liver
and
kidney,
respectively,
but
the
major
metabolites
in
these
tissues
were
the
glucuronide
conjugate
of
PCA,
which
accounted
for
40%
and
55%
of
the
TRR
in
liver
and
kidney,
respectively,
and
a
glucuronide
conjugate
of
N­
hydroxypentachloroaniline
(
NOHPCA),
which
accounted
for
28%
of
the
TRR
in
liver.
Other
minor
metabolites
identified
in
liver
and
kidney
each
accounted
for

4.5%
of
the
TRR
and
included
NOHPCA,
tetrachloroaniline
methyl
sulfoxide
(
TCAM
sulfoxide),
tetrachlorothioanisole
(
TCTA),
tetrachloro(
methylthio)
thiophenol
(
TCTP
S­
Met),
and
a
pentachlorothiophenol
(
PCTP)
dimer.
In
muscle,
the
major
14C­
residues
included
PCA
(
40.9%
35
TRR),
PCTP
(
10.5%
TRR),
and
a
combination
of
TCTA
and
tetrachlorophenyl
methyl
sulfoxide
(
37.3%
TRR).

In
Uniroyal's
poultry
metabolism
study,
three
groups
of
laying
hens
were
dosed
orally
with
[
14C]
PCNB
for
six
consecutive
days
at
levels
equivalent
to
107,
274
or
512
ppm
in
the
diet.
Based
on
Uniroyal's
currently
registered
uses
for
PCNB,
these
dietary
levels
are
equivalent
to
430x,
1100x,
and
2050x
the
maximum
dietary
burden.
For
the
high­
dose
group
(
512
ppm
dose
level),
TRR
were
5.75
in
egg
yolks,
0.29
ppm
in
egg
whites,
3.81
ppm
in
liver,
0.30­
0.71
ppm
in
muscle,
10.1
ppm
in
fat,
and
5.92
ppm
in
skin
with
attached
fat.
In
fat,
PCNB
was
identified
as
the
major
residue,
accounting
for
45.7%
of
the
TRR.
Other
major
metabolites
identified
in
fat
included
PCA
(
13.7%
TRR)
and
TCA
sulfoxide
(
29.1%
TRR).
In
liver,
PCTP
(
55.9%
TRR)
and
pentachlorothioanisole
sulfoxide
(
18.6%
TRR)
were
identified
as
the
major
solvent­
extractable
residues;
the
major
14C­
residues
in
base
hydrolysates
(
36.6%
TRR)
of
liver
post­
extracted
solids
(
PES)
were
identified
as
PCA
and
PCTA.
In
yolks,
PCA
(
11%
TRR),
PCTA
(
2.1%
TRR),
and
PCTP
(
4.0%
TRR)
were
each
identified,
but
the
majority
of
radioactivity
(
75%
TRR)
in
yolks
remained
unextracted.
Base
hydrolysis
of
the
yolk
PES
released
28.8%
of
the
TRR,
which
was
composed
primarily
of
PCTA,
along
with
trace
amounts
of
PCB,
HCB,
PCNB
and
PCA.
In
muscle,
the
major
14C­
residue
was
TCP
sulfone
(
62%
TRR),
along
with
minor
amounts
of
PCTA
(
5.6%
TRR).

Amvac
has
also
submitted
separate
ruminant
and
poultry
metabolism
studies.
In
Amvac's
goat
metabolism
study,
two
goats
were
dosed
orally
with
[
14C]
PCNB
for
five
consecutive
days
at
levels
equivalent
to
797
or
1,012
ppm
in
the
diet;
however,
only
milk
and
tissues
from
the
low
dose
goat
(
797
ppm)
were
analyzed.
TRR
in
milk
reached
a
maximum
of
5.98
ppm
on
Day
3
and
declined
to
2.37
ppm
by
the
time
of
sacrifice.
TRR
in
tissues
were
10.3
ppm
in
kidney,
13.37
ppm
in
liver,
0.541
ppm
in
muscle,
and
15.2­
26.9
ppm
in
fat.
PCA
was
identified
as
the
principal
metabolite
in
milk,
kidney,
muscle
and
fat,
accounting
for
31.2­
59.2%
of
the
TRR.
Five
unknown
polar
metabolites,
each
accounting
for
<
5%
of
the
TRR,
were
also
isolated
from
kidney,
fat
and/
or
muscle.
Minor
amounts
(
1.5­
6.4%
TRR)
of
PCTA
were
also
identified
in
these
matrices.
In
liver,
PCA
and
PCTA
accounted
for
9.6%
and
1.3%
of
the
TRR,
respectively.
However,
the
majority
(
40%
TRR)
of
the
radioactivity
in
liver
was
associate
with
an
unknown
polar
metabolite
released
by
base
hydrolysis.
The
Agency
concluded
that
this
goat
metabolism
study
is
not
adequate.
Further
analyses
are
required
to
characterize
major
unidentified
radioactive
unknown
components
in
milk
and
tissues.

In
Amvac's
poultry
metabolism
study,
two
groups
of
laying
hens
were
dosed
orally
with
[
14C]
PCNB
for
five
consecutive
days
at
levels
equivalent
to
309
and
554
ppm
in
the
diet.
At
sacrifice,
TRR
in
egg
yolks
and
whites
were
1.22
ppm
and
0.017
ppm,
respectively,
from
the
low
dose
group
and
2.66
ppm
and
0.038
ppm,
respectively,
from
the
high
dose
group.
For
the
low
dose
group,
TRR
in
tissues
were
1.47
ppm
in
kidney,
1.97
ppm
in
liver,
0.13
ppm
in
muscle,
2.11
ppm
in
fat,
and
1.12
ppm
in
skin
with
attached
fat.
For
the
high
dose
group,
TRR
in
tissues
were
1.85
ppm
in
kidney,
2.42
ppm
in
liver,
0.31
ppm
in
muscle,
4.25
ppm
in
fat,
and
2.18
ppm
in
skin
with
attached
fat.
In
muscle
and
fat,
PCNB
was
the
major
14C­
residue,
accounting
for
55.8%
of
the
TRR
in
muscle
and
59.8%
of
the
TRR
in
fat.
The
metabolites
PCA
and
PCTA
were
also
detected
in
muscle
at
4.7%
and
2.1%
of
the
TRR,
respectively,
and
in
fat
at
6.4%
and
10.3%
of
36
the
TRR,
respectively.
In
liver
extracts,
PCNB,
PCA
and
PCTA
each
accounted
for

3.2%
of
the
TRR;
however,
the
majority
of
the
radioactivity
in
liver
was
not
adequately
characterized.
The
Agency
concluded
that
Amvac's
poultry
metabolism
study
is
not
adequate
and
that
further
analyses
are
required
to
characterize
and
identify
the
major
radioactive
components
in
eggs
and
tissues.

After
considering
the
age
of
the
samples
from
Amvac's
ruminant
and
poultry
metabolism
studies,
HED
(
J.
Abbotts,
4/
16/
96)
recommended
that
Amvac
should
conduct
new
animal
metabolism
studies.

OPPTS
GLN
860.1340:
Residue
Analytical
Methods
Adequate
analytical
methodology
is
available
for
enforcing
tolerances
of
PCNB
residues,
as
currently
defined,
in
plant
commodities.
The
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
currently
lists
two
GC
method
(
Methods
A
and
I)
for
the
determinating
residues
of
PCNB
per
se.
In
addition,
residues
of
PCNB,
its
metabolites
PCA
and
MPCPS,
and
the
impurities
PCB
and
HCB
are
completely
recovered
through
the
multi­
residue
methods
listed
in
PAM
Vol.
I
(
Methods
302,
303,
and
304).

Uniroyal
has
submitted
a
method
description
and
validation
data
for
an
adequate
GC/
ECD
method
(
Method
CAM­
24­
73
and
its
modifications)
for
collecting
data
on
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in
plants
commodities.
This
method
is
basically
the
same
as
the
original
(
Method
CAM
11­
72),
with
modifications
in
extraction
solvents,
clean­
up
steps,
and
the
use
of
more
modern
instrumentation
(
e.
g.,
capillary
GC
columns
in
place
of
the
older,
packed
columns)
in
order
to
be
able
to
analyze
PCNB
and
degradates/
metabolites
in
other
cotton
matrices
such
as
meal,
soapstock,
and
oil.
(
MRID
43976901,
Gaydosh,
K,
Smudin,
D.,
Terraclor
10G
on
Cotton:
Processing
Study).

Uniroyal
also
submitted
a
description
for
a
GC/
ECD
method
(
CAM­
11­
72)
for
determining
residues
in
cottonseed;
however,
method
validation
data
were
not
provided
for
this
method.
Data
are
required
validating
Method
CAM­
11­
72
as
modified
10/
28/
87
and
3/
15/
88
for
analysis
in
cottonseed.

In
conjunction
with
their
field
trial
data,
Amvac
has
submitted
a
method
description
and
validation
data
for
adequate
GLC/
ECD
methods
(
Amvac
Methods
MP­
PCNC­
MA1
and
MP­
PCNC­
MA2)
for
collecting
data
on
residues
of
PCNB,
PCA,
PCTA
(
MPCPS),
PCB,
HCB,
and
TCNB
in
plant
commodities.

In
addition,
the
available
residue
data
on
livestock
feed
items
indicate
that
tolerances
will
be
required
for
animal
commodities.
Therefore,
the
registrants
must
submit
methods
for
determining
PCNB
residues
of
concern
in
animal
commodities.
37
It
is
the
recommendation
of
the
Agency
that
since
all
the
identified
metabolites
of
PCNB
(
>
80
metabolites)
are
of
concern,
a
radiovalidated
common
moiety
method
be
developed
by
the
registrants.
The
registrants
should
also
make
sure
that
any
future
submission
clearly
states
the
levels
of
Total
Radioactive
Residue
(
TRR),
PCNB,
PCA,
and
PCTA.

OPPTS
GLN
860.1360:
Multiresidue
Method
Testing
The
Agency
has
determined
that
PCNB,
PCA,
MPCPS
(
PCTA),
PCB,
and
HCB
are
completely
recovered
through
PAM
Vol.
I,
Methods
302,
303
and
304.
No
additional
data
are
required
(
D.
Edwards,
8/
1/
86).

OPPTS
GLN
860.1380:
Storage
Stability
Data
The
PCNB
Update
(
6/
90)
cited
storage
stability
data
from
Uniroyal
indicating
that
PCNB,
PCA,
PCB,
MPCPS,
and
HCB
were
stable
in
frozen
wheat
grain
and
kidney
beans
for
up
to
6
months;
however,
storage
stability
data
on
frozen
corn
grain,
soybeans,
peppers,
tomatoes,
catsup,
and
tomato
pomace
showed
variable
declines
(
20­
40%)
in
these
residues
over
6
months
of
storage.
Uniroyal
later
submitted
additional
data
from
this
study
examining
storage
intervals
up
to
14
months
for
kidney
beans,
peppers,
tomatoes,
and
catsup.
After
14
months
of
frozen
storage,
residues
of
PCNB,
PCA,
PCB,
MPCPS,
and
HCB
declined
by
6­
48%
in
kidneys
beans,
43­
75%
in
peppers,
55­
92%
in
tomatoes,
and
>
92%
in
catsup.

More
recent
storage
stability
data
from
Uniroyal
indicates
that
PCNB,
PCA,
PCB,
HCB,
and
MPCPS
are
stable
for
at
least
12
months
in
peanuts
and
cottonseed
stored
at
<
0
C
and
in
cabbage
and
potatoes
stored
at
­
20
C.
Uniroyal
has
also
submitted
data
indicating
that
residues
of
PCNB,
its
impurity
HCB,
and
the
metabolites
PCA,
PCB,
TCA,
MPCPS
(
PCTA),
TCTASOO
and
PCTASO
are
stable
at
­
25
C
for
at
least
24
months
in
lettuce,
turnip
tops
and
roots,
and
wheat
forage,
grain,
and
straw.

Amvac
has
submitted
storage
stability
data
on
tomatoes,
peanuts,
potatoes,
snap
beans,
and
broccoli.
Residues
of
PCNB,
PCA,
PCTA,
HCB,
PCB
and
TCNB
(
both
isomers)
were
stable
in
frozen
(
0<
C)
tomatoes,
peanuts
and
broccoli
residues
for
up
to
439
days
(
14.4
months).
Residues
of
PCNB,
PCA,
PCTA,
HCB,
PCB
and
2,3,5,6­
TCNB
were
stable
for
up
to
439
days
(
14.4
months)
in
frozen
potatoes.
Residues
of
the
metabolite
2,3,5,6­
TCNB
declined
in
frozen
potatoes
by
48%
after
30
days
of
frozen
storage,
but
remained
relatively
stable
thereafter
for
up
to
439
days.
As
2,3,5,6­
TCNB
is
not
a
currently
regulated
residue,
the
observed
decline
will
have
no
impact
on
the
acceptability
of
Amvac's
potato
field
trials.

Amvac
must
submit
storage
stability
data
to
support
their
cottonseed,
peanut,
potato,
and
tomato
processing
studies.
38
OPPTS
GLN
860.1500:
Magnitude
of
the
Residue
in
Crop
Plants
As
Uniroyal
and
Amvac
are
separately
supporting
the
use
of
PCNB,
the
adequacy
of
the
available
field
trial
data
will
be
considered
separately
for
each
registrant.
Uniroyal
has
fulfilled
requirements
for
magnitude
of
the
residue
data
on
the
following
crops/
commodities:
garlic,
Brassica
vegetables,
peppers
and
tomatoes;
data
for
cottonseed
are
under
review.
Uniroyal
has
submitted
adequate
field
trial
data
depicting
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in/
on
these
crops
following
applications
made
according
to
the
current
maximum
labeled
rates.
Geographic
representation
is
adequate
and
a
sufficient
number
of
trials
reflecting
representative
formulation
classes
were
conducted.

Amvac
has
not
fulfilled
requirements
for
magnitude
of
the
residue
data
in/
on
any
crops.
Brief
summaries
of
the
available
field
trial
data
are
presented
below
by
crop
for
each
registrant.

Root
and
Tuber
Vegetables
Potatoes.
An
interim
tolerance
of
0.1
ppm
has
been
in
effect
for
residues
of
PCNB
per
se
in
or
on
potato.
The
new
tolerance
expression
for
supported
plant
and
animal
commodities
includes
PCNB,
PCA,
and
PCTA
based
on
the
4/
16/
2004
MARC's
decision.

Uniroyal
is
supporting
a
SLN
for
state
of
ME
with
75%
WP
formulation
(
EPA
SLN
No.
ME­
790001)
at
0.62
lb
ai/
gal/
2000
lb
seed
potatoes
applied
as
a
spray
or
dip
just
prior
to
cutting
and/
or
planting.
Field
trial
data
and
processing
data
to
support
the
SLN
registration
in
ME
are
still
outstanding.

Amvac
has
submitted
inadequate
residue
data
from
29
tests
reflecting
a
single
broadcast,
pre­
plant
incorporated
(
PPI)
application
or
an
in­
furrow
application
of
PCNB
(
10%
G
or
2
lb/
gal
EC)
to
potato
plants
at
planting
at
25
lb
ai/
A
(
PPI)
or
at
11.6­
11.7
lb
ai/
14,500
feet
of
row
(
in­
furrow),
a
rate
equivalent
to
10
lb
ai/
12,400
linear
feet
of
row
(
each
1x
the
maximum
labeled
rate).
Combined
residues
were
<
0.030­
0.238
ppm
in/
on
28
potato
samples
harvested
at
maturity
following
application
of
PCNB
(
10%
G)
as
either
a
broadcast
PPI
application
or
in­
furrow
application.
Combined
residues
were
<
0.06­
1.01
ppm
in/
on
30
potato
samples
harvested
at
maturity
following
application
of
PCNB
(
2
lb/
gal
EC)
as
either
a
broadcast
PPI
application
or
infurrow
application.

Amvac
has
not
fulfilled
the
required
number
of
field
trials
in
support
of
PCNB
use
on
potato.
An
additional
total
of
36
field
trials
must
be
conducted
with
10%
G
and
2
lb/
gal
EC
formulations
for
both
PPI
and
in­
furrow
applications
in
regions
1
(
1
test),
region
2
(
1
test),
region
5
(
2
tests),
region
9
(
1
test),
and
region
11
(
4
tests).

Bulb
Vegetables
39
Garlic.
An
interim
tolerance
of
0.1
ppm
is
in
effect
for
residues
of
PCNB
per
se
in
or
on
garlic.
The
new
tolerance
expression
for
supported
plant
and
animal
commodities
includes
PCNB,
PCA,
and
PCTA
based
on
the
4/
16/
2004
MARC's
decision.

Residue
data
cited
in
the
Reregistration
standard
(
6/
86)
indicate
that
the
combined
residues
of
PCNB
and
its
currently
regulated
residues
are

0.008
ppm
in/
on
garlic
following
an
application
at
[
14C]
PCNB
1.5x
the
maximum
labeled
rate.
These
data
were
originally
submitted
by
Olin
Mathieson
Chemical
Corporation
(
now
The
Uniroyal
Company).

Amvac
magnitude
of
residue
data
for
garlic
remains
outstanding.

Brassica
Leafy
Vegetables
Head
and
Stem
Brassica
Vegetables
Crop
Subgroup
Broccoli.
An
interim
tolerance
of
0.1
ppm
is
in
effect
for
residues
of
PCNB
per
se
in
or
on
broccoli.
The
new
tolerance
expression
for
supported
plant
and
animal
commodities
includes
PCNB,
PCA,
and
PCTA
based
on
the
4/
16/
2004
MARC's
decision.

Uniroyal
has
submitted
residue
data
from
4
tests
reflecting
broadcast,
banded,
and
transplant
soildrench
applications
to
broccoli
using
10%
G
and
75%
WP
formulations
at
the
maximum
labeled
rate
(
30
lb
ai/
A).
The
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
were
<
0.01­
0.0943
ppm
in/
on
51
samples
of
broccoli
harvested
at
maturity
(
64­
83
days
post­
treatment);
HCB
residues
were
<
0.002
in/
on
all
samples.

Amvac
has
submitted
residue
data
from
15
tests
reflecting
a
single
banded,
pre­
plant
incorporated
(
PPI)
broadcast
or
soil­
drench
application
to
broccoli
plants
at
transplanting
using
10%
G
or
75%
WP
formulations
at
the
maximum
labeled
rate
(
30
lb
ai/
A
for
banded
and
PPI
application
or
4.5
lb
ai/
100
gal.
for
soil
drench).
Following
either
a
broadcast
PPI
or
banded
application
of
PCNB
(
75%
WP),
the
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.03­<
0.065
ppm
in/
on
12
samples
of
mature
broccoli
from
6
tests.
Following
a
soil
drench
application
of
PCNB
(
75%
WP),
the
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.03­<
0.089
ppm
in/
on
6
samples
of
broccoli
from
3
tests.
Following
either
a
broadcast
PPI
or
banded
application
of
PCNB
(
10%
G),
the
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.03­<
0.065
ppm
in/
on
12
samples
of
broccoli
from
6
tests.
In
addition
to
the
currently
regulated
compounds,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOD
(<
0.005
ppm)
in/
on
all
broccoli
samples
from
each
treatment.

Amvac
needs
to
submit
a
total
of
4
additional
field
trials
in
region
10;
i.
e.,
1
test
reflecting
a
single
banded,
pre­
plant
incorporated
(
PPI)
broadcast
at
transplanting
using
75%
WP
formulations
at
the
maximum
labeled
rate
(
30
lb
ai/
A)
and
3
tests
reflecting
a
soil­
drench
application
at
transplanting
using
10%
G
formulations
at
4.5
lb
ai/
100
gal.
PHI
should
be
>
72
days.
40
Brussel
sprouts
and
Cauliflower.
Data
from
broccoli
will
be
translated
to
support
the
equivalent
uses
on
Brussels
sprouts
and
cauliflower.

Cabbage.
Uniroyal
has
submitted
adequate
residue
data
from
7
tests
reflecting
broadcast,
banded,
and
transplant
soil­
drench
applications
to
cabbage
using
10%
G
and
75%
WP
formulations
at
the
maximum
labeled
rate
(
30
lb
ai/
A).
The
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
were
<
0.01­
0.0984
ppm
in/
on
134
samples
of
cabbage
harvested
at
maturity
(
67­
125
days
post­
treatment);
HCB
residues
were

0.002
ppm.
One
sample
had
combined
residues
(
0.1083
ppm)
in
excess
of
the
0.1
ppm
tolerance,
but
this
sample
resulted
from
a
soil
drench
application
of
the
75%
WP
at
transplanting
at
4.5
lb
ai/
100
gal
solution.
The
maximum
use
rate
for
a
soil
drench
application
to
Brassica
vegetable
on
Uniroyal's
labels
is
1.5
lb
ai/
100
gal.

Amvac
has
submitted
adequate
residue
data
from
25
tests
reflecting
a
single
banded,
PPI
broadcast
or
soil­
drench
application
to
cabbage
plants
at
transplanting
using
10%
G
and
75%
WP
formulations
at
the
maximum
labeled
rate
(
30
lb
ai/
A
for
banded
and
PPI
applications
or
4.5
lb
ai/
100
gal.
for
the
soil
drench).
With
the
exception
of
four
samples,
residues
of
PCNB,
PCA,
and
PCTA
were
each
<
0.01
ppm
(<
LOQ;
combined
LOQ
of
0.03
ppm)
in/
on
cabbage
(
with
and
without
wrapper
leaves)
samples
(
n=
88)
from
each
treatment.
Three
samples
of
cabbage
(
RAC)
from
the
soil
drench
application
(
75%
WP)
had
PCNB
residues
of
0.012,
0.019,
and
0.054
ppm
and
one
of
these
samples
had
PCA
residues
of
0.013
ppm;
one
sample
of
cabbage
(
RAC)
from
the
broadcast
application
(
10%
G)
had
PCNB
residues
of
0.015
ppm.
The
maximum
combined
residues
of
PCNB,
PCA,
and
PCTA,
which
are
the
currently
regulated
residues,
were
0.077
ppm
in/
on
cabbage
(
RAC)
following
a
soil
drench
application
of
PCNB
(
75%
WP).
In
addition
to
the
regulated
residues,
residues
of
PCTA,
TCNB
(
both
isomers),
PCB
and
HCB
were
each
<
0.005
ppm
(<
LOD)
in/
on
all
cabbage
samples.

Residue
data
from
Uniroyal
and
Amvac
support
establishing
a
permanent
tolerance
at
0.1
ppm
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
head
and
stem
Brassica
vegetables
Crop
Subgroup.
Additional
residue
data
for
broccoli
from
Amvac
are
required.

Leafy
Brassica
Greens
Crop
Subgroup
Collards,
Kale,
Mustard
greens.
The
PCNB
Update
(
6/
90)
indicated
that
IR­
4
has
submitted
adequate
data
to
support
the
0.2
ppm
tolerance
for
the
combined
residues
of
PCNB,
PCA,
and
MPCPS,
provided
that
the
use
is
restricted
to
GA.

Legume
Vegetables
Beans.
Uniroyal
has
submitted
data
from
25
tests
depicting
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in/
on
snap
beans,
lima
beans,
and
dry
beans
harvested
14­
78
days
following
the
last
of
four
soil
band
applications
of
the
75%
WP
at
0.5­
5
lb
ai/
A/
application
or
the
2
lb/
gal
EC
at
1.9­
2
lb
ai/
A/
application.
Applications
began
at
planting
and
were
repeated
at
2­
week
intervals,
for
a
maximum
seasonal
rate
of
8
lb
ai/
A.
The
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
were
<
0.25­

0.432
ppm
in/
on
55
samples
of
snap
beans
harvested
14
DAT,
<
0.25­
41

0.255
ppm
in/
on
22
samples
of
lima
beans
harvested
35
or
63
DAT,
and
<
0.25­

0.366
ppm
in/
on
34
samples
of
dry
beans
harvested
35­
78
DAT.
Residues
of
MPCPS,
PCB
and
HCB
were
below
the
method
LOQ
(<
0.05
ppm)
in
all
samples.
Reanalysis
of
the
bean
samples
from
the
above
tests
using
a
method
with
a
lower
LOQ
(
0.002
ppm)
indicated
that
combined
residues
were
<
0.01­
0.242
ppm;
however,
the
available
storage
stability
data
indicate
that
residues
would
have
declined
substantially
during
the
intervals
samples
were
held
prior
to
the
reanalysis.

Although
residues
exceeding
the
current
0.1
ppm
tolerance
were
detected
in
beans,
however,
these
tests
were
conducted
at
rates
higher
than
the
label
rates.
The
current
Uniroyal
labels
allow
for
only
a
single
field
application
at
planting
to
beans
(
excluding
cowpeas)
at
a
maximum
of
1.5
lb
ai/
A.
Data
are
required
reflecting
Uniroyal's
current
use
pattern
for
beans
in
order
to
accurately
assess
residues
in
beans.
In
addition,
the
labeled
use
on
dry
beans
could
potentially
include
use
on
soybeans.
Therefore,
field
trial
data
are
required
reflecting
the
use
PCNB
on
soybeans
at
the
maximum
rate.
Alternatively,
the
registrant
could
prohibit
direct
field
applications
to
soybeans,
in
which
case
separate
field
trial
data
for
soybeans
would
not
be
required.
(
The
Agency
notes
that
Uniroyal
has
submitted
two
magnitude
of
the
residue
studies
on
snap
beans
and
dry
beans,
MRIDs
43118202
and
43118203,
which
are
currently
under
review.)

Amvac
has
submitted
residue
data
from
10
tests
on
dry
beans
reflecting
four
banded
applications
of
PCNB
(
75%
WP
or
2
lb/
gal
EC)
to
dry
beans
totaling
7.5
lb
ai/
A
(
maximum
seasonal
labeled
rate
not
specified).
Mature
dry
beans
were
collected
41­
64
days
after
the
last
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.030­<
0.194
ppm
in/
on
10
dry
bean
samples
treated
with
the
75%
WP
and
<
0.030­<
0.165
ppm
in/
on
10
dry
bean
samples
treated
with
the
2
lb/
gal
EC
formulation.
In
addition,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOQ
(<
0.01
ppm)
in/
on
all
dry
bean
samples.
The
dry
bean
field
trial
data
are
not
adequate,
as
the
number
of
crop
field
trials
and
geographic
representation
are
inadequate.
An
additional
4
tests
must
be
conducted
using
each
formulation
in
EPA
Region
5
(
2
tests)
and
Regions
7
and
8
(
1
test
each),
for
a
total
of
eight
additional
tests.

Amvac
has
submitted
residue
data
from
8
tests
on
snap
beans
reflecting
four
banded
applications
of
PCNB
(
75%
WP
or
2
lb/
gal
EC)
to
snap
bean
plants
totaling
7.5­
8.2
lb
ai/
A
(
maximum
seasonal
labeled
rate
not
specified).
Mature
snap
beans
were
collected
either
7,
10,
14,
or
20
days
after
the
last
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.063­
2.38
ppm
in/
on
8
snap
bean
samples
treated
with
the
75%
WP
and
<
0.036­
1.08
ppm
in/
on
8
snap
bean
samples
treated
with
the
2
lb/
gal
EC
formulation.
In
addition,
residues
of
PCB,
HCB,
and
2,3,5,6­
TCNB
were
each
<
LOD
(<
0.005
ppm)
in/
on
all
treated
samples.
Residues
of
2,3,4,5­
TCNB
were
also
<
LOD
(<
0.005
ppm)
in/
on
12
samples
from
3
tests
and
<
0.005­
0.014
ppm
in/
on
4
samples
from
one
test.
The
snap
bean
field
trial
data
are
not
adequate,
as
the
number
of
crop
field
trials
and
geographic
representation
are
inadequate.
No
tests
were
conducted
in
EPA
Region
5.
In
addition,
different
post­
treatment
intervals
(
7,
10,
14,
or
20
days)
were
utilized
at
each
test
site,
resulting
in
substantial
differences
in
the
residue
values.
Additional
field
trial
residue
data
are
required
from
12
tests
(
6
per
formulation)
at
a
PHI
specified
by
the
registrant.
Tests
should
include
locations
in
Region
5.
42
Amvac
has
submitted
residue
data
from
6
tests
on
lima
beans
reflecting
four
banded
applications
of
PCNB
(
75%
WP
or
2
lb/
gal
EC,
3
tests
each)
to
bean
plants
totaling
7.5
lb
ai/
A
(
maximum
seasonal
labeled
rate
not
specified).
Whole
pods
of
mature
lima
beans
were
collected
42­
57
days
after
the
last
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.015­<
0.147
ppm
in/
on
6
lima
bean
samples
treated
with
the
75%
WP
and
<
0.015­<
0.0409
ppm
in/
on
6
samples
treated
with
the
2
lb/
gal
EC
formulation.
In
addition,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOD
(<
0.005
ppm)
in/
on
all
lima
bean
samples.
The
lima
bean
field
trial
data
are
not
adequate,
as
the
number
of
crop
field
trials
and
geographic
representation
are
inadequate.
An
additional
3
tests
must
be
conducted
in
EPA
Region
2
(
2
tests)
and
Region
11
(
1
test)
with
each
formulation
(
75%
WP
and
2
lb/
gal
EC)
for
a
total
of
six
additional
tests.

Soybeans.
Both
Uniroyal's
and
Amvac's
labeled
uses
on
dry
beans
could
potentially
include
use
on
soybeans.
Therefore,
field
trial
data
are
required
reflecting
the
use
PCNB
on
soybeans
at
the
maximum
rate.
Alternatively,
the
registrant
could
prohibit
direct
field
applications
to
soybeans,
in
which
case
separate
field
trial
data
for
soybeans
would
not
be
required.

Fruiting
Vegetables
(
except
Cucurbits)

Peppers.
Uniroyal
has
submitted
adequate
data
depicting
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in/
on
peppers
harvested
71­
104
days
following
either
an
in­
furrow
application
of
the
75%
WP
at
planting
at
7.5
lb
ai/
A
(
1x
the
maximum
rate)
or
a
soil
drench
application
at
transplanting
at
3.75
lb
ai/
100
gal
water
(
1.6x).
Residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
were
each

0.05
ppm
in/
on
20
samples
of
peppers,
for
combined
residues
<
0.25
ppm.
Reanalysis
of
the
pepper
samples
from
the
above
tests
using
a
method
with
a
lower
LOQ
(
0.002
ppm)
indicated
that
combined
residues
were
<
0.01
ppm;
however,
the
available
storage
stability
data
indicate
that
residues
would
have
declined
substantially
during
the
intervals
samples
were
held
prior
to
the
reanalysis.
Considering
only
the
currently
regulated
metabolites
(
PCNB,
PCA,
and
MPCPS)
the
maximum
combined
residues
in/
on
peppers
would
be
<
0.15
ppm.

Amvac
has
also
submitted
residue
data
from
8
tests
reflecting
a
single
application
of
PCNB
(
75%
WP)
to
pepper
plants
at
planting
as
either
a
soil
drench
application
(
4
tests)
at
3.75
lb
ai/
100
gal.
or
as
an
in­
furrow
application
(
4
tests)
at
a
rate
equivalent
to
7.5
lb
ai/
A.
Pepper
fruit
was
harvested
at
normal
crop
maturity,
49­
105
days
after
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.03
ppm
in/
on
all
8
pepper
samples
from
the
soil
drench
application
and
<
0.03­
0.091
ppm
in/
on
8
pepper
samples
from
the
in­
furrow
application.
In
addition,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOD
(<
0.005
ppm)
in/
on
all
pepper
samples.
The
pepper
field
trial
data
are
not
adequate,
as
the
number
and
geographic
representation
of
the
field
trials
are
inadequate.
An
additional
5
tests
must
be
conducted
in
EPA
Regions
2,
3,
and
5
(
1
test
each)
and
Region
5
(
2
tests)
using
each
application
type
(
in­
furrow
and
soil
drench)
for
a
total
of
10
additional
tests.
If
a
tolerance
for
PCNB
residues
in/
on
all
peppers
is
desired,
then
an
additional
2
tests
must
also
be
conducted
on
non­
bell
peppers
using
each
application
type
(
in­
furrow
and
soil
drench)
for
a
total
of
4
additional
tests.
43
Tomatoes.
Uniroyal
has
submitted
adequate
data
from
9
tests
depicting
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in/
on
tomatoes
harvested
69­
113
days
following
either
an
in­
furrow
application
of
the
75%
WP
at
planting
at
7.5
lb
ai/
A
(
1x
the
maximum
rate)
or
a
soil
drench
application
at
transplanting
at
3.75
lb
ai/
100
gal
water
(
1.6x).
Residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
were
each

0.05
ppm
in/
on
26
samples
of
tomatoes,
for
combined
residues
<
0.25
ppm.
Reanalysis
of
18
tomato
samples
from
the
above
tests
using
a
method
with
a
lower
LOQ
(
0.002
ppm)
indicated
that
combined
residues
were
<
0.01­

0.02
ppm;
however,
the
available
storage
stability
data
for
tomatoes
indicate
that
residues
would
have
declined
substantially
during
the
intervals
samples
were
held
prior
to
the
reanalysis.
Considering
only
the
currently
regulated
metabolites
(
PCNB,
PCA,
and
MPCPS)
the
maximum
combined
residues
in/
on
tomatoes
would
be
<
0.15
ppm.

Amvac
has
submitted
residue
data
from
10
tests
reflecting
a
single
application
of
PCNB
(
75%
WP)
to
tomato
plants
at
transplanting
as
either
a
soil
drench
application
(
5
tests)
at
3.75
lb
ai/
100
gal.
or
as
an
in­
furrow
application
(
5
tests)
at
a
rate
equivalent
to
7.5
lb
ai/
A.
Tomato
fruit
was
harvested
at
normal
crop
maturity
81­
108
days
after
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.030
ppm
in/
on
all
10
tomato
fruit
samples
from
the
in­
furrow
application
and
<
0.030­<
0.042
ppm
in/
on
10
tomato
fruit
samples
from
the
soil
drench
application.
Quantifiable
PCNB
residues
were
found
only
in
one
sample,
which
had
residues
of
PCNB
per
se
at
0.022
ppm.
In
addition,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOQ
(<
0.01
ppm)
in/
on
all
tomato
samples.
The
tomato
field
trial
data
are
not
adequate,
as
the
number
and
geographic
representation
of
the
field
trials
are
inadequate.
An
additional
11
tests
using
the
soil
drench
application
method
and
an
additional
11
tests
using
the
in­
furrow
application
method
must
be
conducted;
the
tests,
for
each
application
method,
should
be
in
EPA
Regions
1
and
3
(
1
test
each)
and
Region
10
(
9
tests).

The
available
residue
data
from
Uniroyal
and
Amvac
would
support
establishing
a
permanent
tolerance
at
0.2
ppm
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
fruiting
vegetables
(
except
Cucurbits),
however,
additional
tests
must
be
conducted
by
Amvac
before
a
final
decision
can
be
made.

Miscellaneous
Commodities
Cotton.
Uniroyal
has
submitted
data
from
20
tests
on
cotton
reflecting
an
in­
furrow
application
at
planting
of
a
2
lb/
gal
EC
or
10%
G
formulation
at
2
lb
ai/
A
(
1x
Uniroyal's
current
maximum
rate);
however,
these
data
are
not
adequate
because
the
field
trial
samples
were
analyzed
by
Craven
Laboratories.
The
PCNB
Update
(
6/
90)
also
required
cotton
field
trial
data
reflecting
the
use
of
a
WP
formulation;
however,
considering
that
the
application
is
a
soil
application
applied
at
planting,
the
Agency
concludes
that
cotton
field
trial
data
reflecting
use
of
a
WP
formulation
is
not
required.
(
The
Agency
notes
that
Uniroyal
has
submitted
additional
field
trial
data
on
cotton,
MRIDs
42534114,
42534115,
and
43574901
reflecting
use
of
G
and
EC
formulations
which
are
currently
under
review.)

Amvac
has
submitted
residue
data
from
15
tests
reflecting
a
single
application
of
PCNB
to
cotton
plants
at
planting
as
either
a
banded
application
(
10%
G
in
5
tests)
at
2.0
lb
ai/
A
or
as
an
in­
44
furrow
application
(
10%
G
in
5
tests
and
2
lb/
gal
EC
in
5
tests)
at
0.15
lb
ai/
1000
linear
feet
of
row,
equivalent
to
2.0
lb
ai/
A
(
13,000
feet
of
row),
which
is
equivalent
to
the
maximum
label
rate.
Cotton
(
lint
and
seed)
was
harvested
at
normal
crop
maturity
135­
173
days
after
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.015­<
0.017
ppm
in/
on
all
30
cottonseed
regardless
of
application
method
or
formulation
used.
Residues
of
PCNB,
PCA,
and
PCTA
were
each
<
LOD
(
0.005
ppm)
in/
on
all
samples,
with
the
exception
of
three
treated
samples,
which
had
PCNB
residues
of
0.005­
0.007
ppm.
In
addition
to
the
currently
regulated
compounds,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOD
(<
0.005
ppm)
in/
on
all
cottonseed
samples
regardless
of
formulation
or
application
method.
The
cotton
field
trial
data
are
not
adequate,
as
the
number
of
crop
field
trials
and
geographic
representation
are
inadequate.
An
additional
4
tests
must
be
conducted
in
EPA
Region
2
(
1
tests)
and
Region
8
(
3
tests)
with
each
formulation­
application
scenario
(
10%
G
in
in­
furrow
application,
10%
G
in
banded
application,
and
EC
formulation
in
in­
furrow
application)
for
a
total
of
12
additional
tests.

Additional
residue
data
are
required
from
both
Uniroyal
and
Amvac
to
support
establishing
a
permanent
tolerance
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
cottonseed.
Data
are
also
required
from
both
Uniroyal
and
Amvac
depicting
PCNB
residues
in/
on
cotton
gin
byproducts
following
application
of
PCNB
at
the
maximum
labeled
rate.

Peanuts.
The
PCNB
Update
(
6/
90)
required
residue
data
supporting
the
use
of
EC,
FlC,
and
G
formulations
of
PCNB
on
peanuts.
Uniroyal
has
submitted
field
trial
data
from
12
tests
reflecting
two
broadcast
or
banded
foliar
applications
of
PCNB
(
10%
G,
75%
WP,
2
lb/
gal
EC,
or
4
lb/
gal
FlC)
to
peanut
plants
beginning
at
pegging
at
3­
7
lb
ai/
A/
application,
for
a
total
of
10
lb
ai/
A/
season.
A
total
of
12
tests
were
conducted
on
peanuts:
2
tests
using
two
banded
applications
of
the
10%
G
at
5
lb
ai/
A/
application;
2
tests
using
two
banded
applications
of
the
75%
WP
at
7
lb
ai/
A
and
then
3
lb
ai/
A;
2
tests
using
broadcast
(
chemigation)
applications
of
the
75%
WP
at
6
lb
ai/
A
and
then
4
lb
ai/
A;
3
tests
using
two
broadcast
(
chemigation)
applications
of
the
2
lb/
gal
EC
at
5
lb
ai/
A;
and
3
tests
using
two
broadcast
(
chemigation)
applications
of
the
4
lb/
gal
FlC
at
5
lb
ai/
A.
Mature
peanuts
were
collected
43­
47
days
after
the
last
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
0.017­
0.089
ppm
in/
on
4
peanut
nutmeat
samples
treated
with
the
10%
G,
0.007­
0.024
ppm
in/
on
8
peanut
nutmeat
samples
treated
with
the
75%
WP,
0.093­
0.330
ppm
in/
on
6
peanut
nutmeat
samples
treated
with
the
2
lb/
gal
EC,
and
0.021­
0.156
ppm
in/
on
6
peanut
nutmeat
samples
treated
with
the
4
lb/
gal
FlC.
In
addition,
residues
of
PCB
were
<
0.001­
0.057
ppm
and
residues
of
HCB
were
<
0.0005­
0.0126
ppm
in/
on
all
peanut
samples
from
all
use
patterns.

The
peanut
field
trial
data
are
not
adequate,
as
the
number
and
geographic
representation
of
the
field
trials
are
inadequate.
Although
a
total
of
12
trials
were
conducted
on
peanuts,
four
different
formulations
were
used.
The
Agency
notes
that
Uniroyal
formulations
currently
registered
for
use
on
peanuts
include
two
granular
(
G)
formulations,
a
wettable
powder
(
WP),
and
a
flowable
concentrate
(
FlC),
and
each
of
these
formulations
specify
a
maximum
seasonal
use
rate
of
2
lb
ai/
A.
An
additional
10
field
trials
should
be
conducted
in
EPA
Regions
2
(
8
tests),
Region
3
and
8
(
each
1
test)
with
the
each
of
the
three
supported
formulation
for
a
total
of
30
field
trials.
Samples
of
peanut
hay
must
be
taken
and
be
analyzed
as
well.
45
Amvac
has
submitted
residue
data
from
6
tests
reflecting
a
single
post­
emergence
application
of
PCNB
(
2
lb/
gal
EC,
10%
G
or
75%
WP)
to
peanuts
at
pegging
as
either
a
12­
inch
banded
application
(
5
tests)
or
as
a
broadcast
chemigation
(
1
test)
application
at
10
lb
ai/
A
(
the
maximum
label
rate).
Mature
peanuts
were
collected
44­
51
days
after
application.
The
combined
residues
of
PCNB,
PCA,
and
PCTA
were
0.158­
0.544
ppm
in/
on
6
nutmeat
samples
treated
with
the
10%
G
as
a
banded
application,
<
0.012­
0.078
ppm
in/
on
4
nutmeat
samples
treated
with
the
75%
WP
as
a
banded
application,
and
0.312­
0.383
ppm
in/
on
2
samples
treated
with
the
2
lb/
gal
EC
as
a
broadcast
application.
In
addition,
residues
of
PCB
were
<
0.005­
0.062
ppm,
TCNB
(
each
isomer)
residues
were
<
0.005­
0.030
ppm,
and
HCB
residues
were
<
0.005­
0.014
ppm
in/
on
all
peanut
samples.

As
all
nutmeat
samples
from
the
field
trials
reported
in
MRID
41870206
were
ground
with
the
shells
before
analysis,
the
residue
data
from
these
samples
are
not
useful
for
tolerance
assessment.

Amvac's
peanut
field
trial
data
are
not
adequate,
as
the
number
of
crop
field
trials
and
geographic
representation
are
inadequate.
A
total
of
30
additional
tests
must
be
conducted:
1)
An
additional
9
tests
must
be
conducted
with
10%
G
formulation
in
EPA
Region
2
(
7
tests)
and
Regions
3
and
8
(
1
test
each).
2)
An
additional
10
tests
must
be
conducted
with
75%
WP
formulation
in
EPA
Region
2
(
7
tests),
and
Regions
3,
6,
and
8
(
1
test
each).
3)
An
additional
11
tests
must
be
conducted
with
75%
EC
formulation
in
EPA
Region
2
(
8
tests),
and
Regions
3,
6,
and
8
(
1
test
each).

Additional
residue
data
are
required
from
both
Uniroyal
and
Amvac
to
support
establishing
a
permanent
tolerance
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
peanuts.

Crops
with
Only
Seed
Treatment
Uses
Seed
treatment
uses
of
PCNB
have
been
removed
from
all
of
Uniroyal's
PCNB
end­
use
product
labels;
therefore,
no
additional
data
are
required
from
Uniroyal
pertaining
to
residues
in
crops
with
only
seed
treatment
uses.

However,
there
are
four
PCNB
end­
use
products
currently
registered
to
Amvac
with
seed
treatment
uses
on
cereal
grains
(
barley,
corn,
oats,
rice,
sorghum
and
wheat)
beans
and
peas,
cotton,
peanuts,
safflower,
soybeans,
and
sugar
beets.
Amvac
has
submitted
a
study
following
the
uptake
of
radioactivity
in
corn,
peas,
rice,
safflower,
sugar
beets,
and
wheat
grown
from
seed
treated
with
[
14C]
PCNB
at
1.3­
1.8x
the
maximum
labeled
rates.
Based
on
this
study,
the
Agency
has
concluded
that
Amvac's
seed
treatments
are
food/
feed
uses.
Data
are
required
depicting
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in/
on
RACs
of
barley,
corn,
oats,
peas,
rice,
safflower,
sorghum,
sugar
beets,
and
wheat
grown
from
seed
treated
with
PCNB
at
the
maximum
labeled
rate.

Amvac
has
submitted
adequate
residue
data
from
7
tests
reflecting
a
single
seed
treatment
of
PCNB
(
2
lb/
gal
EC)
to
soybeans
at
0.75
lb
ai/
bushel
(
1.25
lb
ai/
100
lb
seed),
which
is
10x
the
46
maximum
label
rate.
Soybean
commodities
were
collected
125­
145
days
(
seeds),
80­
118
days
(
forage),
and
91­
145
days
(
hay)
after
application.
With
the
exception
of
one
hay
sample,
the
combined
residues
of
PCNB,
PCA,
and
PCTA
were
<
0.015
ppm
(<
LOD)
in/
on
14
samples
each
of
soybean
seeds,
forage,
and
hay.
One
hay
sample
had
PCNB
residues
of
0.006
ppm,
for
combined
residues
of
<
0.016
ppm.
In
addition,
residues
of
PCB,
TCNB
(
two
isomers),
and
HCB
were
each
<
LOD
(<
0.005
ppm)
in/
on
all
soybean
seed,
forage,
and
hay
samples,
with
the
exception
of
two
hay
samples
from
OH
having
PCB
residues
of
0.005
and
0.006
ppm.
Amvac
needs
to
submit
additional
2
tests
in
region
4
and
11
tests
in
region
5.
The
available
residue
data
would
support
establishing
a
separate
tolerance
at
0.02
ppm
in/
on
soybean
forage,
hay,
and
seeds
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA,
however,
additional
tests
must
be
conducted
by
Amvac
before
a
final
decision
can
be
made.

Imported
Crops
Ginseng.
Since
extensive
detected
residues
(
some
times
above
10
ppm)
have
been
reported
on
ginseng
by
Food
and
Drug
Administration
monitoring
program,
residue
data
should
be
generated
for
ginseng
in
the
representative
countries
and
tolerance
should
be
proposed.

OPPTS
GLN
860.1520:
Magnitude
of
the
Residue
in
Processed
Food/
Feed
As
Uniroyal
and
Amvac
are
separately
supporting
the
use
of
PCNB,
the
adequacy
of
the
available
processing
studies
will
be
considered
separately
for
each
registrant.
Uniroyal
has
submitted
adequate
processing
studies
for
succulent
beans,
potatoes,
and
tomatoes.
These
studies
indicate
that
PCNB
residues
and
its
impurities
do
not
concentrate
in
regulated
processed
commodities
derived
from
tomatoes;
residues
also
did
not
concentrate
in
potato
chips,
flakes,
or
granules.
Residues
were
shown
to
concentrate
by
1.6x
in
bean
cannery
waste
and
5.4x
in
wet
potato
peel.
However,
bean
cannery
waste
is
no
longer
a
regulated
feed
item
and
Uniroyal
is
not
supporting
any
uses
on
potatoes.
Uniroyal
has
also
submitted
processing
studies
on
cotton
[
MRID
43976901]
and
peanuts
[
MRID
43976902]
that
are
under
review.

Amvac
has
also
submitted
processing
studies
for
succulent
beans,
cottonseed,
peanuts,
potatoes,
and
tomatoes.
These
studies
indicate
that
PCNB
residues
and
its
impurities
do
not
concentrate
in
regulated
processed
commodities
derived
from
cottonseed,
peanuts,
and
tomatoes.
Residues
also
did
not
concentrate
in
potato
granules,
chips
or
flakes,
but
concentrated
on
average
7x
in
wet
potato
peel.
However,
supporting
storage
stability
data
are
required
to
upgrade
all
of
Amvac's
processing
studies
to
adequate.
The
processing
studies
are
summarized
below
by
crop.

Both
registrants
currently
have
uses
on
beans
listed
their
current
PCNB
labels.
As
this
use
could
include
applications
to
soybeans,
both
registrants
should
conduct
a
soybean
processing
study.
Alternatively
the
labels
could
be
amended
to
prohibit
direct
field
applications
to
soybean,
in
which
case
a
processing
study
would
not
be
required.

Beans,
succulent.
Uniroyal
submitted
an
adequate
succulent
bean
processing
study
using
snap
beans
harvested
14
days
after
the
last
of
multiple
applications
of
PCNB
totaling
40
lb
ai/
A
(
26x
47
the
current
maximum
rate).
The
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
concentrated
in
cannery
waste
by
1.6x;
however,
bean
cannery
waste
is
no
longer
a
regulated
feed
item.

Amvac
also
submitted
a
processing
study
using
snap
beans
harvested
7
or
14
days
following
the
last
of
four
banded
application
of
PCNB
(
75%
WP)
totaling
7.5,
22.5,
or
37.5
lb
ai/
A
(
1x,
3,
and
5x).
The
study
was
deemed
inadequate
as
residue
data
were
provide
only
for
the
RAC
treated
at
1x
and
for
the
processed
fractions
(
processed
beans
and
cannery
waste)
from
the
5x
treatment.
However,
no
additional
data
are
required
as
bean
cannery
waste
is
no
longer
a
regulated
commodity.

Cottonseed.
Uniroyal
previously
submitted
a
cottonseed
processing;
however,
the
processing
study
is
not
adequate
as
the
residue
data
were
generated
by
Craven
Laboratories.
Uniroyal
has
since
submitted
an
alternate
cottonseed
processing
study
(
MRID
43976901)
that
is
currently
under
review.

Amvac
has
also
submitted
cottonseed
processing
studies
using
seed
from
plants
treated
with
PCNB
(
2
lb/
gal
EC)
at
6
and
10
lb
ai/
A
(
3x
and
10x)
as
an
in­
furrow
application
at
planting.
The
data
indicate
that
the
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
did
not
concentrate
in
cottonseed
hulls,
meal,
soapstock,
or
crude
and
refined
oil.
However,
supporting
storage
stability
data
for
cottonseed
processed
fractions
are
required
to
upgrade
this
processing
study.
Samples
from
this
processing
study
were
stored
frozen
for
29­
232
days
prior
to
analysis.

Peanut.
Uniroyal
previously
submitted
a
peanut
processing;
however,
the
study
is
not
adequate
as
the
residue
data
were
generated
by
Craven
Laboratories.
Uniroyal
has
since
submitted
an
alternate
peanut
processing
study
(
MRID
43976902)
which
is
currently
under
review.

Amvac
has
also
submitted
peanut
processing
studies
using
peanuts
treated
with
PCNB
(
75%
WP)
at
36
and
50
lb
ai/
A
(
3.6
and
10x)
as
a
banded
application
at
pegging.
The
data
indicate
that
the
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
did
not
concentrate
in
peanut
presscake
(
meal),
soapstock
or
crude
and
refined
oil.
However,
supporting
storage
stability
data
for
peanut
processed
fractions
are
required
to
upgrade
this
processing
study.
Samples
from
this
peanut
processing
study
were
stored
frozen
for
9­
204
days
prior
to
analysis.

Potato.
As
Uniroyal
is
no
longer
supporting
the
use
of
PCNB
on
potatoes,
processing
data
on
potatoes
from
Uniroyal
are
no
longer
necessary.
However,
the
available
Uniroyal
potato
processing
studies
are
adequate
and
indicate
that
the
combine
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
did
not
concentrate
in
chips,
flakes
or
granules,
but
concentrated
by
6.2x
and
4.5x
in
wet
peel
from
two
tests
(
average
of
5.4x).

Amvac
has
also
submitted
potato
processing
studies
using
potatoes
treated
with
PCNB
(
2
lb/
gal
EC)
at
12
and
50
lb
ai/
A
(
1.2
and
5x)
as
an
in­
furrow
application
at
planting.
The
data
indicate
that
the
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
did
not
concentrate
in
potato
granules,
chips
or
flakes,
but
concentrated
on
average
by
2­
12.7x
(
average
of
7x)
in
wet
peel.
Considering
both
the
7x
concentration
factor
and
the
HAFT
residues
(
0.95
ppm)
from
Amvac's
48
potato
field
trials,
the
maximum
expected
combined
residues
in
wet
peel
would
be
6.65
ppm.
However,
supporting
storage
stability
data
for
processed
potato
fractions
are
required
to
upgrade
this
processing
study.
Samples
from
this
potato
processing
study
were
stored
frozen
for
8­
218
days
prior
to
analysis.

Tomato.
Uniroyal
has
submitted
an
adequate
tomato
processing
study
using
tomatoes
treated
at
5x
the
maximum
rate.
Although
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
were
not
detected
(
each
at
<
0.05
ppm)
in
whole
tomatoes
treated
at
5x,
the
data
indicate
that
the
combined
residues
concentrated
by
2x
in
dry
pomace,
but
did
not
concentrate
in
juice,
catsup,
paste,
puree,
or
wet
pomace.

Amvac
has
also
submitted
a
tomato
processing
study
using
tomatoes
treated
with
PCNB
(
75%
WP)
at
75
lb
ai/
A
(
10x)
as
an
in­
furrow
application
at
transplanting.
The
data
indicate
that
the
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB
and
HCB
did
not
concentrate
in
tomato
puree,
catsup,
or
juice,
but
concentrated
on
average
by
32x
in
wet
pomace
and
63x
in
dry
pomace.
However,
supporting
storage
stability
data
for
tomato
processed
fractions
are
required
to
upgrade
Amvac's
tomato
processing
study.
Samples
from
this
processing
study
were
stored
frozen
for
63­
227
days
prior
to
analysis.

OPPTS
GLN
860.1480:
Magnitude
of
the
Residue
in
Meat,
Milk,
Poultry,
and
Eggs
The
calculation
of
dietary
burden
is
shown
in
table
below.
As
MARC
decided
that
PCNB
and
all
its
metabolites
(>
80)
are
of
concern,
TRR­
level
residues
in
registered
and
unregistered
crops
which
have
associated
feed
items
are
used
for
estimating
the
dietary
burden.
This
is
because
detected
levels
of
PCNB
and/
or
its
metabolites
have
been
widely
observed
on
unregistered
crops
that
were
sampled
by
PDP
and
FDA,
substantiating
the
very
long
half­
life
of
PCNB
and/
or
its
residues
in
soil
(
1555
days,
C.
A.
Sutton,
"
Pentachloronitrobenzene,
Revised
Drinking
Water
Assessment",
D291286,
12/
22/
2003)
reported
in
literature.
49
Calculation
of
maximum
dietary
burdens
of
livestock
animals
for
PCNB
residues.

Feed
Commodity
1,
3
%
Dry
Matter
2
%
Diet
2
TRR
(
ppm)
2
Dietary
Burden
from
Registered
and
Unregistered
Crops
(
ppm)
3,4,5
Dietary
Burden
from
Registered
Crops
(
ppm)
3,4
5
Beef
Cattle
potato
waste
15
40
8.0
21.3
21.3
peanut
meal
85
15
0.4
0.07
0.07
forage
(
wheat
source)
25
25
5.05
5.05
­­

straw
and
hay
(
wheat
source)
88
20
25.9
5.89
­­

TOTAL
BURDEN
100
32.31
21.37
Dairy
Cattle
potato
waste
15
40
8.0
21.3
21.3
peanut
meal
85
15
0.4
0.07
0.07
forage
(
wheat
source)
25
25
5.05
5.05
­­

straw
and
hay
(
wheat
source)
88
20
25.9
5.89
­­

TOTAL
BURDEN
100
32.31
21.37
Poultry
peanut
meal
N/
A
25
0.4
0.1
0.1
wheat
grain
89
75
0.38
0.285
0
TOTAL
BURDEN
100
0.385
0.1
Swine
potato
culls
N/
A
50
1.1
0.55
0.55
peanut
meal
N/
A
15
0.4
0.6
0.6
Other
feed
stuff
­­
35
0
0
0
TOTAL
BURDEN
100
1.15
1.15
1.
Diet
was
chosen
based
on
consultation
with
HED
scientist,
Jerry
Stokes
in
Dec.
2003;
personal
communication.

2.
From
Table
1
of
residue
chemistry
860
guideline
series
(
August
1996).

3.
Residues
for
potato
waste
are
based
on
the
TRR
in
potato
metabolism
study
(
1.12
ppm)
and
average
concentration
factor
for
potato
wet
peel
in
Amvac
processing
study
(
7x)
and
those
for
peanut
meal
are
based
on
TRR
in
peanut
metabolism
study
(~
1.72/
5
to
get
TRR
for
1x
use
rate);
the
highest
combined
residues
of
PCNB,
PCA,
and
PCTA
from
potato
field
trials
is
1.01
ppm
(
for
2
lb/
gal
EC
in
in­
furrow
application
almost
equal
to
10
lb
ai/
12,400
linear
feet
of
row
with
50
PHI
of
89­
135
days),
that
for
peanut
nutmeat
from
field
trials
is
0.330
ppm
(
for
2
lb
ai/
gal
EC
for
total
application
rate
of
10
lb
ai/
A
with
PHI
of
45­
47
days),
and
for
peanut
hulls,
the
highest
combined
residues
of
PCNB,
PCA,
and
PCTA
from
field
trials
is
1.09
ppm
(
for
10%
G
formulation
in
total
application
rate
of
10
lb
ai/
A
and
PHI
of
43­
45
days).
The
closeness
of
TRR
from
metabolism
studies
and
field
trial
data
further
supports
use
of
TRR
values
and
that
this
value
for
potato
waste,
potato
culls,
and
peanut
meal
is
not
an
overestimate.

4.
Contribution
=
[
TRR
/
%
DM
(
if
cattle)]
X
%
diet).

5.
Dietary
burden
from
registered
and
unregistered
crops
for
beef
cattle/
dairy
includes
contribution
from
rotated
wheat
forage/
hay/
straw
which
contain
carried
over
residues
of
PCNB
and
its
metabolites
(
see
MRID
41562905).
Dietary
burden
from
registered
crops
are
presented
for
comparison.

Reregistration
requirements
for
magnitude
of
the
residue
in
meat,
milk,
poultry,
and
eggs
are
fulfilled.
Adequate
poultry
and
ruminant
feeding
studies
are
available
depicting
residues
of
PCNB,
PCA,
PCA,
MPCPS,
PCB
and
HCB
in
meat,
milk,
poultry
and
eggs.
Results
from
these
studies
are
summarized
below.

In
the
available
ruminant
feeding
study,
Holstein
cows
(
3
cows/
group)
were
fed
a
combination
of
PCNB
and
5­
ethoxy­
3­(
trichloro­
methyl)­
1,2,4­
thiadiazole
for
up
to
15
weeks.
Based
on
daily
feed
consumption,
the
PCNB
feeding
levels
were
equivalent
to
0.1,
1.0,
10,
and
1000
ppm
in
the
diet.
Milk
was
sampled
weekly,
and
fat
biopsy
samples
were
collected
after
1,
2,
4,
6,
and
8
weeks
of
dosing
at
the
0.1,
1.0,
and
10
ppm
dose
levels.
Cows
in
the
1000
ppm
dose
group
were
sacrificed
after
1
month
of
dosing,
and
cows
in
the
other
dose
groups
were
sacrificed
after
12­
15
weeks
of
dosing.
Samples
of
milk,
fat,
liver,
kidney,
and
muscle
were
analyzed
for
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB.
Detection
limits
were
reported
to
be
0.001
ppm
for
each
analyte,
except
MPCPS
(
LOD
=
0.01
ppm).
Residues
of
PCA
(
0.001­
0.009
ppm)
and
HCB
(
0.001­
0.018
ppm)
were
detected
in
milk
from
the
10
ppm
dose
group;
all
other
analytes
were
nondetectable
in
milk.
Only
PCA
(
0.062­
0.186
ppm)
and
HCB
(
0.036­
0.347
ppm)
were
detected
in
tissues
(
not
specified)
from
the
10
ppm
dose
group,
and
only
HCB
was
detected
in
fat
from
the
1
ppm
(
HCB,
0.007­
0.037
ppm)
and
0.1
ppm
(
HCB,
ND­
0.016
ppm)
dose
groups.

Possible
tolerances
for
livestock
(
cattle,
goats,
horses,
and
sheep)
commodities
were
calculated
using
residue
data
for
PCNB,
PCA,
and
MPCPS
from
the
10
ppm
dose
group
and
adjusting
for
the
dietary
burdens
of
beef
cattle
and
dairy
cattle
(
milk).
Based
on
the
above
assumptions,
a
tolerance
of
0.05
ppm
should
be
established
for
residues
in
milk
and
tolerances
of
1.0
ppm
should
be
established
for
residues
in
meat,
fat,
and
meat­
byproducts
(
mbyp)
of
cattle,
goats,
horse,
and
sheep.

Data
from
the
ruminant
feeding
study
(
1
ppm
dose
group)
was
used
to
assess
potential
tolerances
for
hog
commodities.
Residues
of
PCNB,
PCA,
and
MPCPS
were
non­
detectable
in
cattle
tissues
from
the
1
ppm
dose
group,
but
PCA
residues
were
detected
in
the
10
ppm
dose
group.
Therefore,
tolerances
for
hog
commodities
(
meat,
fat,
and
mbyp)
should
be
established
at
the
51
enforcement
method
LOQ.
However,
an
enforcement
method
for
animal
commodities
is
not
currently
available
and
both
Uniroyal
and
Amvac
must
submit
an
enforcement
method
for
animal
commodities.

In
a
poultry
feeding
study,
Red
Comet
Chickens
were
fed
PCNB
(
98%
ai,
containing
1.5%
HCB)
at
levels
equivalent
to
0.05,
1.0,
5.0,
15,
75,
and
300
ppm
in
the
diet
for
13­
15
weeks.
Eggs
were
collected
at
2­
13
day
intervals,
and
samples
of
fat,
liver,
and
breast
muscle
were
collected
at
sacrifice.
Samples
of
egg
yolks
and
white,
fat,
liver,
muscle
were
analyzed
for
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB.
Detection
limits
were
not
reported.
Maximum
combined
residues
are
reported
in
the
table
below.

Maximum
combined
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in
tissues
and
eggs
from
poultry
dosed
with
PCNB
(
containing
1.5%
HCB)
in
the
diet
for
13­
15
weeks.

Matrix
PCNB
dose
level
(
ppm
in
diet)

0.05
1.0
5.0
15.0
75
300
fat

0.157
a

0.176

0.485

2.502

9.166
43.41
liver

0.017
b

0.033

0.123

0.172

1.059
7.08
breast
muscle
ND
c
ND
ND
ND

0.047
0.73
egg
yolk

0.014
b
NR
d

0.182

0.544

3.307
12.58
egg
whites
ND

0.006
ND

0.002

0.010
0.05
a
In
fat
from
hens
dosed
at
0.05
ppm,
combined
residues
were
comprised
of
PCNB
(
0.018
ppm),
PCA
(
0.073
ppm),
and
HCB
(
0.066
ppm).
b
Residues
were
comprised
only
of
HCB
in
liver
(
0.017
ppm)
and
egg
yolk
(
0.014
ppm)
from
hens
dosed
at
0.05
ppm.
c
ND
=
not
detected
(
level
unspecified).
The
GC/
ECD
method
used
was
validated
to
0.002
ppm
for
each
analyte
(
combined
LOQ
of
0.006
ppm
for
PCNB,
PCA,
and
MPCPS).
d
Not
reported
in
PCNB
Registration
Standard
Residue
Chemistry
Chapter
(
6/
30/
86).

Possible
tolerances
for
poultry
commodities
were
calculated
using
residue
data
for
PCNB,
PCA,
and
MPCPS
from
the
1.0
ppm
dose
group
and
adjusting
for
the
calculated
dietary
burden
of
poultry.
Based
on
the
above
assumptions,
a
tolerance
of
0.5
ppm
should
be
established
for
poultry
fat
and
tolerances
of
0.05
ppm
should
be
established
for
eggs
and
poultry
mbyp.
A
tolerance
of
poultry
meat
is
not
required
as
detectable
residues
are
unlikely
to
occur
in
meat.

OPPTS
GLN
860.1400:
Magnitude
of
the
Residue
in
Water,
Fish,
Irrigated
Crops
52
PCNB
is
not
registered
for
use
on
aquatic
sites
or
crops;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

OPPTS
GLN
860.1460:
Magnitude
of
the
Residue
in
Food­
handling
Establishments
PCNB
is
not
registered
for
use
in
food­
handling
establishments;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

OPPTS
GLN
860.1650:
Submittal
of
Analytical
Reference
Standards
Analytical
reference
standards
for
PCNB
have
been
submitted
from
both
Amvac
(
July
1999)
and
Uniroyal
(
July
2001).
However,
reference
standards
are
not
available
for
the
other
two
residues
of
concern,
PCA
and
MPCPS.
Both
registrants
should
submit
reference
standards
for
PCA
and
MPCPS
to
the
follow
address.

USEPA
National
Pesticide
Standards
Repository/
Analytical
Chemistry
Branch/
OPP
Attn:
Richard
(
Dick)
Griffith
or
Charles
Stafford
710
Mapes
Road
Fort
George
G.
Meade,
MD
20755­
5350
OPPTS
GLN
860.1850:
Confined
Accumulation
in
Rotational
Crops
Both
Uniroyal
and
Amvac
have
submitted
inadequate
confined
rotational
crop
studies.

Uniroyal
submitted
a
confined
rotational
crop
study
in
which
[
14C]
PCNB
was
applied
to
a
sandy
loam
soil
at
2.0,
10,
or
30
lb
ai/
A.
Turnips
were
planted
1
year
after
application
at
2.0
or
10
lb
ai/
A,
and
lettuce
(
10
lb
ai/
A
only)
and
wheat
(
all
rates)
were
planted
30,
120,
and
365
days
after
treatment.
Total
radioactive
residues
were
>
0.05
ppm
in
all
samples
except
wheat
grain
planted
1
year
after
application
at
2.0
lb
ai/
A.
Analyses
of
turnip
tops
and
roots,
lettuce,
and
wheat
forage
and
straw
of
identified
up
to
30
metabolites,
the
majority
of
which
accounted
for
only
minor
portions
(<
10%)
of
the
14C­
residues,
and
the
metabolic
profile
was
similar
between
the
three
crops.
PCNB
was
reduced
to
form
PCA,
which
was
the
major
non­
polar
residue
in
rotational
crops.
PCNB
may
also
undergo
glutathione
conjunction
and
cleavage
to
form
PCTA.
Subsequent
oxidation
and
dechlorination
reactions
produced
a
number
of
tri,
tetra,
and
pentachloro
sulfonic
acid,
sulfoxide,
and
sulfone
metabolites.
The
confined
rotational
crop
study
for
PNCB
is
adequate
only
for
10
lb
ai/
A
use
rate;
the
highest
labeled
use
rate
for
PCNB
on
any
rotated
crop
(
30
lb
ai/
A)
was
not
used
in
this
study
for
the
three
matrices
(
used
only
for
wheat
forage).
In
the
Uniroyal
submitted
rotational
crops
studies,
the
TRR
was
>
0.05
ppm,
therefore
requiring
a
complete
characterization
and
identification
of
metabolites.
Such
a
characterization
and
identification
was
conducted
for
lettuce,
turnip
and
wheat
forage
and
not
for
wheat
grain.
53
Amvac
also
submitted
a
confined
rotational
crop
study,
which
was
originally
reviewed
by
EFGWB
(
D.
Spatz,
5/
3/
93).
In
this
study,
[
14C]
PCNB
was
applied
to
a
sandy
loam
soil
at
31
lb
ai/
A
(
1X).
Lettuce,
turnips,
and
wheat
were
planted
at
30,
120,
and
365
days
after
treatment
in
a
greenhouse,
and
immature
and
mature
plant
samples
were
collected
for
analysis.
Total
radioactive
residues
(
TRR)
in
the
various
crops
and
crop
parts
ranged
from
0.06
ppm
(
lettuce)
to
24.57
ppm
(
wheat
hulls).

The
ChemSAC
decided
(
in
June
2003)
that
based
on
all
available
data,
PCNB­
treated
crops
should
only
be
rotated
to
the
labeled
crops.

OPPTS
GLN
860.1900:
Field
Accumulation
in
Rotational
Crops:

The
ChemSAC
decided
(
in
June
2003)
that
based
on
all
available
data,
PCNB­
treated
crops
should
only
be
rotated
to
the
labeled
crops,
therefore
no
field
accumulation
studies
on
(
unregistered)
rotational
crops
are
needed.
However,
such
studies
on
registered
crops
are
required
as
they
are
likely
to
contain
residues
exceeding
the
current
tolerance
level.
Both
Uniroyal
and
Amvac
should
submit
field
accumulation
in
registered
rotated
crops.

Uniroyal
has
submitted
limited
field
rotational
crop
studies.
However,
these
studies
are
not
adequate
as
a
representative
root
crop
was
not
included
at
the
30­
and
120­
day
plant­
back
interval
and
because
PCNB
(
10%
G)
was
applied
at
10
lb
ai/
A/
season,
which
is
not
the
highest
use
rate
on
rotated
crops.
In
addition,
these
studies
did
not
address
rotation
to
registered
crops.
As
noted
above,
field
accumulation
studies
on
registered
rotational
crops
are
required.

Amvac
has
not
submitted
field
accumulation
studies
on
rotational
crops.

Field
accumulation
studies
on
registered
rotational
crops
are
required.
Plant
back
interval
in
these
studies
should
reflect
the
interval
desired
on
product
labels.
The
registrants
are
advised
to
consult
the
Agency
in
regard
to
which
crops
to
be
used
in
these
studies.
For
information
on
conducting
field
accumulation
studies
on
rotational
crops,
the
registrant
should
refer
to
OPPTS
Guideline
No.
860.1900.
54
Table
A1.
Food/
Feed
Use
Patterns
Subject
To
Reregistration
for
PCNB
End­
use
Products
Registered
to
Uniroyal
Chemical
Company
(
Case
0128).

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Application
Ratea
(
lb
ai/
A)
Use
Limitations
b,
c
Beans
(
excluding
cowpeas)

In­
furrow
application
at
planting
Ground
equipment
10%
G
[
400­
402]

15%
G
[
400­
458]

2
lb/
gal
EC
[
400­
400]

75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
1.5
Feeding
treated
vines
or
hay
to
livestock
is
prohibited.

Soil
drench
to
seedlings
in
beds
or
containers
prior
to
transplanting
Ground
equipment
75%
WP
[
400­
399]

75%
WDG
[
400­
479]

4
lb/
gal
FlC
[
400­
453]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.75
lb
ai/
5
cubic
yards
of
growing
media.

Preplant
incorporated
into
growing
media
of
bedding
plants
Ground
equipment
10%
G
[
400­
402]

15%
G
[
400­
458]
0.15
lb
ai/
cubic
yard
Table
A1.
Continued.

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Application
Ratea
(
lb
ai/
A)
Use
Limitations
b,
c
55
Brassica
Leafy
Vegetables
Group
In­
furrow
at
planting
application
or
preplant
incorporated
banded
or
broadcast
application
Ground
equipment
10%
G
[
400­
402]

15%
G
[
400­
458]

75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
30
Do
not
exceed
30
lb
ai/
A/
season,
regardless
of
the
application
method.
Use
on
collards,
kale,
and
mustard
greens
is
restricted
to
the
state
of
GA.

Soil
drench
immediately
after
transplanting
Ground
equipment
75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
1.5
lb
ai/
100
gal
(
½
pint
plant)

Soil
drench
to
seedlings
in
beds
or
containers
prior
to
transplanting
Ground
equipment
75%
WP
[
400­
399]

75%
WDG
[
400­
479]

4
lb/
gal
FlC
[
400­
453]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.75
lb
ai/
5
cubic
yards
of
growing
media.

Preplant
incorporated
into
growing
media
of
bedding
plants
Ground
equipment
15%
G
[
400­
457]

15%
G
[
400­
458]

10%
G
[
400­
402]
0.15
lb
ai/
cubic
yard
Cotton
In­
furrow
application
at
planting
Ground
equipment
75%
WP
[
400­
399]

2
lb/
gal
EC
[
400­
400]

10%
G
[
400­
402]

15%
G
[
400­
458]
2.0
Do
not
exceed
2
lb
ai/
A/
season
regardless
of
formulations
used.
Apply
over
the
seed
and
to
the
surrounding
soil.

Do
not
allow
grazing
or
feeding
of
cotton
foliage
by
livestock.

4
lb/
gal
FlC
[
400­
453]

2
lb/
gal
FlC
[
400­
455]

15%
G
[
400­
456]
1.5
Table
A1.
Continued.

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Application
Ratea
(
lb
ai/
A)
Use
Limitations
b,
c
56
1.5
lb/
gal
EC
[
400­
475]

6.5%
G
[
400­
408]

6.5%
G
[
400­
411]

6.5%
G
[
400­
412]
1.0
Garlic
In­
furrow
application
at
planting
Ground
equipment
75%
WP
[
400­
399]

2
lb/
gal
EC
[
400­
400]

4
lb/
gal
FlC
[
400­
453]
20­
21
For
in
furrow
application,
apply
over
the
seed
clove
and
to
the
surrounding
soil.
For
seed
clove
treatment,
mix
in
sufficient
water,
add
a
sticker
to
the
spray
solution,
and
mist
spray
for
complete
coverage
of
cloves.
Apply
only
at
planting
time,
and
do
not
apply
more
than
21
lb
ai/
A,

regardless
of
application
method.

Direct
spray
treatment
of
seed
cloves
prior
to
planting
10
lb
ai/
1,000
lb
seed
cloves
Peanuts
In­
furrow
application
at
planting
Ground
equipment
10%
G
[
400­
402]

15%
G
[
400­
458]

75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
2.0
Do
not
exceed
2
lb
ai/
A/
season
regardless
of
formulations
used.
Feeding
of
vines
to
livestock
and
hogging
down
of
peanuts
are
prohibited.

Do
not
use
on
peanuts
grown
in
CA.

Peppers,
hot
(
direct
seeded)

In­
furrow
application
at
planting
Ground
equipment
10%
G
[
400­
402]

15%
G
[
400­
458]

4
lb/
gal
FlC
[
400­
453]
1.3­
1.5
Apply
over
the
seed
and
to
the
surrounding
soil.
Table
A1.
Continued.

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Application
Ratea
(
lb
ai/
A)
Use
Limitations
b,
c
57
Peppers
In­
furrow
application
at
planting
Ground
equipment
15%
G
[
400­
458]

75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
7.2­
7.5
Soil
drench
application
at
transplanting
Ground
equipment
75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
2.25
lb
ai/
100
gal
Do
not
exceed
20
lb
ai/
A/
season
Soil
drench
to
seedlings
in
beds
or
containers
prior
to
transplanting
Ground
equipment
75%
WP
[
400­
399]

75%
WDG
[
400­
479]

4
lb/
gal
FlC
[
400­
453]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.75
lb
ai/
5
cubic
yards
of
growing
media.

Preplant
incorporated
into
growing
media
of
bedding
plants
Ground
equipment
15%
G
[
400­
457]

15%
G
[
400­
458]

10%
G
[
400­
402]
0.15
lb
ai/
cubic
yard
Table
A1.
Continued.

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Application
Ratea
(
lb
ai/
A)
Use
Limitations
b,
c
58
Tomatoes
In­
furrow
application
at
planting
Ground
equipment
15%
G
[
400­
458]

75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
7.2­
7.5
Do
not
exceed
7.2­
7.5
lb
ai/
A/
season.

Soil
drench
application
at
transplanting
Ground
equipment
75%
WP
[
400­
399]

4
lb/
gal
FlC
[
400­
453]
2.25
lb
ai/
100
gal
Do
not
exceed
7.0
lb
ai/
A/
season
for
planting
of
5000
plants/
A
or
16.5
lb
ai/
A/
season
for
plantings
of
11,733
plants/
A.

Soil
drench
to
seedlings
in
beds
or
containers
prior
to
transplanting
Ground
equipment
75%
WP
[
400­
399]

75%
WDG
[
400­
479]

4
lb/
gal
FlC
[
400­
453]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.75
lb
ai/
5
cubic
yards
of
growing
media.

Preplant
incorporated
into
growing
media
of
bedding
plants
Ground
equipment
15%
G
[
400­
457]

15%
G
[
400­
458]

10%
G
[
400­
402]
0.15
lb
ai/
cubic
yard
a
A
maximum
of
one
application
per
season
is
allowed
for
all
uses,
with
the
exception
of
soil
drench
applications
to
vegetable
bedding
plants.
Labels
allow
for
up
to
two
applications,
with
the
second
application
made
4­
6
weeks
after
the
first.

b
Planting
root
crops
in
PCNB
treated
fields
within
12
months
of
broadcast
and
banding
applications
unless
PCNB
is
registered
for
use
on
those
crops
is
prohibited.

c
A
12­
hour
restricted
entry
interval
(
REI)
is
specified
on
each
label,
except
for
EPA
Reg
Nos.
400­
408,
­
411,
­
412,
and
­
475,
which
have
REIs
of
48
hours.
59
Table
A2.
Food/
Feed
Use
Patterns
Subject
To
Reregistration
for
PCNB
End­
use
Products
Registered
to
Amvac
Chemical
Company
(
Case
0128).

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Application
Rate
Max.
#

of
Appl.
Minimum
RTIa
(
Days)
Use
Limitations
b,
c
Direct
Crop
or
Soil
Applications
Beans
(
excluding
cowpeas)

In­
furrow
application
at
planting
Ground
equipment
10%
G
[
5481­
211]

2
lb/
gal
EC
[
5481­
212]

75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

20%
DF
[
5481­
450]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
bush
beans:
1.5
lb
ai/
A
or
14,500
linear
ft.

pole
beans:
1.5
lb/
8,340
linear
ft
1
Not
Applicable
(
NA)
In
furrow
applications
should
be
made
at
planting
with
only
one
treatment
per
season.

Do
not
feed
treated
vines
or
hay
to
livestock
Repeated
basally
directed
applications
until
bloom
Ground
equipment
2
lb/
gal
EC
[
5481­

212]
75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

75%
WP
[
5481­
453]
1.5
lb
ai/
A
Not
specified
(
NS)
14
Except
in
CA,
multiple
basally
directed
applications
can
be
made
to
dry
and
snap
beans
2­
3
week
intervals.
Do
not
apply
after
first
bloom
or
exceed
a
maximum
of
10
lb
ai/
A/
season.

Do
not
feed
treated
vines
or
hay
to
livestock
6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
2.0
lb
ai/
A
Multiple
basally
directed
applications
can
be
made
to
dry
and
snap
beans
at
2­
3
week
intervals.

Do
not
apply
after
start
of
pod
formation,

and
do
not
feed
treated
vines
to
livestock.

A
maximum
seasonal
rate
is
not
specified.
Table
A2
(
Continued)

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Application
Rate
Max.
#

of
Appl.
Minimum
RTIa
(
Days)
Use
Limitations
b,
c
60
Brassica
Leafy
Vegetables
Preplant
incorporated
broadcast
application
Ground
equipment
6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
30
lb
ai/
A
1
Use
on
collards,
kale,
and
mustard
greens
is
restricted
to
the
state
of
GA.

Do
not
apply
more
than
30
lb
ai/
A/
season,
regardless
of
the
method
of
application
or
the
formulation
used.

Banded
incorporated
application
immediately
after
planting
Ground
equipment
22.8
lb
ai/
A
Soil
drench
immediately
after
transplanting
Ground
equipment
1.5
lb
ai/
100
gal
Broccoli,
Brussels
sprouts,
Cabbage,
and
Cauliflower
Preplant
incorporated
broadcast
application
Ground
equipment
10%
G
[
5481­
211]

75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

20%
DF
[
5481­
450]

75%
WP
[
5481­
453]
30
lb
ai/
A
1
NA
Banded
incorporated
application
immediately
after
planting
Ground
equipment
22.5
lb
ai/
A
Soil
drench
immediately
after
transplanting
Ground
equipment
75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

20%
DF
[
5481­
450]

75%
WP
[
5481­
453]
4.5
lb
ai/
100
gal
Soil
drench
to
seedlings
grown
in
containers
prior
to
transplanting
Ground
equipment
6
lb/
gal
FlC
[
5481­
471]
0.28
lb
ai/
100
gal
(
0.28
lb
ai/
5
cubic
yards)
2
NS
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.56
or
0.75
lb
ai/
5
cubic
yards
of
growing
media.

4
lb/
gal
FlC
[
5481­
472]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
Table
A2
(
Continued)

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Application
Rate
Max.
#

of
Appl.
Minimum
RTIa
(
Days)
Use
Limitations
b,
c
61
Cotton
In­
furrow
application
at
planting
Ground
equipment
10%
G
[
5481­
211]

2
lb/
gal
EC
[
5481­
212]

75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

20%
DF
[
5481­
450]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
2.0
lb
ai/
A
1
NA
Apply
over
the
seed
and
to
the
surrounding
soil.

Do
not
allow
grazing
or
feeding
of
cotton
foliage
by
livestock.

Labels
5481­
471
and
­
472
specify
a
maximum
seasonal
rate
of
2.0
lb
ai/
A.

30%
D
[
5481­
308]
1.5
lb
ai/
A
10%
D
[
5481­
311]

6.5%
G
[
5481­
415]
1.0
lb
ai/
A
Garlic
In­
furrow
application
at
planting
Ground
equipment
2
lb/
gal
EC
[
5481­
212]

75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
20­
21
lb
ai/
A
1
NA
For
in
furrow
application,
apply
over
the
seed
clove
and
to
the
surrounding
soil.

For
seed
clove
treatment,
mix
in
sufficient
water,
add
a
sticker
to
the
spray
solution,
and
mist
spray
for
complete
coverage
of
cloves.

On
labels
5481­
212,
­
279,
­
441,
and
­

453,
the
use
on
garlic
grown
in
CA
is
prohibited.

Labels
5481­
471
and
­
472
specify
a
maximum
seasonal
rate
of
20
lb
ai/
A.

Direct
spray
treatment
of
seed
cloves
prior
to
planting
75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
10
lb
ai/
1,000
lb
of
seed
cloves
Table
A2
(
Continued)

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Application
Rate
Max.
#

of
Appl.
Minimum
RTIa
(
Days)
Use
Limitations
b,
c
62
Peanuts
Banded
application
at
planting
Ground
equipment
2
lb/
gal
EC
[
5481­
212]
2.0
lb
ai/
A
1
NA
Apply
over
the
seed
and
to
the
surrounding
soil.

Do
not
apply
more
than
10
lb
ai/
A/
season
regardless
of
the
application
methods
used.

Feeding
of
vines
to
livestock
and
hogging
down
of
peanuts
are
prohibited.

A
45­
day
PHI
is
specified
on
labels
5481­
279,
­
453,
471,
and
­
472;
the
remaining
labels
do
not
specify
a
PHI.

Banded,
incorporated
application
over
the
row
at
planting
Ground
equipment
10%
G
[
5481­
211]

75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

20%
DF
[
5481­
450]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
10
lb
ai/
A
or
12,400
linear
ft
1
NA
Soil
application
at
cultivation
Ground
equipment
3.3
lb
ai/
A
or
12,400
linear
ft.
3
NS
Banded
application
over
row
at
pegging
Ground
equipment
10
lb
ai/
A
or
12,400
linear
ft.
1
NA
Peppers
In­
furrow
application
at
planting
Ground
equipment
75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
7.5
lb
ai/
A
1
NA
Soil
drench
at
transplanting
Ground
equipment
3.75
lb
ai/
100
gal
Soil
drench
to
seedlings
grown
in
containers
prior
to
transplanting
Ground
equipment
6
lb/
gal
FlC
[
5481­
471]
0.28
lb
ai/
100
gal
(
0.28
lb
ai/
5
cubic
yards)
2
NS
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.56
or
0.75
lb
ai/
5
cubic
yards
of
growing
media.

4
lb/
gal
FlC
[
5481­
472]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
Table
A2
(
Continued)

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Application
Rate
Max.
#

of
Appl.
Minimum
RTIa
(
Days)
Use
Limitations
b,
c
63
Potatoes
Broadcast
preplantincorporated
application
Ground
equipment
10%
G
[
5481­
211]

2
lb/
gal
EC
[
5481­
212]

20%
DF
[
5481­
450]
25
lb
ai/
A
1
NA
In­
furrow
application
at
planting
Ground
equipment
10%
G
[
5481­
211]

2
lb/
gal
EC
[
5481­
212]

20%
DF
[
5481­
450]
10
lb
ai/
12,400
linear
feet
Banded
application
at
planting
Ground
equipment
6
lb/
gal
FlC
[
5481­
471]
20
lb
ai/
A
Apply
in
8.5
inch
banded
over
furrow
at
planting.

Do
not
apply
more
than
20
lb
ai/
A/
season
regardless
of
the
method
of
application
or
the
formulation
used.

4
lb/
gal
FlC
[
5481­
472]
5
lb
ai/
A
Tomatoes
In­
furrow
application
at
planting,
or
pre­
plant
incorporated
application
to
transplants
Ground
equipment
75%
WP
[
5481­
279]

75%
DF
[
5481­
441]

75%
WP
[
5481­
453]

6
lb/
gal
FlC
[
5481­
471]

4
lb/
gal
FlC
[
5481­
472]
7.5
lb
ai/
A
1
NA
Rate
based
on
48"
row
spacing
for
staked
tomatoes
and
72"
row
spacing
for
flat
tomatoes.

Labels
for
5481­
279,
­
441,
and
­
453
prohibit
use
on
tomatoes
grown
in
CA.

Labels
for
5481­
471and
­
472
specify
a
maximum
seasonal
rate
of
7.5
lb
ai/
A.

Soil
drench
at
transplanting
Ground
equipment
3.75
lb
ai/
100
gal
Soil
drench
to
seedlings
grown
in
containers
prior
to
transplanting
Ground
equipment
6
lb/
gal
FlC
[
5481­
471]
0.28
lb
ai/
100
gal
(
0.28
lb
ai/
5
cubic
yards)
2
NS
One
repeat
application
can
be
made
4­
6
weeks
after
the
first
application,
for
a
total
of
0.56
or
0.75
lb
ai/
5
cubic
yards
of
growing
media.

4
lb/
gal
FlC
[
5481­
472]
0.375
lb
ai/
100
gal
(
0.375
lb
ai/
5
cubic
yards)
Table
A2
(
Continued)

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Application
Rate
Max.
#

of
Appl.
Minimum
RTIa
(
Days)
Use
Limitations
b,
c
64
Seed
Treatments
Seed
treatment
Liquid
or
slurry
type
seed
treatment
equipment
2
lb/
gal
EC
[
5481­
212]

1.7
lb/
gal
FlC
[
5481­
215]

2
lb/
gal
RTU
[
5481­
442]

1.7
lb/
gal
FlC
[
5481­
445]
barley:
0.156
lb
ai/
100
lb
seed
beans,
corn,
wheat:
0.05
lb
ai/
100
lb
seed
cotton:
0.25
lb
ai/
100
lb
seed
oats,
sugar
beet:
0.19
lb
ai/
100
lb
seed
peanuts,
safflower:
0.06
lb
ai/
100
lb
seed
peas,
soybeans:
0.11
lb
ai/
100
lb
seed
rice:
0.14lb
ai/
100
lb
seed
sorghum:
0.03
lb
ai/
100
lb
seed
Do
not
use
treated
seed
for
feed,
food
or
oil
purposes.

Labels
for
5481­
212
and
­
422
do
not
include
a
use
on
peanut
seed,
and
the
label
for
5481­
212
prohibits
application
to
corn,
rice,
and
safflower
seeds
for
use
in
CA.

a
RTI=
retreatment
interval.

b
With
the
exceptions
of
three
formulations
used
only
for
seed
treatment
(
EPA
Reg
Nos.
5481­
215,
­
442,
and
­
445),
the
labels
prohibit
planting
root
crops
in
PCNB
treated
fields
within
12
months
of
broadcast
and
banding
applications
unless
PCNB
is
registered
for
use
on
those
crops.

c
A
12­
hour
restricted
entry
interval
(
REI)
is
specified
on
each
label,
except
for
one
6.5%
G
formulation
[
EPA
Reg
No.
5481­
415],
which
has
a
24­
hour
REI.
(
continued;
footnotes
follow)
65
Table
B1.
Residue
Chemistry
Science
Assessments
for
Reregistration
of
PCNB
formulations
registered
to
Uniroyal
Chemical
Co.

GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
860.1200:
Directions
for
Use
N/
A
Yes2
See
Table
A.

860.1300:
Plant
Metabolism
N/
A
Yes3
00001676
00002827
00114183
00114184
00114185
00114186
00114187
41341201
41341202
41341203
415629014
415629024
415629034
415629044
444691015
453073016
453073027
453073036
860.1300:
Animal
Metabolism
N/
A
No8
00114205
00114966
41341204
41341205
416928014
416928024
416928054
417358019
419088016
441675016
860.1340:
Residue
Analytical
Methods
­
Plant
commodities
N/
A
No
00001570
00001669
00001670
00001707
00001862
00014327
00028428
00053075
00064197
00097719
00097734
00097735
00097738
00097739
00097740
00097741
00097791
408167014
408167024
408167034
408167044
414376014
415213014
415213024
415213034
415213044
415213064
416928034
­
Animal
commodities
N/
A
Yes10
00014327
00109656
860.1360:
Multiresidue
Methods
N/
A
No
4275520111
860.1650:
Analytical
Reference
Standards
NA
Yes12
860.1380:
Storage
Stability
Data
N/
A
No
00059120
40921600
40921601
4144890113
415213054
4182950114
4182950213
448147015
Table
B1
(
Continued)

GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
(
continued;
footnotes
follow)
66
860.1500:
Crop
Field
Trials
Root
and
Tuber
Vegetables
Group
­
Potato
0.1
§
180.319
Yes15
00001861
00059933
00097742
00129447
00156362
40816701
414376024
Bulb
Vegetables
Group
­
Garlic
0.1
§
180.319
No
00097786
Brassica
Leafy
Vegetables
Group
­
Broccoli
0.1
§
180.319
No
00097736
40816702
­
Brussels
Sprouts
0.1
§
180.319
No16
­
Cabbage
0.1
§
180.319
No
00001861
00097720
40816703
­
Cauliflower
0.1
§
180.319
No15
­
Collards
0.2
§
180.291
No
00158795
­
Kale
0.2
§
180.291
No
00158795
­
Mustard
Greens
0.2
§
180.291
No
00158795
Legume
Vegetables
Group
­
Beans
0.1
§
180.319
Yes17
00001861
00097734
00097764
40816704
415213034
4311820218
4311820317
­
Soybeans
Yes19
Fruiting
Vegetables
Group
­
Peppers
0.1
§
180.319
No
00097801
40816705
415213044
415213064
­
Tomatoes
0.1
§
180.319
No
00001861
00097743
415213014
415213024
Miscellaneous
Commodities
Table
B1
(
Continued)

GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
(
continued;
footnotes
follow)
67
­
Cotton
0.1
§
180.291
Yes20
00001704
00002228
00028427
00064194
00097740
00109402
4134120621
4253411417
4253411517
4357490117
­
Peanuts
1.0
§
180.319
Yes22
00001704
00001859
00001862
00031296
00059932
00060784
00097741
00125805
41002507
4143760120
435492016
435492026
435492036
Seed
Treatment
Uses
None
No23
00053075
00059146
00059147
00059155
40862901
4179260124
4179260223
4179260323
4179260423
4179260523
4179260623
Imported
Crops
­
Ginseng
None
Yes25
860.1520:
Processed
Food/
Feed
­
Beans,
cannery
waste
None
No
40816704
415213034
­
Cottonseed
None
Yes17
4134120620
4397690117
­
Peanut
None
Yes17
4143760120
4397690217
­
Potato
None
No
40070401
40088401
40457401
414376024
­
Soybean
None
Yes26
­
Tomato
None
No
415213014
415213024
860.1480:
Meat,
Milk,
Poultry,
and
Eggs
­
Meat,
Meat­
by­
products,
and
fat
of
cattle,
goats,
hogs,
horses,
and
sheep
None
Yes27
00014326
­
Milk
None
­
Meat
and
Meat­
by­
products
of
poultry
None
Yes25
00097757
00109656
­
Eggs
None
860.1400:
Water,
Fish,
and
Irrigated
Crops
NA
NA
Table
B1
(
Continued)

GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
68
1.
Italicized
references
were
reviewed
in
the
PCNB
Registration
Standard
dated
6/
30/
86,
and
Bolded
references
were
reviewed
in
the
PCNB
Reregistration
Standard
Update
dated
6/
19/
90.
All
other
references
were
reviewed
as
noted.

2.
Based
upon
the
available
residue
data
and/
or
changes
in
data
requirements,
the
Agency
is
recommending
changes
to
use
directions.
The
recommended
label
amendments
are
listed
in
the
SUMMARY
OF
SCIENCE
FINDINGS,
under
Directions
for
Use.

3.
The
nature
of
the
residue
in
plants
is
not
adequately
understood.
Additional
data
are
required
to
upgrade
the
plant
metabolism
study
on
cabbage
and
the
most
recent
peanut
metabolism
study.

4.
CBRS
Nos.
6945,
6954,
6779
and
7396,
DP
Barcodes
D158943,
D212909­
10,
D212912­
14
and
D212916
J.
Abbotts,
4/
24/
96.

5.
DP
Barcodes
D269994,
D269996,
D270146,
and
D270187,
M.
Sahafeyan,
9/
10/
01.

6.
DP
Barcode
D283392;
M.
Sahafeyan,
5/
27/
03.

7.
DP
Barcode
D283391;
M.
Sahafeyan,
5/
27/
03
8.
Uniroyal
is
asked
to
submit
the
original
study
on
ruminant
metabolism
to
clarify
the
TRR
in
milk.

9.
CBRS
No.
7605,
DP
Barcode
D160683,
R.
Perfetti,
2/
3/
92.

10.
As
the
available
residue
data
on
livestock
feed
items
indicate
that
tolerances
will
be
required
for
animal
commodities,
Uniroyal
must
propose
a
tolerance
enforcement
method
for
determining
PCNB
residues
of
concern
in
animal
commodities.

11.
CBRS
No.
11874,
DP
Barcode
D191283,
L.
Edwards,
5/
21/
93.

12.
Reference
standards
for
PCA
and
MPCPS,
which
are
residues
of
concern,
must
be
submitted
to
the
following
address:
USEPA
National
Pesticide
Standards
Repository/
Analytical
Chemistry
Branch/
OPP
Attn:
Richard
(
Dick)
Griffith
or
Charles
Stafford
710
Mapes
Road
Fort
George
G.
Meade,
MD
20755­
5350
13.
DEB
No.
6760,
E.
Haeberer,
6/
28/
90.

14.
CBRS
No.
7877,
DP
Barcode
D163419,
R.
Perfetti,
2/
3/
92.
860.1460:
Food
Handling
NA
NA
860.1850:
Confined
Rotational
Crops
NA
No
415629056
4209440528
4284110126
4284110226
4284110326
4284110426
4284110526
445775015
860.1900:
Field
Rotational
Crops
None
Yes29
440810016
441135016
69
15.
Field
trial
data
and
processing
data
to
support
a
SLN
in
state
of
ME
for
75%
WP
formulation
are
outstanding.

16.
Residue
data
from
broccoli
field
trials
will,
by
translation,
fulfill
data
requirements
for
Brussels
sprouts
and
cauliflower.

17.
In
order
to
accurately
assess
residue
in/
on
beans,
data
are
required
reflecting
Uniroyal's
current
use
pattern
for
beans,
which
allows
for
only
a
single
field
application
at
planting
to
beans
(
excluding
cowpeas)
at
a
maximum
of
1.5
lb
ai/
A.

18.
These
studies
have
been
submitted
by
Uniroyal
and
are
currently
under
review.

19.
Uniroyal's
labeled
uses
on
dry
beans
could
potentially
include
use
on
soybeans.
Therefore,
field
trial
data
are
required
reflecting
the
use
PCNB
on
soybeans
at
the
maximum
rate.
Alternatively,
the
registrant
could
prohibit
direct
field
applications
to
soybeans,
in
which
case
separate
field
trial
data
for
soybeans
would
not
be
required.

20.
Data
are
required
from
Uniroyal
depicting
residues
in/
on
cottonseed
following
application
of
PCNB
(
2
lb/
gal
EC
and
10%
G)
at
the
maximum
labeled
rate
(
2
lb
ai/
A).
Uniroyal
has
submitted
additional
field
trial
data
on
cotton
[
MRIDs
42534114,
42534115,
and
43574901]
reflecting
use
of
G
and
EC
formulations,
which
are
currently
under
review.
Residue
data
depicting
PCNB
residues
in/
on
cotton
gin
by­
products
(
gin
trash)
is
also
required
from
six
trials,
three
from
each
type
of
harvesting
equipment
(
stripper
and
mechanical
picker).

21.
These
data
were
generated
by
Craven
Laboratories
and
will
not
be
used
for
assessing
tolerances.

22.
Although
a
total
of
12
trials
were
conducted
on
peanuts,
four
different
formulations
were
used.
The
Agency
notes
that
Uniroyal
formulations
currently
registered
for
use
on
peanuts
include
two
granular
(
G)
formulations,
a
wettable
powder
(
WP),
and
a
flowable
concentrate
(
FlC),
and
each
of
these
formulations
specify
a
maximum
seasonal
use
rate
of
2
lb
ai/
A.
An
additional
10
field
trials
should
be
conducted
in
EPA
Regions
2
(
8
tests),
Region
3
and
8
(
each
1
test)
with
the
each
of
the
three
supported
formulation
for
a
total
of
30
field
trials.
Samples
of
peanut
hay
must
be
taken
and
analyzed
as
well.

23.
Seed
treatment
uses
are
no
longer
listed
on
any
of
Uniroyal's
PCNB
labels;
therefore
no
additional
residue
data
are
required
from
crops
that
previously
only
had
seed
treatment
uses.

24.
Uniroyal
submitted
studies
pertaining
to
its
seed
treatment
uses
(
MRIDs
41792601­
41792605).
These
studies
were
not
review
by
the
Agency;
however,
Uniroyal
has
since
deleted
all
seed
treatment
uses
from
its
labels.

25.
Residue
data
for
ginseng
should
be
generated
in
the
representative
countries
and
tolerance
should
be
proposed.

26.
A
soybean
processing
study
is
required.
Alternatively,
the
registrant
could
prohibit
field
applications
to
soybeans,
in
which
case
a
soybean
processing
study
would
not
be
required.

27.
Data
requirements
for
plant
metabolism,
storage
stability,
and
magnitude
of
the
residues
in/
on
feed
commodities
must
be
fulfilled
before
requirements
for
animal
feeding
studies
can
be
established.

28.
CBRS
No.
12326,
DP
Barcode
D193790,
F.
Fort,
12/
27/
94.

29.
The
ChemSAC
decided
(
in
June
2003)
that
based
on
all
available
data,
PCNB­
treated
crops
should
only
be
rotated
to
the
labeled
crops,
therefore
field
accumulation
studies
on
registered
rotated
crop
are
required.
70
Plant
back
interval
in
these
studies
should
reflect
the
interval
desired
on
product
labels.
The
registrants
are
advised
to
consult
the
Agency
in
regard
to
which
crops
to
be
used
in
these
studies.
For
information
on
conducting
field
accumulation
studies
on
rotational
crops,
the
registrant
should
refer
to
OPPTS
Guideline
No.
860.1900.
(
continued;
footnotes
follow)
71
Table
B2.
Residue
Chemistry
Science
Assessments
for
Reregistration
of
PCNB
formulations
registered
to
Amvac
Chemical
Corp.

GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
860.1200:
Directions
for
Use
N/
A
Yes2
See
Table
A.

860.1300:
Plant
Metabolism
N/
A
Yes3
422221014
424827015
424827025
860.1300:
Animal
Metabolism
N/
A
Yes6
41303101
41303301
418236017
418397018
860.1340:
Residue
Analytical
Methods
­
Plant
commodities
N/
A
No
418702049
­
Animal
commodities
N/
A
Yes10
860.1360:
Multiresidue
Methods
N/
A
No11
860.1650:
Analytical
Reference
Standards
NA
Yes12
860.1380:
Storage
Stability
Data
N/
A
Yes13
418702049
860.1500:
Crop
Field
Trials
Root
and
Tuber
Vegetables
Group
­
Potato
0.1
§
180.319
Yes14
418702089
Bulb
Vegetables
Group
­
Garlic
0.1
§
180.319
Yes15
Brassica
Leafy
Vegetables
Group
­
Broccoli
0.1
§
180.319
Yes16
418702019
­
Brussels
Sprouts
0.1
§
180.319
No17
­
Cabbage
0.1
§
180.319
No
4187020218
­
Cauliflower
0.1
§
180.319
No15
­
Collards
0.2
§
180.291
No
00158795
­
Kale
0.2
§
180.291
No
00158795
­
Mustard
Greens
0.2
§
180.291
No
00158795
Legume
Vegetables
Group
GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
(
continued;
footnotes
follow)
72
­
Beans
0.1
§
180.319
Yes19
418702049
418702059
418702099
­
Soybeans
None
Yes20
Fruiting
Vegetables
Group
­
Peppers
0.1
§
180.319
Yes21
418702079
­
Tomatoes
0.1
§
180.319
Yes22
418702109
Miscellaneous
Commodities
­
Cottonseed
0.1
§
180.291
Yes23
418702039
­
Peanuts
1.0
§
180.319
Yes24
4187020625
427186019
Crops
with
Seed
Treatment
Uses
None
Yes26
4175820127
418713019
Imported
Crops
­
Ginseng
None
Yes28
860.1520:
Processed
Food/
Feed
­
Beans,
cannery
waste
None
No29
4197580430
­
Cottonseed
None
Yes31
4197580126
­
Peanut
None
Yes32
4197580226
­
Potato
None
Yes33
4197580326
­
Soybean
None
Yes34
­
Tomato
None
Yes35
4197580526
860.1480:
Meat,
Milk,
Poultry,
and
Eggs
None
Yes
­
Meat,
Meat­
by­
products,
and
fat
of
cattle,
goats,
hogs,
horses,
and
sheep
­
Milk
­
Meat
and
Meat­
by­
products
of
poultry
­
Eggs
860.1400:
Water,
Fish,
and
Irrigated
Crops
NA
NA
860.1460:
Food
Handling
NA
NA
860.1850:
Confined
Rotational
Crops
NA
No
4259920136
GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
73
1.
Bolded
references
were
reviewed
in
the
PCNB
Reregistration
Standard
Update
dated
6/
19/
90.
All
other
references
were
reviewed
as
noted.

2.
Based
upon
the
available
residue
data
and/
or
changes
in
data
requirements,
the
Agency
is
recommending
changes
to
use
directions.
The
recommended
label
amendments
are
listed
in
the
SUMMARY
OF
SCIENCE
FINDINGS,
under
Directions
for
Use.

3.
The
nature
of
the
residue
in
plants
is
not
adequately
understood.
Additional
data
are
required
to
upgrade
Amvac's
existing
plant
metabolism
studies
on
peanuts,
cabbage,
and
potatoes.
In
considering
all
three
of
Amvacs'
plant
metabolism
studies,
the
Agency
(
D184350
and
D181195,
J.
Abbotts,
4/
16/
96)
noted
that
the
early
metabolites
in
peanut,
potato,
and
cabbage
are
similar,
and
the
HPLC
profiles
of
polar
metabolites
are
also
similar
for
these
crops.
Provided
a
new
acceptable
metabolism
study
is
completed
on
potato
or
cabbage,
including
identification
of
the
Unknown
metabolites
D
and
H,
the
Agency
would
be
willing
to
conclude
that
the
nature
of
the
residue
in
plants
was
adequately
understood.

4.
CBRS
No.
9533,
DP
Barcode
D175304,
J.
Abbotts,
7/
31/
92.

5.
CBRS
Nos.
10815
and
10324,
DP
Barcodes
D184350
and
D181195,
J.
Abbotts,
4/
16/
96.

6.
The
nature
of
the
residues
in
animals
is
not
adequately
understood.
The
Agency
concluded
that
additional
data
and
information
are
required
to
upgrade
the
available
ruminant
and
poultry
metabolism
studies
submitted
by
Amvac.
However,
after
considering
the
age
of
the
samples
from
Amvac's
ruminant
and
poultry
metabolism
studies,
HED
(
J.
Abbotts,
4/
16/
96)
recommended
that
Amvac
should
submit
new
animal
metabolism
studies.

7.
CB
No.
7871,
DP
Barcode
D163420,
C.
Olinger,
12/
4/
91.

8.
CBRS
No.
7925,
DP
Barcode
D163838,
R.
Perfetti,
2/
3/
92.

9.
Amvac's
submission
(
MRID
41870204)
included
three
studies
which
were
reviewed:
Magnitude
of
residue
study
on
dry
beans
(
860.1500),
DP
Barcode
D292054,
M.
Sahafeyan,
8/
5/
2003.
Residue
analytical
method
(
860.
1340),
DP
Barcode
D292055,
M.
Sahafeyan,
8/
6/
2003.
Storage
stability
(
860.1380),
DP
Barcode
D292056,
M.
Sahafeyan,
7/
30/
2003.

10.
As
the
available
residue
data
on
livestock
feed
items
indicate
that
tolerances
will
be
required
for
animal
commodities,
Amvac
must
propose
a
tolerance
enforcement
method
for
determining
PCNB
residues
of
concern
in
animal
commodities.

11.
The
Agency
has
determined
that
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
are
completely
recovered
through
PAM
Vol.
I,
Methods
302,
303
and
304.
No
additional
data
are
required
(
D.
Edwards,
8/
1/
86).

12.
Reference
standards
for
PCA
and
MPCPS,
which
are
residues
of
concern,
must
be
submitted
to
the
following
address:
USEPA
National
Pesticide
Standards
Repository/
Analytical
Chemistry
Branch/
OPP
Attn:
Richard
(
Dick)
Griffith
or
Charles
Stafford
710
Mapes
Road
860.1900:
Field
Rotational
Crops
None
Yes37
74
Fort
George
G.
Meade,
MD
20755­
5350
13.
Supporting
storage
stability
data
are
required
to
upgrade
all
of
Amvac's
processing
studies
(
cottonseed,
peanut,
potato,
and
tomato).

14.
An
additional
total
of
36
field
trials
must
be
conducted
with
10%
G
and
2
lb/
gal
EC
formulations
in
each
PPI
and
in­
furrow
applications
in
regions
1
(
1
test),
region
2
(
1
test),
region
5
(
2
tests),
region
9
(
1
test),
and
region
11
(
4
tests).

15.
As
the
available
garlic
field
trial
data
were
originally
submitted
by
Olin
Chemical
Company
to
which
Amvac
does
not
have
any
rights,
Amvac
must
conduct
new
garlic
field
studies
at
the
maximum
labeled
rate.

16.
An
additional
7
tests
in
EPA
Region
10
using
75%
WP
at
30
lb
ai/
A
in
broadcast
PPI
application
(
1
test),
in
banded
application
(
1
test),
using
75%
WP
at
4.5
lb
ai/
100
gal.
in
soil
drench
application
with
PHI
>
72
days
(
3
tests),
using
10%
WP
at
30
lb
ai/
A
in
broadcast
PPI
application
at
transplant
with
PHI
>
72
days
(
1test),
using
10%
G
at
30
lb
ai/
A
in
banded
application
with
PHI
>
72
days
(
1
test)
must
be
conducted.

17.
Residue
data
from
broccoli
field
trials
will,
by
translation,
fulfill
data
requirements
for
Brussels
sprouts
and
cauliflower.

18.
DP
Barcode
D292044,
M.
Sahafeyan,
7/
31/
03.

19.
An
additional
4
tests
must
be
conducted
on
dry
beans
using
each
formulation
in
EPA
Region
5
(
2
tests)
and
Regions
7
and
8
(
1
test
each),
for
a
total
of
eight
additional
tests.
Additional
field
trial
residue
data
on
snap
beans
are
required
from
12
tests
(
6
per
formulation)
at
a
PHI
specified
by
the
registrant.
Tests
should
include
locations
in
Region
5.
An
additional
3
tests
must
be
conducted
on
lima
beans
in
EPA
Region
2
(
2
tests)
and
Region
11
(
1
test)
with
each
formulation
(
75%
WP
and
2
lb/
gal
EC)
for
a
total
of
six
additional
tests.

20.
Labeled
uses
on
dry
beans
could
potentially
include
use
on
soybeans.
Therefore,
field
trial
data
are
required
reflecting
the
use
PCNB
on
soybeans
at
the
maximum
rate.
Alternatively,
the
registrant
could
prohibit
direct
field
applications
to
soybeans,
in
which
case
separate
field
trial
data
for
soybeans
would
not
be
required.

21.
An
additional
5
tests
must
be
conducted
on
peppers
in
EPA
Regions
2,
3,
and
5
(
1
test
each)
and
Region
5
(
2
tests)
using
each
application
type
(
in­
furrow
and
soil
drench)
for
a
total
of
10
additional
tests.
If
a
tolerance
for
PCNB
residues
in/
on
all
peppers
is
desired,
then
an
additional
2
tests
must
also
be
conducted
on
non­
bell
peppers
using
each
application
type
(
in­
furrow
and
soil
drench)
for
a
total
of
4
additional
tests.

22.
An
additional
11
tests
using
the
soil
drench
application
method
and
an
additional
11
tests
using
the
infurrow
application
method
must
be
conducted
on
tomatoes;
the
tests,
per
each
application
method,
should
be
conducted
in
EPA
Regions
1
and
3
(
1
test
each)
and
Region
10
(
9
tests).

23.
Field
residue
data
depicting
PCNB
residues
in/
on
cotton
gin
by­
products
(
gin
trash)
is
required
from
six
trials,
three
from
each
type
of
harvesting
equipment
(
stripper
and
mechanical
picker).

24.
A
total
of
30
additional
tests
(
for
both
nutmeat
and
hay)
must
be
conducted:
1)
An
additional
9
tests
must
be
conducted
with
10%
G
formulation
in
EPA
Region
2
(
7
tests)
and
Regions
3
and
8
(
1
test
each).
2)
An
additional
10
tests
must
be
conducted
with
75%
WP
formulation
in
EPA
Region
2
(
7
tests),
and
Regions
3,
6,
and
8
(
1
test
each).
3)
An
additional
11
tests
must
be
conducted
with
75%
EC
formulation
in
EPA
Region
2
(
8
tests),
and
Regions
3,
6,
and
8
(
1
test
each).
75
25.
As
all
nutmeat
samples
from
Amvac's
field
trials
reported
in
MRID
41870206
were
ground
with
the
shells
before
analysis,
the
residue
data
from
these
samples
are
considered
invalid
and
were
not
reviewed.

26.
Based
on
data
from
Amvac's
[
14C]
PCNB
seed­
treatment
study,
data
are
required
depicting
residues
of
PCNB,
PCA,
MPCPS,
PCB,
and
HCB
in/
on
RACs
of
barley,
corn,
oats,
peas,
rice,
safflower,
sorghum,
sugar
beets,
and
wheat
grown
from
seed
treated
with
PCNB
at
the
maximum
labeled
rate.

27.
CBRS
No.
7689,
DP
Barcode
D161390,
R.
Perfetti,
3/
2/
92.

28.
Residue
data
for
ginseng
should
be
generated
in
the
representative
countries
and
tolerance
should
be
proposed.

29.
Bean
cannery
waste
is
no
longer
a
regulated
commodity.

30.
CBRS
No.
8463,
DP
Barcode
D167850,
R.
Perfetti,
4/
15/
92.

31.
To
upgrade
Amvac's
cottonseed
processing
study,
data
are
required
depicting
the
frozen
storage
stability
of
residues
(
PCNB,
PCA,
MPCPS,
PCB
and
HCB)
in
processed
cottonseed
fractions.
Cottonseed
processed
fractions
were
stored
frozen
for
29­
232
days
prior
to
analysis.

32.
To
upgrade
Amvac's
peanut
processing
study,
data
are
required
depicting
the
frozen
storage
stability
of
residues
(
PCNB,
PCA,
MPCPS,
PCB
and
HCB)
in
processed
peanut
fractions.
Peanut
processed
fractions
were
stored
frozen
for
9­
204
days
prior
to
analysis.

33.
To
upgrade
Amvac's
potato
processing
study,
data
are
required
depicting
the
frozen
storage
stability
of
residues
(
PCNB,
PCA,
MPCPS,
PCB
and
HCB)
in
processed
potato
fractions.
Potato
processed
fractions
were
stored
frozen
for
8­
218
days
prior
to
analysis.

34.
Amvac
needs
to
submit
additional
2
tests
in
region
4
and
11
tests
in
region
5.
A
soybean
processing
study
is
required.
Alternatively,
the
registrant
could
prohibit
direct
applications
to
soybeans
(
other
than
seed
treatment),
in
which
case
a
soybean
processing
study
would
not
be
required.

35.
To
upgrade
Amvac's
tomato
processing
study,
data
are
required
depicting
the
frozen
storage
stability
of
residues
(
PCNB,
PCA,
MPCPS,
PCB
and
HCB)
in
processed
tomato
fractions.
Tomato
processed
fractions
were
stored
frozen
for
63­
227
days
prior
to
analysis.

36.
CBRS
No.
12157,
DP
Barcode
D192838,
F.
Fort,
9/
11/
95
and
EFGWB
review,
D.
Spatz,
5/
3/
93.

37.
The
ChemSAC
decided
(
in
June
2003)
that
based
on
all
available
data,
PCNB­
treated
crops
should
only
be
rotated
to
the
labeled
crops,
therefore
field
accumulation
in
registered
rotated
crop
are
required.
Plant
back
interval
in
these
studies
should
reflect
the
interval
desired
on
product
labels.
The
registrants
are
advised
to
consult
the
Agency
in
regard
to
which
crops
to
be
used
in
these
studies.
For
information
on
conducting
field
accumulation
studies
on
rotational
crops,
the
registrant
should
refer
to
OPPTS
Guideline
No.
860.1900.
76
TOLERANCE
REASSESSMENT
SUMMARY
Permanent
tolerances
for
PCNB
residues
in/
on
plant
commodities
are
currently
expressed
as
residues
of
PCNB
per
se
[
40
CFR
§
180.291(
a)]
or
as
the
combined
residues
of
PCNB,
and
its
metabolites,
PCA
and
MPCPS
[
40
CFR
§
180.291(
b)].
There
are
also
interim
tolerances,
which
are
also
expressed
as
PCNB
per
se
[
40
CFR
§
180.319].
There
are
presently
no
tolerances
for
PCNB
in
animal
commodities.

The
MARC
met
on
April
16th
,
2003
to
determine
the
residues
of
concern
for
tolerance
expression
and
for
risk
assessment.
The
MARC
decided
that
as
all
the
metabolites
of
PCNB
are
polychlorinated
phenyl
compounds
and
thus
of
toxicological
concern,
PCNB
and
all
its
metabolites
(
including
minor
metabolites)
are
of
concern
in
plants
and
animal
commodities;
they
are
currently
more
than
80
identified
metabolites
of
concern.
However,
the
residues
of
concern
for
tolerance
setting
purposes
in
primary
and
rotational
crops,
and
livestock
are
PCNB,
PCA,
and
PCTA.

Tolerances
listed
under
§
180.319
should
be
reassigned
to
§
180.291(
a)
as
time­
limited
or
permanent
tolerances.
Furthermore,
all
the
current
tolerance
expressions
which
include
PCNB
per
se
should
be
changed
to
include
PCNB,
PCA,
and
PCTA
per
the
MARC
decision
on
4/
16/
2003.

A
summary
of
the
PCNB
tolerance
reassessment
and
recommended
modifications
in
commodity
definitions
are
presented
in
Table
C.

Tolerances
Listed
Under
40
CFR
§
180.291(
a):

Residue
data
for
cottonseed
must
be
submitted
by
both
Uniroyal
and
Amvac
before
final
decision
is
made.
The
current
tolerance
expressions
which
include
PCNB
per
se
should
be
changed
to
include
PCNB,
PCA,
and
PCTA
per
the
MARC
decision
on
4/
16/
2003.

Tolerances
Listed
Under
40
CFR
§
180.291(
b):

Adequate
residue
data
are
available
on
collards,
kale,
and
mustard
greens
grown
in
GA;
these
data
indicate
that
the
current
0.2
ppm
regional
tolerance
is
adequate.

Tolerances
Listed
Under
40
CFR
§
180.319:

All
tolerances
for
PCNB
listed
as
"
Interim
tolerances"
should
be
reassigned
to
§
180.291
and
established
as
permanent
or
time­
limited
tolerances.
Furthermore,
all
the
current
tolerance
expressions
which
include
PCNB
per
se
should
be
changed
to
include
PCNB,
PCA,
and
PCTA
per
the
MARC
decision
on
4/
16/
2003.
77
Residue
data
from
Uniroyal
and
Amvac
support
establishing
a
permanent
tolerance
at
0.1
ppm
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
head
and
stem
Brassica
vegetables
Crop
Subgroup.
However,
additional
residue
data
for
broccoli
from
Amvac
are
required.

The
available
residue
data
from
Uniroyal
would
support
establishing
a
permanent
tolerance
at
0.2
ppm
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
fruiting
vegetables
(
except
Cucurbits);
however,
additional
tests
must
be
conducted
by
Amvac
before
a
final
decision
can
be
made.

Based
on
the
available
residue
data
from
Uniroyal,
permanent
tolerances
should
be
established
for
garlic
at
0.05
ppm.
However,
residue
data
must
be
submitted
by
Amvac.

Residue
data
are
required
from
both
Uniroyal
and
Amvac
are
required
to
establish
a
permanent
tolerance
in/
on
potatoes.

The
available
residue
data
from
Uniroyal
and
Amvac
would
support
a
temporary
tolerance
of
0.2
ppm
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
legumes;
however,
additional
tests
must
be
conducted
before
a
permanent
tolerance
could
be
established.

The
available
residue
data
from
Uniroyal
and
Amvac
would
support
establishing
a
permanent
tolerance
at
0.5
ppm
for
the
combined
residues
of
PCNB,
PCA,
and
PCTA
in/
on
peanut
nutmeats,
however,
additional
tests
must
be
conducted
before
a
final
decision
can
be
made.

Tolerances
Needed
Under
40
CFR
§
180.291(
a):

New
tolerances
are
needed
for
PCNB
residues
in/
on
cotton
gin
byproducts
and
potato,
wet
peel.
Data
are
required
from
both
Uniroyal
and
Amvac
depicting
PCNB
residues
in/
on
cotton
gin
byproducts
following
application
of
PCNB
at
the
maximum
labeled
rate.

Based
on
Amvac's
potato
field
trials,
the
HAFT
residues
for
potatoes
are
0.95
ppm.
Considering
the
HAFT
residues
and
the
7x
average
concentration
factor
observed
in
Amvac's
potato
processing
studies,
the
maximum
expected
combined
residues
in
potato
wet
peel
would
be
6.65
ppm.
Therefore,
a
tolerance
of
7.0
ppm
should
be
established
for
the
combined
residues
of
PCNB
in
potato,
wet
peel.
However,
supporting
storage
stability
data
for
processed
potato
fractions
are
required
to
upgrade
this
processing
study.
Samples
from
the
potato
processing
study
were
stored
frozen
for
up
to
218
days
prior
to
analysis.

New
tolerances
are
also
needed
for
PCNB
residues
in/
on
RACs
of
barley,
corn,
oats,
peas,
rice,
safflower,
sugar
beets,
soybeans,
and
wheat
grown
from
seed
treated
with
PCNB
at
the
maximum
labeled
rate.

Adequate
residue
data
are
available
from
Amvac
supporting
the
seed
treatment
of
soybeans.
These
data
indicate
that
separate
tolerances
should
be
established
at
0.02
ppm
in/
on
soybean
forage,
hay,
and
seeds.
However,
seed
treatment
data
for
cereal
grains,
peas,
safflower,
and
sugar
beets
remain
outstanding.
78
Based
upon
the
available
feeding
studies
and
the
calculated
theoretical
dietary
burdens
for
livestock,
tolerances
are
required
for
animal
commodities.
Based
on
the
regulated
residues
in
animals,
i.
e.,
PCNB,
PCA,
and
MPCPS,
a
tolerance
of
0.05
ppm
should
be
established
for
milk
and
tolerances
of
1.0
ppm
should
be
established
for
residues
in
meat,
fat,
and
mbyp
of
cattle,
goats,
horse,
and
sheep.
Tolerances
should
also
be
established
at
the
enforcement
method
LOQ
for
residues
in
hog
fat,
meat,
and
mbyp;
however,
an
enforcement
method
for
animal
commodities
is
not
currently
available.

A
tolerance
of
0.5
ppm
should
be
established
for
residues
in
poultry
fat,
and
tolerances
of
0.05
ppm
should
be
established
for
residues
in
eggs
and
poultry
mbyp.
A
tolerance
of
poultry
meat
is
not
required
as
detectable
residues
are
unlikely
to
occur
in
meat.
79
(
continued;
footnotes
follow)
Table
C.
Tolerance
Reassessment
Summary
for
PCNB.

Commodity
Current
Tolerance
(
ppm)
Tolerance
Reassessment
(
ppm)
Comment/
Correct
Commodity
Definition
Tolerances
listed
under
40
CFR
§
180.291(
a):

Cottonseed
0.1
TBD
a
Residue
data
are
required
from
both
Uniroyal
and
Amvac.

Tolerances
listed
under
40
CFR
§
180.291(
b):

Collards
0.2
0.2
Residue
data
from
IR­
4
support
the
current
regional
tolerance
in
state
of
Georgia.
Kale
0.2
0.2
Mustard
Greens
0.2
0.2
Tolerances
listed
under
40
CFR
§
180.319
b:

Beans
0.1
TBD
Residue
data
are
required
from
both
Uniroyal
and
Amvac.

Broccoli
0.1
0.1
The
available
residue
data
from
Uniroyal
and
Amvac
on
broccoli
and
cabbage
would
support
a
permanent
0.1
ppm
tolerance
for
the
Head
and
Stem
Brassica
Vegetable
Crop
Subgroup.
Additional
residue
data
for
broccoli
from
Amvac
are
required.
Brussels
Sprouts
0.1
Cabbage
0.1
Cauliflower
0.1
Garlic
0.1
0.05
Residue
data
from
Uniroyal
indicate
that
the
tolerance
could
be
lowered.
Residue
data
must
be
submitted
by
Amvac.

Peanuts
1.0
TBD
Additional
residue
data
are
required
from
both
Uniroyal
and
Amvac.

Potatoes
0.1
1.0
Available
residue
data
from
Amvac
indicate
that
the
tolerance
should
be
increased.
Additional
residue
data
are
required
from
both
Uniroyal
and
Amvac.

Peppers
0.1
0.2
Residue
data
from
Uniroyal
on
peppers
and
tomatoes
would
support
a
permanent
0.2
ppm
tolerance
for
the
Fruiting
Vegetables
(
except
Cucurbits)
Crop
Group.
Additional
residue
data
from
Amvac
are
required.
Tomatoes
0.1
Table
C.
Continued.

Commodity
Current
Tolerance
(
ppm)
Tolerance
Reassessment
(
ppm)
Comment/
Correct
Commodity
Definition
80
Tolerances
That
Need
To
Be
Proposed
under
40
CFR
§
180.291(
a)

Cotton
gin
byproducts
­­
TBD
New
field
trial
data
are
required.

Potato,
wet
peel
­­
7.0
Based
on
a
7x
concentration
factor
and
the
HAFT
residues
(
0.95
ppm)
from
Amvac's
potato
field
trials
Barley,
grain,
hay
and
straw
­­
TBD
Data
are
required
from
Amvac
depicting
PCNB
residues
in/
on
RACs
derived
from
seed
treated
with
PCNB
at
the
maximum
labeled
rate.
Corn,
grain,
forage
and
fodder
­­

Oat,
forage,
grain,
hay
and
straw
­­

Peas
­­

Rice,
grain
and
straw
­­

Safflower,
seed
­­

Sorghum
forage,
grain,
and
stover
­­

Soybean,
forage,
hay
and
seeds
­­
0.02
The
available
data
from
Amvac
would
support
separate
tolerances
on
soybean
forage,
hay,
and
seeds
at
0.02
ppm
Sugar
beet,
roots
and
tops
­­
TBD
Residue
data
are
required.

Wheat,
forage,
grain,
hay
and
straw
­­

milk
­­
0.05
Based
on
data
from
the
cattle
feeding
study
and
assuming
a
dietary
burden
of
32.3
ppm
for
dairy
cattle.

Cattle
fat,
meat,
and
mbyp
­­
1.0
Based
on
data
from
the
cattle
feeding
study
and
assuming
a
dietary
burden
of
32.3
ppm
for
beef
cattle.
Goat
fat,
meat,
and
mbyp
­­
1.0
Horse
fat,
meat,
and
mbyp
­­
1.0
Sheep
fat,
meat,
and
mbyp
­­
1.0
Hog
fat,
meat,
and
mbyp
­­
TBD
Tolerances
of
hog
commodities
should
be
established
at
the
method
LOQ;
however,
a
enforcement
method
has
not
yet
been
submitted
for
livestock
commodities.

Eggs
­­
0.05
Tolerances
are
based
on
the
available
feeding
study
and
assuming
a
dietary
burden
of
0.38
ppm
for
poultry
Poultry,
fat
­­
0.5
Poultry,
mbyp
B
0.05
a
TBD
=
To
be
determined.
Tolerance
cannot
be
determined
at
this
time
because
additional
data
are
required
or
are
currently
under
review.
b
CFR
reports
these
as
"
interim"
tolerances.
Tolerances
listed
under
§
180.319
should
be
reassigned
to
§
180.291(
a)
as
time­
limited
or
permanent
tolerances.
Furthermore,
all
the
current
tolerance
expressions
which
include
PCNB
per
se
should
be
changed
to
include
PCNB,
PCA,
and
PCTA
per
the
MARC
decision
on
4/
16/
2003.
81
DIETARY
EXPOSURE
ASSESSMENT
SUMMARY
A)
PCNB
A
revised
probabilistic
chronic
dietary
risk
assessment
was
completed
on
March
31st,
2004
(
Mohsen
Sahafeyan,
D298352,
3/
31/
2004).
This
chronic
dietary
risk
assessment
is
considered
to
be
a
highly
refined
assessment
using
all
available
monitoring
data,
%
CT
(
percent
crop
treated)
information,
and
processing
factors.
However,
because
monitoring
data
did
not
analyze
for
all
PCNB
metabolites
of
concern
(
86
identified
metabolites),
the
ratio
of
total
radioactive
residues
(
TRR)
to
PCNB
from
available
metabolism
studies
is
used
in
combination
with
monitoring
residue
data
on
PCNB.
Otherwise,
TRR
values
by
themselves
were
used
to
estimate
the
total
residues
of
concern.

This
risk
assessment
was
performed
with
both
Dietary
Exposure
Evaluation
Model­
Food
Consumption
Intake
Database
(
DEEM­
FCIDJ)
and
Lifeline
models.
The
1994­
1998
USDA's
Continuing
Surveys
of
Food
Intake
by
Individuals
(
CSFII)
was
used
by
both
models
for
a
consumption
data
base.
Since
the
results
from
both
models
were
close,
only
those
from
DEEMFCID
model
are
summarized
below.

Two
chronic
dietary
risk
assessment
were
conducted.
The
first
one
includes
both
registered
and
unregistered
commodities.
This
is
because
monitoring
residue
data
show
considerable
number
of
detects
in
unregistered
commodities.
That
is
believed
to
be
due
to
rotational
crop
effect
based
on
the
available
studies
and
evidences.
It
is
believed
that
the
wide
presence
of
PCNB
and/
or
its
residues
on
unregistered
crops
are
due
to
its
uptake
from
soil
by
rotated
crops
(
rather
than
illegal
use),
which
in
turn
is
due
to
a
very
long
half
life
(
1555
days)
of
PCNB
and/
or
its
metabolites
in
soil.
The
Chemistry
Science
Advisory
Committee
(
ChemSAC)
has
concluded
that
rotational
crop
restrictions
to
registered
crops
beyond
1
year
is
not
enforceable
and
thus
is
impractical.
Therefore,
there
is
no
practical
expectation
that
dietary
risks
from
PCNB
on
these
unregistered
crops
could
be
mitigated
by
further
restrictions
on
crop
rotations.

The
second
risk
assessment
includes
only
registered
commodities
and
was
conducted
in
the
interest
of
completeness
but
may
not
reflect
the
existing
total
dietary
risk
in
the
food
chain
from
use
of
PCNB
and
its
metabolites.

An
important
reminder
is
that
the
chronic
dietary
risk
estimates
are
subject
to
change
should
the
2004
monitoring
data
on
milk
samples
(
unavailable
yet)
from
United
States
Agriculture
Department,
Pesticide
Data
Program
(
USDA­
PDP)
indicate
the
presence
of
higher
levels
of
PCNB
and
its
metabolites
than
what
was
assumed
in
that
assessment.

The
results
of
these
chronic
dietary
risk
assessments
show
that
the
risk
for
all
population
subgroups
are
below
the
level
of
concern;
i.
e.,
100%
cPAD.
For
the
chronic
dietary
risk
due
to
all
crops,
i.
e.,
both
registered
and
unregistered
crops,
the
general
U.
S.
population
had
12%
cPAD
and
population
subgroup
children
1­
2
years
old
had
the
highest
estimated
risk
of
34%
cPAD.
For
the
chronic
dietary
risk
due
to
registered
crops,
the
general
U.
S.
population
had
10%
cPAD
and
population
subgroup
children
1­
2
years
old
had
the
highest
estimated
risk
of
27%
cPAD.
82
When
water
was
added
to
the
analysis,
%
cPAD
exceeded
100%
for
all
populations
except
youth
13­
19
with
%
cPAD
of
78%
and
adults
20­
49
with
%
cPAD
of
97%;
all
other
population
subgroups
exceeded
the
100%
cPAD
mark
and
thus
are
of
concern.
The
estimated
risk
including
water
for
general
U.
S.
population
is
105%
cPAD
and
the
highest
estimated
risk
is
for
population
subgroup
all
infants
with
the
313%
cPAD.

B)
PCP
Residues
of
free
PCP,
a
known
carcinogen,
and
conjugated
PCP
were
found
in
some
crops,
and
were
detected
in
an
anaerobic
soil
metabolism
study
and
a
terrestrial
field
dissipation
study.
With
one
exception,
the
conjugated
PCP
residues
were
thiol
compounds
that
are
not
expected
to
form
the
phenol
during
metabolism/
degradation.
Of
potential
concern,
because
it
may
cleave
to
form
PCP,
is
PCP­
glycoside
(
PCP­
Gly)
that
was
found
in
potato
callus
and
peels
in
an
early,
inadequate,
metabolism
study
(
MRID#
41562903).
In
a
more
recent,
adequate,
potato
metabolism
study,
callus
and
peels
were
not
sampled
separately,
but
no
PCP­
Gly
was
found
in
any
potato
samples.
Free
PCP
was
detected
in
a
rotational
crop
study
on
turnip
one
year
following
soil
treatment
at
10
or
2
lbs
ai/
A.
The
concentrations
were
<
0.001
ppm
in
tops
and
<
0.004
ppm
in
roots.
In
the
case
of
the
rotational
crop
study,
PCNB
is
not
registered
for
use
on
turnips,
but
turnips
were
rotated
into
a
field
where
crops
were
treated
with
PCNB.

A
first
tier
worst­
case
analysis
was
conducted
assuming
0.004
ppm
residues
of
PCP
in
all
tuber
crops
and
using
the
recently
revised
Q
1*
(
3/
4
scaling
factor)
of
0.07
x
10­
1
mg/
kg­
day.
Under
these
circumstances,
the
potential
risk
may
be
5
x
10­
8
(
general
population),
which
is
not
of
concern.

CODEX
HARMONIZATION
As
there
are
no
established
or
proposed
Codex
maximum
residue
limits
(
MRLs)
for
PCNB,
harmonization
of
U.
S.
tolerances
with
Codex
is
not
required.
83
AGENCY
MEMORANDA
CITED
IN
THIS
DOCUMENT
DP
Barcode:
None
Subject:
Addendum
to
the
Residue
Chemistry
Chapter
of
the
PCNB
Registration
Standard
B
Analytical
Methods
and
Regulatory
Incidents.
From:
D.
Edwards
To:
A.
Rispin/
H.
Jacoby
Dated:
8/
1/
86
MRID(
s):
None
CBRS
No.:
6760
DP
Barcode:
None
Subject:
PCNB
(
Terrachlor),
Storage
Stability
Studies
in
Cabbage
and
Potatoes.
From:
E.
Haeberer
To:
L.
Rossi/
S.
Cerrelli
Dated:
6/
28/
90
MRID(
s):
41448901
CB
No.:
7871
DP
Barcode:
D163420
Subject:
Amvac
Corporation
Response
to
the
PCNB
Reregistration
Standard:
Residue
Chemistry
Data
From:
C.
Olinger
To:
L.
Rossi
Dated:
12/
4/
91
MRID(
s):
41823601
CBRS
No.:
7605
DP
Barcode:
D160683
Subject:
Uniroyal
Chemical
Co.:
Response
to
the
PCNB
Reregistration
Standard:
Goat
Metabolism
From:
R.
Perfetti.
To:
W.
Burnam/
L.
Rossi
Dated:
2/
3/
92
MRID(
s):
41735801
84
CBRS
No.:
7877
DP
Barcode:
D163419
Subject:
Uniroyal
Chemical
Co.:
Response
to
the
PCNB
Reregistration
Standard:
Storage
Stability
Study
From:
R.
Perfetti.
To:
W.
Burnam/
L.
Rossi
Dated:
2/
3/
92
MRID(
s):
41829501
and
41829502
CBRS
No.:
7925
DP
Barcode:
D163838
Subject:
AMVAC
Chemical
Corp.:
Response
to
the
PCNB
Reregistration
Standard:
Supplemental
Poultry
Metabolism
Data
From:
R.
Perfetti.
To:
W.
Burnam/
L.
Rossi
Dated:
2/
3/
92
MRID(
s):
41839701
CBRS
No.:
7689
DP
Barcode:
D161390
Subject:
AMVAC
Chemical
Corp.:
Response
to
the
PCNB
Reregistration
Standard:
Seed
Treatment
Uptake
Information
From:
R.
Perfetti.
To:
W.
Burnam/
L.
Rossi
Dated:
3/
2/
92
MRID(
s):
41758201
CBRS
No.:
8463
DP
Barcode:
D167850
Subject:
AMVAC
Chemical
Corp.:
Response
to
the
PCNB
Reregistration
Standard:
Residue
Chemistry
Data.
From:
R.
Perfetti
To:
W.
Burnam/
L.
Rossi
Dated:
4/
15/
92
MRID(
s):
41975800­
41975805
85
CBRS
No.:
9533
DP
Barcode:
D175304
Subject:
PCNB
(
Pentachloronitrobenzene).
Nature
of
the
Residue
in
Peanuts.
From:
J.
Abbotts
To:
S.
Cerrelli
Dated:
7/
31/
92
MRID(
s):
42222101
CBRS
No.:
11874
DP
Barcode:
D191283
Subject:
The
Metabolites
of
PCNB
through
FDA
Multi­
Residue
Protocols
C
&
D.
From:
L.
Edwards
To:
H.
Hundley
Dated:
5/
21/
93
MRID(
s):
42755201
CBRS
No.:
12326
DP
Barcode:
D193790
Subject:
Pentachloronitrobenzene
(
PCNB).
Rotational
Crop
Study.
From:
F.
Fort
To:
S.
Cerraelli/
L.
Propst
Dated:
12/
27/
94
MRID(
s):
42094405,
42841101
through
42841105
CBRS
No.:
12157
DP
Barcode:
D192838
Subject:
PCNB.
Rotational
Crop
Studies
(
AMVAC).
From:
F.
Fort
To:
S.
Cerrelli/
L.
Propst
Dated:
9/
11/
95
MRID(
s):
42599201
CBRS
Nos.:
6945,
6954,
6779,
7396
DP
Barcode:
D158943,
D212909,
D2112910,
D212912
through
D212914,
and
D212916
Subject:
PCNB,
Pentachloronitrobenzene.
AMVAC.
Nature
of
the
Residue
in
Potatoes
and
Cabbage.
From:
J.
Abbots
To:
S.
Cerrelli
Dated:
4/
16/
96
MRID(
s):
42482701
and
42482702
86
CBRS
Nos.:
6945,
6954,
6779,
7396
DP
Barcode:
D158943,
D212909,
D2112910,
D212912
through
D212914,
and
D212916
Subject:
PCNB.
Registrant
Uniroyal
Response
on
Residue
Chemistry.
From:
J.
Abbots
To:
S.
Cerrelli
Dated:
4/
24/
96
MRID(
s):
41692801­
41692805,
408866209,
41562901­
41562904,
40866001­
4086603,
40816701,
41437601,
41437602,
40816702,
40816703,
40816704,
41521303,
40816705,
41521301,
41521302,
and
41521304­
41521306
DP
Barcodes:
D269994,
D269996,
D270146,
and
D270187
Subject:
PCNB.
Uniroyal
Response
to
Review
of
Potato
Metabolism
Study,
along
with
Storage
Stability
Data,
and
a
Confined
Rotational
Crop
Study.
From:
Mohsen
Sahafeyan
To:
Jill
Bloom
Dated:
9/
10/
2003
MRID(
s):
44469101,
44814701,
44577501,
44348301,

DP
Barcodes:
D291353
Subject:
Memorandum
to
Metabolism
Assessment
Review
Committee
to
discuss
PCNB
residues
of
concern
for
inclusion
in
dietary
risk
assessment.
From:
M.
Sahafeyan
and
L.
Chitlik
To:
Yan
W.
Donovan
Dated:
4/
8/
2003
MRID(
s):
No
MRID
TXR
no.:
0051921
Subject:
The
Outcome
of
the
HED
Metabolism
Assessment
Review
Committee
Held
on
April
16th,
2003
to
discuss
residues
of
concern
in
risk
assessment
and
tolerance
expression
of
Pentachloronitrobenzene
(
PCNB).
From:
M.
Sahafeyan
and
L.
Chitlik
To:
Yan
W.
Donovan
Dated:
5/
27/
2003
MRID(
s):
No
MRID
DP
Barcodes:
D243499
Subject:
Assessment
of
the
Dietary
Cancer
Risk
of
Hexachlorobenzene
and
Pentachlorobenzene
as
impurities
in
Chlorothalonil,
PCNB,
Picloram,
and
several
other
pesticides.
DP
Barcode
D243499.
Chemical
codes
061001
(
Hexachlorobenzene)
&
081901
(
Chlorothalonil).
From:
William
Smith
87
To:
Mary
Clock
Dated:
2/
26/
1998
MRID(
s):
No
MRID
88
RESIDUE
CHEMISTRY
CITATIONS
00001570
Griffith,
W.
P.
(
1973)
Determination
of
Terrazole
®
(
5­
Ethoxy­
3­
Trichloromethyl­
1,2,4­
Thiadiazole)
and
Terraclor
®
(
Pentachloronitrobenzene)
and
Allied
Metabolites
in
Plant
Tissues
or
Harvest
Samples.
Method
CAM­
24­
73
dated
Jul
3,
1973.
(
Unpublished
study
received
Feb
4,
1977
under
1258­
812;
submitted
by
Olin
Corp.,
Agricultural
Div.,
Little
Rock,
Ark.;
CDL:
095799­
M)

00001669
Ackermann,
H.
J.;
Baltrush,
H.
A.;
Berges,
H.
H.;
Brookover,
D.
O.;
Brown,
B.
B.
(
1958)
Spectrophotometric
determination
of
pentachloronitrobenzene
on
food
and
forage
crops:
Fungicide
residues.
Agricultural
and
Food
Chemistry
6(
10):
747­
750.
(
Also
in
unpublished
submission
received
Jan
26,
1969
under
9F0754;
submitted
by
Olin
Mathieson
Chemical
Corp.,
New
York,
N.
Y.;
CDL:
091301­
I)

00001670
Methratta,
T.
P.;
Montagna,
R.
W.;
Griffith,
W.
P.
(
1967)
Determination
of
Terraclor
in
crops
and
soil
by
electron­
capture
gas
chromatography.
Agricultural
and
Food
Chemistry
15(
4):
648­
650.
(
Also
in
unpublished
submission
received
Jan
26,
1969
under
9F0754;
submitted
by
Olin
Mathieson
Chemical
Corp.,
New
York,
N.
Y.;
CDL:
091301­
J)

00001676
Geenty,
F.
O.
(
1968)
Metabolic
and
Material
Balance
Study
of
Pentachloronitrobenzene
(
PCNB)
in
Cotton
Plants:
Analytical
Method:
CASR­
3­
68.
Method
dated
May
3,
1968.
(
Unpublished
study
received
Jan
26,
1969
under
9F0754;
submitted
by
Olin
Mathieson
Chemical
Corp.,
New
York,
N.
Y.;
CDL:
091301­
Q)

00001704
Langston,
R.;
Van
Schaik,
B.
(
1968)
Residue
Analyses
of
Some
Edible
Crops
Grown
in
Soils
Treated
with
Carbon­
14
Labeled
Pentachloronitrobenzene.
Undated
Method.
(
Journal
Paper
No.
972;
unpublished
study
received
Feb
16,
1968
under
1258­
GO(
818);
prepared
by
Purdue
Univ.­­
Layfayette,
Agricultural
Experiment
Station,
submitted
by
Olin
Mathieson
Chemical
Corp.,
New
Haven,
Conn.;
CDL:
101585­
F)

00001707
Kuchar,
E.
J.
(
1969)
Residues
of
Terraclor
(
Pentachloronitrobenzene­
PCNB)
in
Alfalfa:
CASR­
7­
69.
(
Unpublished
study
that
includes
Method
CAM­
14­
69
dated
Nov
25,
1969
entitled:
Determination
of
Pentachloronitrobenzene
(
PCNB,
Olin
5275)
in
Alfalfa:
Analytical
Method,
received
Mar
24,
1970
under
9F0754;
submitted
by
Olin
Mathieson
Chemical
Corp.,
New
Haven,
Conn.;
CDL:
091299­
C)

00001859
Kuchar,
E.
J.
(
1973)
Miscellaneous
Analytical
Investigations
Concerned
with
Terraclor:
CASR­
3­
73.
(
Unpublished
study
received
Jul
31,
1972
under
1F1083;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
090841­
I)

00001861
Kuchar,
E.
J.
(
1973)
Residues
of
Terraclor,
Impurities
and
Metabolites
in
Various
Crops
(
1969­
1972):
CASR­
2­
73.
(
Unpublished
study
that
includes
method
CAM­
12­
70
dated
Apr
28,
1970,
received
Jul
31,
1972
under
1F1083;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
090841­
K)
89
00001862
Kuchar,
E.
J.
(
1973)
Residues
of
Terraclor,
Terraclor­
Super
X
in
Peanuts­­
1969,
70,
71
Crops:
CASR­
1­
73.
(
Unpublished
study
that
includes
method
CAM­
6­
70
dated
Mar
13,
1970,
received
Jul
31,
1972
under
1F1083;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
090841­
L)

00002228
Kuchar,
E.
J.
(
1970)
Residues
of
Terraclor­
Super
X
in
Cotton
Seed:
CASR­
6­
70.
(
Unpublished
study
received
May
28,
1970
under
0F0997;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
091717­
H)

00002827
Gorbach,
S.;
Wagner,
U.
(
1967)
Pentachloronitrobenzene
residues
in
potatoes.
Journal
of
Agriculture
and
Food
Chemistry
15(
4):
654­
656.
(
Also
in
unpublished
submission
received
Feb
16,
1968
under
1258­
818;
submitted
by
Olin
Mathieson
Chemical
Corp.,
New
Haven,
Conn.;
CDL:
101585­
G)

00014326
Kuchar,
E.
J.;
Griffith,
W.
P.;
Thomas,
R.
J.
(
1969)
Analytical
Investigations
Concerned
with
Terraclor­­
Terrazole
Cow
Feeding
Studies:
CASR­
4­
69.
(
Unpublished
study
received
on
unknown
date
under
0F0997;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
C.
L.:
098490­
K)

00014327
Griffith,
W.
P.
(
1969)
Determination
of
5­
Ethoxy­
3­
trichloromethyl­
1,2,4­
thiadiazole
(
Olin
52424)
and
Pentachloronitrobenzene
(
PCNB,
Olin
5275)
and
Allied
Metabolites
in
Cow's
Milk.
Method
CAM­
1­
69
dated
Feb
1,
1969.
(
Unpublished
study
received
on
unknown
date
under
0F0997;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
098490­
L)

00031296
Rushing,
K.
W.;
Slagowski,
J.
L.;
Western,
G.
L.
(
1977)
Residue
Chemistry
Data
To
Support
the
Use
of
Ortho
Difolatan­
PCNB
45­
25
Seed
Protectant
for
Peanuts:
Summary.
(
Unpublished
study
received
Apr
8,
1980
under
239­
2480;
prepared
in
cooperation
with
Morse
Laboratories,
Inc.,
submitted
by
Chevron
Chemical
Co.,
Richmond,
Calif.;
CDL:
242303­
A)

00028427
Thomas,
R.
J.;
Venezia,
P.
M.;
Iacoviello,
S.
A.
(
1980)
Residues
of
Terrazole
¼
(
R)
µ
.
..,
Terraclor
¼
(
R)
µ
.
..,
Impurities
and
Metabolites
in
Cotton
Seed,
1979:
CASR­
4­
80.
(
Unpublished
study
received
Feb
20,
1980
under
1258­
EX­
12;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
241820­
A)

00028428
Olin
Corporation
(
1972)
Determination
of
Terraclor...
and
Terrazole...
in
Cotton
Seed.
Method
CAM­
11­
72
dated
Apr
4,
1972.
(
Unpublished
study
received
Feb
20,
1980
under
1258­
EX­
12;
CDL:
241820­
B)

00053075
Chemagro
Corporation
(
1960)
Synopsis
of
Pentachloronitrobenzene
(
PCNB)
Analytical
and
Residue
Data
(
Sugar
Beets).
(
Unpublished
study
received
Apr
4,
1960
under
unknown
admin.
no.;
prepared
in
cooperation
with
Olin
Mathieson
Chemical
Corp.;
CDL:
119239­
A)

00059120
Thomas,
M.
P.
(
1965)
Letter
sent
to
S.
I.
Cohen
dated
Jun
11,
1965:
Storage
stability
of
Olin­
2424
and
Terraclor
in
cottonseed.
(
Unpublished
study
received
May
28,
1970
under
0F0997;
submitted
by
Olin
Chemicals,
Consumer
Products,
Div.
of
Olin
Corp.,
Stamford,
Conn.;
CDL:
091717­
AF)
90
00059146
Kuchar,
E.
J.
(
1968)
Letter
sent
to
H.
H.
Klein
dated
Feb
2,
1968:
Residues­­
seed
treatment
samples.
(
Unpublished
study
received
Feb
16,
1968
under
1258­
818;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
101585­
K)

00059147
Sisken,
H.
R.
(
1967)
Letter
sent
to
H.
H.
Klein
dated
Oct
4,
1967:
PCNB
and
2424
residue
in
soybean
plants.
(
Unpublished
study
received
Feb
16,
1968
under
1258­
818;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
101585­
L)

00059155
Kuchar,
E.
J.
(
1968)
Letter
sent
to
H.
H.
Klein
dated
Feb
7,
1968:
Residues­­
seed
treatment.
(
Unpublished
study
received
Feb
16,1968
under
1258­
818;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
101585­
Z)

00059932
Kuchar,
E.
J.
(
1970)
Letter
sent
to
H.
H.
Klein
dated
Oct
14,
1970:
Terraclor
experiments­­
peanut
related
material.
(
Unpublished
study
received
Jul
31,
1972
under
1F1083;
submitted
by
Olin
Chemicals,
Consumer
Products,
Div.
of
Olin
Corp.,
Stamford,
Conn.;
CDL:
090841­
F)

00059933
Kuchar,
E.
J.
(
1973)
Letter
sent
to
R.
F.
Philpitt
dated
Jan
23,
1973:
Terraclor
residues­
­
Idaho
potatoes.
(
Unpublished
study
received
Feb
5,
1973
under
1F1083;
submitted
by
Olin
Chemicals,
Consumer
Products,
Div.
of
Olin
Corp.,
Stamford,
Conn.;
CDL:
090841­
G)

00060784
Kuchar,
E.
J.
(
1969)
Letter
sent
to
H.
H.
Klein
dated
Jul
29,
1969:
Planter's
peanut
oil­­
Terraclor
content.
(
Unpublished
study
received
Mar
24,
1970
under
9F0754;
submitted
by
Olin
Mathieson
Chem.
Corp.,
New
York,
N.
Y.;
CDL:
091299­
M)

00064194
Olin
Corporation
(
1972)
Residues
of
Terraclor­
Super
X
in
Cotton
Seed­­
1971
Crop:
CASR­
7­
72.
(
Unpublished
study
received
Apr
19,
1972
under
0F0997;
CDL:
111184­
A)

00064197
Thomas,
M.
P.
(
1964)
Determination
of
5­
Ethoxy­
3­
trichloromethyl­
1,2,4­
thiadiazole
(
Olin
2424)
and
Pentachloronitrobenzene
(
PCNB,
Olin
275)
in
Cottonseed.
Method
No.
CAM­
18­
64
dated
Jun
12,
1964.
(
Unpublished
study
received
Apr
19,
1972
under
0F0997;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
111184­
E)

00097719
Thomas,
M.
P.;
Geenty,
F.
O.;
Griffith,
W.
P.
(
1964)
Terraclor
Residues
in
1964
Potatoes
from
2­
lb.
EC
Treatment:
CASR­
31­
64.
(
Unpublished
study
received
Dec
16,
1964
under
1258­
279;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
024735­
B)

00097720
Baltrush,
H.
A.
(
1956)
Method
of
Analysis
of
Terraclor
in
Cabbage.
(
Unpublished
study
received
Feb
23,
1956
under
1258­
279;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
024737­
A)

00097734
Olin
Corporation
(
1967)
PCNB
and
2424
Residues
on
Various
Crops.
(
Compilation;
unpublished
study
received
Jan
26,
1969
under
9F0754;
CDL:
091300­
C)
91
00097735
Ackermann,
H.
J.;
Minnick,
E.
J.
(
1956)
Traces
of
Pentachloronitrobenzene
Analyses
in
Bell
Peppers.
Interim
analytical
rept.
(
Unpublished
study
received
Jan
26,
1969
under
9F0754;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
091300­
E)

00097736
Baltrush,
H.
A.
(
1956)
Analysis
for
Terraclor
in
Cabbage
and
Broccoli:
Submitter
Report
No.
ACD­
21­
56.
(
Unpublished
study
received
Jan
26,
1969
under
9F0754;
prepared
by
Purdue
Univ.,
Agricultural
Experiment
Station,
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
091300­
F)

00097738
Olin
Corporation
(
1969)
Residue
Studies
of
Terraclor
in
Forage
Crops.
(
Compilation;
unpublished
study,
including
report
nos.
ACD­
15­
56
and
CASR­
7­
69,
received
Jan
26,
1969
under
9F0754;
CDL:
091300­
I)

00097739
Olin
Corporation
(
1965)
Celery:
Residue
Studies
of
Terraclor.
(
Compilation;
unpublished
study
received
Jan
26,
1969
under
9F0754;
CDL:
091300­
J)

00097740
Olin
Corporation
(
1964)
Residue
Studies
of
Terraclor
on
Cotton.
(
Compilation;
unpublished
study,
including
report
nos.
ACD­
19­
56
and
CASR­
18­
64,
received
Jan
26,
1969
under
9F0754;
CDL:
091300­
K)

00097741
Olin
Corporation
(
1969)
Residue
Studies
of
Terraclor
on
Peanuts.
(
Compilation;
unpublished
study,
including
report
nos.
ACD­
54­
58
and
CASR­
4­
65,
received
Jan
26,
1980
under
9F0754;
CDL:
091300­
L)

00097742
Olin
Corporation
(
1967)
Residue
Studies
of
Terraclor
on
Potatoes.
(
Compilation;
unpublished
study,
including
report
nos.
ACD­
4­
55,
ACD­
14­
56,
CASR­
17­
64...,
received
Jan
26,
1969
under
9F0754;
CDL:
091300­
M)

00097743
Ackermann,
H.
J.;
Brookover,
D.
O.;
McTurck,
M.
A.
(
1956)
Analysis
for
Terraclor
in
Tomatoes:
Report
No.
ACD­
31­
56.
(
Unpublished
study
received
Jan
26,
1969
under
9F0754;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
091300­
N)

00097757
Kuchar,
E.
J.;
Griffith,
W.
P.
(
1975)
Analytical
Investigations
Concerned
with
Feeding
Terraclor
¼
(
R)
µ
to
Chickens:
CASR­
8­
75.
(
Unpublished
study
received
Nov
17,
1975
under
0F1083;
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
097596­
A)

00097764
Ackermann,
H.
J.;
Minnick,
E.
J.;
Curtis,
J.
A.
(
1954)
Pentachloronitrobenzene
Residue
Analysis:
A­
9.01
Interim
Analytical
Report.
(
Unpublished
study
received
Jul
20,
1954
under
1258­
158;
prepared
by
Mathieson
Chemical
Corp.,
submitted
by
Olin
Corp.,
Stamford,
Conn.;
CDL:
101581­
A)

00097786
Olin
Mathieson
Chemical
Corporation
(
1956)
Method
for
Analysis
of
Terraclor
in
Garlic.
(
Unpublished
study
received
on
unknown
date
under
unknown
admin.
no.;
CDL:
119241­
A)
92
00097791
Olin
Corporation
(
1958)
Methods
of
Extraction,
Clean­
up
and
Analyses
of
Terraclor
Residues
in
Peanut
Kernels,
Shells
and
Hay.
(
Compilation;
unpublished
study
received
Mar
14,
1958
under
unknown
admin.
no.;
CDL:
119260­
A)

00097801
Olin
Corporation
(
1954)
Analysis
of
Terraclor
Residues
in
Bell
Peppers
from
Cockeysville,
Maryland,
Pleasant
Hill
Farm.
(
Unpublished
study
received
Feb
14,
1957
under
unknown
admin.
no.;
CDL:
223052­
B)

00109402
Ciba­
Geigy
Corp.
(
1981)
Metalaxyl­­
Cotton
In­
furrow
Applications
of
Ridomil
2E
and
5G
Including
Mixtures
with
PCNB:
Report
No.
ABR­
81046.
(
Compilation;
unpublished
study
received
Jul
28,
1982
under
100­
607;
CDL:
247934­
A)

00109656
Dunn,
J.;
Bush,
P.;
Booth,
N.;
et
al.
(
1979)
Effect
of
pentachloronitrobenzene
upon
egg
production,
hatchability,
and
residue
accumulation
in
the
tissues
of
white
leghorn
hens.
Toxicology
and
Applied
Pharmacology
48:
425­
433.
(
Submitter
3562;
also
In
unpublished
submission
received
Aug
11,
1982
under
1258­
517;
submitted
by
Olin
Corp.,
Stamford,
CT;
CDL:
071045­
D)

00114183
Begum,
S.;
Scheunert,
I.;
Haque,
A.;
et
al.
(
1979)
Conversion
of
14C
pentachloronitrobenzene
in
onions.
Pesticide
Biochemistry
and
Physiology
11:
189­
200.
(
Submitter
3512;
also
In
unpublished
submission
received
Sep
7,
1982
under
1258­
517;
submitted
by
Olin
Corp.,
Stamford,
CT;
CDL:
248282­
B)

00114184
Olin
Corp.
(
1980)
PCNB
Metabolism
in
Peanuts.
(
Compilation
of
reports
by
U.
S.
Dept.
of
Agriculture,
Science
and
Education
Administration,
Agricultural
Research,
Metabolism
and
Radiation
Research
Laboratory;
unpublished
study;
CDL:
248282­
C)

00114185
Lamoureux,
G.;
Rusness,
D.
(
1980)
In
vitro
Metabolism
of
Pentachloronitrobenzene
to
Pentachloromethylthiobenzene
by
Onion:
Characterization
of
Glutathione
S­
Transferase,
Cysteine
C­
S
Lyase,
and
S­
Adenosylmethionine
Methyl
Transferase
Activities:
Olin.
3549.
(
U.
S.
Dept.
of
Agriculture,
Science
and
Education
Administration,
Agricultural
Research,
Metabolism
and
Radiation
Research
Laboratory;
unpublished
study;
CDL:
248282­
D)

00114186
Lamoureux,
G.;
Rusness,
D.
(
1979)
Catabolism
of
Glutathione
Conjugates
of
Pesticides
in
Higher
Plants:
óOlin|
3550.
(
U.
S.
Dept.
of
Agriculture,
Science
and
Education
Administration,
Agricultural
Research,
Metabolism
and
Radiation
Research
Laboratory;
unpublished
study;
CDL:
248282­
E)

00114187
Okazaki,
H.
(
1979)
Formation
of
methyl
pentachlorophenyl
sulfoxide
and
sulfone
from
pentachloronitrobenzene
in
soil
and
plants.
J.
Pesticide
Sci.
4:
355­
360.
(
Submitter
3577;
also
In
unpublished
submission
received
Sep
7,
1982
under
1258­
517;
submitted
by
Olin
Corp.,
Stamford,
CT;
CDL:
248282­
F)

00114205
Aschbacher,
P.;
Feil,
V.
(
1976)
Metabolism
of
Pentachloronitrobenzene
in
the
Goat:
Olin.
3139.
(
U.
S.
Agricultural
Research
Service,
Metabolism
and
Radiation
Research
Laboratory;
unpublished
paper
presented
at
the
Symphosium
on
Fate
of
Pesticides
in
Large
93
Animals;
172nd
American
Chemical
Society
National
Meeting,
Pesticide
Div.;
Aug
29­
Sep
3,
1976;
San
Francisco,
CA;
unpublished
study;
CDL:
248283­
N)

00114966
Dow
Chemical
Co.
(
1967)
The
Results
of
Tests
on
the
Amount
of
Residue
Remaining,
Including
a
Description
of
the
Analytical
Method
Used.
(
Compilation;
unpublished
study
received
Apr
13,
1967
under
7F0593;
CDL:
090764­
H)

00125805
Olin
Corp.
(
1983)
Residues
of
Etridiazol
in
Peanuts.
(
Compilation;
unpublished
study
received
Mar
2,
1983
under
1258­
555;
CDL:
071421­
A)

00129447
Olin
Corp.
(
1977)
Residue
of
PCNB
on
or
in
Potatoes.
(
Compilation;
unpublished
study
received
Jul
7,
1983
under
1258­
517;
CDL:
250699­
A)

00156362
Uniroyal
Chemical
Co.
(
1986)
Terrachlor
and
Its
Metabolites
and
Impurities
in
Processed
Potatoes.
Unpublished
study
prepared
in
cooperation
with
Michigan
State
Univ.
and
Morse
Laboratories.
27
p.

00158795
Interregional
Research
Project
No.
4
(
1986)
The
Results
of
Tests
on
the
Amount
of
PCNB
Residues
Remaining
in
or
on
Collards,
Kale
and
Mustard
Greens
Including
a
Description
of
the
Analytical
Method
Used:
Amendment.
Unpublished
study.
38
p.

40070401
Ball,
J.,
comp.
(
1987)
Magnitude
of
the
Residue
in
Processed
Potatoes
PCNB
and
it's
Metabolites
and
Impurities:
Morse
Lab.
No.
42428
and
Uniroyal
No.
UR1403.
Unpublished
compilation
prepared
by
Uniroyal
Chemical
Co.,
Inc.
in
cooperation
with
Morse
Laboratories.
81
p.

40088401
Ball,
J.
(
1987)
Magnitude
of
the
Residue
in
Fried
Treated
Processed
Potatoes
PCNB
and
its
Metabolites
and
Impurities:
Morse
Lab
No.
42370
and
Uniroyal
No.
UR1404.
Unpublished
compilation
prepared
by
Uniroyal
Chemical
Co.,
Inc.
in
cooperation
with
Morse
Laboratories,
Inc.
73
p.

40457401
Ball,
J.
(
1987)
Magnitude
of
the
Residue
Terraclor
Residues
in
Processed
Potatoes.
Unpublished
compilation
prepared
in
cooperation
with
Michigan
State
Univ.
and
Morse
Laboratories,
Inc.
689
p.

40816701
Ball,
J.
(
1988)
Magnitude
of
the
Residue
Terraclor
and
Its
Metabolites
in
Potatoes:
Uniroyal
Report
No.
UR
1414.
Unpublished
study
prepared
by
Morse
Laboratories,
Inc.
in
cooperation
with
Pan­
Agricultural
Labs,
Inc.
245
p.

40816702
Ball,
J.
(
1988)
Magnitude
of
the
Residue:
Terraclor
and
Its
Metabolites
in
Broccoli:
Uniroyal
Report
No.
UR­
1408.
Unpublished
study
prepared
by
Morse
Laboratories,
Inc.
in
cooperation
with
Pan­
Agricultural
Laboratory
and
Collins
Agricultural
Consultants,
Inc.
141
p.

40816703
Ball,
J.
(
1988)
Magnitude
of
the
Residue:
Tettaclor
and
Its
Metabolite
in
Cabbage:
Uniroyal
Report
No.
UR­
1413.
Unpublished
study
prepared
by
Morse
Laboratories,
Inc.
in
cooperation
with
Pan
Agricultural
Labs,
Inc.
and
D.
L.
Watson
Consulting
Services
94
&
Enterprises,
Inc.
301
p.

40816704
Ball,
J.
(
1988)
Magnitude
of
the
Residue:
Terraclor
and
Its
Metabolites
in
Beans:
HAS
A026001C:
Uniroyal
Study
No.
UR­
1409.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
225
p.

40816705
Ball,
J.
(
1988)
Magnitude
of
the
Residue:
Terraclor
and
Its
Metabolites
in
Peppers:
Uniroyal
Report
No.
UR­
1410:
Huntingdon
Lab
No.
A026.001B.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services,
Inc.
in
cooperation
with
Pan
Agricultural
Labs,
Inc.
85
p.

40862901
Selman,
F.;
Feutz,
E.;
Leak,
T.
(
1988)
Determining
the
Uptake
and
Translocation
of
carbon
14.
PCNB
Used
in
the
Seed
Treatment
of
Corn
(
Zea
mays),
Wheat
(
Triticum
aestivum),
Soybean
(
Glycine
max),
Peas
(
Pisum
sativum),
and
Sugarbeets
(
Beta
vulgaris):
ABC
Preliminary
Report
No.
35972.
Unpublished
study
prepared
by
Analytical
Bio­
chemistry
Laboratories,
Inc.
43
p.

40921600
Uniroyal
Chemical
Co.
(
1988)
Residue
Data
submitted
for
the
support
of
Terraclor
Registration
Standard.
Transmittal
of
1
study.

40921601
Ball,
J.
(
1988)
Stability
of
Terraclor
and
Allied
Metabolites
in
Frozen
Wheat,
Corn,
Soybeans,
Kidney
Beans,
Peppers,
Tomatoes,
Catsup,
and
Dry
Tomato
Pomace:
Project
ID.
6012­
198A.
Unpublished
study
prepared
by
Hazleton
Laboratories
America
and
Huntingdon
Analytical
Service.
329
p.

41002507
Ball,
J.
(
1989)
Residues
of
PCNB
and
Its
Metabolites
and
Impurities
in
Peanuts
Treated
with
Terraclor
2EC
and
Terraclor
4F
in
Irrigation
Equipment:
Laboratory
Project
ID:
6012­
252.
Unpublished
study
prepared
by
Hazleton
Laboratories
America.
223
p.

41303101
Cheng,
T.
(
1989)
(
Carbon
­
14)­
PCNB:
Nature
of
the
Residue
in
Livestock
­
Laying
Hens:
Lab
Project
Number:
6274­
104.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
75
p.

41303301
Cheng,
T.
(
1989)
(
Carbon
­
14)­
PCNB:
Nature
of
the
Residue
in
Livestock
­
Lactating
Goats:
Lab
Project
Number:
6274/
103.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
75
p.

41341201
Parkins,
M.
(
1990)
Progress
Report
on
PCNB
Metabolism
in
Potatoes:
Lab
Project
Number:
8760.
Unpublished
study
prepared
by
W.
R.
Landis
Associates,
Inc.
in
cooperation
with
Uniroyal
Chemical
Co.
5
p.

41341202
Tortora,
N.
(
1990)
Metabolism
of
14C­
PCNB
in
Peanut
(
Progress
Report):
Lab
Project
Number:
8758.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.
8
p.

41341203
Tortora,
N.
(
1989)
Metabolism
of
14C­
PCNB
in
Cabbage
(
Progress
Report):
Lab
Project
Number:
8756.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.
5
p.
95
41341204
Parkins,
M.
(
1989)
Progress
Report
on
PCNB
Metabolism
in
Chickens:
Lab
Project
Number:
8762.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
and
Uniroyal
Chemical
Co.
6
p.

41341205
McManus,
J.
(
1989)
Progress
Report
on
PCNB
Metabolism
in
Chickens:
Lab
Project
Number:
8762.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
37
p.

41341206
Ball,
J.
(
1989)
Magnitude
of
the
Residue
in
Terraclor
Treated
Cottonseed
and
Cottonseed
Fractions:
Lab
Project
Number:
WSM­
87011;
UNRLCRV­
2;
UR1412.
Unpublished
study
prepared
by
Texas
A&
M
University
System,
Craven
Laboratories
and
Uniroyal
Chemical
Co.,
Inc.
190
p.

41437601
Ball,
J.
(
1990)
Magnitude
of
the
Residue
in
Terraclor
Treated
Peanuts
and
Peanut
Fractions:
Lab
Project
Number:
KHG­
87(
51­
56):
UNRLCRV­
1:
UN1421.
Unpublished
study
prepared
by
Texas
A&
M
Univ.,
System
and
Craven
Laboratories.
347
p.

41437602
Ball,
J.
(
1990)
Residues
of
PCNB
and
its
Metabolites
in
Processed
Potatoes:
Lab
Project
Number:
RP­
88003:
AWW­
88­
003:
88­
1801.
Unpublished
study
prepared
by
AgVise
in
cooperation
with
Michigan
State
Univ.
and
others.
139
p.

41448901
Ball,
J.
(
1990)
Terraclor
Storage
Stability
in
Crops
(
Cabbage
and
Potatoes):
Lab
Ticket
Nos.
47103;
47104:
Study
UR1404.
Unpublished
study
prepared
by
Uniroyal
Chemical
and
Morse
Laboratories,
Inc.
159
p.

41521301
Ball,
J.
(
1990)
Magnitude
of
the
Residue
Terraclor
and
its
Metabolites
and
Impurities
in
Tomatoes
and
Processed
Tomatoes:
Uniroyal
Report
No.:
UR­
1411:
Huntingdon
Lab
No.
A026.001A.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services,
Inc.
in
cooperation
with
Pan
Agricultural
Labs,
Inc.
and
Univ.
of
California.
281
p.

41521302
Ball,
J.
(
1990)
Determination
of
Terraclor
and
Its
Metabolites
and
Impurities
in
Tomatoes
and
Processed
Tomatoes,
at
a
Two
PPB
Quantitation
Limit:
Huntingdon
HAS
A026.005.01:
Uniroyal
Report
No.
UR­
1411
Addendum.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
55
p.

41521303
Ball,
J.
(
1990)
Determination
of
Terraclor
and
Its
Metabolites
and
Impurities
in
Beans
and
Bean
Cannery
Waste,
at
a
Two
PPB
Quantitation
Limit:
Huntingdon
HAS
A026.005.03:
Uniroyal
Report
No.
UR­
1409
Addendum.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
57
p.

41521304
Ball,
J.
(
1990)
Magnitude
of
the
Residue:
Terraclor
and
its
Metabolites
in
Peppers:
Clewiston,
Florida:
Uniroyal
Report
No.
UR­
1410
Addendum
A:
Huntingdon
Lab.
No.
A026.001B
Addendum.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services,
Inc.
in
association
with
Pan
Agricultural
Labs,
Inc.
48
p.
96
41521305
Ball,
J.
(
1990)
Stability
of
Terraclor
and
Allied
Metabolites
in
Frozen
Beans,
Peppers,
Tomatoes
and
Tomato
Products:
HAS
Report
No.:
A026.001E;
A026.005.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
44
p.

41521306
Ball,
J.
(
1990)
Determination
of
Terraclor
and
its
Metabolites
and
Impurities
in
Peppers
at
a
Two
PPB
Quantitation
Limit:
Lab
Project
No.
HAS
A026.005;
Uniroyal
Report
No.:
UR­
1410
Addendum
B.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
41
p.

41562901
Putterman,
G.
(
1990)
Summary
of
Enclosed
Reports
on
the
Metabolism
of
Carbon
14.
Pentachloronitrobenzene
(
PCNB)
in
Cabbage,
Potato
and
Peanut.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
7
p.

41562902
Mcmanus,
J.
(
1990)
Metabolism
of
Carbon
14.­
Pentachloronitrobenzene
(
PCNB)
in
Peanut:
Final
Report:
Lab
Project
Number:
8758.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
23
p.

41562903
Parkins,
M.
(
1990)
The
Metabolism
of
PCNB
in
Field
Grown
Potatoes:
Lab
Project
Number:
8760.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
47
p.

41562904
McManus,
J.;
Maisonet,
F.
(
1990)
Metabolism
of
Pentachlorobenzene
in
Cabbage­
Metabolite
Identification:
Lab
Project
Number:
8756.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
23
p.

41562905
Halls,
J.;
Timothy,
D.
(
1990)
Confined
Accumulation
Study
of
Carbon
14.­
PCNB
on
Rotational
Crops
Treatment,
Sampling
and
Combustion
Analysis:
Lab
Project
Number:
8755:
35971.
Unpublished
study
prepared
by
Analytical
Bio­
Chemistry
Laboratories,
Inc.
49
p.

41692801
Parkins,
M.
(
1990)
Pentachlorobenzene:
Nature
of
the
Residue
in
Poultry­
Laying
Hens:
Lab
Project
Number:
8762:
HLA
6111­
119.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
in
association
with
Hazleton
Laboratories
America
Inc.
121
p.

41692802
Daun,
R.
(
1990)
Pentachlorobenzene:
Nature
of
the
Residue
in
Live­
stock­
Lactating
Goats:
Lab
Project
Number:
HLA
6111­
118.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
67
p.

41692803
Uniroyal
Chemical
Co.
(
1990)
Residue
Analytical
Methods­­
Plants.
Unpublished
study.
47
p.

41692804
Gaydosh,
K.
(
1990)
Response
to
EPA
Comments
on
Uniroyal
PCNB
Residue
Chemistry
Data.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.
20
p.

41692805
McManus,
J.
(
1990)
Response
to
EPA's
Comments
on
Uniroyal
Study
"
Metabolism
of
PCNB
in
the
Goat:
Metabolite
Identification":
Lab
Project
Number:
8761.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
26
p.
97
41735801
McManus,
J.
(
1990)
Metabolism
of
Pentachloronitrobenzene
In
the
Goat:
Identification
of
Metabolites
In
Muscle:
Lab
Project
Number
8761A.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.
21
p.

41758201
Halls,
T.
(
1991)
Determination
of
the
Uptake
and
Translocation
of
carbon
14C­
PCNB
Used
in
Seed
Treatment
of
Corn,
Peas,
Rice,
Safflower,
Sugar­
beets
and
Wheat:
Lab
Project
Number:
37205.
Unpublished
study
prepared
by
Analytical
Bio­
chemistry
Lab.,
Inc.
166
p.

41792601
Gaydosh,
K.
(
1991)
Magnitude
of
the
Residues:
PCNB
and
Related
Metabolites
and
Impurities
in
RTU­
PCNB
Treated
Barley:
Lab
Project
Number:
UR­
1418:
01495:
HLA
6012­
198D.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
195
p.

41792602
Gaydosh,
K.
(
1991)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolites
and
Impurities
in
RTU­
PCNB
Treated
Soybeans:
Lab
Project
Number:
UR­
1416:
01494:
HLA
6012­
198C.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
160
p.

41792603
Gaydosh,
K.
(
1991)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolites
and
Impurities
in
PCNB­
RTU
Treated
Sugarbeets:
Lab
Project
Number:
UR­
1416:
01491:
HLA
6012­
198E.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
126
p.

41792604
Gaydosh,
K.
(
1991)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolites
and
Impurities
in
RTU­
PCNB
Trated
Peas:
Lab
Project
Number:
UR­
1417:
01489:
HLA
6012­
198E.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
131
p.

41792605
Gaydosh,
K.
(
1991)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolite
and
Impurities
in
RTU­
PCNB
Treated
Field
Corn:
Lab
Project
Number:
UR­
1416:
01486­
1987:
HLA
6012­
198.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
155
p.

41792606
Gaydosh,
K.
(
1991)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolites
and
Impurities
in
RTU­
PCNB
Treated
Wheat:
Lab
Project
Number:
UR­
1419:
01492:
HLA
6012­
198A.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
235
p.

41823601
Cheng,
T.
(
1991)
Supplement
to
Carbon
14.­
PCNB:
Nature
of
the
Residue
in
Livestock­­
Lactating
Goats
(
MRID
41303301):
Lab
Project
Number:
HLA
6274­
103­
1.
Unpublished
study
prepared
by
Hazleton
Labs
America,
Inc.
82
p.

41829501
Gaydosh,
K.
(
1991)
Pentachloronitrobenzene
(
PCNB),
Chemical
Code
No.
056502
Terraclor,
EPA
(...):
Storage
Stability
of
PCNB
and
Its
Allied
Metabolites
and
Impurities
in
Peanuts:
Lab
Project
Number:
RP­
89065:
6012­
308.
Unpublished
study
prepared
by
Hazelton
Laboratories
America,
Inc.
145
p.

41829502
Gaydosh,
K.
(
1991)
Pentachloronitrobenzene
(
PCNB),
Chemical
Code
No.
056502
Terraclor,
EPA
(...):
Storage
Stability
of
PCNB
and
Its
Allied
Metabolites
and
Impurities
in
Cotton:
Lab
Project
Number:
RP­
89066:
6012­
309.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
139
p.
98
41839701
Cheng,
T.
(
1991)
Supplement
to:
Carbon
14.­
PCNB:
Nature
of
the
Residue
in
Livestock
­
Laying
Hens
(...):
Lab
Project
Number:
HLA16274­
104­
1.
Unpublished
study
prepared
by
Hazleton
Laboratories
Americas,
Inc.
72
p.

41870201
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Broccoli:
Lab
Project
Number:
PAL­
PB­
BR.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
185
p.

41870202
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Cabbage:
Lab
Project
Number:
PAL­
PB­
CB.
Unpublished
Study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
305
p.

41870203
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Cottonseed:
Lab
Project
Number:
PAL­
PB­
CS.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
289
p.

41870204
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Dry
Beans:
Lab
Project
Number:
PAL­
PB­
DB.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
431
p.

41870205
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Lima
Beans:
Lab
Project
Number:
PAL­
PB­
LB.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
205
p.

41870206
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Peanuts:
Lab
Project
Number:
PAL­
PB­
PT.
Unpublished
Study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
479
p.

41870207
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Peppers:
Lab
Project
Number:
PAL­
PB­
PP.
Unpublished
Study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
214
p.

41870208
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Potatoes:
Lab
Project
Number:
PAL­
PB­
PO.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
401
p.

41870209
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Snap
Beans:
Lab
Project
Number:
PAL­
PB­
BS.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
228
p.

41870210
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB)
Residues
on
Tomatoes:
Lab
Project
Number:
PAL­
PB­
TO.
Unpublished
study
prepared
by
Pan­
Agricultural
Laboratories,
Inc.
&
Hazleton
Laboratories
America,
Inc.
250
p.
99
41871301
LeRoy,
R.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB):
Residues
on
Soybeans:
Lab
Project
Number:
PAL­
PB­
SY.
Unpublished
study
prepared
by
Pan­
Agicultural
Labs,
Inc.
and
Hazleton
Labs
America.
387
p.

41908801
Parkins,
D.
(
1991)
Pentachloronitrobenzene:
Nature
of
the
Residue
in
Poultry­
Laying
Hens:
Lab
Project
Number:
8762.
Unpublished
study
prepared
by
UNIROYAL
Chemical
Co.,
Inc.
40
p.

41975801
LeRoy,
R.;
Cassidy,
J.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB):
Residues
in
Processed
Cottonseed:
Lab
Project
No:
PAL­
PB­
CS­
P.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.,
and
Pan­
Agricultural
Labs,
Inc.
267
p.

41975802
LeRoy,
R.;
Cassidy,
J.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB):
Residues
in
Processed
Peanuts:
Lab
Project
No:
PAL/
PB/
PT/
P.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.,
and
Pan­
Agricultural
Labs.,
Inc.
289
p.

41975803
LeRoy,
R.;
Cassidy,
J.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB):
Residues
in
Processed
Potatoes:
Lab
Project
No:
PAL­
PB­
PO­
P.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.,
and
Pan­
Agricultural
Labs.,
Inc.
307
p.

41975804
LeRoy,
R.;
Cassidy,
J.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB):
Residues
in
Processed
Snap
Beans:
Lab
Project
No:
PAL­
PB­
SB­
P.
Unpublished
study
prepared
by
Hazleton
Labora
tories
America,
Inc.,
and
Pan­
Agricultural
Labs.,
Inc.
173
p.

41975805
LeRoy,
R.;
Cassidy,
J.
(
1991)
The
Magnitude
of
Pentachloronitrobenzene
(
PCNB):
Residues
in
Processed
Tomatoes:
Lab
Project
Number:
PAL­
PB­
TO­
P.
Unpublished
study
prepared
by
Hazleton
Laboratories
America,
Inc.,
and
Pan­
Agricultural
Labs,
Inc.
232
p.

42094405
White,
C.
(
1991)
Response
to
EPA
Rejection
of
Confined
Accumulation
Rotational
Crops
(...)
and
Progress
Report.
Unpublished
study
prepared
by
Uniroyal
Chem.
Co.,
Inc.
113
p.

42222101
Premkumar,
N.;
Brown,
D.
(
1992)
Metabolism
of
Carbon
14.
PCNB
in
Peanuts:
Final
Report:
Lab
Project
Number:
RPT
37197.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
465
p.

42482701
Premkumar,
N.;
Brown,
D.
(
1992)
Metabolism
of
(
carbon­
14)
PCNB
in
Potatoes:
Amended
Final
Report:
Lab
Project
Number:
37196.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
323
p.

42482702
Premkumar,
N.;
Brown,
D.
(
1992)
Metabolism
of
(
carbon­
14)
PCNB
in
Cabbage:
Amended
Final
Report:
Lab
Project
Number:
37204.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
400
p.

42534114
Gaydosh,
K.
(
1992)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolites
and
Impurities
in
Cotton
Treated
with
Terraclor
10G,
Terraclor
2E
and
Terraclor
Flowable:
Lab
100
Project
Number:
RP­
91020:
004­
13.
Unpublished
study
prepared
by
Centre
Analytical
Labs.
257
p.

42534115
Gaydosh,
K.
(
1992)
Magnitude
of
the
Residue:
PCNB
and
Related
Metabolites
and
Impurities
in
Cotton
Treated
with
Terraclor
2E
and
Terraclor
Flowable:
Lab
Project
Number:
RP­
88001:
HLA
6012­
251.
Unpublished
study
prepared
by
Hazleton
Labs
America,
Inc.
484
p.

42599201
Heath,
J.
(
1992)
PCNB:
Accumulation
in
Confined
Rotational
Crops:
Lab
Project
Number:
36920.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
92
p.

42718601
Stenner,
S.;
Stanek,
M.;
Grice,
M.
(
1992)
Field
Residue
Study
with
PCNB
on
Peanuts:
Revised
Final
Report:
Lab
Project
Number:
HWI
6274­
109.
Unpublished
study
prepared
by
Hazleton
Wisconsin,
Inc.
295
p.

42755201
Ver
Hey­
Vorndam,
M.
(
1993)
Testing
of
Metabolites
of
PCNB
through
FDA
Multiresidue
Protocols
C
and
D
Multiresidue
Study:
Final
Report:
Lab
Project
Number:
RP­
93012:
UNIROYAL­
1190.
Unpublished
study
prepared
by
Colorado
Analytical
Research
&
Development
Corp.
193
p.

42841101
Putterman,
G.
(
1993)
PCNB:
Confined
Rotational
Crops:
Study
Overview.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co,
Inc.
7
p.

42841102
White,
C.
(
1993)
Uniroyal
Comments
Including
Raw
Data
from
the
In
Life
Study
Entitled:
"
Confined
Accumulation
Study
of
(
carbon
14)­­
PCNB
on
Rotational
Crops
Treatment,
Sampling
and
Combustion
Analysis:
Lab
Project
Number:
H632.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co,
Inc.
99
p.

42841103
Murty,
V.;
Ford,
C.
(
1993)
Characterization
of
Pentachloronitrobenzene
Metabolites
in
Rotational
Wheat:
Lab
Project
Number:
8755:
35971:
9058.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co,
Inc.
and
ABC
Labs.
295
p.

42841104
Ford,
C.;
Murty,
V.
(
1993)
Characterization
of
Pentachloronitrobenzene
Metabolites
in
Rotational
Lettuce:
Lab
Project
Number:
8755:
35971:
9039.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co,
Inc.
and
ABC
Labs.
143
p.

42841105
Ford,
C.;
Murty,
V.
(
1993)
Characterization
of
Pentachloronitrobenzene
Metabolites
in
Rotational
Turnip:
Lab
Project
Number:
8755:
9055:
35971.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co,
Inc.
and
ABC
Labs.
97
p.

43118202
Gaydosh,
K.
(
1993)
Magnitude
of
the
Residue:
Terraclor
75W,
Terraclor
2EC
and
Terraclor
Flowable
on
Snap
Beans:
Lab
Project
Number:
RP/
93009:
004/
33:
RGC/
93/
010.
Unpublished
study
prepared
by
Centre
Analytical
Lab.
and
Uniroyal
Chemical
Ltd.
314
p.

43118203
Gaydosh,
K.
(
1994)
Magnitude
of
the
Residue:
Terraclor
75W,
Terraclor
2EC
and
Terraclor
Flowable
on
Dry
Beans:
Lab
Project
Number:
004/
34:
JGC/
93/
016:
AWW/
93/
016.
Unpublished
study
prepared
by
Centre
Analytical
Lab.
322
p.
101
43549201
Gaydosh,
K.
(
1994)
Terraclor
75W
on
Peanuts:
Magnitude
of
the
Residue
Study:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
RP­
90032:
30800:
CRA­
90­
085.
Unpublished
study
prepared
by
Crop
Guard,
Inc.;
National
Environmental
Testing;
and
Uniroyal
Chemical
Ltd.
196
p.

43549202
Gaydosh,
K.
(
1994)
Terraclor
10G
and
75W
on
Peanuts:
Magnitude
of
the
Residue
Study:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
RP­
90033:
30900:
CRA­
90­
087.
Unpublished
study
prepared
by
Crop
Guard,
Inc.;
National
Environmental
Testing;
and
S.
T.
A.
R.,
Inc.
227
p.

43549203
Gaydosh,
K.
(
1994)
Terraclor
Flowable
and
Terraclor
2E
on
Peanuts:
Magnitude
of
the
Residue
Study:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
RP­
91022:
34200:
KHG­
91­
065.
Unpublished
study
prepared
by
Crop
Guard,
Inc.;
National
Environmental
Testing;
and
Uniroyal
Chemical
Ltd.
326
p.

43574901
Gaydosh,
K.
(
1994)
Terraclor
10G
and
Terraclor
2E
on
Cotton:
Magnitude
of
the
Residue
Study:
(
Data
submitted
as
alternate
to
Craven
Laboratories
generated
data):
Lab
Project
Numbers:
WSM­
90­
007:
CRA­
90­
089:
004­
07.
Unpublished
study
prepared
by
Central
Analytical
Labs.,
Inc.;
S­
L
Agri­
Development;
and
Agri­
Search.
251
p.

43976901
Gaydosh,
K.;
Smudin,
D.
(
1996)
Terraclor
10G
on
Cotton:
Processing
Study:
(
Data
submitted
as
alternate
to
Craven
Laboratories
generated
data):
Lab
Project
Number:
WSM­
90­
002:
1RP­
93008:
004­
35.
Unpublished
study
prepared
by
S­
L
Agri­
Development;
Texas
A&
M
University;
and
Centre
Analytical
Labs,
Inc.
402
p.

43976902
Gaydosh,
K.;
Smudin,
D.
(
1996)
Terraclor
10EC
on
Peanuts:
Processing
Study:
(
Data
submitted
as
alternate
to
Craven
Laboratories
generated
data):
Lab
Project
Number:
KHG­
92­
006:
RP­
92018:
004­
28.
Unpublished
study
prepared
by
Georgia
Agri­
Scientific,
Inc.;
Texas
A&
M
University;
and
Centre
Analytical
Labs,
Inc.
394
p.

44081001
Gaydosh,
K.
(
1996)
Terraclor
10G
Rotational
Crop
Study:
Residue
Levels
of
PCNB
and
Related
Metabolites
and
Impurities
in
Wheat
and
Lettuce
Planted
30
and
120
Days
After
Terraclor
10G
Applied
to
Bare
Soil
at
Peanut
Application
Rates:
Lab
Project
Number:
RP­
92009:
KHG­
92­
004:
CRA­
92­
002.
Unpublished
study
prepared
by
S.
T.
A.
R.,
Inc.;
Hickey's
Agri­
Services
Lab;
and
Centre
Analytical
Labs.,
Inc.
535
p.

44113501
Gaydosh,
K.
(
1996)
Terraclor
10G
Rotational
Crop
Study:
Residue
Levels
of
PCNB
and
Related
Metabolites
and
Impurities
in
Wheat,
Turnip,
and
Lettuce
Planted
365
Days
After
Terraclor
10G
Applied
to
Bare
Soil
at
Peanut
Application
Rates:
Lab
Project
Number:
RP­
91029:
KHG­
91­
068:
CRA­
91­
081.
Unpublished
study
prepared
by
Centre
Analytical
Laboratories,
Inc.;
S.
T.
A.
R.,
Inc.;
and
Hickey's
Agri­
Services
Lab.
693
p.

44167501
Balba,
H.
(
1996)
Response
to
EPA/
Dynamac
Review
for
Nature
of
Residues
in
Plants
and
Animals:
(
PCNB):
Lab
Project
Number:
8761.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
43
p.
102
44469101
McManus,
J.
(
1997)
Response
to
EPA/
Dynamac
Review
for
Nature
of
Residues
in
Potato
Plants:
PCNB.
Unpublished
study
prepared
by
Uniroyal
Chemical
Co.,
Inc.
26
p.

44577501
Harned,
W.;
Carter,
D.;
Yu,
W.
et
al.
(
1998)
Confined
Rotational
Crop
Analytical
and
Field
Study
on
PCNB:
Amended
Final
Report:
Lab
Project
Number:
9270:
92094:
RPT00266.
Unpublished
study
prepared
by
ABC
Laboratories
California,
XenoBiotic
Laboratories,
Inc.,
Uniroyal
Chemical
Co.,
Inc.
969
p.
{
OPPTS
860.1850}

44814701
Gaydosh,
K.
(
1999)
Freezer
Storage
Stability
of
PCNB
and
Allied
Metabolites
and
Impurities
in
Wheat,
Turnip,
and
Lettuce:
Lab
Project
Number:
RP­
920409:
004­
32A:
004­
32B.
Unpublished
study
prepared
by
Centre
Analytical
Laboratories,
Inc.
742
p.
{
OPPTS
860.1380}

45307301
Putterman,
G.
(
2001)
Summary
of
Enclosed
Reports
on
the
Metabolism
of
(
carbon
14)­
Pentachloronitrobenzene
(
PCNB)
in
Peanut
and
Potato.
Unpublished
study
prepared
by
Uniroyal
Chemical
Company,
Inc.
7
p.
(
OPPTS
860.1300}

45307302
McManus,
J.;
DeMatteo,
V.
(
1999)
Distribution
and
Metabolism
of
(
carbon
14)­(
UL)­
PCNB
in
Peanuts:
Lab
Project
Number:
97033.
Unpublished
study
prepared
by
Uniroyal
Chemical
Company,
Inc.
157
p.{
OPPTS
860.1300}

45307303
Fang,
N.;
Mertz,
J.
(
1999)
Metabolism
of
(
carbon
14)­(
UL)­
PCNB
in
Potatoes
as
a
Soil
Treatment:
Lab
Project
Number:
97013.
Unpublished
study
prepared
by
Uniroyal
Chemical
Company,
Inc.
261
p.
{
OPPTS
860.1300}
