1
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
MEMORANDUM
DATE:
April
18,
2006
SUBJECT:
Phosmet:
Postapplication
Risk
Analysis
For
Hand
Thinning
Fruit
Trees
FROM:
Matthew
Lloyd,
Industrial
Hygienist
Reregistration
Branch
1
Health
Effects
Division
(
HED)

THROUGH:
Whang
Phang,
Ph.
D.,
Branch
Senior
Scientist
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

TO:
Diane
Isbell,
Chemical
Review
Manager
Reregistration
Branch
2
Health
Effects
Division
(
7508C)

DP
Barcode:
DP296577
PC
Code:
059201
Attached
is
the
Postapplication
Risk
Analysis
For
Hand
Thinning
Fruit
Trees
for
Phosmet.

Reviewer:
Jeff
Evans
(
4/
18/
06)
2
Executive
Summary
The
following
is
an
assessment
of
potential
occupational
postapplication
exposures
and
risks
to
adults
from
hand
thinning
fruit
trees
that
have
been
treated
with
phosmet.
Short­
and
intermediate­
term
exposures
and
risks
were
assessed
for
application
rates
of
1,
2,
3,
and
3.75
pounds
active
ingredient
per
acre
using
the
results
from
a
postapplication
biomonitoring
study
for
thinning
peach
trees
(
MRID
466823­
01)
and
a
dislodegable
foliar
residue
study
on
pears
(
MRID
404253­
01)
that
had
been
described
and
used
in
the
IRED.

Noncancer
risks
were
calculated
using
the
Margin
of
Exposure
(
MOE)
approach,
which
is
a
ratio
of
the
body
burden
to
the
toxicological
endpoint
of
concern.
An
MOE
of
100
or
greater
is
not
of
concern
to
HED.
The
toxicological
endpoint
of
concern
is
4.5
mg/
kg/
day
for
short­
term
exposures
and
1.1
mg/
kg/
day
for
intermediate
term
exposures.
Short
term
and
intermediate­
term
exposure
intervals
have
been
defined
the
same
as
"
The
revised
Occupational
and
Residential
Exposure
aspects
of
the
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document
(
RED)
for
Phosmet"
[
DP
Barcode
D262366].
The
incidental
oral
endpoints
were
used
in
this
assessment,
since
the
exposures
were
from
a
biomonitoring
study.

As
summarized
in
Table
1
below,
all
MOEs
except
the
1
lb
ai/
A
were
of
concern
at
the
current
restricted­
entry
interval
(
REI)
of
3
days.
Short­
term
MOEs
were
110,
54,
36,
and
29
and
intermediate­
term
MOEs
were
26,
13,
8.8,
and
7.0
for
application
rates
of
1,
2,
3,
and
3.75
pounds
active
ingredient
per
acre,
respectively.
Short­
term
risks
were
at
or
below
the
Agency's
level
of
concern
on
days
3,
13,
19,
and
22
after
treatment
for
the
1,
2,
3,
and
3.75
pounds
active
ingredient
per
acre
application
rates,
respectively.
Intermediate­
term
risks
were
at
or
below
the
Agency's
level
of
concern
at
days
24,
34,
40,
and
44
after
treatment
for
the
1,
2,
3,
and
3.75
pounds
active
ingredient
per
acre
application
rates,
respectively.

Table
1.
Phosmet
Risk
Summary
for
Fruit
Tree
Thinning
Activities
MOE
at
REI
of
2
days
MOE
at
the
Current
REI
of
3
days
REI
at
which
MOE
is
$
100
Application
Rate
(
lb
ai/
A)
Shortterm
Intermediateterm
Shortterm
Intermediateterm
Short­
term
Intermediate­
term
1.0
100
25
110
26
2
days
(
MOE
=
100)
1
24
days
(
MOE
=
110)
2.0
50
12
54
13
13
days
(
MOE
=
104)
34
days
(
MOE
=
102)
3.0
34
8.2
36
8.8
19
days
(
MOE
=
103)
40
days
(
MOE
=
102)
3.75
27
6.6
29
7.0
22
days
(
MOE
=
101)
44
days
(
MOE
=
106)
1
 
Current
Restricted
Entry
Interval
is
3
days
Postapplication
Exposure
Assessment
The
following
equations
and
assumptions
were
used
to
calculate
total
exposures
and
risks
from
hand
thinning
fruit
trees
treated
with
phosmet.

Equations
The
following
equations
were
used
to
calculate
total
dose
and
risk
for
the
postapplication
scenarios.
The
equations
use
the
absorbed
dose
values
from
a
chemical­
specific
biomonitoring
3
study
(
MRID
466823­
01)
and
dislodgeable
foliar
residue
(
DFR)
values
from
a
chemical­
specific
DFR
study
(
MRID
404253­
01).
Noncancer
risks
were
calculated
using
the
Margin
of
Exposure
(
MOE)
approach,
which
is
a
ratio
of
the
body
burden
to
the
toxicological
endpoint
of
concern.
MOEs
were
calculated
starting
at
2
days
after
treatment
(
DAT)
until
the
MOEs
were
not
of
concern
to
HED.

Total
Absorbed
Dose
XDAT
=
Absorbed
Dose
2DAT
*
(
DFR
XDAT
/
DFR
2DAT)

Where:
Total
Absorbed
Dose
XDAT
=
The
total
absorbed
dose
received
from
exposure
to
a
pesticide
in
a
given
scenario
for
"
x"
days
after
treatment
(
mg
pesticide
active
ingredient/
kg
body
weight/
exposure)
Total
Absorbed
Dose
2DAT
=
Total
Absorbed
Dose
from
Phosmet
Biomonitoring
Study
(
MRID
466823­
01)
for
2
DAT,
adjusted
for
application
rate
(
mg/
kg/
exposure)
DFR
XDAT
=
DFR
value
from
DFR
study
(
MRID
404253­
01)
for
"
x"
DAT
(:
g/
cm2),
adjusted
for
application
rate
(
mg/
kg/
day)
DFR
2DAT
=
DFR
value
from
DFR
study
(
MRID
404253­
01)
for
2
DAT
(:
g/
cm2),
adjusted
for
application
rate
(
mg/
kg/
day)

Short­
and
Intermediate­
Term
MOE
=
NOAEL
/
Total
Absorbed
Dose
XDAT
Where:
MOE
=
Margin
of
Exposure,
value
used
by
HED
to
represent
risk
or
how
close
a
chemical
exposure
is
to
being
a
concern
(
unitless);
NOAEL
=
Dose
level
in
a
toxicity
study,
where
no
observed
adverse
effects
(
NOAEL)
occurred
in
the
study
Total
Absorbed
Dose
XDAT
=
Total
Daily
Dose
for
"
x"
days
after
treatment
(
mg/
kg/
day)

Application
Rate
The
risks
were
assessed
at
application
rates
of
1,
2,
3
and
3.75
pounds
active
ingredient
per
acre.
Table
2
below
indicates
the
maximum
application
rates
used
in
the
IRED
for
assessing
postapplication
risks
for
tasks
involving
tree
fruits.
The
IRED
listed
a
maximum
of
4
pounds
active
ingredient
per
acre
for
western
apples
and
pears,
however,
the
current
maximum
label
rate
for
any
tree
fruits
is
3.75
pounds
active
ingredient
per
acre.
The
application
rate
in
the
peach
biomonitoring
study
was
3
pounds
active
ingredient
per
acre.
The
application
rate
in
the
pear
dislodgeable
foliar
residue
study
was
5
pounds
active
ingredient
per
acre.

Table
2.
Maximum
Application
Rates
Established
in
IRED
for
Tree
Fruits
Crop
PHI
(
days)
REI
Application
Rate
Activity
IRED
Apples
(
eastern)
7
3
days
1.5
lbs
ai/
A
(
max
of
21
lbs
ai/
A/
yr)
Thinning,
Harvesting,
Pruning
Apples
(
western)
7
3
days
4
lbs
ai/
A
(
max
of
21
lbs
ai/
A/
yr)
Thinning,
Harvesting,
Pruning
4
Apricots
14
3
days
3
lbs
ai/
A
(
max
of
9.1
lbs
ai/
A/
yr)
Thinning,
Harvesting,
Pruning
Nectarines
14
3
days
3
lbs
ai/
A
(
max
of
9.1
lbs
ai/
A/
yr)
Thinning,
Harvesting,
Pruning
Peaches
14
3
days
3
lbs
ai/
A
(
max
of
12
lbs
ai/
A/
yr)
Thinning,
Harvesting
Pears
7
3
days
4
lbs
ai/
A
(
max
of
11.2
lbs
ai/
A/
yr)
Thinning,
Harvesting,
Pruning
Plums/
Prunes
7
3
days
3
lbs
ai/
A
(
max
of
9.1
lbs
ai/
A/
yr)
Thinning,
Harvesting,
Pruning
Duration
of
Exposure
Adverse
effects
were
identified
at
durations
of
exposure
ranging
from
short­
term
(#
7
days)
to
intermediate­
term
(
exposure
durations
>
7
but
#
30
days)
[
see
DP
Barcode
D262366].
Longterm
exposures
to
phosmet
are
not
expected;
therefore,
long­
term
exposures
and
risks
are
not
assessed.
Additionally,
no
cancer
endpoint
was
identified;
therefore,
cancer
risks
are
not
assessed.

Toxicological
Data
The
toxicological
endpoints
for
incidental
oral
exposure
were
selected
for
this
assessment,
since
the
exposure
is
from
a
biomonitoring
study.
The
short­
term
incidental
oral
endpoint
is
4.5
mg/
kg/
day
and
the
intermediate­
term
incidental
oral
endpoint
is
1.1
mg/
kg/
day.
The
uncertainty
factor
is
100;
therefore,
an
MOE
of
100
or
greater
is
not
of
concern
to
HED.

Absorbed
Dose
The
absorbed
dose
values
were
from
a
chemical
specific
post­
application
study
entitled,
"
Biomonitoring
of
Workers
Hand­
Thinning
Peaches
Treated
With
Phosmet
Insecticide"
(
D.
Baugher,
2005,
MRID
Number:
466823­
01),
which
was
submitted
by
the
Registrant
(
Gowan
Company).
In
this
study,
two
days
after
the
peaches
had
been
treated
with
phosmet
by
airblast
at
an
application
rate
of
3
pounds
active
ingredient
per
acre,
16
workers
hand
thinned
peaches
for
6.5
hours
on
one
day.
The
workers
in
the
study
were
wearing
a
long­
sleeve
shirt,
long
pants,
shoes,
socks,
jacket
(
occasionally
in
the
morning),
and
mixed
head
wear.
Total
phosmet
absorbed
doses
were
calculated
by
HED
from
urine
samples
collected
from
each
worker
on
the
day
of
the
exposure
event
through
4
days
after
the
exposure
event.
The
urine
samples
were
analyzed
for
the
phosmet
metabolites
sulfonyl
(
SO)
and
sulfinyl
(
SI).
The
basic
algorithm
used
for
calculating
the
absorbed
dose,
explanations
of
the
factors
in
the
equation,
and
explanation
of
other
study­
specific
factors
used
to
calculate
the
absorbed
doses
are
presented
below.
A
summary
of
the
biomonitoring
results
is
presented
in
Table
3.
The
overall
geometric
mean
absorbed
dose
is
0.134
mg/
kg/
day.

AD
=
(
3MRn
*
MWF)
/
(
F1
*
F2
*
F3
*
BW)

where:
5
AD
=
Absorbed
Dose
of
the
Active
Ingredient
(
mg/
kg/
day
of
exposure)
MRn
=
Metabolite
Recovered
daily
in
biomonitoring
study
(
mg/
day)
for
the
number
of
consecutive
days
that
metabolites
were
assayed
(
mg/
day)
MWF
=
Molecular
Weight
Factor
­
ratio
of
the
molecular
weight
of
the
active
ingredient
to
the
molecular
weight
of
the
metabolite
recovered
(
unitless)
F1
=
Percent
of
active
ingredient
taken
in
that
is
expected
to
be
excreted
in
urine
F2
=
Percent
of
active
ingredient
excreted
as
measurable
metabolite
in
urine
F3
=
Percent
of
metabolite
expected
to
be
excreted
in
urine
within
the
timeframe
of
sampling
(
n
days)
BW
=
Body
weight
of
the
population
at
risk
(
i.
e.,
70
kg
for
adults,
60
kg
if
female­
specific
endpoint)

 
Metabolite
Recovered:
The
sulfinyl
values
were
added
to
the
sulfonyl
values
in
those
samples
where
the
sulfinyl
was
incompletely
oxidized
into
sulfonyl.
The
sulfinyl
samples
were
first
adjusted
using
the
results
of
the
sulfinyl
standard
that
found
150%
of
the
expected.
Then
the
sulfinyl
values
were
normalized
to
the
molecular
weight
of
sulfonyl
(
adjustment
factor
of
1.07
using
the
molecular
weight
of
257
for
sulfonyl
divided
by
the
molecular
weight
of
241
for
sulfinyl)
and
added
to
the
sulfonyl
values.

 
Molecular
Weight
Factor:
The
total
SO
equivalents
were
converted
to
total
phosmet
using
a
molecular
weight
conversion
factor
of
1.235
mg
phosmet
per
mg
SO.

 
Factor
1:
The
data
were
corrected
by
dividing
by
95%,
for
the
fact
that
only
approximately
95%
of
the
administered
radioactivity
was
excreted
in
urine
in
the
rat
oral
metabolism
study.

 
Factor
2:
The
data
were
corrected
by
dividing
by
93.5%,
for
the
fact
that
based
on
the
modeling
of
the
data
in
the
biomonitoring
study
(
not
on
data
from
the
rat
oral
metabolism
study),
only
approximately
93.5%
of
the
metabolites
were
excreted
in
human
urine
during
the
period
of
urine
collection
in
the
biomonitoring
study.

 
Factor
3:
The
data
were
corrected
by
dividing
by
55%,
for
the
fact
that
approximately
55%
of
the
total
phosmet
is
converted
to
sulfonyl
and
sulfinyl
and
excreted
in
urine
in
the
rat
oral
metabolism
study.
The
55%
value
is
obtained
from
the
protocol
for
this
biomonitoring
study,
where
it
states
that
50­
60%
of
the
total
phosmet
in
the
rat
oral
metabolism
study
is
converted
to
sulfonyl
and
sulfinyl.

 
Bodyweight:
The
actual
bodyweights
reported
in
the
biomonitoring
study
for
each
subject
were
used.

 
Field
Fortification
Recovery
Factor:
The
data
were
corrected
by
dividing
by
84%,
which
is
the
recovery
correction
factor
obtained
when
averaging
all
the
field
fortification
samples.

 
Creatinine
Adjustment
Factor:
Many
of
the
24­
hr
urine
samples
had
incomplete
creatinine
excretion.
All
samples
were
corrected
using
projected
creatinine
correction
values,
including
those
samples
with
actual
creatinine
levels
that
were
higher
than
the
projected
levels.
6
 
Workday
Adjustment
Factor:
A
thunderstorm
occurred
for
15
minutes
in
the
afternoon
on
the
monitoring
day.
The
workers
took
cover
during
the
thunderstorm.
Following
the
thunderstorm,
the
workers
re­
entered
the
orchard
to
thin,
even
though
there
was
a
light
rain.
According
to
the
crew
foreman,
the
subjects
would
normally
be
expected
to
work
in
light
rain.
When
the
rain
intensity
increased,
the
subjects
left
the
orchard.
The
workday
was
shortened
to
6.5
hours
due
to
the
rainy
weather.
The
dose
was
normalized
to
an
8­
hour
workday
by
multiplying
the
dose
by
a
factor
of
1.23
(
8
hours/
6.5
hours).

DFR
Values
The
DFR
values
were
taken
from
a
chemical
specific
post­
application
study
conducted
using
pear
trees
in
California
(
MRID
404253­
01).
The
values
were
also
used
in
the
Phosmet
Interim
Reregistration
Eligibility
Decision
(
IRED)
dated
10/
2001.
In
this
study,
phosmet
was
applied
to
pears
at
an
application
rate
of
5
pounds
active
ingredient
per
acre
and
DFR
samples
were
collected
on
Days
0,
1,
2,
3,
4,
5,
7,
10,
14,
21,
and
28
after
the
last
application.
A
linear
regression
was
performed
and
the
resulting
decline
DFR
values
were
used
in
this
risk
assessment.

A
DFR
study
using
peach
trees
in
Georgia
was
also
conducted
(
466823­
01).
Data
from
this
study
were
not
used
because
of
a
rain
event
that
occurred
at
the
end
of
the
exposure
day.
According
to
the
Study
Report,
the
rain
affected
the
dissipation
kinetics
and
a
meaningful
dissipation
curve
could
not
be
developed.
7
Risk
Summary
HED
Risk
Summary
A
detailed
summary
of
the
estimated
exposure
risks
(
short­
term
and
intermediate­
term)
are
presented
in
Tables
4a,
4b,
4c
and
4d
for
application
rates
of
1,
2,
3,
and
3.75
pounds
active
ingredient
per
acre
respectively.

At
an
application
rate
of
1
pound
active
ingredient
per
acre,
the
short­
term
MOE
was
100
and
the
intermediate 
term
MOE
was
25
at
2
days
after
treatment.
At
the
current
REI
of
3
days,
the
short­
term
MOE
was
110
and
the
intermediate 
term
MOE
was
26.
The
MOEs
are
not
a
concern
at
2
days
after
treatment
for
short­
term
exposures
(
MOE
=
100)
[
though
the
current
REI
=
3
days]
and
at
24
days
after
treatment
for
intermediate­
term
exposures
(
MOE
=
110).

At
an
application
rate
of
2
pounds
active
ingredient
per
acre,
the
short­
term
MOE
was
50
and
the
intermediate 
term
MOE
was
12
at
2
days
after
treatment.
At
the
current
REI
of
3
days,
the
short­
term
MOE
was
54
and
the
intermediate 
term
MOE
was
13.
The
MOEs
are
not
a
concern
at
13
days
after
treatment
for
short­
term
exposures
(
MOE
=
104)
and
at
34
days
after
treatment
for
intermediate­
term
exposures
(
MOE
=
102).

At
an
application
rate
of
3
pounds
active
ingredient
per
acre,
the
short­
term
MOE
was
34
and
the
intermediate 
term
MOE
was
8.2
at
2
days
after
treatment.
At
the
current
REI
of
3
days,
the
short­
term
MOE
was
36
and
the
intermediate­
term
MOE
was
8.8.
The
MOEs
are
not
a
concern
at
19
days
after
treatment
REI
for
short­
term
exposures
(
MOE
=
103)
and
at
a
40
day
REI
for
intermediate­
term
exposures
(
MOE
=
102).

At
an
application
rate
of
3.75
pounds
active
ingredient
per
acre,
the
short­
term
MOE
was
27
and
the
intermediate 
term
MOE
was
6.6
at
2
days
after
treatment.
At
the
current
REI
of
3
days,
the
short­
term
MOE
was
29
and
the
intermediate­
term
MOE
was
7.0.
The
MOEs
are
not
a
concern
at
22
days
after
treatment
for
short­
term
exposures
(
MOE
=
101)
and
at
44
days
after
treatment
for
intermediate­
term
exposures
(
MOE
=
106).

In
the
Phosmet
IRED
(
10/
2001),
risks
were
calculated
for
peach
thinning
activities
for
an
application
rate
of
3
pounds
active
ingredient
per
acre
and
using
the
short­
and
intermediate­
term
(<
30
days)
NOAEL
of
15
mg/
kg/
day.
The
MOE
at
a
3­
day
REI
was
18.
The
MOE
is
not
a
concern
at
a
30­
day
REI
(
MOE
=
105).
These
MOEs
were
calculated
using
the
pear
DFR
data
(
MRID
404253­
01)
and
the
transfer
coefficient
from
HED
Science
Policy
for
Exposure
3.1:
Agricultural
Transfer
Coefficients
(
dated
August
7,
2000)
for
high
exposure
activities.
The
shortterm
MOE
for
peach
thinning
in
the
Phosmet
IRED
on
day
3
after
application
is
approximately
one
half
the
short­
term
MOEs
calculated
in
this
risk
assessment.
However,
the
short­
term
risks
for
peach
thinning
remain
a
concern
until
day
30
in
the
IRED,
whereas
the
short­
term
risks
are
not
of
concern
by
day
19
using
the
biological
monitoring
study.

Registrant
Submitted
Risk
Summary
The
Registrant
(
Gowan
Company)
submitted
a
memo
to
EPA
on
February
12,
2006
which
describes
factors
they
used
to
calculate
absorbed
doses
and
MOEs.
The
factors
discussed
in
the
memo,
as
well
factors
discussed
in
the
biomonitoring
study
(
466823­
01)
are
provided
below.
Also
provided
are
EPA's
values
for
comparison
purposes.
EPA
identified
flaws
with
some
of
the
8
correction
factors
used
by
Gowan;
therefore,
MOEs
were
calculated
using
the
EPA
assumptions
only.
The
MOEs
presented
by
Gowan
in
the
February
12,
2006
memo
to
EPA
are
approximately
2
times
higher
than
the
MOEs
calculated
by
EPA
in
this
risk
assessment.
The
Gowan
memo
indicates
that
MOEs
are
not
of
concern
at
an
REI
of
2
days
for
the
2
pounds
active
ingredient
per
acre
application
rate.

Factor
EPA
Gowan
Metabolite
Recovered:
Corrected
for
incomplete
oxidation
of
sulfinyl
to
sulfonyl
Did
not
correct
for
incomplete
oxidation
of
sulfinyl
to
sulfonyl
Molecular
Weight
Factor:
Yes
(
Same)
Yes
(
Same)
Factor
1:
Yes
(
93.5%)
No
Factor
2:
Yes
(
Same)
Yes
(
Same)
Factor
3:
55%
67.6%
Body
Weight:
Yes
(
Same)
Yes
(
Same)
Field
Fortification
Recovery:
84%
No
Creatinine
Adjustment:
Yes
(
Same)
Yes
(
Same)
Workday
Adjustment:
Yes
(
8
hours/
6.5
hours)
No
DFR
Adjustment:
Yes
(
from
MRID
404253­
01)
Not
needed
References
Gowan,
2006.
Memoradum
to
Ms.
Diane
Isbell
with
USEPA
from
Elizabeth
Codrea
with
Gowan
Company,
Re:
Follow
up
to
conference
call
on
February
1,
2006.
Dated
February
12.
2006
9
Table
3.
Phosmet
Doses
Calculated
From
MRID
466823­
01
Metabolites
Recovered
in
Urine
(
mg/
24­
hour
collection)
Phosmet
Dose
Sulfonyl
Equivalents
Worker
Replicate
Day
After
Treatment
SO
Unoxidized
SI
Total
SO
Equivalents
(
Fg/
day)
Creatinine
Adjustment
Factor
Worker
Body
Weight
(
kg)
mg/
daya
mg/
kg/
exposureb
Day
0
0.427
NA
397
1.27
1.868
Day
+
1
0.181
NA
206
1.31
1.001
Day
+
2
0.097
NA
120
1.34
0.597
Day
+
3
0.042
NA
45
1.35
0.225
Worker
A
Day
+
4
0.051
NA
69
1.28
66.8
0.326
0.060
Day
0
0.727
NA
1,294
1.71
8.196
Day
+
1
0.219
NA
425
1.90
2.990
Day
+
2
0.17
NA
291
1.41
1.518
Day
+
3
0.088
NA
69
1.82
0.463
Worker
B
Day
+
4
0.111
NA
174
1.22
91.4
0.787
0.153
Day
0
1.258
NA
1,245
1.03
4.751
Day
+
1
1.442
NA
779
1.76
5.076
Day
+
2
0.701
NA
470
1.66
2.888
Day
+
3
0.208
NA
108
1.52
0.609
Worker
C
Day
+
4
0.116
0.0338
117
0.90
59.5
0.389
0.230
Day
0
0.164
NA
98
1.46
0.532
Day
+
1
0.599
NA
776
0.87
2.500
Day
+
2
0.228
NA
397
0.90
1.322
Day
+
3
0.105
NA
162
0.98
0.587
Worker
D
Day
+
4
0.095
NA
155
0.84
65
0.482
0.083
Day
0
0.582
0.0745
453
0.85
1.426
Day
+
1
1.456
NA
1,223
1.18
5.346
Day
+
2
0.556
NA
648
0.88
2.111
Day
+
3
0.374
NA
191
2.36
1.667
Worker
E
Day
+
4
0.066
NA
69
0.64
60.5
0.164
0.177
Day
0
1.626
NA
4,390
0.89
14.472
Day
+
1
0.965
NA
1,308
1.13
5.473
Day
+
2
0.467
NA
584
1.52
3.287
Day
+
3
0.284
NA
327
1.28
1.548
Worker
F
Day
+
4
0.123
NA
239
1.27
69.1
1.122
0.375
Day
0
0.235
NA
235
1.24
1.079
Day
+
1
0.234
NA
330
1.04
1.271
Day
+
2
0.061
NA
49
1.54
0.278
Day
+
3
0.041
0.0038
32
1.46
0.172
Worker
G
Day
+
4
0.065
NA
47
1.69
85.5
0.297
0.036
Worker
I
Day
0
0.464
0.0165
384
0.95
70.5
1.353
0.077
10
Table
3.
Phosmet
Doses
Calculated
From
MRID
466823­
01
Metabolites
Recovered
in
Urine
(
mg/
24­
hour
collection)
Phosmet
Dose
Sulfonyl
Equivalents
Worker
Replicate
Day
After
Treatment
SO
Unoxidized
SI
Total
SO
Equivalents
(
Fg/
day)
Creatinine
Adjustment
Factor
Worker
Body
Weight
(
kg)
mg/
daya
mg/
kg/
exposureb
Day
+
1
0.658
0.0234
697
0.94
2.427
Day
+
2
0.366
NA
329
1.22
1.489
Day
+
3
0.05
0.0057
31
1.00
0.113
Day
+
4
0.017
0.0163
17
1.13
0.070
Day
0
2.625
NA
4,082
1.11
16.782
Day
+
1
0.768
0.0273
1,531
1.00
5.671
Day
+
2
0.385
NA
789
0.99
2.894
Day
+
3
0.25
NA
520
0.92
1.772
Worker
J
Day
+
4
0.189
NA
454
0.90
72.7
1.512
0.394
Day
0
0.911
NA
1,512
1.83
10.250
Day
+
1
0.575
NA
874
1.45
4.694
Day
+
2
0.333
NA
211
2.70
2.115
Day
+
3
0.187
NA
389
0.90
1.297
Worker
L
Day
+
4
0.12
0.0068
61
1.73
64.1
0.390
0.292
Day
0
0.462
NA
624
0.84
1.941
Day
+
1
0.118
NA
71
3.46
0.907
Day
+
2
0.236
NA
179
0.82
0.545
Day
+
3
0.1
NA
102
0.64
0.242
Worker
M
Day
+
4
0.069
NA
78
0.79
47.7
0.228
0.081
Day
0
1.392
NA
1,322
1.55
7.592
Day
+
1
0.237
NA
192
2.12
1.507
Day
+
2
0.27
NA
317
2.21
2.597
Day
+
3
0.247
NA
266
1.92
1.888
Worker
N
Day
+
4
0.224
NA
260
1.25
80
1.203
0.185
Day
0
1.934
NA
1,199
1.73
7.684
Day
+
1
0.767
NA
506
2.22
4.163
Day
+
2
0.253
NA
220
1.17
0.954
Day
+
3
0.131
NA
97
1.65
0.592
Worker
O
Day
+
4
0.169
NA
128
2.13
65.5
1.013
0.220
Day
0
1.035
NA
973
2.67
9.622
Day
+
1
0.554
NA
704
1.90
4.951
Day
+
2
0.183
NA
242
3.19
2.865
Day
+
3
0.143
NA
212
1.76
1.380
Worker
P
Day
+
4
0.176
NA
248
1.86
96.4
1.710
0.213
Day
0
0.363
0.0129
372
1.54
2.123
Day
+
1
0.179
NA
179
1.84
1.220
Worker
Q
Day
+
2
0.075
NA
78
1.29
70
0.374
0.067
11
Table
3.
Phosmet
Doses
Calculated
From
MRID
466823­
01
Metabolites
Recovered
in
Urine
(
mg/
24­
hour
collection)
Phosmet
Dose
Sulfonyl
Equivalents
Worker
Replicate
Day
After
Treatment
SO
Unoxidized
SI
Total
SO
Equivalents
(
Fg/
day)
Creatinine
Adjustment
Factor
Worker
Body
Weight
(
kg)
mg/
daya
mg/
kg/
exposureb
Day
+
3
0.049
NA
49
1.57
0.282
Day
+
4
0.12
NA
128
1.42
0.675
Day
0
0.37
0.0132
408
1.72
2.600
Day
+
1
0.18
NA
194
1.76
1.261
Day
+
2
0.144
NA
151
2.38
1.333
Day
+
3
0.062
NA
84
1.78
0.552
Worker
R
Day
+
4
0.178
0.0063
122
2.65
117.7
1.194
0.059
Day
0
5.77
Day
+
1
3.15
Day
+
2
1.70
Day
+
3
0.837
Overall
Average
Day
+
4
0.723
0.169
Day
0
3.69
Day
+
1
2.58
Day
+
2
1.35
Day
+
3
0.595
Overall
Geometric
Mean
Day
+
4
0.532
0.134
Abbreviations:
SO
=
sulfonyl,
SI
=
sulfinyl
a.
Phosmet
Dose
(
mg/
day)
=
[
Total
SO
Equivalents
(
Fg/
day)
*
Molecular
Weight
Conversion
(
257/
241)
*
Creatinine
Adjustment
Factor
(
unitless)
*
Workday
Adjustment
Factor
(
1.23)
*
Unit
conversion
factor
(
1
mg/
1,000
Fg)]
/
[
Factor
1
(
95%)
*
Factor
2
(
93.5%)
*
Factor
3
(
55%)
*
Recovery
Adjustment
Factor
(
84%)]
b.
Phosmet
Dose
(
mg/
kg/
exposure)
=
3Phosmet
Dose
for
Day
0
through
Day+
4
(
mg/
day)
/
Body
weight
(
kg)
12
Table
4a.
Short­
term
(
ST)
and
Intermediate­
Term
(
IT)
Risks
for
1
lb
ai/
A
Application
Rate
MOEse,
f,
g
DATa
Total
Adjusted
Phosmet
Dose
for
2
DATGeometric
Mean
from
Table
1
(
mg/
kg/
day)
Application
Rate
in
Biomonitoring
Study
(
lb
ai/
A)
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rateb
(
mg/
kg/
day)
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
Application
Rate
in
DFR
Study
(
lb
ai/
A)
DFR
Value
Normalized
for
Application
Ratec
(
Fg/
cm2)
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFRd
(
mg/
kg/
day)
ST
IT
2
0.134
3
0.045
4.41
5
0.88
0.0263
100
25
3
0.134
3
0.045
4.13
5
0.83
0.0246
110
26
4
0.134
3
0.045
3.87
5
0.77
0.0230
120
28
5
0.134
3
0.045
3.62
5
0.72
0.0216
120
30
6
0.134
3
0.045
3.39
5
0.68
0.0202
130
32
7
0.134
3
0.045
3.17
5
0.63
0.0189
140
34
8
0.134
3
0.045
2.97
5
0.59
0.0177
150
37
9
0.134
3
0.045
2.78
5
0.56
0.0165
160
39
10
0.134
3
0.045
2.60
5
0.52
0.0155
170
42
11
0.134
3
0.045
2.43
5
0.49
0.0145
180
45
12
0.134
3
0.045
2.28
5
0.46
0.0136
200
48
13
0.134
3
0.045
2.13
5
0.43
0.0127
209
51
14
0.134
3
0.045
1.99
5
0.40
0.0119
223
55
15
0.134
3
0.045
1.87
5
0.37
0.0111
238
58
16
0.134
3
0.045
1.75
5
0.35
0.0104
255
62
17
0.134
3
0.045
1.64
5
0.33
0.0097
272
66
18
0.134
3
0.045
1.53
5
0.31
0.0091
291
71
19
0.134
3
0.045
1.43
5
0.29
0.0085
310
76
20
0.134
3
0.045
1.34
5
0.27
0.0080
332
81
21
0.134
3
0.045
1.25
5
0.25
0.0075
354
87
22
0.134
3
0.045
1.17
5
0.23
0.0070
379
93
23
0.134
3
0.045
1.10
5
0.22
0.0065
405
99
24
0.134
3
0.045
1.03
5
0.21
0.0061
432
110
a.
DAT
=
Days
after
Treatment
b.
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rate
(
mg/
kg/
day)
=
Total
Adjusted
Phosmet
Dose
for
2
DAT
(
mg/
kg/
day)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
biomonitoring
study
(
lb
ai/
A))
c.
DFR
Value
Normalized
for
Application
Rate
(
Fg/
cm2)
=
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
DFR
study
(
lb
ai/
A))
d.
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
=
Absorbed
Dose
2DAT
*
(
DFR
XDAT
/
DFR
2DAT)
e.
MOE
=
NOAEL
(
4.5
mg/
kg/
day
for
short­
term
and
1.1
for
intermediate­
term)
/
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
f.
MOEs
shown
in
bold
indicate
the
day
that
does
not
exceed
HED's
level
of
concern.
g.
ST
=
short­
term
exposures
(
 
7
days),
IT
=
intermediate­
term
exposures
exposure
durations
(>
7
but
 
30
days)
13
Table
4b.
Short­
term
(
ST)
and
Intermediate­
Term
(
IT)
Risks
for
2
lb
ai/
A
Application
Rate
MOEse,
f,
g
DATa
Total
Adjusted
Phosmet
Dose
for
2
DATGeometric
Mean
from
Table
1
(
mg/
kg/
day)
Application
Rate
in
Biomonitoring
Study
(
lb
ai/
A)
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rateb
(
mg/
kg/
day)
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
Application
Rate
in
DFR
Study
(
lb
ai/
A)
DFR
Value
Normalized
for
Application
Ratec
(
Fg/
cm2)
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFRd
(
mg/
kg/
day)
ST
IT
2
0.134
3
0.089
4.41
5
1.77
0.0893
50
12
3
0.134
3
0.089
4.13
5
1.65
0.0836
54
13
4
0.134
3
0.089
3.87
5
1.55
0.0783
58
14
5
0.134
3
0.089
3.62
5
1.45
0.0732
61
15
6
0.134
3
0.089
3.39
5
1.36
0.0685
66
16
7
0.134
3
0.089
3.17
5
1.27
0.0642
70
17
8
0.134
3
0.089
2.97
5
1.19
0.0600
75
18
9
0.134
3
0.089
2.78
5
1.11
0.0562
80
20
10
0.134
3
0.089
2.60
5
1.04
0.0526
86
21
11
0.134
3
0.089
2.43
5
0.97
0.0492
91
22
12
0.134
3
0.089
2.28
5
0.91
0.0461
98
24
13
0.134
3
0.089
2.13
5
0.85
0.0431
104
26
14
0.134
3
0.089
1.99
5
0.80
0.0404
111
27
15
0.134
3
0.089
1.87
5
0.75
0.0378
119
29
16
0.134
3
0.089
1.75
5
0.70
0.0354
127
31
17
0.134
3
0.089
1.64
5
0.65
0.0331
136
33
18
0.134
3
0.089
1.53
5
0.61
0.0310
145
36
19
0.134
3
0.089
1.43
5
0.57
0.0290
155
38
20
0.134
3
0.089
1.34
5
0.54
0.0271
166
41
21
0.134
3
0.089
1.25
5
0.50
0.0254
177
43
22
0.134
3
0.089
1.17
5
0.47
0.0238
189
46
23
0.134
3
0.089
1.10
5
0.44
0.0222
202
49
24
0.134
3
0.089
1.03
5
0.41
0.0208
216
53
25
0.134
3
0.089
0.96
5
0.39
0.0195
231
56
26
0.134
3
0.089
0.90
5
0.36
0.0182
247
60
27
0.134
3
0.089
0.84
5
0.34
0.0171
264
64
28
0.134
3
0.089
0.79
5
0.32
0.0160
282
69
29
0.134
3
0.089
0.74
5
0.30
0.0149
301
74
30
0.134
3
0.089
0.69
5
0.28
0.0140
322
79
31
0.134
3
0.089
0.65
5
0.26
0.0131
344
84
32
0.134
3
0.089
0.61
5
0.24
0.0123
367
90
33
0.134
3
0.089
0.57
5
0.23
0.0115
392
96
34
0.134
3
0.089
0.53
5
0.21
0.0107
419
102
a.
DAT
=
Days
after
Treatment
b.
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rate
(
mg/
kg/
day)
=
Total
Adjusted
Phosmet
Dose
for
2
DAT
(
mg/
kg/
day)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
biomonitoring
study
(
lb
ai/
A))
c.
DFR
Value
Normalized
for
Application
Rate
(
Fg/
cm2)
=
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
DFR
study
(
lb
ai/
A))
d.
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
=
Absorbed
Dose
2DAT
*
(
DFR
XDAT
/
DFR
2DAT)
14
e.
MOE
=
NOAEL
(
4.5
mg/
kg/
day
for
short­
term
and
1.1
for
intermediate­
term)
/
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
f.
MOEs
shown
in
bold
indicate
the
day
that
does
not
exceed
HED's
level
of
concern.
g.
ST
=
short­
term
exposures
(
 
7
days),
IT
=
intermediate­
term
exposures
exposure
durations
(>
7
but
 
30
days)
15
Table
4c.
Short­
term
(
ST)
and
Intermediate­
Term
(
IT)
Risks
for
3
lb
ai/
A
Application
Rate
MOEse,
f,
g
DATa
Total
Adjusted
Phosmet
Dose
for
2DAT
­
Geometric
Mean
from
Table
1
(
mg/
kg/
day)
Application
Rate
in
Biomonitoring
Study
(
lb
ai/
A)
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rateb
(
mg/
kg/
day)
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
Application
Rate
in
DFR
Study
(
lb
ai/
A)
DFR
Value
Normalized
for
Application
Ratec
(
Fg/
cm2)
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFRd
(
mg/
kg/
day)
ST
IT
2
0.134
3
0.134
4.41
5
2.65
0.1340
34
8.2
3
0.134
3
0.134
4.13
5
2.48
0.1254
36
8.8
4
0.134
3
0.134
3.87
5
2.32
0.1174
38
9.4
5
0.134
3
0.134
3.62
5
2.17
0.1099
41
10
6
0.134
3
0.134
3.39
5
2.03
0.1028
44
11
7
0.134
3
0.134
3.17
5
1.90
0.0962
47
11
8
0.134
3
0.134
2.97
5
1.78
0.0901
50
12
9
0.134
3
0.134
2.78
5
1.67
0.0843
53
13
10
0.134
3
0.134
2.60
5
1.56
0.0789
57
14
11
0.134
3
0.134
2.43
5
1.46
0.0738
61
15
12
0.134
3
0.134
2.28
5
1.37
0.0691
65
16
13
0.134
3
0.134
2.13
5
1.28
0.0647
70
17
14
0.134
3
0.134
1.99
5
1.20
0.0605
74
18
15
0.134
3
0.134
1.87
5
1.12
0.0567
79
19
16
0.134
3
0.134
1.75
5
1.05
0.0530
85
21
17
0.134
3
0.134
1.64
5
0.98
0.0496
91
22
18
0.134
3
0.134
1.53
5
0.92
0.0465
97
24
19
0.134
3
0.134
1.43
5
0.86
0.0435
103
25
20
0.134
3
0.134
1.34
5
0.80
0.0407
111
27
21
0.134
3
0.134
1.25
5
0.75
0.0381
118
29
22
0.134
3
0.134
1.17
5
0.70
0.0356
126
31
23
0.134
3
0.134
1.10
5
0.66
0.0334
135
33
24
0.134
3
0.134
1.03
5
0.62
0.0312
144
35
25
0.134
3
0.134
0.96
5
0.58
0.0292
154
38
26
0.134
3
0.134
0.90
5
0.54
0.0274
165
40
27
0.134
3
0.134
0.84
5
0.51
0.0256
176
43
28
0.134
3
0.134
0.79
5
0.47
0.0240
188
46
29
0.134
3
0.134
0.74
5
0.44
0.0224
201
49
30
0.134
3
0.134
0.69
5
0.41
0.0210
214
52
31
0.134
3
0.134
0.65
5
0.39
0.0196
229
56
32
0.134
3
0.134
0.61
5
0.36
0.0184
245
60
33
0.134
3
0.134
0.57
5
0.34
0.0172
262
64
34
0.134
3
0.134
0.53
5
0.32
0.0161
279
68
35
0.134
3
0.134
0.50
5
0.30
0.0151
299
73
36
0.134
3
0.134
0.46
5
0.28
0.0141
319
78
37
0.134
3
0.134
0.44
5
0.26
0.0132
341
83
38
0.134
3
0.134
0.41
5
0.24
0.0124
364
89
39
0.134
3
0.134
0.38
5
0.23
0.0116
389
95
40
0.134
3
0.134
0.36
5
0.21
0.0108
416
102
16
a.
DAT
=
Days
after
Treatment
b.
Total
Adjusted
Phosmet
Dose
for
2
Day
REI
Normalized
for
Application
Rate
(
mg/
kg/
day)
=
Total
Adjusted
Phosmet
Dose
for
2
Day
REI
(
mg/
kg/
day)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
biomonitoring
study
(
lb
ai/
A))
c.
DFR
Value
Normalized
for
Application
Rate
(
Fg/
cm2)
=
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
DFR
study
(
lb
ai/
A))
d.
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
=
Absorbed
Dose
2DAT
*
(
DFR
XDAT
/
DFR
2DAT)
e.
MOE
=
NOAEL
(
4.5
mg/
kg/
day
for
short­
term
and
1.1
for
intermediate­
term)
/
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
f.
MOEs
shown
in
bold
indicate
the
day
that
does
not
exceed
HED's
level
of
concern.
g.
ST
=
short­
term
exposures
(
 
7
days),
IT
=
intermediate­
term
exposures
exposure
durations
(>
7
but
 
30
days)
17
Table
4d.
Short­
term
(
ST)
and
Intermediate­
Term
(
IT)
Risks
for
3.75
lb
ai/
A
Application
Rate
MOEse,
f,
g
DATa
Total
Adjusted
Phosmet
Dose
for
2DAT
­
Geometric
Mean
from
Table
1
(
mg/
kg/
day)
Application
Rate
in
Biomonitoring
Study
(
lb
ai/
A)
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rateb
(
mg/
kg/
day)
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
Application
Rate
in
DFR
Study
(
lb
ai/
A)
DFR
Value
Normalized
for
Application
Ratec
(
Fg/
cm2)
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFRd
(
mg/
kg/
day)
ST
IT
2
0.134
3
0.168
4.41
5
3.31
0.1675
27
6.6
3
0.134
3
0.168
4.13
5
3.10
0.1568
29
7.0
4
0.134
3
0.168
3.87
5
2.90
0.1467
31
7.5
5
0.134
3
0.168
3.62
5
2.71
0.1373
33
8.0
6
0.134
3
0.168
3.39
5
2.54
0.1285
35
8.6
7
0.134
3
0.168
3.17
5
2.38
0.1203
37
9.1
8
0.134
3
0.168
2.97
5
2.23
0.1126
40
9.8
9
0.134
3
0.168
2.78
5
2.08
0.1054
43
10
10
0.134
3
0.168
2.60
5
1.95
0.0986
46
11
11
0.134
3
0.168
2.43
5
1.82
0.0923
49
12
12
0.134
3
0.168
2.28
5
1.71
0.0864
52
13
13
0.134
3
0.168
2.13
5
1.60
0.0809
56
14
14
0.134
3
0.168
1.99
5
1.50
0.0757
59
15
15
0.134
3
0.168
1.87
5
1.40
0.0708
64
16
16
0.134
3
0.168
1.75
5
1.31
0.0663
68
17
17
0.134
3
0.168
1.64
5
1.23
0.0620
73
18
18
0.134
3
0.168
1.53
5
1.15
0.0581
77
19
19
0.134
3
0.168
1.43
5
1.07
0.0543
83
20
20
0.134
3
0.168
1.34
5
1.01
0.0509
88
22
21
0.134
3
0.168
1.25
5
0.94
0.0476
95
23
22
0.134
3
0.168
1.17
5
0.88
0.0446
101
25
23
0.134
3
0.168
1.10
5
0.82
0.0417
108
26
24
0.134
3
0.168
1.03
5
0.77
0.0390
115
28
25
0.134
3
0.168
0.96
5
0.72
0.0365
123
30
26
0.134
3
0.168
0.90
5
0.68
0.0342
132
32
27
0.134
3
0.168
0.84
5
0.63
0.0320
141
34
28
0.134
3
0.168
0.79
5
0.59
0.0299
150
37
29
0.134
3
0.168
0.74
5
0.55
0.0280
161
39
30
0.134
3
0.168
0.69
5
0.52
0.0262
172
42
31
0.134
3
0.168
0.65
5
0.49
0.0246
183
45
32
0.134
3
0.168
0.61
5
0.45
0.0230
196
48
33
0.134
3
0.168
0.57
5
0.43
0.0215
209
51
34
0.134
3
0.168
0.53
5
0.40
0.0201
224
55
35
0.134
3
0.168
0.50
5
0.37
0.0188
239
58
36
0.134
3
0.168
0.46
5
0.35
0.0176
255
62
37
0.134
3
0.168
0.44
5
0.33
0.0165
273
67
38
0.134
3
0.168
0.41
5
0.31
0.0154
291
71
39
0.134
3
0.168
0.38
5
0.29
0.0145
311
76
18
Table
4d.
Short­
term
(
ST)
and
Intermediate­
Term
(
IT)
Risks
for
3.75
lb
ai/
A
Application
Rate
MOEse,
f,
g
DATa
Total
Adjusted
Phosmet
Dose
for
2DAT
­
Geometric
Mean
from
Table
1
(
mg/
kg/
day)
Application
Rate
in
Biomonitoring
Study
(
lb
ai/
A)
Total
Adjusted
Phosmet
Dose
for
2
DAT
Normalized
for
Application
Rateb
(
mg/
kg/
day)
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
Application
Rate
in
DFR
Study
(
lb
ai/
A)
DFR
Value
Normalized
for
Application
Ratec
(
Fg/
cm2)
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFRd
(
mg/
kg/
day)
ST
IT
40
0.134
3
0.168
0.36
5
0.27
0.0135
333
81
41
0.134
3
0.168
0.33
5
0.25
0.0127
355
87
42
0.134
3
0.168
0.31
5
0.23
0.0119
380
93
43
0.134
3
0.168
0.29
5
0.22
0.0111
406
99
44
0.134
3
0.168
0.27
5
0.21
0.0104
433
106
a.
DAT
=
Days
after
Treatment
b.
Total
Adjusted
Phosmet
Dose
for
2
Day
REI
Normalized
for
Application
Rate
(
mg/
kg/
day)
=
Total
Adjusted
Phosmet
Dose
for
2
Day
REI
(
mg/
kg/
day)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
biomonitoring
study
(
lb
ai/
A))
c.
DFR
Value
Normalized
for
Application
Rate
(
Fg/
cm2)
=
DFR
Value
from
MRID
404253­
01
(
Fg
/
cm2)
*
(
Application
rate
for
risk
assessment
(
lb
ai/
A)
/
Application
rate
in
DFR
study
(
lb
ai/
A))
d.
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
=
Absorbed
Dose
2DAT
*
(
DFR
XDAT
/
DFR
2DAT)
e.
MOE
=
NOAEL
(
4.5
mg/
kg/
day
for
short­
term
and
1.1
for
intermediate­
term)
/
Total
Phosmet
Absorbed
Dose
Adjusted
for
DFR
(
mg/
kg/
day)
f.
MOEs
shown
in
bold
indicate
the
day
that
does
not
exceed
HED's
level
of
concern.
g.
ST
=
short­
term
exposures
(
 
7
days),
IT
=
intermediate­
term
exposures
exposure
durations
(>
7
but
 
30
days)
19
