UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
August
8,2001
MEMORANDUM
SUBJECT:
Review
of
Diuron
Poisoning
Incident
Data
Chemical:
#
035505
FROM:
Ruth
H.
Allen,
Ph.
D.,
M.
P.
H.,
Environmental
Epidemiologist
Chemistry
and
Exposure
Branch
Health
Effects
Division
(
7509C)

THROUGH:
Francis
B.
Suhre,
Senior
Scientist
Chemistry
and
Exposure
Branch
1
Health
Effects
Division
(
7509C)

TO:
Diana
Locke,
Risk
Assessor
Reregistration
Branch
2
Health
Effects
Division
(
7509C)

BACKGROUND
In
response
to
the
request
that
Health
Effects
Division
Epidemiology
Group
review
the
incident
data
on
diuron,
the
following
data
bases
were
reviewed
for
the
poisoning
incident
data
on
the
active
ingredient
cacodylic
acid.

1)
OPP
Incident
Data
System
(
IDS)
­
reports
of
incidents
from
various
sources,
including
required
Federal
Insecticide
Fungicide
and
Rodenticide
Act
(
FIFRA)
Section
6
(
a)
(
2)
registrants,
other
federal
and
state
health
and
environmental
agencies
and
individual
consumers,
submitted
to
OPP
since
1992.
Reports
submitted
to
the
Incident
Data
System
represent
anecdotal
reports
or
allegations
only,
unless
otherwise
stated.
Typically
no
conclusions
can
be
drawn
implicating
the
pesticide
as
a
cause
of
any
of
the
reported
health
effects.
Nevertheless,
sometimes
with
enough
cases
and/
or
enough
documentation
risk
mitigation
measures
may
be
suggested.

2)
American
Association
of
Poison
Control
Centers
(
AAPCC)
­
as
the
result
of
Data­
Call­
Ins
issued
in
1993,
OPP
received
Poison
Control
2
Center
data
covering
the
years
1985
through
1992
for
28
organophosphate
and
carbamate
chemicals.
Most
of
the
national
Poison
Control
Centers
(
PCCs)
participate
in
a
national
data
collection
system,
the
Toxic
Exposure
Surveillance
System
which
obtains
data
from
about
70
centers
at
hospitals
and
universities.
PCCs
provide
telephone
consultation
for
individuals
and
health
care
providers
on
suspected
poisonings,
involving
drugs,
household
products,
pesticides,
etc.

3)
California
Department
of
Food
and
Agriculture
(
replaced
by
the
Department
of
Pesticide
Regulation
in
1991)
­
California
has
collected
uniform
data
on
suspected
pesticide
poisonings
since
1982.
Physicians
are
required,
by
statute,
to
report
to
their
local
health
officer
all
occurrences
of
illness
suspected
of
being
related
to
exposure
to
pesticides.
The
majority
of
the
incidents
involve
workers.
Information
on
exposure
(
worker
activity),
type
of
illness
(
systemic,
eye,
skin,
eye/
skin
and
respiratory),
likelihood
of
a
causal
relationship,
and
number
of
days
off
work
and
in
the
hospital
are
provided.

4)
National
Pesticide
Telecommunications
Network
(
NPTN)
­
NPTN
is
a
toll­
free
information
service
supported
by
OPP.
A
ranking
of
the
top
200
active
ingredients
for
which
telephone
calls
were
received
during
calendar
years
1984­
1991,
inclusive
has
been
prepared.
The
total
number
of
calls
was
tabulated
for
the
categories
human
incidents,
animal
incidents,
calls
for
information,
and
others.

DIURON
REVIEW
I.
Incident
Data
System(
IDS)

II.
American
Association
of
Poison
Control
Centers
(
AAPCC)

For
the
reporting
period
1993­
1996,

III.
California
Pesticide
Illness
Surveillance
Program
Case
reports
are
described
in
investigation
by
the
Worker
Health
and
Safety
Branch
or
the
Department
of
Pesticide
Regulations
of
the
California
Environmental
Protection
Agency.

IV.
National
Pesticide
Telecommunication
Network
(
NPTN)

In
the
1984­
1991
inclusive
NPTN
ranking
of
the
top
200
active
