August
9,
2001
MEMORANDUM
SUBJECT:
Addendum
to
the
Revised
Residential
Exposure
Assessment
and
Recommendations
for
the
Reregistration
Eligibility
Decision
Document
for
Disulfoton.
D276829.

FROM:
Christina
Jarvis,
Environmental
Protection
Specialist
Reregistration
Branch
2
Health
Effects
Division
(
7509C)

THROUGH:
Alan
Nielsen,
Branch
Senior
Scientist
Reregistration
Branch
2
Health
Effects
Division
(
7509C)

TO:
Christina
Scheltema
Reregistration
Branch
3
Special
Review
and
Reregistration
Division
(
7508W)

Attached
please
find
the
revised
Tables
4
and
5
for
the
disulfoton
residential
risk
assessment
chapter.
These
tables
supercede
tables
4
and
5
from
the
May
31,
2001
document
titled
 
Revised
Residential
Exposure
Assessment
And
Recommendations
For
The
Reregistration
Eligibility
Decision
Document
For
Disulfoton
 
(
(
S.
Recore
and
C.
Jarvis
memo,
D275170)
.
The
only
changes
in
these
tables
are
the
correction
of
the
inhalation
unit
exposure
value
for
the
Bayer
Advanced
Garden
2­
in­
1
Systemic
Rose
and
Flower
Care
®
from
0.013
F
g/
lbs
ai
to
13
F
g/
lbs
ai
and
the
corresponding
inhalation
risk
values.

Short­
term
inhalation
MOEs
and
total
short­
term
MOEs
associated
with
the
use
of
Bayer
Advanced
Garden
2­
in­
1
Systemic
Rose
and
Flower
Care
®
are
still
considered
to
be
above
the
Agency
 
s
level
of
concern
(
MOEs
>
100)
.
Table
4:
Residential
Handler
Dermal
and
Inhalation
Exposures
to
Disulfoton
at
Baseline
Exposure
Scenario
(
Scenario
#
)
Baseline
Dermal
Unit
Exposure
(
mg/
lb
ai)
a
Baseline
Inhalation
Unit
Exposure
(
F
g/
lb
ai)
b
Maximum
Application
Rate
c
Crop
Type
or
Target
d
Amount
Handled
Per
Day
e
Daily
Dermal
Exposure
(
mg/
day)
f
Daily
Inhalation
Exposure
(
mg/
day)
g
Mixer/
Loader/
Applicator
Exposure
Loading/
applying
granulars
using
a
belly
grinder
(
1)
110
62
0.3
lb
ai/
1000
ft
2
Flower
Gardens
(
pre­

planting)
1,000
ft
2
33
0.019
0.069
lb
ai/
1000
ft
2
Vegetable
Gardens
(
pre­
planting)
1,000
ft
2
7.8
0.
0043
Loading/
applying
granulars
using
a
push­
type
spreader
(
2)
0.68
0.91
0.069
lb
ai/
1000
ft
2
Vegetable
Gardens
1,
000
ft
2
0.047
6.3E­
5
0.3
lb
ai/
1000
ft
2
Flower
Gardens
1,
000
ft
2
0.20
2.7E­
4
0.01
lb
ai/
4
ft
shrub
Ornamental
Shrubs
25
shrubs
0.17
2.3E­
4
0.0013
lb
ai/
bush
Roses
50
bushes
0.043
5.7E­
4
Table
4:
Residential
Handler
Dermal
and
Inhalation
Exposures
to
Disulfoton
at
Baseline
(
continued)

Exposure
Scenario
(
Scenario
#
)
Baseline
Dermal
Unit
Exposure
(
mg/
lb
ai)
a
Baseline
Inhalation
Unit
Exposure
(
F
g/
lb
ai)
b
Maximum
Application
Rate
Crop
Type
or
Target
d
Amount
Handled
Per
Day
e
Daily
Dermal
Exposure
(
mg/
day)
f
Daily
Inhalation
Exposure
(
mg/
day)
g
Loading/
applying
granulars
using
a
spoon,
measuring
scoop,
shaker
can
or
by
hand
(
3)
3.5
0.
045
0.069
lb
ai/
1,000
ft
2
Vegetable
Gardens
1,
000
ft
2
0.24
3.1E­
6
0.3
lb
ai/
1000
ft
2
Flower
Gardens
1,
000
ft
2
1.04
1.4E­
5
0.01
lb
ai/
4
ft
shrub
Ornamental
Shrubs
25
shrubs
0.86
1.1E­
5
0.00034
lb
ai/
6"
pot
Potted
Plant
20
pots
0.
023
3.0E­
7
0.0013
lb
ai/
bush
Roses
50
bushes
0.22
2.8E­
6
Loading/
applying
Bayer
Advanced
Garden
2­
in­
1
Systemic
Rose
and
Flower
Care
®
Disulfoton
1%
%

granulars
using
a
measuring
cup/
lid
(
4)
0.03
13
0.21
lb
ai/
1000
ft
2
Flowerbeds
1,000
ft
2
0.0063
2.7E­
3
0.092
13
0.01
lb
ai/
4
ft.
bush
Shrubs
25
0.023
3.3E­
3
0.092
13
0.0013
lb
ai/
bush
Roses
50
bushes
0.
0060
8.5E­
4
Application
of
insecticidal
spikes
(
5)
No
Data
No
Data
No
Data
No
Data
No
Data
No
Data
No
Data
Table
4:
Residential
Handler
Dermal
and
Inhalation
Exposures
to
Disulfoton
at
Baseline
(
continued)

Footnotes:
a
Baseline
Dermal
Unit
Exposure
represents
short
pants,
short
sleeved
shirt,
no
gloves,
and
open
mixing/
loading.

b
Baseline
Inhalation
Exposure
represents
no
respirator.

c
Application
Rates
are
maximum
rate
values
found
on
disulfoton
labels
(
EPA
Reg.
No.
4­
153,
3125­
517,
7401­
323,
8660­
191,
9404­
3,
46260­
2,
46260­
12,
46260­
35)
.

d
Crop
Type
or
Target
provides
a
general
description
of
the
intended
uses
of
disulfoton.
Separate
categories
are
presented
because
of
the
distinct
differences
in
application
rates
and
amount
handled.

e
Daily
Amount
Handled
values
are
default
estimates
from
Exposure
SAC
Policy
12,
or
the
best
professional
judgement
of
square
footage,
or
number
of
bushes,
shrubs,
or
pots
that
could
be
treated
in
a
single
day
for
each
exposure
scenario.
12
f
Daily
Dermal
Exposure
(
mg/
day)
=
Unit
Exposure
(
mg/
lb
ai)
*
Appl.
rate
*
Amount
Handled
per
day.

g
Daily
Inhalation
Exposure
(
mg/
day)
=
Unit
Exposure
(
µ
g/
lb
ai)
*
(
1mg/
1000
µ
g)
Conversion
*
Application
Rate
(
lb
ai/
A)
*
Acres
treated
(
acres/
day)
.

h
Residential
application
of
disulfoton
using
a
belly
grinder
are
applicable
for
pre­
plant
treatment
applications
only.

I
Unit
exposure
data
for
application
of
granules
by
hand
were
used
as
surrogate
values
for
these
scenarios.

j
Application
rates
for
small
vegetable
gardens
are
based
on
38­
inch
row
spacing
(
EPA
Reg.
No.
7401­
323)
.
Table
5:
Residential
Handler
Short­
term
Risks
from
Disulfoton
at
Baseline
Exposure
Scenario
(
Scenario
#
)
Crop
Type
or
Target
a
Amount
Handled
Per
Day
b
Maximum
Application
Rate
Baseline
Dermal
Baseline
Inhalation
Baseline
Total
Daily
Dose
(
mg/
kg/
day)

c
Short
term
MOE
d
Daily
Dose
(
mg/
kg/
day)
e
Short
term
MOE
f
Short­
term
MOE
g
Mixer/
Loader/
Applicator
Risks
Loading/
applying
granulars
using
a
belly
grinder
(
1)
Flower
Gardens
(
pre­

planting)
1,000
ft
2
0.3
lb
ai/
1000
ft
2
0.47
1.1
2.
7E­
4
170
1.1
Vegetable
Gardens
(
pre­
planting)
1,000
ft
2
0.069
lb
ai/
1000
ft
2
0.11
4.6
6.
1E­
5
740
4.6
Loading/
applying
granulars
using
a
push­
type
spreader
(
2)
Vegetable
Gardens
1,
000
ft
2
0.069
lb
ai/
1,000
ft
2
h
6.7E­
4
750
1.0E­
6
5.0E4
740
Flower
Gardens
1,
000
ft
2
0.3
lb
ai/
1,000
ft
2
0.0029
172
4.0E­
6
1.2E4
170
Ornamental
Shrubs/

Small
Trees
25
shrubs
0.01
lb
ai/
4
ft.
shrub
0.
0024
210
3.0E­
6
1.4E4
200
Roses
50
bushes
0.
00126
lb
ai/
bush
6.
1E­
4
820
1.0E­
6
5.5E4
810
Table
5:
Residential
Handler
Short­
term
Risks
from
Disulfoton
at
Baseline
(
continued)

Exposure
Scenario
(
Scenario
#
)
Crop
Type
or
Target
a
Amount
Handled
Per
Day
b
Maximum
Application
Rate
Baseline
Dermal
Baseline
Inhalation
Baseline
Total
Daily
Dose
(
mg/
kg/
day)
c
Short
term
MOE
d
Daily
Dose
(
mg/
kg/
day)
e
Short
term
MOE
f
Short­
term
MOE
g
Mixer/
Loader/
Applicator
Risks
Loading/
applying
granulars
using
a
spoon,
measuring
scoop,
shaker
can
or
by
hand
(
3)
Vegetable
Gardens
1,
000
ft
2
0.069
lb
ai/
1,000
ft
2
h
0.0034
150
4.4E­
8
1.0E6
150
Flower
Gardens
1,
000
ft
2
0.3
lb
ai/
1,000
ft
2
0.015
34
1.9E­
7
2.3E5
34
Ornamental
Shrubs/

Small
Trees
25
shrubs
0.01
lb
ai/
4
ft.
shrub
0.
012
41
1.6E­
7
2.8E5
41
Potted
Plants
20
pots
0.
00034
lb
ai/
6"
pot
3.3E­
4
1500
4E­
9
1.0E7
1500
Roses
50
bushes
0.
00126
lb
ai/
bush
0.
0031
160
4.1E­
8
1.1E6
160
Table
5:
Residential
Handler
Short­
term
Risks
from
Disulfoton
at
Baseline
(
continued)

Exposure
Scenario
(
Scenario
#
)
Crop
Type
or
Target
a
Amount
Handled
Per
Day
b
Maximum
Application
Rate
Baseline
Dermal
Baseline
Inhalation
Baseline
Total
Daily
Dose
(
mg/
kg/
day)
c
Short
term
MOE
d
Daily
Dose
(
mg/
kg/
day)
e
Short
term
MOE
f
Short­
term
MOE
g
Mixer/
Loader/
Applicator
Risks
Loading/
applying
Bayer
Advanced
Garden
2­
in­
1
Systemic
Rose
and
Flower
Care
®

Disulfoton
1%

granulars
using
a
measuring
cup/
lid
(
4)
Flowerbeds
1000
ft
2
0.21
lb
ai/
1000
ft
2
9.0E­
5
5600
3.9E­
5
1.2E3
960
Shrubs
25
shrubs
0.01
lb
ai/
4
ft
shrub
3.
3E­
4
1500
4.6E­
5
9.7E2
490
Roses
50
bushes
0.
0013
lb
ai/
bush
9.
0E­
5
5900
1.2E­
5
3.7E3
1900
Application
of
insecticidal
spikes
(
5)
Roses/
Trees
No
Data
No
Data
No
Data
No
Data
No
Data
No
Data
No
Data
Footnotes:
a
Crop
Type
or
Target
provides
a
general
description
of
the
intended
use
of
various
products
containing
disulfoton.
Separate
categories
are
presented
because
of
the
distinct
differences
in
application
rates
and
acres
treated.

b
Amount
Handled
Per
Day
values
are
from
default
estimates
of
square
footage
or
number
of
bushes,
shrubs,
or
pots
treated
a
single
day
for
each
exposure
scenario
of
concern.
Daily
Dermal
Dose
(
mg/
kg/
day)
=
Daily
Dermal
Exposure
(
mg/
day)
/
Body
weight
(
70
kg)
.

d
Short­
term
Dermal
MOE
=
NOAEL
(
0.5
mg/
kg/
day)
/
Daily
Dermal
Dose
(
mg/
kg/
day)
.

e
Daily
Inhalation
Dose
(
mg/
kg/
day)
=
Daily
Inhalation
Exposure
(
mg/
day)
/
Body
weight
(
70
kg)
.

f
Short­
term
Inhalation
MOE
=
NOAEL
(
0.045
mg/
kg/
day)
/
Daily
Inhalation
Dose
(
mg/
kg/
day)
.

g
Total
Short­
term
MOE
=
1/
[
(
1/
Short­
term
Dermal
MOE)
+
(
1/
Short­
term
Inhalation
MOE)
]
.

h
Application
rates
for
small
vegetable
gardens
are
based
on
38­
inch
row
spacing
(
EPA
Reg
No.
7401­
323)
.

c
