Determination of an AEL for HFO-1234ze (Consumers)

Recommended AEL: 		180 ppm				

	

Basis and

Endpoints: 	Hematology and clinical chemistry changes,
inflammation/vacuolation of heart muscle

Study: 	Sub-acute (4-week) inhalation toxicity study, including
Unscheduled DA Synthesis and Micronucleus test, with HFO-1234ze in rats
(TNO, 2006)

Protocol:	Nose-only inhalation, 6 hours/day, 5 days/week for 4 weeks 

Concentrations:			0, 1,000, 5,000, 10,000 and 15,000 ppm

NOAEC:			10,000 ppm

LOAEC:			15,000 ppm

HEC]: 				1800 (10,000 x 6/24 x 5/7) 

Uncertainty Factors:	10 (composite factor of 3 for animal-to-human
extrapolation and 3 for intrahuman variability)



