Determination of an AEL for HFO-1234ze (Occupational Workers)

Recommended AEL: 		375 ppm (8-hour Time Weighted Average)				

	

Basis and

Endpoints: 	Hematology and clinical chemistry changes, mononuclear
infiltration of heart tissue

Study: 	Sub-chronic (13-week) inhalation toxicity study with HFO-1234ze
in rats (TNO, 2008)

Protocol:	Nose-only inhalation, 6 hours/day, 5 days/week for 13 weeks 

Concentrations:			0, 1,500, 5,000 and 15,000 ppm

NOAEC:			5,000 ppm

LOAEC:			15,000 ppm

HEC]: 				3750 (5000 x 6/8) 

Uncertainty Factors:	10 (composite factor of 3 for animal-to-human
extrapolation and 3 for lack of reproductive and developmental study in
the database)



